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26-07-2023 | Gastric Cancer | Original Paper

Effect of physical activity on incidence and mortality in patients with gastric cancer: evidence from real-world studies

Authors: Shaodi Ma, Haixia Liu, Chenyu Sun, Muzi Meng, Guangbo Qu, Yuemeng Jiang, Birong Wu, Juan Gao, Linya Feng, Peng Xie, Weihang Xia, Yehuan Sun

Published in: Cancer Causes & Control | Issue 12/2023

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Abstract

Purpose

Physical activity (PA) has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between PA and the risk of developing gastric cancer (GC). The purpose of this study was to evaluate the impact of PA on the incidence and mortality risk of GC through a meta-analysis, as well as investigate potential dose-response relationships.

Methods

A systematic literature search was conducted in 10 electronic databases and 4 registries. The combined relative risks (RRs) were calculated using a random-effects model with 95% confidence interval (CIs) to assess the effect of PA on the risk of GC. Relevant subgroup analyses and sensitivity analyses were performed.

Results

The results showed that PA correlated with lower incidence of GC (RR: 0.83, 95% CI: 0.77–0.90), decreased risk of GC mortality (RR: 0.76, 95% CI: 0.66–0.89). The results of the subgroup analysis showed that PA was associated with reduced incidence of GC across gender, different regions, study designs, different sites of GC and different types of PA. A linear relationship was found for frequency of PA.

Conclusions

This meta-analysis found that PA was associated with a reduced risk of GC incidence and mortality. The correlation between PA and GC occurrence was in a dose-response relationship.
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Metadata
Title
Effect of physical activity on incidence and mortality in patients with gastric cancer: evidence from real-world studies
Authors
Shaodi Ma
Haixia Liu
Chenyu Sun
Muzi Meng
Guangbo Qu
Yuemeng Jiang
Birong Wu
Juan Gao
Linya Feng
Peng Xie
Weihang Xia
Yehuan Sun
Publication date
26-07-2023
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 12/2023
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-023-01763-2

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