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Open Access 25-04-2024 | Gastric Cancer | Case Report

A gastric invasive tubular adenocarcinomatous lesion arising from foveolar-type neoplasia: molecular histogenesis

Authors: Tamotsu Sugai, Noriyuki Uesugi, Koichi Hamada, Takayuki Nagahashi, Yoshinori Horikawa, Masamichi Suzuki, Ryo Sugimoto, Naoki Yanagawa

Published in: Clinical Journal of Gastroenterology

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Abstract

Here, we report a rare case of a depressed lesion exhibiting both tubular differentiated adenocarcinomatous (TDA) and intraepithelial foveolar neoplasia (IFN) components (with the histological appearance of foveolar hyperplasia due to low-grade atypia). Histologically, the TDA surrounded the IFN, suggesting that the TDA may have originated from the IFN. Therefore, we examined molecular alterations in the TDA and IFN components separately. MUC5AC and MUC6 expression was observed immunohistochemically in both components. p53 expression was wild type in both components, suggesting no mutation of TP53. We investigated allelic imbalances at multiple loci (1p, 3p, 4p, 5q, 8q, 9p, 13q, TP53, 18q, and 22q), mutations (KRAS, BRAF, and GNAS), and DNA methylation and microsatellite status in both components using PCR-based analyses. Although multiple allelic imbalances were common to both components, allelic imbalances at 3p and TP53 were found only in the TDA component. No mutations were found, and DNA methylation status was low epigenotype for both components. Ultimately, this tumor was considered microsatellite stable. Considering the origin of TDA, which is frequently encountered in routine practice, IFN may develop into TDA.
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Metadata
Title
A gastric invasive tubular adenocarcinomatous lesion arising from foveolar-type neoplasia: molecular histogenesis
Authors
Tamotsu Sugai
Noriyuki Uesugi
Koichi Hamada
Takayuki Nagahashi
Yoshinori Horikawa
Masamichi Suzuki
Ryo Sugimoto
Naoki Yanagawa
Publication date
25-04-2024
Publisher
Springer Nature Singapore
Published in
Clinical Journal of Gastroenterology
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-024-01974-3
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