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Open Access 01-06-2025 | Research

Financial toxicity amongst cancer patients and survivors: a comparative study of the United Kingdom and United States

Authors: Tran Thu Ngan, Emily Tonorezos, Michael Donnelly, Ciaran O’Neill

Published in: Supportive Care in Cancer | Issue 6/2025

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Abstract

Background

The study investigated the experiences of financial toxicity (FT) amongst cancer patients/survivors in the United Kingdom (UK) and the United States (USA/US).

Methods

Six hundred cancer patients/survivors residing in the UK (n = 319) or USA/US (n = 281) completed an online cross-sectional survey using the COmprehensive Score for financial Toxicity (COST)—a validated measure of FT. Severity of FT was defined as ‘no’ (COST scores ≥ 26), ‘mild’ (14–25), and ‘moderate/severe’ (0–13).

Results

Thirty-four percent of UK participants faced FT which was significantly lower compared to the USA/US at 55% (crude OR = 2.44, 95% CI 1.73–3.42). An ordered logistic regression model showed that in the USA/US, being 65 + years old (adjusted OR = 0.19, 95% CI 0.07–0.48), retired (aOR = 0.26, 95% CI 0.09–0.75), and having a higher household income (aOR ranged 0.03–0.19) decreased the risk of FT, whilst being female increased the risk (aOR = 1.83, 95% CI 1.01–3.32). In the UK, age and sex did not have an effect, but higher income and being retired showed an identical pattern compared to the US.

Conclusions

FT was less prevalent and less severe in the UK, compared to the USA/US. The high prevalence of FT underscores the need to provide an additional level of protection to the most vulnerable groups than is currently offered in either country.
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Metadata
Title
Financial toxicity amongst cancer patients and survivors: a comparative study of the United Kingdom and United States
Authors
Tran Thu Ngan
Emily Tonorezos
Michael Donnelly
Ciaran O’Neill
Publication date
01-06-2025
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 6/2025
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-025-09568-6

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