Issue 1/2025
Content (37 Articles)
Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial
- Open Access
- Acute Myeloid Leukemia
- Research
Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang
Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia
- Open Access
- Acute Lymphoblastic Leukemia
- Research
Tingting Yang, Yetian Dong, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Jiazhen Cui, Simao Huang, Guoqing Wei, Delin Kong, Jia Geng, Alex H. Chang, He Huang, Yongxian Hu
A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma
- Open Access
- Osimertinib
- Research
Dantong Sun, Helei Hou, Feiyue Feng, Weizheng Wu, Jingyu Tan, Tongji Xie, Jiayu Liu, Jinsong Wang, Haili Qian, Junling Li, Puyuan Xing
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
- Open Access
- Review
Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu, Yuan Gao, Jing Luo, Zhihua Wang, Jing Wang, Le Li
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
- Open Access
- Research
Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
- Open Access
- Rituximab
- Research
Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu
Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion
- Open Access
- Correspondence
Meiling Zhou, Kaishan Luo, Chao Su, Yan Sun, Zuyan Huang, Shuo Ma, Xun Gao, Jiwei Wang, Chen Zhang, Pengcheng Han, Guoqiu Wu
Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics
- Open Access
- Biomarkers
- Review
Songting Shou, Ayidana Maolan, Di Zhang, Xiaochen Jiang, Fudong Liu, Yi Li, Xiyuan Zhang, En Geer, Zhenqing Pu, Baojin Hua, Qiujun Guo, Xing Zhang, Bo Pang
EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes
- Open Access
- Myelodysplastic Syndrome
- Correspondence
Qi Zhang, Yingwan Luo, Li Ye, Yuxia Wang, Lu Wang, Wenli Yang, Wei Lang, Shuanghong Zhu, Lingxu Jiang, Weimei Jin, Chen Mei, Xinping Zhou, Yanling Ren, Liya Ma, Gaixiang Xu, Bowatte Gedara Lakmal Vimukthi Bandara Bowattage, Hongyan Tong, Jie Sun
A non-conditioned bone marrow transplantation mouse model to study clonal hematopoiesis and myeloid malignancies
- Open Access
- Conditioning
- Correspondence
Sofia Bentivegna, Marwa Almosailleakh, Lin-Pierre Zhao, Mikkel Bruhn Schuster, Sébastien Benquet, Alexander Balhuizen, Helga Fibiger Munch-Petersen, Lene Dissing Sjö, Mads Hald Andersen, Nicolas Dulphy, Bo Porse, Kirsten Grønbæk
Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects
- Open Access
- Cancer Therapy
- Review
Zhe Cheng, Huichao Huang, Meilong Yin, Huaizheng Liu
Targeting secretory autophagy in solid cancers: mechanisms, immune regulation and clinical insights
- Open Access
- Review
Xinyu Li, Haiying Zhao
Distinct response to IL-1β blockade in liver- and lung-specific metastasis mouse models of pancreatic cancer with heterogeneous tumor microenvironments
- Open Access
- Metastasis
- Research
Sophia Y. Chen, Heng-Chung Kung, Birginia Espinoza, India Washington, Kai Chen, Kaiyi Mu, Haley Zlomke, Michael Loycano, Rulin Wang, William R. Burns, Juan Fu, Lei Zheng
CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells
- Open Access
- Chronic Myeloid Leukemia
- Research
Jiang Guoyun, Qin Yuefeng, Huang Zhenglan, Yuan Zuowei, Zhou Hongyan, Yuan Ying, Feng Wenli
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
- Open Access
- Acute Myeloid Leukemia
- Research
Mingyue Yao, Wenzhong Yan, Yafang Wang, Yu Zhao, Xiaowei Xu, Yujun Chen, Chengcheng Yu, Yingnian Li, Hualiang Jiang, Jie Shen, Jianjun Cheng, Chengying Xie
Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction
- Open Access
- Glioblastoma
- Research
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu
The CD64/CD28/CD3ζ chimeric receptor reprograms T-cell metabolism and promotes T-cell persistence and immune functions while triggering antibody-independent and antibody-dependent cytotoxicity
- Open Access
- Head and Neck Cancer
- Research
Sara Caratelli, Francesca De Paolis, Domenico Alessandro Silvestris, Silvia Baldari, Illari Salvatori, Apollonia Tullo, Giulia Lanzilli, Aymone Gurtner, Alberto Ferri, Cristiana Valle, Simona Padovani, Valeriana Cesarini, Tommaso Sconocchia, Loredana Cifaldi, Roberto Arriga, Giulio Cesare Spagnoli, Soldano Ferrone, Adriano Venditti, Piero Rossi, Graziano Pesole, Gabriele Toietta, Giuseppe Sconocchia
Molecular profiling of skin cells identifies distinct cellular signatures in radiation-induced skin injury across various stages in the murine dataset
- Open Access
- Radiotherapy
- Research
Hongxuan Yu, Tao Zhong, Ying Xu, Zengfu Zhang, Jiachun Ma, Jupeng Yuan, Minglei Wang, Meng Wu, Jinming Yu, Yuequn Ma, Dawei Chen
Alcohol accelerates the development of esophageal squamous cell carcinoma through elevated Gram-negative bacteria in peripheral circulation
- Open Access
- Correspondence
Zehua Zhang, Le Kang, Yanfen Gu, Zhuyun Leng, Tao Chen, Meidong Xu
Bridging therapy with histotripsy prior to liver transplantation for hepatocellular carcinoma: a first case report
- Open Access
- Hepatocellular Carcinoma
- Correspondence
Melis Uysal, Chase J Wehrle, Christopher Coppa, Suneel Kamath, Smitha Krishnamurthi, Charles Martin, Mohamed El Hag, Mazhar Khalil, Masato Fujiki, Andrea Schlegel, Charles Miller, Koji Hashimoto, Federico Aucejo, David CH Kwon, Jaekeun Kim
Suppression of CYLD by HER3 confers ovarian cancer platinum resistance via inhibiting apoptosis and by inducing drug efflux
- Open Access
- Ovarian Cancer
- Research
Ye Zhang, Jian-Ge Qiu, Wei Wang, Fan-Li Sun, Xue Wang, Wen-Jing Liu, Xiao-Yu Jia, Hongbin Ji, Lin Wang, Bing-Hua Jiang
A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche
- Open Access
- Research
Hussein Ghamlouch, Dylan C. Gagler, Patrick Blaney, Eileen M. Boyle, Yubao Wang, Jason Avigan, Jinyoung Choi, Ola Landgren, Aristotelis Tsirigos, Francesco Maura, Gareth J. Morgan, Faith E. Davies
TET2 downregulation enhances the antitumor efficacy of CD19 CAR T cells in a preclinical model
- Open Access
- CAR T-Cell Therapy
- Correspondence
Yeongrin Kim, Moonjung Jeun, Heung Kyoung Lee, Ji U Choi, Simon Park, Chi Hoon Park
Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions
- Open Access
- Gefitinib
- Research
Munkyung Choi, Yong June Choi, Young Joo Lee, Yujeong Lee, Jin-Haeng Chung, Keon Wook Kang
IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism
- Open Access
- Acute Myeloid Leukemia
- Research
Fenli Zhang, Zhiheng Li, Fang Fang, Yixin Hu, Zhixu He, Yanfang Tao, Yizhen Li, Zimu Zhang, Bi Zhou, Ying Yang, Yumeng Wu, Yijun Wu, Zhongling Wei, Ailian Guo, Ling Xu, Yongping Zhang, Xiaolu Li, Yan Li, Chunxia Yang, Man Zhou, Jian Pan, Shaoyan Hu, Xiaoyan Yang
TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors
- Open Access
- Solid Tumor
- Research
Sheng Zhu, Zhengyang Zhou, Ruixin Gu, Zixin Zhao, Yingfeng Zhang, Yudi Miao, Qi Lei, Tianxing Liu, Guokai Wang, Chenyi Dai, Yi Huo, Jinghao You, Lejun Lv, Cheng Li, Ming Yin, Chengyan Wang, Hongkui Deng
Mesothelin-targeted CAR-T cells secreting NKG2D-BiTEs exhibit potent efficacy against triple-negative breast cancer
- Open Access
- Breast Cancer
- Correspondence
Muhammad Auwal Saliu, Qi Wang, Mansur Dabai Salisu, Yuanfeng Ren, Pengchao Zhang, Rabiatu Bako Suleiman, Bingbing Cao, Yiqiao Xu, Xudong Liu, Frederic Lluis, Maoxuan Liu, Xiaochun Wan
CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy
- Open Access
- Correspondence
Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan
Ibrutinib and acalabrutinib use and risk of incident atrial fibrillation: a propensity-matched analysis
- Open Access
- Acalabrutinib
- Correspondence
Joachim Alexandre, Jonaz Font, Thibault Lenormand, Sylvain Chantepie, Hippolyte Bardet, Gandhi Damaj, Charles Dolladille, Damien Legallois, Angélique Da-Silva, Paul Milliez, Arnaud Bisson, Laurent Fauchier
Matching-adjusted indirect comparison of efficacy and safety of lisocabtagene maraleucel and mosunetuzumab for the treatment of third-line or later relapsed or refractory follicular lymphoma
- Open Access
- CAR T-Cell Therapy
- Research
Loretta J. Nastoupil, Ashley Bonner, Pearl Wang, Lamees Almuallem, Jigar Desai, Thalia Farazi, Jinender Kumar, Saurabh Dahiya
Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage
- Open Access
- Acute Myeloid Leukemia
- Correspondence
Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik, Randi Olsen, Lorena Arranz
Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies
- Open Access
- Metastasis
- Review
Mengqi Lv, Yefei Huang, Yansu Chen, Kun Ding
Development of a bispecific antibody–drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors
- Open Access
- Solid Tumor
- Research
Meiying Luo, Xiaohuan Wang, Guoji Yu, Jing Ji, Long Li, Fan Song
Exosomal PD-L1 and lactate versus tissue PD-L1 as biomarkers for clinical outcomes of PD-1 Blockade plus chemotherapy in metastatic esophagogastric signet ring cell carcinoma
- Open Access
- Cytostatic Therapy
- Correspondence
Yuanyuan Tian, Wei Shi, Jing Wang, Wenjie Zhang, Lingling Xia, Lijuan Gao, Hu Qiu, Zhenhua Yu, Yongfeng Zhang, Yongshun Chen
Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer
- Open Access
- Lung Cancer
- Research
Jingsheng Cai, Zheng Liu, Shaoyi Chen, Jingwei Zhang, Haoran Li, Xun Wang, Feng Yang, Shaodong Wang, Xiao Li, Yun Li, Kezhong Chen, Jun Wang, Ming Sun, Mantang Qiu
Efficacy and safety of immune checkpoint inhibitors in metastatic penile squamous cell carcinoma: a retrospective multicenter analysis
- Open Access
- Checkpoint Inhibitors
- Correspondence
Timothy Schieber, Kelly Brunk, Anna Clennon, Benjamin L. Woolbright, Leonidas E. Bantis, Dennis Grauer, Tiewei Cheng, Saqib Abbasi, Elizabeth Wulff-Burchfield, Rahul Parikh, Haoran Li
Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy
- Open Access
- Review
Qiongjie Hu, Yueli Shi, Huang Wang, Liuwen Bing, Zhiyong Xu
