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Open Access 16-05-2024 | Invited Review

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status

Authors: Gökhan İpekoğlu, Necdet Apaydın, Tuğba Çetin, Ahsen Nur Eren, Pelinsu Topçu, Büşra Yücelsoy, Güngör Civelek, Mert Sakar

Published in: European Journal of Applied Physiology | Issue 7/2024

Abstract

Purpose

Genetic factors are important in terms of athletic performance. Recent studies to determine the relationship between the genes that lead to physiological responses have attracted attention. In this respect, this meta-analysis study was designed to examine the relationship between genetic polymorphism (BDKRB2 rs5810761, GNB3 rs5443, HIF1A rs11549565, MCT1 rs1049434, NOS3 rs2070744) and endurance athlete’s status.

Methods

The search included studies published from 2009 to 2022. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned. Only case-control studies were included in the meta-analysis. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned, and a total of 31 studies met the criteria for inclusion in the meta-analysis. Relevant data from the included studies were collected and analyzed using a random effects or fixed effects model. The effect size was calculated as the odds ratio or a risk ratio the corresponding 95% confidence intervals.

Results

According to the results of the analysis, BDKRB2 rs5810761 + 9 allele, and NOS3 rs2070744 T allele were significantly more prevalent in endurance athletes (p < 0.05). Genotype distributions of BDKRB2 rs5810761, MCT1 rs1049434, and NOS3 rs2070744 showed significant differences in the dominant model (p < 0.05). However, no significant association was found between endurance athlete status and GNB3 rs5443 and HIF1A rs11549465 polymorphisms.

Conclusion

These results show that some gene polymorphisms play an important role in endurance athlete status and suggest that having a specific genetic basis may also confer a physiological advantage for performance.

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Title: Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status
Authors: Gökhan İpekoğlu
Necdet Apaydın
Tuğba Çetin
Ahsen Nur Eren
Pelinsu Topçu
Büşra Yücelsoy
Güngör Civelek
Mert Sakar
Publication date: 16-05-2024
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 7/2024
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-024-05498-z

EASD 2024

Springer Medicine

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status

Abstract

Purpose

Methods

Results

Conclusion

EASD 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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