Skip to main content
Top

05-03-2025 | Esophagus Resection

Post-esophagectomy hiatal hernia following minimally invasive esophagectomy in esophageal cancer patients

Authors: Thitiporn Chobarporn, Alia P. Qureshi, John G. Hunter, Stephanie G. Wood

Published in: Surgical Endoscopy

Login to get access

Abstract

Introduction

Minimally invasive esophagectomy (MIE) has emerged as the preferred surgical method for esophageal cancer resulting from lower morbidity rates for MIE compared to open surgery. However, post-esophagectomy hiatal hernia (PEHH), also known as paraconduit hernia, once rare, is now increasingly observed as a late complication. This study aims to ascertain the prevalence, predictive factors, and surgical management of PEHH following MIE in esophageal cancer patients.

Methods

We retrospectively reviewed esophageal cancer patients who underwent MIE between 2013 and 2023. Patients with PEHH were identified through clinical presentation and CT scans and compared to those without PEHH using statistical tests. Variables with p-values less than 0.2 were subjected to multivariate analysis.

Results

Among 371 patients, predominantly male with locally advanced disease (stages 2–4, 90.8%), 25 (6.7%) developed PEHH after a median interval of 24 months post-MIE. The PEHH group exhibited significantly lower BMI and shorter ICU stays. On multivariate analysis BMI < 25 kg/m2 (OR 2.96, CI 1.22–7.20, p = 0.02) and ICU stays (OR 0.67, CI 0.47–0.96, p = 0.03) were independent predictors of PEHH. Surgical repair was performed in 84% of PEHH cases, with 60% symptomatic and 48% emergency surgery. The minimally invasive approach was implemented in 15 patients (71.4%). Primary repair was successfully conducted in 14 cases (66.7%), while mesh was used in one-third of patients.

Conclusion

The increasing prevalence of PEHH with MIE warrants attention. A lower BMI and shorter ICU stay was associated with PEHH. Most cases are symptomatic and effectively managed through minimally invasive techniques.
Literature
1.
go back to reference Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249CrossRefPubMed Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249CrossRefPubMed
2.
go back to reference Biere SSAY, van Berge Henegouwen MI, Maas KW, Bonavina L, Rosman C, Garcia JR et al (2012) Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 379(9829):1887–1892CrossRefPubMed Biere SSAY, van Berge Henegouwen MI, Maas KW, Bonavina L, Rosman C, Garcia JR et al (2012) Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 379(9829):1887–1892CrossRefPubMed
3.
go back to reference Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al (2020) Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer, analysis of a multicenter, open-label, randomized phase III controlled trial: the MIRO trial. Ann Surg 271(6):1023–1029CrossRefPubMed Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al (2020) Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer, analysis of a multicenter, open-label, randomized phase III controlled trial: the MIRO trial. Ann Surg 271(6):1023–1029CrossRefPubMed
4.
go back to reference Straatman J, van der Wielen N, Cuesta MA, Daams F, Roig Garcia J, Bonavina L et al (2017) Minimally invasive versus open esophageal resection: three-year follow-up of the previously reported randomized controlled trial: the TIME trial. Ann Surg 266(2):232–236CrossRefPubMed Straatman J, van der Wielen N, Cuesta MA, Daams F, Roig Garcia J, Bonavina L et al (2017) Minimally invasive versus open esophageal resection: three-year follow-up of the previously reported randomized controlled trial: the TIME trial. Ann Surg 266(2):232–236CrossRefPubMed
5.
go back to reference Low DE, Kuppusamy MK, Alderson D, Cecconello I, Chang AC, Darling G et al (2019) Benchmarking complications associated with esophagectomy. Ann Surg 269(2):291–298CrossRefPubMed Low DE, Kuppusamy MK, Alderson D, Cecconello I, Chang AC, Darling G et al (2019) Benchmarking complications associated with esophagectomy. Ann Surg 269(2):291–298CrossRefPubMed
6.
go back to reference Murad H, Huang B, Ndegwa N, Rouvelas I, Klevebro F (2021) Postoperative hiatal herniation after open vs. minimally invasive esophagectomy; a systematic review and meta-analysis. Int J Surg 93:106046CrossRefPubMed Murad H, Huang B, Ndegwa N, Rouvelas I, Klevebro F (2021) Postoperative hiatal herniation after open vs. minimally invasive esophagectomy; a systematic review and meta-analysis. Int J Surg 93:106046CrossRefPubMed
7.
go back to reference Gooszen JAH, Slaman AE, van Dieren S, Gisbertz SS, van Berge Henegouwen MI (2018) Incidence and treatment of symptomatic diaphragmatic hernia after esophagectomy for cancer. Ann Thorac Surg 106(1):199–206CrossRefPubMed Gooszen JAH, Slaman AE, van Dieren S, Gisbertz SS, van Berge Henegouwen MI (2018) Incidence and treatment of symptomatic diaphragmatic hernia after esophagectomy for cancer. Ann Thorac Surg 106(1):199–206CrossRefPubMed
8.
go back to reference Gust L, Nafteux P, Allemann P, Tuech JJ, El Nakadi I, Collet D et al (2019) Hiatal hernia after oesophagectomy: a large European survey. Eur J Cardiothorac Surg 55(6):1104–1112CrossRefPubMed Gust L, Nafteux P, Allemann P, Tuech JJ, El Nakadi I, Collet D et al (2019) Hiatal hernia after oesophagectomy: a large European survey. Eur J Cardiothorac Surg 55(6):1104–1112CrossRefPubMed
10.
go back to reference Messenger DE, Higgs SM, Dwerryhouse SJ, Hewin DF, Vipond MN, Barr H et al (2015) Symptomatic diaphragmatic herniation following open and minimally invasive oesophagectomy: experience from a UK specialist unit. Surg Endosc 29(2):417–424CrossRefPubMed Messenger DE, Higgs SM, Dwerryhouse SJ, Hewin DF, Vipond MN, Barr H et al (2015) Symptomatic diaphragmatic herniation following open and minimally invasive oesophagectomy: experience from a UK specialist unit. Surg Endosc 29(2):417–424CrossRefPubMed
11.
go back to reference Dolan JP, McLaren PJ, Diggs BS, Schipper PH, Tieu BH, Sheppard BC et al (2017) Evolution in the treatment of esophageal disease at a single academic institution: 2004–2013. J Laparoendosc Adv Surg Tech A 27(9):915–923CrossRefPubMedPubMedCentral Dolan JP, McLaren PJ, Diggs BS, Schipper PH, Tieu BH, Sheppard BC et al (2017) Evolution in the treatment of esophageal disease at a single academic institution: 2004–2013. J Laparoendosc Adv Surg Tech A 27(9):915–923CrossRefPubMedPubMedCentral
13.
go back to reference Hennessy MM, Ivanovski I, Spartalis E, Chrysikos D, Athanasiou A (2019) Diaphragmatic hernia following esophagectomy for esophageal cancer: a systematic review. J BUON 24(5):1793–1880 Hennessy MM, Ivanovski I, Spartalis E, Chrysikos D, Athanasiou A (2019) Diaphragmatic hernia following esophagectomy for esophageal cancer: a systematic review. J BUON 24(5):1793–1880
14.
go back to reference Hanna AN, Guajardo I, Williams N, Kucharczuk J, Dempsey DT (2020) Hiatal hernia after esophagectomy: an underappreciated complication? J Am Coll Surg 230(4):700–707CrossRefPubMed Hanna AN, Guajardo I, Williams N, Kucharczuk J, Dempsey DT (2020) Hiatal hernia after esophagectomy: an underappreciated complication? J Am Coll Surg 230(4):700–707CrossRefPubMed
15.
go back to reference Bronson NW, Luna RA, Hunter JG, Dolan JP (2014) The incidence of hiatal hernia after minimally invasive esophagectomy. J Gastrointest Surg 18(5):889–893CrossRefPubMed Bronson NW, Luna RA, Hunter JG, Dolan JP (2014) The incidence of hiatal hernia after minimally invasive esophagectomy. J Gastrointest Surg 18(5):889–893CrossRefPubMed
16.
go back to reference Benjamin G, Ashfaq A, Chang YH, Harold K, Jaroszewski D (2015) Diaphragmatic hernia post-minimally invasive esophagectomy: a discussion and review of literature. Hernia 19(4):635–643CrossRefPubMed Benjamin G, Ashfaq A, Chang YH, Harold K, Jaroszewski D (2015) Diaphragmatic hernia post-minimally invasive esophagectomy: a discussion and review of literature. Hernia 19(4):635–643CrossRefPubMed
17.
go back to reference Crespin OM, Farjah F, Cuevas C, Armstrong A, Kim BT, Martin AV et al (2016) Hiatal herniation after transhiatal esophagectomy: an underreported complication. J Gastrointest Surg 20(2):231–236CrossRefPubMed Crespin OM, Farjah F, Cuevas C, Armstrong A, Kim BT, Martin AV et al (2016) Hiatal herniation after transhiatal esophagectomy: an underreported complication. J Gastrointest Surg 20(2):231–236CrossRefPubMed
18.
go back to reference Iwasaki H, Tanaka T, Miyake S, Yoda Y, Noshiro H (2020) Postoperative hiatal hernia after minimally invasive esophagectomy for esophageal cancer. J Thorac Dis 12(9):4661–4669CrossRefPubMedPubMedCentral Iwasaki H, Tanaka T, Miyake S, Yoda Y, Noshiro H (2020) Postoperative hiatal hernia after minimally invasive esophagectomy for esophageal cancer. J Thorac Dis 12(9):4661–4669CrossRefPubMedPubMedCentral
19.
go back to reference Ulloa Severino B, Fuks D, Christidis C, Denet C, Gayet B, Perniceni T (2016) Laparoscopic repair of hiatal hernia after minimally invasive esophagectomy. Surg Endosc 30(3):1068–1072CrossRefPubMed Ulloa Severino B, Fuks D, Christidis C, Denet C, Gayet B, Perniceni T (2016) Laparoscopic repair of hiatal hernia after minimally invasive esophagectomy. Surg Endosc 30(3):1068–1072CrossRefPubMed
21.
go back to reference Ganeshan DM, Correa AM, Bhosale P, Vaporciyan AA, Rice D, Mehran RJ et al (2013) Diaphragmatic hernia after esophagectomy in 440 patients with long-term follow-up. Ann Thorac Surg 96(4):1138–1145CrossRefPubMed Ganeshan DM, Correa AM, Bhosale P, Vaporciyan AA, Rice D, Mehran RJ et al (2013) Diaphragmatic hernia after esophagectomy in 440 patients with long-term follow-up. Ann Thorac Surg 96(4):1138–1145CrossRefPubMed
22.
go back to reference Matthews J, Bhanderi S, Mitchell H, Whiting J, Vohra R, Hodson J et al (2016) Diaphragmatic herniation following esophagogastric resectional surgery: an increasing problem with minimally invasive techniques?: post-operative diaphragmatic hernias. Surg Endosc 30(12):5419–5427CrossRefPubMed Matthews J, Bhanderi S, Mitchell H, Whiting J, Vohra R, Hodson J et al (2016) Diaphragmatic herniation following esophagogastric resectional surgery: an increasing problem with minimally invasive techniques?: post-operative diaphragmatic hernias. Surg Endosc 30(12):5419–5427CrossRefPubMed
23.
go back to reference Brenkman HJ, Parry K, Noble F, van Hillegersberg R, Sharland D, Goense L et al (2017) Hiatal hernia after esophagectomy for cancer. Ann Thorac Surg 103(4):1055–1062CrossRefPubMed Brenkman HJ, Parry K, Noble F, van Hillegersberg R, Sharland D, Goense L et al (2017) Hiatal hernia after esophagectomy for cancer. Ann Thorac Surg 103(4):1055–1062CrossRefPubMed
24.
go back to reference Lung K, Carroll PA, Rogalla P, Yeung J, Darling G (2021) Paraconduit hernia in the era of minimally invasive esophagectomy: underdiagnosed? Ann Thorac Surg 111(6):1812–1819CrossRefPubMed Lung K, Carroll PA, Rogalla P, Yeung J, Darling G (2021) Paraconduit hernia in the era of minimally invasive esophagectomy: underdiagnosed? Ann Thorac Surg 111(6):1812–1819CrossRefPubMed
25.
go back to reference Kent MS, Luketich JD, Tsai W, Churilla P, Federle M, Landreneau R et al (2008) Revisional surgery after esophagectomy: an analysis of 43 patients. Ann Thorac Surg. 86(3):975–83 (discussion 67-74)CrossRefPubMed Kent MS, Luketich JD, Tsai W, Churilla P, Federle M, Landreneau R et al (2008) Revisional surgery after esophagectomy: an analysis of 43 patients. Ann Thorac Surg. 86(3):975–83 (discussion 67-74)CrossRefPubMed
28.
go back to reference Kohn GP, Price RR, DeMeester SR, Zehetner J, Muensterer OJ, Awad Z et al (2013) Guidelines for the management of hiatal hernia. Surg Endosc 27(12):4409–4428CrossRefPubMed Kohn GP, Price RR, DeMeester SR, Zehetner J, Muensterer OJ, Awad Z et al (2013) Guidelines for the management of hiatal hernia. Surg Endosc 27(12):4409–4428CrossRefPubMed
29.
go back to reference Erkmen CP, Raman V, Ghushe ND, Trus TL (2013) Laparoscopic repair of hiatal hernia after esophagectomy. J Gastrointest Surg 17(8):1370–1374CrossRefPubMed Erkmen CP, Raman V, Ghushe ND, Trus TL (2013) Laparoscopic repair of hiatal hernia after esophagectomy. J Gastrointest Surg 17(8):1370–1374CrossRefPubMed
30.
go back to reference Takeda FR, Tustumi F, Filho MAS, Silva MO, Junior UR, Sallum RAA et al (2020) Diaphragmatic hernia repair after esophagectomy: technical report and lessons after a series of cases. J Laparoendosc Adv Surg Tech A 30(4):433–437CrossRefPubMed Takeda FR, Tustumi F, Filho MAS, Silva MO, Junior UR, Sallum RAA et al (2020) Diaphragmatic hernia repair after esophagectomy: technical report and lessons after a series of cases. J Laparoendosc Adv Surg Tech A 30(4):433–437CrossRefPubMed
31.
go back to reference Narayanan S, Sanders RL, Herlitz G, Langenfeld J, August DA (2015) Treatment of diaphragmatic hernia occurring after transhiatal esophagectomy. Ann Surg Oncol 22(11):3681–3686CrossRefPubMed Narayanan S, Sanders RL, Herlitz G, Langenfeld J, August DA (2015) Treatment of diaphragmatic hernia occurring after transhiatal esophagectomy. Ann Surg Oncol 22(11):3681–3686CrossRefPubMed
32.
go back to reference Frantzides CT, Madan AK, Carlson MA, Stavropoulos G (2002) A Prospective, randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair vs simple cruroplasty for large hiatal hernia. Arch Surg 137(6):649–652CrossRefPubMed Frantzides CT, Madan AK, Carlson MA, Stavropoulos G (2002) A Prospective, randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair vs simple cruroplasty for large hiatal hernia. Arch Surg 137(6):649–652CrossRefPubMed
33.
go back to reference Puccetti F, Cossu A, Parise P, Barbieri L, Elmore U, Carresi A et al (2021) Diaphragmatic hernia after Ivor Lewis esophagectomy for cancer: a retrospective analysis of risk factors and post-repair outcomes. J Thorac Dis 13(1):160–168CrossRefPubMedPubMedCentral Puccetti F, Cossu A, Parise P, Barbieri L, Elmore U, Carresi A et al (2021) Diaphragmatic hernia after Ivor Lewis esophagectomy for cancer: a retrospective analysis of risk factors and post-repair outcomes. J Thorac Dis 13(1):160–168CrossRefPubMedPubMedCentral
34.
go back to reference Vallbohmer D, Holscher AH, Herbold T, Gutschow C, Schroder W (2007) Diaphragmatic hernia after conventional or laparoscopic-assisted transthoracic esophagectomy. Ann Thorac Surg 84(6):1847–1852CrossRefPubMed Vallbohmer D, Holscher AH, Herbold T, Gutschow C, Schroder W (2007) Diaphragmatic hernia after conventional or laparoscopic-assisted transthoracic esophagectomy. Ann Thorac Surg 84(6):1847–1852CrossRefPubMed
35.
go back to reference Van Sandick JW, Knegjens JL, Van Lanschot JJB, Obertop H (1999) Diaphragmatic herniation following oesophagectomy. Br J Surg 86(1):109–112CrossRefPubMed Van Sandick JW, Knegjens JL, Van Lanschot JJB, Obertop H (1999) Diaphragmatic herniation following oesophagectomy. Br J Surg 86(1):109–112CrossRefPubMed
Metadata
Title
Post-esophagectomy hiatal hernia following minimally invasive esophagectomy in esophageal cancer patients
Authors
Thitiporn Chobarporn
Alia P. Qureshi
John G. Hunter
Stephanie G. Wood
Publication date
05-03-2025
Publisher
Springer US
Published in
Surgical Endoscopy
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-025-11639-y
SPONSORED

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by:
  • Viatris
Developed by: Springer Healthcare
Watch now
Video