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MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for obesity and its related medical conditions. The contraindications of the past are the indications of the future.
The use of aspirin in colorectal cancer should be targeted rather than routine. This algorithm integrates crucial factors such as absolute CRC risk, PI3K/PIK3CA status, and bleeding risk to maximize benefit while reducing harm.
Mitochondrial dysfunction is an early and pivotal event in acute pancreatitis. Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed strategies work?
This international consensus statement integrates epidemiological, mechanistic, and interventional research findings, emphasizing the clinical relevance of maintaining adequate vitamin D status across a range of systems.
Radiofrequency ablation does not improve overall survival for patients with locally advanced pancreatic cancer who are undergoing chemotherapy, and is associated with poorer quality of life.
CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.
Successful use of mirikizumab in three patients with active ulcerative colitis was guided by clinical presentation plus high neutrophilic infiltration of the colonic epithelium (Geboes Grade 3.2).
Although colonic metastases from breast cancer are extremely rare, it is important for patients with a history of breast cancer who present with GI symptoms to undergo prompt endoscopic evaluation.
A woman taking adalimumab for ileocolic Crohn’s disease presented with symptoms mimicking a flare. CT revealed extensive venous thrombosis, but respiratory symptoms developed and disseminated tuberculosis was diagnosed.
Clinical recommendations for diagnosis and management
Around 10 to 20% of people will complain of dysphagia during their lifetime but uncertainty remains about optimal diagnostic work-up and management.
Prof. Edoardo Savarino takes us through the highlights of the updated UEG and ESNM dysphagia guidelines and the difference they could make to patient outcomes.
The burden of allergic disorders in Indian children is substantial and rising [ 1 , 2 ] Recent estimates from the Global Asthma Network (GAN) and International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3 reveal that the prevalence of …
Colorectal cancer (CRC) represents a major global health burden, ranking as the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. As per estimates from the Global Cancer Observatory …
Lymphadenectomy (LND) is a critical component of gastrectomy in curative multimodality treatment for gastric cancer (GC). Although its role in standard gastrectomy is well-established, its utility in non-standard scenarios remains uncertain. This …
Sleeve gastrectomy (SG) is one of the most commonly performed bariatric procedures worldwide, accounting for approximately 60% of all metabolic and bariatric surgeries [ 1 , 2 ]. Its widespread adoption is a result of its perceived procedural …
How do nutrition, supplements and antibiotics impact patient outcomes?
Recent research suggests that the gut microbiome could be an important modulator of response to CAR T-cell therapy in patients with hematologic cancers.
Prof. Marion Subklewe takes us through the latest evidence, highlighting the impact of antibiotics, nutrition, and dietary supplements, and discusses how to devise interventions to improve patient outcomes.
Severe pain is the most common symptom of chronic pancreatitis. In this live webinar, experts shared the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discussed pertinent cases and provided practical suggestions for use within clinical practice.
Acute pancreatitis (AP) is a common gastrointestinal disorder leading to hospital admissions [ 1 ]. Disease course varies from mild abdominal pain to life-threatening multi-organ failure. To be able to prevent relapse, aetiology and the possible …
Gastric cancer is the fifth most common cancer worldwide in terms of incidence and the fifth leading cause of death. Therefore, improved treatment modalities are needed [ 1 ]. In addition to age, sex, and race, several dietary and lifestyle risk …
Transection of the vagus nerve during gastrectomy is known to impair gallbladder contraction, resulting in reduced bile excretion. This leads to prolonged bile stasis within the gallbladder, thereby promoting gallstone formation [ 1 , 2 ]. For …
Emerging data support the concept that PSC-associated IBD be viewed as a distinct colitis phenotype that is pathophysiologically linked to PSC rather than as a subtype of ulcerative colitis.
MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for obesity and its related medical conditions. The contraindications of the past are the indications of the future.
Biotics have the potential to improve metabolic syndrome by reducing weight gain, insulin resistance, dyslipidemia, inflammation, and improving glycemic control and gut barrier function.
Mitochondrial dysfunction is an early and pivotal event in acute pancreatitis. Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed strategies work?
