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Published in: Infection 6/2022

03-06-2022 | Escherichia Coli | Brief Report

Escherichia coli sequence type 73 bloodstream infections in a centralized Canadian region and their association with companion animals: an ecological study

Authors: Diego Nobrega, Gisele Peirano, Johann D. D. Pitout

Published in: Infection | Issue 6/2022

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Abstract

Purpose

Extraintestinal pathogenic E. coli (ExPEC) are important pathogens causing community-acquired infections in humans, including bloodstream infections (BSIs), and may also colonize and infect animals. Our aim was to investigate associations between incidence rates (IRs) of BSIs caused by ExPEC and number of dogs and cats in communities in Calgary.

Methods

We used a well-characterized collection of blood isolates (n = 685) from Calgary, Alberta, Canada (2016). We used a combination of a seven-single-nucleotide-polymorphism quantitative PCR to type ExPEC into sequence types (STs). Calgary census data were used to estimate IRs per city community, as well as to investigate associations between number of companion animals per community, as obtained from licensing data, and IR of BSIs caused by each dominant ST.

Results

From the 685 isolates available, ExPEC ST131 was most prevalent (21.3% of included isolates), followed by ST73 (13.7%), ST69 (8.2%), ST95 (6.7%), and ST1193 (5.3%), respectively. Incidence of BSIs caused by ExPECs among Calgary residents was 48.8 cases per 100,000 resident-years, whereas communities had on average of 1.7 companion animals per 10 residents. No association between the number of dogs and IR of BSIs caused by ExPECs was detected for any ST. Conversely, the incidence rate of BSIs caused by ST73 was 3.6 times higher (95%CI 1.3–9.99) for every increase of 1 cat per 10 habitants in communities.

Conclusions

Number of cats per habitant was positively associated with the incidence of BSIs caused by ExPEC ST73.
Literature
13.
go back to reference Melendez D, Roberts MC, Greninger AL, Weissman S, No D, Rabinowitz P, et al. Whole-genome analysis of extraintestinal pathogenic Escherichia coli (ExPEC) MDR ST73 and ST127 isolated from endangered southern resident killer whales (Orcinus orca). J Antimicrob Chemother. 2019;74:2176–80. https://doi.org/10.1093/jac/dkz159.CrossRefPubMed Melendez D, Roberts MC, Greninger AL, Weissman S, No D, Rabinowitz P, et al. Whole-genome analysis of extraintestinal pathogenic Escherichia coli (ExPEC) MDR ST73 and ST127 isolated from endangered southern resident killer whales (Orcinus orca). J Antimicrob Chemother. 2019;74:2176–80. https://​doi.​org/​10.​1093/​jac/​dkz159.CrossRefPubMed
Metadata
Title
Escherichia coli sequence type 73 bloodstream infections in a centralized Canadian region and their association with companion animals: an ecological study
Authors
Diego Nobrega
Gisele Peirano
Johann D. D. Pitout
Publication date
03-06-2022
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 6/2022
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-022-01856-1

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