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Open Access 16-01-2024 | Erectile Dysfunction | Original Article

Semen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study

Authors: M. Longo, P. Caruso, C. Varro, M. Tomasuolo, P. Cirillo, L. Scappaticcio, L. Romano, D. Arcaniolo, M. I. Maiorino, G. Bellastella, M. De Sio, K. Esposito

Published in: Journal of Endocrinological Investigation | Issue 7/2024

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Abstract

Purpose

The aim of the present study is to evaluate the association of metabolic and glycemic variables with semen parameters in patients with type 1 diabetes (T1D) with and without erectile dysfunction (ED).

Methods

The study population included 88 adults with T1D using a continuous glucose monitoring, of whom 28 with ED (ED group) and 60 without it (NO ED group). All men completed the International Index of Erectile Function (IIEF-5) and underwent body composition analysis (BIA) and semen analysis.

Results

ED group showed worse HbA1c levels [median (IQR), 8.4 (7.7, 9.9) vs 7.4 (7, 8.2) %, P < 0.001)], higher insulin dose [60 (51, 65) vs 45 (38, 56) UI/die, P = 0.004)] and a higher total body water and intracellular water as compared with ED group. Men in the ED group presented higher semen volume [2.8 (2.6, 4.2) vs 2.5 (2.2, 2.7) mL, P < 0.001] and sperm concentration [24 (19, 29) vs 20 (12, 23) mil/mL, P = 0.010], but reduced sperm progressive motility [28 (25, 35) vs 35 (25, 36) %, P = 0.011], higher rate of non-progressive motility [15 (10, 15) vs 10 (5, 10) %, P < 0.001] and higher rate of typical morphology [7(5, 8) vs 5 (4, 5) %, P = 0.001]. Based on multivariate logistic regression analysis performed to assess the association between clinical variables and ED, intracellular water (OR 3.829, 95% CI 1.205, 12.163, P = 0.023) resulted as the only independent predictor of ED.

Conclusion

Men with T1D and ED showed worse metabolic profile which is associated with poor semen quality, as compared with those without ED.
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Metadata
Title
Semen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study
Authors
M. Longo
P. Caruso
C. Varro
M. Tomasuolo
P. Cirillo
L. Scappaticcio
L. Romano
D. Arcaniolo
M. I. Maiorino
G. Bellastella
M. De Sio
K. Esposito
Publication date
16-01-2024
Publisher
Springer International Publishing
Published in
Journal of Endocrinological Investigation / Issue 7/2024
Electronic ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-023-02285-z

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