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Clinical Reviews in Allergy & Immunology

UHRF1 in Immune Regulation and Diseases: Mechanisms and Therapeutic Implications

Published in:
Authors
Tingyue Guo
Yihui Ruan
Bo Wu
Shulan Sun
Hongxu Liu
Published in
Clinical Reviews in Allergy & Immunology | Issue 1/2025

Abstract

As a key epigenetic regulator, E3 ubiquitin-ligase ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) is essential for maintaining genomic stability. The aberrant activation of UHRF1 has been strongly implicated in cancer progression. Emerging evidence indicates that UHRF1 serves as a pivotal orchestrator of immune homeostasis. This review provides an overview of the impact of UHRF1 on both innate and adaptive immunity, highlighting its epigenetic and regulatory roles in the development and function of macrophages, T lymphocytes, and B lymphocytes. Crucially, the protective mechanisms of UHRF1 in autoimmune disorders while concurrently detailing its tumor-promoting functions are dissected. Finally, this review discusses the therapeutic challenges and future perspectives for targeting UHRF1 in autoimmune disorders and cancers.
Title
UHRF1 in Immune Regulation and Diseases: Mechanisms and Therapeutic Implications
Authors
Tingyue Guo
Yihui Ruan
Bo Wu
Shulan Sun
Hongxu Liu
Publication date
01-12-2025
Publisher
Springer US
Published in
Clinical Reviews in Allergy & Immunology / Issue 1/2025
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-025-09079-6
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images