Skip to main content
Key Specialties
Anesthesiology Cardiology Dermatology Diabetology Endocrinology Gastroenterology General Medicine Geriatrics Hematology Infectious Diseases Internal Medicine Nephrology Neurology Obstetrics and Gynecology Oncology Pediatrics Psychiatry Radiology Respiratory Medicine Rheumatology Surgery Urology
Congress Coverage
2024 ESMO Congress 2024 ERS Congress 2024 EASD Congress 2024 ESC Congress 2024 EAN Congress 2024 ASCO Annual Meeting 2024 ACC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote series | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the systemic effects of menopause, so you can help patients in your clinics through the transition.

Launching: Thursday 12th December 2024
ADVANCED SEARCH
Log in
Top
Archives of Gynecology and Obstetrics

04-11-2024 | Endometriosis | Review

Metabolomics for the identification of biomarkers in endometriosis

Author: Swarnima Pandey

Published in: Archives of Gynecology and Obstetrics

Login to get access

Abstract

Background

Endometriosis affects the quality of life in women during their reproductive years, causing immense pain and can result in infertility. It is characterized by inflammation and the growth of the endometrium outside the uterine cavity. Metabolomics has the potential to resolve the major bottleneck of endometriosis which is delay in diagnosis due to the invasive diagnostic approach.In this review, the author has summarized the identified biomarkers of endometriosis from different bodily fluids. Metabolomics promises a non-invasive diagnostic approach for endometriosis that could aid in earlier diagnosis and prognosis.

Methods

Patients with endometriosis keywords were searched in correspondence with the assigned keywords, including metabolomics from PubMed, from its inception to Dec 2023. The relevant studies from this search were extracted and included in the study.

Results

This article provides information regarding metabolomics studies in endometrisis.

Conclusions

We demonstrated that metabolomics is about to change the world of endometriosis by analyzing and detecting the diagnosis, prognosis, mortality and treatment response biomarkers.
Literature
1.
2.
Angioni S (2017) New insights on endometriosis. Minerva Ginecol 69(5):438–439PubMed
3.
4.
Centini G, Ginetti A, Colombi I, Cannoni A, Giorgi M, Ferreira H et al (2024) Endometriosis of the appendix: prevalence, associated lesions, and proposal of pathogenetic hypotheses. A retrospective cohort study with prospectively collected data. Arch Gynecol Obstet 310(3):1669–75PubMedCrossRef
5.
Appleyard CB, Cruz ML, Hernandez S, Thompson KJ, Bayona M, Flores I (2015) Stress management affects outcomes in the pathophysiology of an endometriosis model. Reprod Sci 22(4):431–441PubMedCrossRef
6.
7.
Kiesel L, Sourouni M (2019) Diagnosis of endometriosis in the 21st century. Climacteric 22(3):296–302PubMedCrossRef
8.
Wischmann TA-O, Ditzen B (2024) Endometriosis: patient-doctor communication and psychological counselling. Arch Gynecol Obstet 309(2):599–610PubMedCrossRef
9.
Dutta M, Singh B, Joshi M, Das D, Subramani E, Maan M et al (2018) Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis. Sci Rep 8(1):6466PubMedPubMedCentralCrossRef
10.
Li J, Guan L, Zhang H, Gao Y, Sun J, Gong X et al (2018) Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages. Reprod Biol Endocrinol 16:42PubMedPubMedCentralCrossRef
11.
Singh M, Jassal R, Khetarpal P (2024) Diagnostic and therapeutic approaches for endometriosis: a patent landscape. Arch Gynecol Obstet 309(3):831–842PubMedCrossRef
12.
Wang Z, Zhu C, Nambi V, Morrison AC, Folsom AR, Ballantyne CM et al (2019) Metabolomic pattern predicts incident coronary heart disease. Arterioscler Thromb Vasc Biol 39:1475–1482PubMedPubMedCentralCrossRef
13.
Pallares-Mendez R, Aguilar-Salinas CA, Cruz-Bautista I, Del Bosque-Plata L (2016) Metabolomics in diabetes, a review. Ann Med 48(1–2):89–102PubMedCrossRef
14.
Pandey S (2024) Metabolomics characterization of disease markers in diabetes and its associated pathologies. Metab Syndr Relat Disord 22:499–509PubMedCrossRef
15.
Pandey S, Adnan Siddiqui M, Fau-Azim A, Azim A, Fau-Trigun SK, Trigun SK, Fau-Sinha N, Sinha N (2021) Serum metabolic profiles of septic shock patients based upon co-morbidities and other underlying conditions. Mol Omics. 17(2):260–76PubMedCrossRef
16.
Pandey S, Azim A, Sinha N (2023) Longitudinal NMR based serum metabolomics to track the potential serum biomarkers of septic shock. Nanotheranostics. 7(2):142–151PubMedPubMedCentralCrossRef
17.
Pandey S, Siddiqui MA, Azim A, Sinha N (2023) Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit. Magn Reson Mater Phys Biol Med 36(4):659–669CrossRef
18.
Pandey S, Siddiqui MA, Trigun SK, Azim A, Sinha N (2022) Gender-specific association of oxidative stress and immune response in septic shock mortality using NMR-based metabolomics. Mol Omics. 18(2):143–153PubMedCrossRef
19.
Siddiqui MA, Pandey S, Azim A, Sinha N, Siddiqui MH (2020) Metabolomics: an emerging potential approach to decipher critical illnesses. Biophys Chem 267:106462PubMedPubMedCentralCrossRef
20.
21.
22.
23.
Dutta M, Joshi M, Fau-Srivastava S, Srivastava S, Fau-Lodh I, Lodh I, Fau-Chakravarty B, Chakravarty B, Fau-Chaudhury K, Chaudhury K (2012) A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis. Mol Biosyst. 8:3281–7PubMedCrossRef
24.
Jana SK, Dutta M, Joshi M, Srivastava S, Chakravarty B, Chaudhury K (2013) 1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis. Biomed Res Int 2013:329058PubMedPubMedCentralCrossRef
25.
Butler LM, Perone Y, Dehairs J, Lupien LE, de Laat V, Talebi A et al (2020) Lipids and cancer: emerging roles in pathogenesis, diagnosis and therapeutic intervention. Adv Drug Deliv Rev 159:245–293PubMedPubMedCentralCrossRef
26.
Wang FQ, Ariztia EV, Boyd LR, Horton FR, Smicun Y, Hetherington JA et al (2010) Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity. Gynecol Oncol 117(1):88–95PubMedCrossRef
27.
Iorio E, Mezzanzanica D, Alberti P, Spadaro F, Ramoni C, D’Ascenzo S et al (2005) Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res 65(20):9369–9376PubMedCrossRef
28.
Vouk K, Hevir N, Fau-Ribić-Pucelj M, Ribić-Pucelj M, Fau-Haarpaintner G, Haarpaintner G, Fau-Scherb H, Scherb H, Fau-Osredkar J, Osredkar J, Fau-Möller G et al (2012) Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis. Hum Reprod. 27:2955–65PubMedCrossRef
29.
Cordeiro FB, Cataldi TR, Perkel KJ, do Vale Teixeira da Costa L, Rochetti RC, Stevanato J et al (2015) Lipidomics analysis of follicular fluid by ESI-MS reveals potential biomarkers for ovarian endometriosis. J Assist Reprod Genet. 32(12):1817–25PubMedPubMedCentralCrossRef
30.
Dutta M, Anitha M, Smith PB, Chiaro CR, Maan M, Chaudhury K et al (2016) Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis. J Proteome Res 15(8):2626–2633PubMedCrossRef
31.
Dominguez F, Ferrando M, Diaz-Gimeno P, Quintana F, Fernandez G, Castells I et al (2017) Lipidomic profiling of endometrial fluid in women with ovarian endometriosisdagger. Biol Reprod 96(4):772–779PubMedCrossRef
32.
Sun Z, Fau-Song J, Song J, Fau-Zhang X, Zhang X, Fau-Wang A, Wang A, Fau-Guo Y, Guo Y, Fau-Yang Y, Yang Y, Fau-Wang X et al (2018) Novel SWATH(TM) technology for follicular fluid metabolomics in patients with endometriosis. Pharmazie. 1:318–32
33.
Starodubtseva N, Chagovets V, Borisova A, Salimova D, Aleksandrova N, Chingin K et al (2019) Identification of potential endometriosis biomarkers in peritoneal fluid and blood plasma via shotgun lipidomics. Clin Mass Spectrom. 13(21–26):21–26PubMedPubMedCentralCrossRef
34.
Chagovets VV, Wang Z, Kononikhin AS, Starodubtseva NL, Borisova A, Salimova D et al (2017) Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry. Sci Rep 7(1):2546PubMedPubMedCentralCrossRef
35.
Wu MH, Lu CW, Chuang PC, Tsai SJ (2010) Prostaglandin E2: the master of endometriosis? Exp Biol Med (Mayw) 235(6):668–677CrossRef
36.
Chrobak A, Sieradzka U, Fau-Sozański R, Sozański R, Fau-Chełmońska-Soyta A, Chełmońska-Soyta A, Fau-Gabryś M, Gabryś M, Fau-Jerzak M, Jerzak M (2009) Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis. Fertil Steril. 92(6):1835–43CrossRef
37.
Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A (2016) Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients. Fertil Steril 106:1733–1741PubMedCrossRef
38.
Braga DA-O, Montani DA-O, Setti AS, Turco EGL, Oliveira-Silva DA-O, Borges E Jr (2019) Metabolomic profile as a noninvasive adjunct tool for the diagnosis of Grades III and IV endometriosis-related infertility. Mol Reprod Dev. 86:1044–52PubMedCrossRef
39.
Zheng R, Du X, Lei Y (2023) Correlations between endometriosis, lipid profile, and estrogen levels. Med (Baltim) 102(29):e34348CrossRef
40.
Yang BC, Liu FY, Wang LQ, Zou Y, Wang F, Deng W, Huang OP (2015) Serum metabolic profiling study of endometriosis by using wooden-tip electrospray ionization mass spectrometry. Anal Methods 7(15):6125–6132CrossRef
41.
Vouk K, Ribic-Pucelj M, Adamski J, Rizner TL (2016) Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients. J Steroid Biochem Mol Biol 159:60–69PubMedCrossRef
42.
Lee YH, Tan CW, Venkatratnam A, Tan CS, Cui L, Loh SF et al (2014) Dysregulated sphingolipid metabolism in endometriosis. J Clin Endocrinol Metab 99(10):E1913–E1921PubMedPubMedCentralCrossRef
43.
Lee YH, Yang JX, Allen JC, Tan CS, Chern BSM, Tan TY et al (2018) Elevated peritoneal fluid ceramides in human endometriosis-associated infertility and their effects on mouse oocyte maturation. Fertil Steril 110:767–777PubMedCrossRef
44.
Castiglione Morelli MA, Iuliano A, Schettini SCA, Petruzzi D, Ferri A, Colucci P et al (2019) NMR metabolic profiling of follicular fluid for investigating the different causes of female infertility: a pilot study. Metabolomics 15(2):19PubMedCrossRef
45.
Marianna S, Alessia P, Susan C, Francesca C, Angela S, Francesca C et al (2017) Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients. Mol Biosyst 13(6):1213–1222PubMedCrossRef
46.
Vicente-Munoz S, Morcillo I, Puchades-Carrasco L, Paya V, Pellicer A, Pineda-Lucena A (2015) Nuclear magnetic resonance metabolomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis. Fertil Steril 104(5):1202–1209PubMedCrossRef
47.
Bozdag G, Igci N, Calis P, Ayhan B, OzelDemiralp D, Mumusoglu S et al (2019) Examination of cervical swabs of patients with endometriosis using Fourier transform infrared spectroscopy. Arch Gynecol Obstet 299(5):1501–1508PubMedCrossRef
Metadata
Title
Metabolomics for the identification of biomarkers in endometriosis
Author
Swarnima Pandey
Publication date
04-11-2024
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-024-07796-5

Keynote series | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the broader systemic effects of menopause, so you can help patients in your clinics through the transition.

Launching: Thursday 12th December 2024
 

Prof. Martha Hickey
Dr. Claudia Barth
Dr. Samar El Khoudary
Developed by: Springer Medicine
Register your interest now
Image Credits