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Endocrinology

Editor's Choice

Cardioprotective effects of adiponectin in diabetes

Explore the diverse roles of adiponectin and its effects on cardiovascular outcomes across diabetes subtypes, especially in diabetic cardiomyopathy, with an emphasis on congestive heart failure.

Closed-loop system improves time in glycemic range in diabetic pregnancy

Pregnant women with type 1 diabetes spend significantly more time within glycemic range with a closed-loop insulin delivery system than with standard care.

Intersection between eating disorders and obesity in youth

The risk for disordered eating and related worsened mental and physical health outcomes is greater in adolescents with obesity than in those without. Assessment for eating disorder symptoms and presentation is vital.

Anti-apoC-III therapies for pancreatitis and CVD

Conventional triglyceride-lowering therapies, such as fibrates and omega-3 fatty acids, have limited efficacy in lowering risk of pancreatitis or ASCVD in patients with severe hypertriglyceridemia. Could APOC3– targeted therapies be a better approach?

Revised obesity definition has implications for clinical management

Including anthropometric criteria in the definition of obesity increases prevalence by nearly 60% compared with the traditional BMI-based classification.

Increasing bodyweight blunts key biomarker response in HF

Elevated NT-proBNP levels are associated with adverse CV outcomes in people with heart failure, but the risks appear blunted by increasing BMI.  

Emerging interventions for resistant hypertension

Interventional therapies appear to be promising options for resistant hypertension. Explore the emerging options of renal and hepatic denervation, baroreceptor activation therapy, carotid body modulation, and cardiac neuromodulation.

MACE risk in type 2 diabetes varies by choice of glucose-lowering agent

Major adverse cardiovascular event risk in people with type 2 diabetes varies by the type of glucose-lowering medication used, with GLP-1 receptor agonists offering the greatest protection.

Vitamin D and bone health

Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.

Thermal imaging for the detection of diabetic foot

Early detection of foot ulcers in people with diabetes is vital but difficult to achieve due to the complex interaction of neuropathy, vascular disease, and immune dysfunction. Is thermal imaging the answer?

AI in adipose imaging

Can the efficiency and accuracy of CVD risk assessment be improved through AI imaging of visceral adipose tissue and ectopic fat? 

Assessing male infertility: semen analysis and beyond

Semen analysis remains the gold standard when evaluating male fertility potential, but could alternative diagnostic approaches and new technologies provide meaningful insights into what is happening within the testis?

IBI311 is a viable treatment for Chinese patients with active thyroid eye disease

Treatment of active thyroid eye disease with the insulin-like growth factor receptor inhibitor IBI311 results in clinically relevant improvements in proptosis outcomes in Chinese patients.

Understanding diabetic platelets

Platelets are a key factor in the micro- and macrovascular complications of diabetes. Explore the platelet changes that occur, underlying molecular mechanisms, the role in vascular complications, and therapeutic perspectives.

Return to flight in a helicopter pilot with lingual thyroid

Ectopic tissue at the tongue base was the sole functioning thyroid gland in a helicopter pilot incidentally diagnosed with lingual thyroid. Clinical stability, lack of symptoms, and treatment response, meant he was deemed fit to fly.

Empagliflozin offers significant renoprotection across multiple patient subgroups

SGLT2 inhibitor empagliflozin significantly reduces the risk for acute and chronic kidney injury, regardless of the acute dip in eGFR soon after initiation and irrespective of the reason for treatment.

Maintaining good health as a young adult reduces CVD in later life

Korean research suggests a high cumulative CV health score from ages 30 to 40 years significantly lowers the risk for CV disease and kidney events in mid-life.

Unique triad of tumors

A woman presenting with a neck swelling was diagnosed with poorly differentiated thyroid carcinoma, parathyroid adenoma, and cervical paraganglioma. Could it reflect a shared embryologic origin from neural crest derivatives?

Sleep and eating behavior

How do sleep parameters, such as duration, quality, timing, social jetlag, and chronotype, impact eating behavior? And what are the clinical implications for diabetes care and management?

Pupil dilation for DR screening carries low risk of acute angle closure

Among more than 80,000 participants of a teleretinal diabetic retinopathy screening program, risk for acute angle closure after pharmacologic pupillary dilation is less than 1 in 40,000 per dilation.

Image Credits
Fat cells 3D render/© Spectral-Design / Stock.adobe.com, Closed-loop insulin system on a pregnant woman/© dzika_mrowka / iStock / Getty Images Plus (symbolic image with model), Boy looking unhappy/© airdone / iStock / Getty Images Plus (symbolic image with model), Three darts in a dart board with one hitting the bull's-eye/© Richard Drury / Getty, Hand stacking three blue wooden blocks with green checkmarks/© izzuan / Stock.adobe.com, Supportive doctor with obese patient/© Halfpoint / Stock.adobe.com (symbolic image with models), High blood pressure diagnostics concept/© sudok1 / Getty Images / iStock, Colourful crowd of people (conceptual graphic)/© JuSun/Getty Images/iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Thermal plantar foot images of a person with diabetes/© (M) 2024, N Christy Evangeline et al. in Big Data, Machine Learning, and Applications. BigDML 2021. Lecture Notes in Electrical Engineering, under exclusive license to Springer Nature Singapore Pte Ltd., CT scan of upper abdomen with contrast media/© Mdv Edwards / Stock.adobe.com, 3D rendered human spermatozoa/© Vink Fan / stock.adobe.com, Ophthalmologist pointing to a model of eye anatomy/© Drazen Zigic / Getty Images / iStock (symbolic image with models), 3D illustration of platelets in blood smear/© Kateryna_Kon / stock.adobe.com, Imaging of ectopic lingual thyroid/© 2025, Pangmin Li et al, BMC Endocr Disord (CC-BY-NC-ND), Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, Zumba class in session/© FatCamera / Getty Images / iStock (symbolic image with models), Histology of patient with thyroid carcinoma, parathyroid adenoma, and paraganglioma/© 2025, Ankush Nayyar et al, J Med Case Reports, Hands reaching for donut/© Andriy / Stock.adobe.com, Dilated pupil/© Ivan-balvan / Getty Images / iStock