Characteristics and outcomes in adult patients with Staphylococcus lugdunensis bacteremia compared to patients with Staphylococcus epidermidis and Staphylococcus aureus bacteremia: a retrospective study in a 16-year period at the university hospital, Japan
- Open Access
- 01-12-2023
- Endocarditis
- Research
Published in:
- Authors
- Satomi Yukawa
- Taro Noguchi
- Koh Shinohara
- Yasuhiro Tsuchido
- Masaki Yamamoto
- Yasufumi Matsumura
- Miki Nagao
- Published in
- BMC Infectious Diseases | Issue 1/2023
Abstract
Background
Staphyococcus lugudnensis (S. lugdunensis) is one of coagulase-negative Staphylococcus species with a potential to cause invasive infections. Few studies have evaluated the characteristics and outcomes of patients with S. lugdunensis bacteremia (SLB) compared with those of patients with Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus) bacteremia.
Methods
We performed a single-center retrospective case–control study of patients aged ≥ 18 who had SLB with at least two sets of positive blood cultures at the Kyoto University Hospital, Japan, from January 2005 to June 2022. Patients who had S. epidermidis bacteremia (SEB) with at least two sets of positive blood cultures and those who had S. aureus bacteremia (SAB) with at least one set of positive blood cultures were randomly selected in a 1:5:5 (SLB:SEB:SAB) ratio.
Results
A total of 22 patients with SLB, 110 patients with SEB, and 110 patients with SAB were included. The proportions of infective endocarditis (IE) and metastatic infections were statistically higher in the SLB group than in the SEB group (14% vs. 2%, p < 0.01 and 18% vs. 5%, p 0.02, respectively) and were not significantly different between the SLB and SAB groups (14% vs. 5%, p 0.16 and 18% vs. 16%, p 0.78, respectively). The seven-day mortality was higher in the SLB group than in the SEB group (9% vs. 1%, p 0.02) and similar between the SLB and SAB groups (9% vs. 7%, p 0.77).
Conclusions
The clinical course and outcome of SLB were worse than those of SEB and similar to those of SAB. Appropriate evaluation and treatment for SAB may be warranted in patients with SLB.
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- Title
- Characteristics and outcomes in adult patients with Staphylococcus lugdunensis bacteremia compared to patients with Staphylococcus epidermidis and Staphylococcus aureus bacteremia: a retrospective study in a 16-year period at the university hospital, Japan
- Authors
-
Satomi Yukawa
Taro Noguchi
Koh Shinohara
Yasuhiro Tsuchido
Masaki Yamamoto
Yasufumi Matsumura
Miki Nagao
- Publication date
- 01-12-2023
- Publisher
- BioMed Central
- Keyword
- Endocarditis
- Published in
-
BMC Infectious Diseases / Issue 1/2023
Electronic ISSN: 1471-2334 - DOI
- https://doi.org/10.1186/s12879-023-08233-9
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