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Neurology and Therapy
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Open Access 09-07-2022 | Electroencephalography | Study Protocol

Interrater and Intrarater Agreement of Epileptic Encephalopathy Among Electroencephalographers for Children with Infantile Spasms Using the Burden of Amplitudes and Epileptiform Discharges (BASED) EEG Grading Scale: Study Design and Statistical Considerations

Authors: Xinting Liu, Jian Chen, Lin Wan, Zhichao Li, Yan Liang, Huimin Yan, Guangyu Zhu, Bo Zhang, Guang Yang

Published in: Neurology and Therapy | Issue 3/2022

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Abstract

Background

Infantile spasms are a serious epilepsy syndrome with a poor prognosis. Electroencephalography (EEG) has been a key component in the prognosis and treatment of infantile spasms. This multi-center study protocol is developed to investigate interrater and intrarater agreement of an electroencephalographic grading scale—the Burden of Amplitudes and Epileptiform Discharges (BASED) score among electroencephalographers.

Methods

Thirty children, aged 0–2 years, with infantile spasms who were hospitalized in the Chinese PLA General Hospital will be recruited into this study by stratified sampling. Seven electroencephalographers from different Class A tertiary hospitals will select a 5-min epoch with the most severe epileptiform discharge, score the EEG reports, and provide the basis for the scoring. The 420 (30 × 7 × 2) scoring results provided by electroencephalographers in two rounds can be analyzed statistically using weighted kappa (weighted \(\kappa\)) statstic, Fless’ kappa (Fless’ \(\kappa\)) statistic, and intraclass correlation coefficient (ICC) to calculate the interrater and intrarater agreement.

Discussion

We will recruit more electroencephalographers than were included in previous studies to assess the interrater and intrarater agreement in the selection of 5-min EEG epochs, the BASED scores, and the basis for scoring. If the BASED score has an adequate interrater and intrarater agreement, the score will have more significance for guiding the clinical management and for predicting the prognosis of patients with infantile spasms.
Appendix
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Metadata
Title
Interrater and Intrarater Agreement of Epileptic Encephalopathy Among Electroencephalographers for Children with Infantile Spasms Using the Burden of Amplitudes and Epileptiform Discharges (BASED) EEG Grading Scale: Study Design and Statistical Considerations
Authors
Xinting Liu
Jian Chen
Lin Wan
Zhichao Li
Yan Liang
Huimin Yan
Guangyu Zhu
Bo Zhang
Guang Yang
Publication date
09-07-2022
Publisher
Springer Healthcare
Published in
Neurology and Therapy / Issue 3/2022
Print ISSN: 2193-8253
Electronic ISSN: 2193-6536
DOI
https://doi.org/10.1007/s40120-022-00382-4

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