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The Journal of Prevention of Alzheimer's Disease

25-09-2024 | Original Research

Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial

Authors: Wen Liu, Deqiang Zheng, X. Li, T. Wang, L. Wang, L. Hao, M. Ju, W. Feng, Z. Guo, X. Sun, H. Yu, Z. Qin, Rong Xiao

Published in: The Journal of Prevention of Alzheimer's Disease

Abstract

Introduction

To investigate the effect of vitamin D3 (VD3) combined with folic acid (FA) intervention on the cognitive function among patients with mild cognitive impairment (MCI) and vitamin D deficiency.

Methods

Our study is a single-center, randomized, controlled trial. A total of 402 patients were randomly assigned to the placebo group (n=135), FA group (n=134), and FA+1600IU VD3 group (n=133). The intervention period was 24 weeks. The primary endpoint was the mean change in Montreal Cognitive Assessment (MoCA) compared to baseline. Secondary endpoints included other cognitive functions, serum vitamin D, folic acid, and homocysteine levels.

Results

The Intention-to-Treat analysis results of MoCA showed that the adjusted Least Squares Means (LSM) differences between the FA+1600IU VD3 group and the placebo or FA group were 0.456 (95% CI −0.198 to 1.11; p=0.171) and 0.038 (95% CI −0.600 to 0.676; p=0.907), respectively, and the Per-protocol set analysis results showed that the adjusted LSM differences between the FA+1600IU VD3 group and the placebo or FA group were 0.659 (95% CI 0.005 to 1.313; p=0.048) and 0.251 (95% CI −0.387 to 0.889; p=0.44), respectively.

Conclusion

The effect of FA+1600IU VD3 intervention for 6 months on overall cognitive function in MCI patients with vitamin D deficiency was not significant, but its role may be underestimated and requires further long-term studies to confirm.

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Title: Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial
Authors: Wen Liu
Deqiang Zheng
X. Li
T. Wang
L. Wang
L. Hao
M. Ju
W. Feng
Z. Guo
X. Sun
H. Yu
Z. Qin
Rong Xiao
Publication date: 25-09-2024
Publisher: Springer International Publishing
Published in: The Journal of Prevention of Alzheimer's Disease
Electronic ISSN: 2426-0266
DOI: https://doi.org/10.14283/jpad.2024.165

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Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial

Abstract

Introduction

Methods

Results

Conclusion

Advances in Alzheimer's

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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Advances in Alzheimer's