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Reviews in Endocrine and Metabolic Disorders

18-12-2024

Effects of growth hormone-releasing hormone deficiency in mice beyond growth

Authors: Lucia Recinella, Maria Loreta Libero, Luigi Brunetti, Alessandra Acquaviva, Annalisa Chiavaroli, Giustino Orlando, Riccarda Granata, Roberto Salvatori, Sheila Leone

Published in: Reviews in Endocrine and Metabolic Disorders

Abstract

This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peripheral tissues. Genetically engineered mice have been instrumental in elucidating the multifaceted roles of GHRH and GH, each offering unique insights into the physiological and pathological roles of these hormones, although in many of these models dissecting the direct effect of GHRH from the effect of GH is not possible. Key findings highlight the effects of GHRH deficiency on emotional behavior, including anxiety and depression, its impact on memory and learning capabilities, as well as on adipose tissue, immune system, inflammation and pain.

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Title: Effects of growth hormone-releasing hormone deficiency in mice beyond growth
Authors: Lucia Recinella
Maria Loreta Libero
Luigi Brunetti
Alessandra Acquaviva
Annalisa Chiavaroli
Giustino Orlando
Riccarda Granata
Roberto Salvatori
Sheila Leone
Publication date: 18-12-2024
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-024-09936-3

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