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01-12-2024 | Research

Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial

Authors: Diego Pradillo-Gallego, Francisco Javier Manzano-Moreno, Francisco Manuel Ocaña-Peinado, Maria Victoria Olmedo-Gaya

Published in: Clinical Oral Investigations | Issue 12/2024

Abstract

Objective

The objective of this randomized controlled clinical trial (RCT) was to compare the frequency of early implant failure, postoperative infection, and pain/inflammation and the degree of implant stability between healthy non-penicillin-allergic individuals receiving a single prophylactic dose of 600 mg clindamycin versus 2 g amoxicillin at 1 h before implant surgery.

Materials and methods

A single-center double-blinded RCT study with parallel groups was undertaken. Eighty-two patients fulfilled study inclusion criteria and were randomly assigned to the amoxicillin (n = 41) or clindamycin (n = 41) group. The primary outcome variable was early implant failure. The presence of infection was evaluated immediately after surgery and on days 7, 14, 30, and 90, and postoperative pain/inflammation was assessed daily on days 1 to 7 post-surgery. Resonance frequency analysis was used to measure primary and secondary implant stability.

Results

One early implant failure was observed (1/81), in a patient from the amoxicillin group. No statistically significant between-group differences were observed in early implant failure rate, postoperative infection rate up to 90 days, pain/inflammation scores during the first week post-surgery, or primary or secondary stability values.

Conclusions

A single dose of 600 mg clindamycin before implant surgery does not increase the risk of early implant failure or infection.

Clinical relevance

These findings suggest that a single dose of 600 mg clindamycin at 1 h before implant surgery is a safe antibiotic prophylactic approach; however, when a more prolonged antibiotic therapy is required, it appears advisable to prescribe an alternative antibiotic to avoid adverse effects.

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Title: Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial
Authors: Diego Pradillo-Gallego
Francisco Javier Manzano-Moreno
Francisco Manuel Ocaña-Peinado
Maria Victoria Olmedo-Gaya
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 12/2024
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-024-06050-1

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