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The Journal of Prevention of Alzheimer's Disease

Open Access 25-09-2024 | Original Research

Effectiveness of a Meta-Cognitive Group Intervention for Older Adults with Subjective Cognitive Decline or Mild Cognitive Impairment: The ASPIRE Randomized Controlled Trial

Authors: Shlomit Rotenberg, N. D. Anderson, M. A. Binns, E. R. Skidmore, A. K. Troyer, J. Richardson, F. Xie, E. Nalder, Y. Bar, N. Davids-Brumer, A. Bernick, D. R. Dawson

Published in: The Journal of Prevention of Alzheimer's Disease

Abstract

Background

Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) can lead to functional and cognitive decline, increasing dementia risk. There is a pressing need for interventions that prevent this deterioration. The ASPIRE (Adult Strategies Put Into Real-world Environments) intervention was developed to improve performance of daily activities.

Objectives

The primary objective was to determine whether ASPIRE was more effective than a Brain Education control intervention in improving performance and satisfaction with daily life activities that were not specifically trained in the intervention. Secondary objectives were to explore: 1) whether ASPIRE was more effective in improving self-reported health and quality of life, and performance on cognitive tests; and 2) maintenance of change over six-months.

Design

Double-blind, two-armed, parallel randomized controlled trial, with a six-month follow-up period.

Setting

Community based, Greater Toronto Area.

Participants

Two-hundred sixty-four older adults (aged 70.8 ± 6.6 years) with SCD or MCI, randomized to ASPIRE (n=131) or a Brain Education active control arm (n= 133).

Intervention

ASPIRE is a 10-week meta-cognitive group intervention focusing on strategy acquisition and application to improve performance of individualized daily activity identified by each participant as important. It involves setting goals, creating tailored plans, and iteratively modifying these plans with support from the group members and facilitator.

Measurements

Performance of and satisfaction with daily activities was rated on a 10-point Likert scale using the Canadian Occupational Performance Measure (COPM). Secondary outcome were subjective cognition, depression, anxiety, self-efficacy, quality of life, and cognitive tests of memory and executive functions.

Results

Post-intervention, clinically significant improvement of untrained activities (two points or more on the COPM) was found in 32.5% in ASPIRE; and 30.6% in the control arm, with no significant between group differences (Performance: (exp(β̂) =0.96, z=−0.15, p=.879); Satisfaction: (exp(β̂) =0.94, z=−0.29, p=.775). The improvements remained stable over six months in both arms. No significant group effects were found on the secondary outcomes, but improvements were found on subjective cognition and self-efficacy in both arms post intervention.

Conclusion

Both a meta-cognitive strategy approach and an adult learning activity resulted in positive changes in subjective cognition, self efficacy, and, to a certain extent, engagement in daily activities.

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Title: Effectiveness of a Meta-Cognitive Group Intervention for Older Adults with Subjective Cognitive Decline or Mild Cognitive Impairment: The ASPIRE Randomized Controlled Trial
Authors: Shlomit Rotenberg
N. D. Anderson
M. A. Binns
E. R. Skidmore
A. K. Troyer
J. Richardson
F. Xie
E. Nalder
Y. Bar
N. Davids-Brumer
A. Bernick
D. R. Dawson
Publication date: 25-09-2024
Publisher: Springer International Publishing
Published in: The Journal of Prevention of Alzheimer's Disease
Electronic ISSN: 2426-0266
DOI: https://doi.org/10.14283/jpad.2024.166

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Effectiveness of a Meta-Cognitive Group Intervention for Older Adults with Subjective Cognitive Decline or Mild Cognitive Impairment: The ASPIRE Randomized Controlled Trial

Abstract

Background

Objectives

Design

Setting

Participants

Intervention

Measurements

Results

Conclusion

Advances in Alzheimer's

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

Background

Objectives

Design

Setting

Participants

Intervention

Measurements

Results

Conclusion

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Advances in Alzheimer's