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18-09-2021 | Original Article

Effect of Glycerol Administration on ECochG and VEMP Findings in Individual with Meniere's Disease

Authors: Pooja Nagarajan, Muthu Selvi Thangaraj

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Special Issue 3/2022

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Abstract

The present study aimed to find the effect of glycerol administration on Electrocochleography (ECochG), cervical and ocular Vestibular Evoked Myogenic Potential (c-VEMP, o-VEMP) findings in individual with Meniere’s disease. Sixteen participants (32 ears) diagnosed with Meniere’s disease underwent ECochG, c-VEMP and o-VEMP for both pre and 1 h post-glycerol administration. Paired t-test indicated that the SP/AP ratio of ECochG measures was significantly improved with post-glycerol administration. There was no significant difference in the mean amplitude of o-VEMP and c-VEMP between pre and post-glycerol administration. However, while individual differences were compared, 75% of the participants reported either improvement in c-VEMP amplitude or newly emerging c-VEMP& o-VEMP. Based on the recommendation by Adams et al. (Otolaryngol Clin North Am 43(5):995–1009, 2010), the improvement on these tests results with post glycerol administration were considered as a significant indicator for the presence of Meniere’s disease.With post glycerol administration, the present study found that 84%of participants were found to have an improvement in the amplitude for ECochG measures. There was an improvement in the amplitude measures of o-VEMP and c-VEMP, which were observed in 75% and 68%of participants respectively with post-glycerol administration. Improvement in the amplitude of test measures with post-glycerol administration were observed to be more for cochlear potentials of ECochG followed by vestibular potentials of c-VEMP and o-VEMP. Thus, improvement of ECochG amplitude with post-glycerol administration might serve as an additional indicator for the presence of Meniere’s disease.
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Metadata
Title
Effect of Glycerol Administration on ECochG and VEMP Findings in Individual with Meniere's Disease
Authors
Pooja Nagarajan
Muthu Selvi Thangaraj
Publication date
18-09-2021
Publisher
Springer India
Published in
Indian Journal of Otolaryngology and Head & Neck Surgery / Issue Special Issue 3/2022
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-021-02856-7