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Graefe's Archive for Clinical and Experimental Ophthalmology

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26-12-2023 | Edema | Retinal Disorders

Relationship between ischemic index, leakage index, and macular edema in branch retinal vein occlusion

Authors: Gongpeng Sun, Xiaoling Wang, Miao Tian, Zuohuizi Yi, Amin Xu, Lu He, Hongmei Zheng, Changzheng Chen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2024

Abstract

Purpose

To investigate the combined association of the ischemic index and leakage index with macular edema on ultra-widefield fluorescein angiography (UWFFA) in patients with branch retinal vein occlusion (BRVO).

Methods

Retrospective image analysis study. The leakage index and ischemic index were calculated using Fiji after aligning early and late UWFFA images. Differences in the ischemic index, leakage index, and central macular thickness (CMT) between ischemic and non-ischemic BRVO were compared. Moreover, the association between the ischemic index, leakage index, and macular edema was analyzed.

Results

Eighty-three patients with BRVO were enrolled, including 53 non-ischemic BRVO and 30 ischemic BRVO patients. No significant differences were observed in leakage index and CMT between ischemic BRVO and non-ischemic BRVO (all P > 0.05). In all included patients, CMT correlated with the panretina and all subregion leakage indexes (all P < 0.01), but not with the ischemic index (all P > 0.05). In the ischemic BRVO group, CMT showed a correlation with the leakage index in several regions, but not with the ischemic index. After adjusting for the ischemic index and other clinical features, CMT remained significantly correlated with the leakage index in all regions.

Conclusion

The leakage index may be a more effective biomarker for monitoring BRVO-associated macular edema compared to the ischemic index. Further follow-up studies are warranted to validate these findings.

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Title: Relationship between ischemic index, leakage index, and macular edema in branch retinal vein occlusion
Authors: Gongpeng Sun
Xiaoling Wang
Miao Tian
Zuohuizi Yi
Amin Xu
Lu He
Hongmei Zheng
Changzheng Chen
Publication date: 26-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Edema
Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2024
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06343-3

ERS Congress 2024

Springer Medicine

Relationship between ischemic index, leakage index, and macular edema in branch retinal vein occlusion

Abstract

Purpose

Methods

Results

Conclusion

ERS Congress 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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