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Open Access 29-10-2024 | Dupilumab | Original Research

Dupilumab is Efficacious in Young Children with Atopic Dermatitis Regardless of Type 2 Comorbidities

Authors: Mark Boguniewicz, Lawrence D. Sher, Amy S. Paller, Peter D. Arkwright, Shigemi Yoshihara, Zhen Chen, Parul Shah, Ainara Rodríguez Marco

Published in: Advances in Therapy | Issue 12/2024

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Abstract

Introduction

Patients with atopic dermatitis (AD) often have other comorbid type 2 inflammatory conditions. The aim of this study was to evaluate the impact of type 2 comorbidities on the response to and safety of dupilumab in young children with AD.

Methods

LIBERTY AD PRESCHOOL part B was a randomized, placebo-controlled trial in children aged 6 months to 5 years with moderate-to-severe AD. In this post hoc analysis, patients were stratified by the presence or absence of caregiver-reported selected type 2 comorbidities at baseline: asthma, allergic rhinitis (AR), and food allergies (FAs).

Results

At week 16, significantly more patients receiving dupilumab versus placebo, with or without asthma and AR, achieved an Investigator’s Global Assessment (IGA) score of 0/1 and a ≥ 75% improvement in Eczema Area and Severity Index (all p < 0.05). Significantly more patients receiving dupilumab versus placebo with FAs and numerically more patients without FAs achieved an IGA score of 0/1 (p = 0.0007 and p = 0.06). Numerically more patients receiving dupilumab versus placebo with asthma and significantly more patients without asthma achieved a ≥ 4-point reduction in the weekly average of daily score on the Worst Scratch/Itch Numeric Rating Scale (WSI-NRS) (p = 0.6 and p < 0.0001). Additionally, significantly more patients receiving dupilumab versus placebo with or without AR (p = 0.008 and p < 0.0001) and with or without FAs (p = 0.0002 and p = 0.004) achieved a ≥ 4-point reduction in the weekly average of daily score on the WSI-NRS. Overall safety was consistent with the known dupilumab safety profile.

Conclusions

Dupilumab treatment improves AD signs and symptoms in children aged 6 months to 5 years with and without type 2 comorbidities such as asthma, AR, and FAs.

Trial Registration

ClinicalTrials.gov registration number NCT03346434.

Infographic

Do type 2 comorbidities impact the response to dupilumab in children with atopic dermatitis? (MP4 103,451 KB)
Literature
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Metadata
Title
Dupilumab is Efficacious in Young Children with Atopic Dermatitis Regardless of Type 2 Comorbidities
Authors
Mark Boguniewicz
Lawrence D. Sher
Amy S. Paller
Peter D. Arkwright
Shigemi Yoshihara
Zhen Chen
Parul Shah
Ainara Rodríguez Marco
Publication date
29-10-2024
Publisher
Springer Healthcare
Published in
Advances in Therapy / Issue 12/2024
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI
https://doi.org/10.1007/s12325-024-02998-4

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