Skip to main content
Key Specialties
Anesthesiology Cardiology Dermatology Diabetology Endocrinology Gastroenterology General Medicine Geriatrics Hematology Infectious Diseases Internal Medicine Nephrology Neurology Obstetrics and Gynecology Oncology Ophthalmology Pediatrics Psychiatry Radiology Respiratory Medicine Rheumatology Surgery Urology
Congress Coverage
ASH 2024 Annual Meeting 2024 ESMO Congress 2024 ERS Congress 2024 EASD Congress 2024 ESC Congress 2024 EAN Congress 2024 ASCO Annual Meeting 2024 ACC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on adolescent vaping

LIVE: Wednesday 29th January, 18:00-19:30 CET

Growing numbers of young people are using e-cigarettes, despite warnings of respiratory effects and addiction. How can doctors tackle the epidemic, and what health effects should you prepare to manage in your clinics?
ADVANCED SEARCH
Log in
Top
Journal of Diabetes & Metabolic Disorders
Published in:

Open Access 01-12-2017 | Research Article

Does honey have any salutary effect against streptozotocin - induced diabetes in rats?

Authors: Zakariya M. Al Aamri, Badreldin H. Ali

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2017

Login to get access

Abstract

Background

Diabetes is a global, growing and costly public health problem. In the literature, there are conflicting reports on the effect of consumption of bee honey on diabetes. We assessed the possible effect of a commercially available bee honey (given orally by gavage at doses of 1 g/kg/day for 4 weeks) on the blood concentrations of glucose, insulin and leptin and body weight of rats with streptozotocin-induced diabetes.

Methods

Thirty-six rats were allocated randomly into six groups equally and treated for 4 weeks as follows: Group.1: non-diabetic rats given distilled water, group.2: non-diabetic rats given honey (1 g/kg), group.3: Diabetic rats given distilled water, group.4: Diabetic rats given honey, group.5: Diabetic rats given insulin (10 IU/kg), and group.6: Diabetic rats given combination of insulin (10 IU/kg) with honey (1 g/kg). The body weight, blood glucose, insulin and leptin concentrations of each rat were measured.

Results

Honey treatment did not significantly affect the glucose, leptin and insulin concentrations of diabetic rats. It did not significantly affect the excessive water intake or urinary output in diabetic rats when compared to the insulin-treated groups. Neither honey nor insulin improved body weight in diabetic rats.

Conclusion

Contrary to the reports of a salutary effect of honey in diabetic humans and rodents, our results showed that consumption of honey caused no significant changes in body weight, or glucose and insulin concentrations. However, further studies with different doses and durations of treatment are warranted.
Literature
1.
American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2012;36(Suppl l):S67–74.PubMedCentral
2.
3.
4.
5.
6.
Mohamed M, Sulaiman S, Jaafar H, Sirajudeen K. Effect of different doses of Malaysian honey on reproductive parameters in adult male rats. Andrologia. 2011;44:182–6.CrossRefPubMed
7.
Sajwani A, Eltayeb E, Farook S, Patzelt A. Sugar and Protein Profiles of Omani Honey from Muscat and Batinah Regions of Oman. Int J Food Prop. 2007;10(4):675–90.CrossRef
8.
Qiu P, Ding H, Tang Y, Xu R. Determination of chemical composition of commercial honey by near-infrared spectroscopy. J Agric Food Chem. 1999;47(7):2760–5.CrossRefPubMed
9.
Abdulrhman M, El Hefnawy M, Ali R, Abdel Hamid I, Abou El-Goud A, Refai D. Effects of honey, sucrose and glucose on blood glucose and C-peptide in patients with type 1 diabetes mellitus. Complement Ther Clin Pract. 2013;19(1):15–9.CrossRefPubMed
10.
Bahrami M, Ataie-Jafari A, Hosseini S, Foruzanfar M, Rahmani M, Pajouhi M. Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial. Int J Food Sci Nutr. 2009;60(7):618–26.CrossRefPubMed
11.
Al-Jabri A, Al-Hosni S, Nzeako B, Al-Mahrooqi Z, Nsanze H. Antibacterial activity of Omani honey alone and in combination with gentamicin. Saudi Med J. 2005;26(5):767–71.PubMed
12.
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Antioxidant Protective Effect of Glibenclamide and Metformin in Combination with Honey in Pancreas of Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2010;11(5):2056–66.CrossRefPubMedPubMedCentral
13.
Moghazy A, Shams M, Adly O, Abbas A, El-Badawy M, Elsakka D, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2010;89(3):276–81.CrossRefPubMed
14.
Zaid S, Sulaiman S, Sirajudeen K, Othman N. The effects of tualang honey on female reproductive organs, tibia bone and hormonal profile in ovariectomised rats - animal model for menopause. BMC Complement Altern Med. 2010;10(1):82.CrossRefPubMedPubMedCentral
15.
Batumalaie K, Qvist R, Yusof K, Ismail I, Sekaran S. The antioxidant effect of the Malaysian Gelam honey on pancreatic hamster cells cultured under hyperglycemic conditions. Clin Exp Med. 2014;14(2):185–95.CrossRefPubMed
16.
Al-Waili N, Salom K, Al-Ghamdi A, Ansari M, Al-Waili A, Al-Waili T. Honey and Cardiovascular Risk Factors, in Normal Individuals and in Patients with Diabetes Mellitus or Dyslipidemia. J Med Food. 2013;16(12):1063–78.CrossRefPubMed
17.
Katsilambros N, Philippides P, Touliatou A, Georgakopoulos K, Kofotzouli L, Frangaki D, et al. Metabolic effects of honey (alone or combined with other foods) in type II diabetics. Acta Diabetol Lat. 1988;25(3):197–203.CrossRefPubMed
18.
Zhou L, Cai X, Zhu Y, Liu W, Gong S, Zhang S, et al. Serum leptin level is associated with glycaemic control in newly diagnosed type 2 diabetes patients: A 1-year cohort study. Diabetes Metab. 2016.
19.
Naito M, Fujikura J, Ebihara K, Miyanaga F, Yokoi H, Kusakabe T, et al. Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice. Diabetes. 2011;60(9):2265–73.CrossRefPubMedPubMedCentral
20.
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. Int J Biol Sci. 2011;7(2):244–52.CrossRefPubMedPubMedCentral
21.
Nasrolahi O, Khaneshi F, Rahmani F, Razi M. Honey and metformin ameliorated diabetes-induced damages in testes of rat; correlation with hormonal changes. Iran J Reprod Med. 2013;11(12):1013–20.PubMedPubMedCentral
22.
Nemoseck T, Carmody E, Furchner-Evanson A, Gleason M, Li A, Potter H, et al. Honey promotes lower weight gain, adiposity, and triglycerides than sucrose in rats. Nutr Res. 2011;31(1):55–60.CrossRefPubMed
23.
Wójcicka G, Jamroz-Wiśniewska A, Marciniak A, Łowicka E, Bełtowski J. The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity. Life Sci. 2010;87(3–4):126–32.CrossRefPubMed
24.
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: effects of antioxidant (Honey) treatment. Int J Mol Sci. 2011;12(3):1888–907.CrossRefPubMedPubMedCentral
25.
Elvert R, Wille A, Wandschneider J, Werner U, Glombik H, Herling A. Energy loss via urine and faeces - a combustive analysis in diabetic rats and the impact of antidiabetic treatment on body weight. Diabetes Obes Metab. 2013;15(4):324–34.CrossRefPubMed
26.
Rajkumar L, Srinivasan N, Balasubramanian K, Govindarajulu P. Increased degradation of dermal collagen in diabetic rats. Indian J Exp Biol. 1991;29(11):1081–3.PubMed
27.
Abdul Sani N, Belani L, Pui Sin C, Abdul Rahman S, Das S, Zar Chi T, et al. Effect of the combination of gelam honey and ginger on oxidative stress and metabolic profile in streptozotocin-induced diabetic Sprague-Dawley rats. Biomed Res Int. 2014;2014:1–9.CrossRef
28.
Meena S, Rajput YS, Pandey AK, Sharma R, Singh R. Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. J Dairy Res. 2016;83:412–9.CrossRefPubMed
29.
Meek TH, Morton GJ. The role of leptin in diabetes: metabolic effects. Diabetologia. 2016;59:928–32.CrossRefPubMed
30.
Wannamethee S, Lowe G, Rumley A, Cherry L, Whincup P, Sattar N. Adipokines and risk of type 2 diabetes in older men. Diabetes Care. 2007;30(5):1200–5.CrossRefPubMed
31.
Schmidt M, Duncan B, Vigo A, Pankow J, Couper D, Ballantyne C, et al. Leptin and incident type 2 diabetes: risk or protection? Diabetologia. 2006;49(9):2086–96.CrossRefPubMed
32.
Franks P, Brage S, Luan J, Ekelund U, Rahman M, Farooqi I, et al. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obes Res. 2005;13(8):1476–84.CrossRefPubMed
33.
McNeely M, Boyko E, Weigle D, Shofer J, Chessler S, Leonnetti D, et al. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999;22(1):65–70.CrossRefPubMed
34.
Vinitha R, Ram J, Snehalatha C, Nanditha A, Shetty A, Arun R, et al. Adiponectin, leptin, interleukin-6 and HbA1c in the prediction of incident type 2 diabetes: A nested case-control study in Asian Indian men with impaired glucose tolerance. Diabetes Res Clin Pract. 2015;109(2):340–6.CrossRefPubMed
35.
Kanaya A, Wassel Fyr C, Vittinghoff E, Harris T, Park S, Goodpaster B, et al. Adipocytokines and incident diabetes mellitus in older adults. Arch Intern Med. 2006;166(3):350–6.CrossRefPubMed
Metadata
Title
Does honey have any salutary effect against streptozotocin - induced diabetes in rats?
Authors
Zakariya M. Al Aamri
Badreldin H. Ali
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Diabetes & Metabolic Disorders / Issue 1/2017
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1186/s40200-016-0278-y

Other articles of this Issue 1/2017

Iranian university students lifestyle and health status survey: study profile

  • Open Access
  • Research article

Risk factors for impaired fasting glucose or diabetes among HIV infected patients on ART in the Copperbelt Province of Zambia

  • Open Access
  • Research article

Effect of melatonin versus vitamin D as antioxidant and Hepatoprotective agents in STZ-induced diabetic rats

  • Open Access
  • Research article

Hypoglycemic effects of tramadol analgesia in hospitalized patients: a case-control study

  • Open Access
  • Research article

Concealed use of herbal and dietary supplements among Thai patients with type 2 diabetes mellitus

  • Open Access
  • Research article

The effect of flour from the rind of the yellow passion fruit on glycemic control of people with diabetes mellitus type 2: a randomized clinical trial

  • Open Access
  • Research article

Keynote webinar | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the broader systemic effects of menopause, so you can help patients in your clinics through the transition.   

Prof. Martha Hickey
Dr. Claudia Barth
Dr. Samar El Khoudary
Developed by: Springer Medicine
Watch now

Keynote webinar | Spotlight on adolescent vaping

  • Live
  • Webinar | 29-01-2025 | 18:00 (CET)

Growing numbers of young people are using e-cigarettes, despite warnings of respiratory effects and addiction. How can doctors tackle the epidemic, and what health effects should you prepare to manage in your clinics?

Watch it live: Wednesday 29th January, 18:00-19:30 CET
 

Prof. Ann McNeill
Dr. Debbie Robson
Benji Horwell
Developed by: Springer Medicine
Join the webinar

Keynote webinar | Spotlight on modern management of frailty

Frailty has a significant impact on health and wellbeing, especially in older adults. Our experts explain the factors that contribute to the development of frailty and how you can manage the condition and reduce the risk of disability, dependency, and mortality in your patients.

Prof. Alfonso Cruz-Jentoft
Prof. Barbara C. van Munster
Prof. Mirko Petrovic
Developed by: Springer Medicine
Watch now

A quick guide to ECGs

Improve your ECG interpretation skills with this comprehensive, rapid, interactive course. Expert advice provides detailed feedback as you work through 50 ECGs covering the most common cardiac presentations to ensure your practice stays up to date. 

PD Dr. Carsten W. Israel
Developed by: Springer Medizin
Start the cases

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Read more
Image Credits