Disease of the Adrenal Glands

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been strongly associated with changes in corticoid receptor function and HPA axis dysregulation. This review gives an overview of the complex role of GC and MC receptors …

Crinecerfont (CRENESSITY™) is a corticotropin releasing factor type 1 (CRF1) receptor antagonist developed by Neurocrine Biosciences for the treatment of classic congenital adrenal hyperplasia (CAH) in adult and paediatric patients. In patients …

Large adrenal tumors (LATs) defined as more than 5 cm are uncommon, with the incidence rate accounting for 8.6–38.6% of adrenal tumors [ 1 ]. LATs cover a range of different pathologies, from benign lesions to adrenal cortical cancer or metastasis.

The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of several …

Adrenal mixed corticomedullary tumors (MCMTs) are rare lesions showing a mixture of two cell populations of cortical and medullary lineage. We describe an MCMT case presented in a 56-year-old woman with a history of arterial hypertension and high …

Cushing’s disease, the most common etiology of endogenous Cushing’s syndrome, is a rare disease characterized by hypercortisolemia resulting from an adrenocorticotropic hormone (ACTH)-producing adenoma [ 1 – 3 ]. Chronic exposure to excess cortisol …

Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear malignant potential based on the histopathological features comprised of the Weiss score. Previous studies reported the …

Adrenal cysts (ACs) are considered rare radiological findings, comprising approximately 1–2% of all adrenal incidentalomas, with an overall incidence ranging between 0.064% and 0.18% [ 1 , 2 ]. They are subdivided into pseudocysts, endothelial …