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Endocrinology Disease of the Adrenal Glands

Disease of the Adrenal Glands

Adrenal cortex senescence: an aging-related pathology?

Adrenal cortex senescence is characterized by an altered output of adrenal cortical hormones, which may be implicated in adverse clinical outcomes, but should it be considered an aging-related pathology?

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Editor's Choice

Pheochromocytoma with heterotaxy syndrome

A unique finding of pheochromocytoma in a young adult with heterotaxy syndrome and a functioning ectopic spleen. The patient remained stable on alpha-blockers having decided not to undergo surgery.

EUS-RFA for aldosterone-producing adrenal adenoma

Endoscopic ultrasound-guided, transgastric radiofrequency ablation offers a minimally invasive treatment for left-sided aldosterone-producing adrenal adenoma.

A hypokalemic hypertension mystery

Reninoma should be considered in young people with hypokalemic hypertension when common causes have been excluded. Excision can cure hypertension and prevent morbidity and mortality.

Anastrozole boosts growth potential in children with CAH

Anastrozole could help optimize growth for children with congenital adrenal hyperplasia and advanced bone age.

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Case Studies

Pheochromocytoma with heterotaxy syndrome

A unique finding of pheochromocytoma in a young adult with heterotaxy syndrome and a functioning ectopic spleen. The patient remained stable on alpha-blockers having decided not to undergo surgery.

A hypokalemic hypertension mystery

Reninoma should be considered in young people with hypokalemic hypertension when common causes have been excluded. Excision can cure hypertension and prevent morbidity and mortality.

Cushing disease or ectopic adrenocorticotrophic hormone syndrome?

A girl with typical signs and symptoms of hypercortisolemia experienced adrenal insufficiency while on oral ketoconazole. Ectopic ACTH syndrome due to a thymic neuroendocrine tumor was diagnosed.

Current Reviews

Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been strongly associated with changes in corticoid receptor function and HPA axis dysregulation. This review gives an overview of the complex role of GC and MC receptors …

Crinecerfont: First Approval

Crinecerfont (CRENESSITY™) is a corticotropin releasing factor type 1 (CRF1) receptor antagonist developed by Neurocrine Biosciences for the treatment of classic congenital adrenal hyperplasia (CAH) in adult and paediatric patients. In patients …

Robotic-assisted versus laparoscopic adrenalectomy for large adrenal tumors: a systematic review and meta-analysis

Large adrenal tumors (LATs) defined as more than 5 cm are uncommon, with the incidence rate accounting for 8.6–38.6% of adrenal tumors [ 1 ]. LATs cover a range of different pathologies, from benign lesions to adrenal cortical cancer or metastasis.

p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair

The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of several …

CME & eLearning

News | Expert Reviews | Cases (Link opens in a new window)

Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver resources covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.

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  • Merck Healthcare KGaA, Darmstadt, Germany
Developed by: Springer Healthcare IME

Further Reading

Adrenal mixed corticomedullary tumors: report of a case with molecular characterization and systematic review

Adrenal mixed corticomedullary tumors (MCMTs) are rare lesions showing a mixture of two cell populations of cortical and medullary lineage. We describe an MCMT case presented in a 56-year-old woman with a history of arterial hypertension and high …

Osilodrostat improves blood pressure and glycemic control in patients with Cushing’s disease: a pooled analysis of LINC 3 and LINC 4 studies

Cushing’s disease, the most common etiology of endogenous Cushing’s syndrome, is a rare disease characterized by hypercortisolemia resulting from an adrenocorticotropic hormone (ACTH)-producing adenoma [ 1 – 3 ]. Chronic exposure to excess cortisol …

The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67

Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear malignant potential based on the histopathological features comprised of the Weiss score. Previous studies reported the …

The diagnostic dilemma of adrenal vascular tumors: analysis of 21 cases and systematic review of the literature

Adrenal cysts (ACs) are considered rare radiological findings, comprising approximately 1–2% of all adrenal incidentalomas, with an overall incidence ranging between 0.064% and 0.18% [ 1 , 2 ]. They are subdivided into pseudocysts, endothelial …