Learn about the potential bidirectional pathophysiological relationship between pituitary dysfunction and long COVID and how it could impact diagnosis and therapy for those with the condition.
Glucocorticoid replacement therapy is essential for patients with secondary adrenal insufficiency, but how should it be managed to avoid the risks associated with under and overtreatment?
Bone complications are common in people with Cushing’s disease. Screening for fractures is encouraged, diagnosis should focus on assessing bone quality, and therapy needs to be multifactorial.
Functional localization tests identified a rare case of ectopic adrenocortical adenoma in a woman with ACTH-independent Cushing syndrome and primary amenorrhea due to gonadotropin deficiency.
Understand the growing role of PET/CT imaging for diagnosis and management of endocrine disorders, from providing functional and anatomical information to monitoring treatment response.
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An expert-led symposium exploring the prevention and management of type 2 diabetes through dietary interventions. Highlights include discussion of the recent EASD guidelines, therapeutic diets, food types and processing, plus psychological factors that influence patient success, and the drivers of healthy eating and diabetes control.
Functional localization tests identified a rare case of ectopic adrenocortical adenoma in a woman with ACTH-independent Cushing syndrome and primary amenorrhea due to gonadotropin deficiency.
Primary adrenal leiomyosarcoma is rare but should be considered a differential diagnosis for nonfunctioning adrenal tumors extending directly to the inferior vena cava. CT-guided biopsy can be useful for diagnosis and management.
A 63-year-old woman presented with multiple, short-succession hospital admissions for heart failure and sustained hypertension despite intensive therapy. A diagnosis of a secondary hyperaldosteronism was made, resulting from renal hypoperfusion due to narrowing of the thoracic aorta by a huge calcified plaque, mimicking an aortic coarctation.
Oral hormone replacement therapy has been and continues to be the cornerstone of adrenocortical insufficiency management. However, the introduction of continuous subcutaneous hydrocortisone infusion (CSHI) shows great potential for advancing the …
Adrenocortical cancer (ACC) is a rare and aggressive disease. Surgery has traditionally been the primary treatment for locally advanced disease with ongoing controversy around the optimal neoadjuvant and adjuvant treatment options. Unfortunately …
Approximately 8% of patients with Cushing syndrome can develop psychosis. Current knowledge on the effective management of psychosis in the course of Cushing syndrome is based mostly on case reports. Treatment is considered difficult and patients’ …
Hirsutism is a relatively common disorder which affects approximately 5% to 15% of women. It is defined by excessive growth of terminal hair in women, which primarily affects areas dependent on androgens, such as the face, abdomen, buttocks, and …
The hypothalamic pituitary adrenal (HPA) axis is a critical regulator of circadian rhythm in humans. Insomnia and disrupted sleep are reported by over 50% of patients with hypercortisolemia due to endogenous Cushing’s syndrome (CS), a rare …
17α Hydroxylase/17–20 lyase deficiency (17OHD) is a rare autosomal recessive form of congenital adrenal hyperplasia (CAH) caused by biallelic mutations in the CYP17A1 gene, encoding cytochrome p450c17. It accounts for about 1% of all CAH forms …
Infants with a congenital anomaly of the kidney and urinary tract sometimes present with hyponatremia, hyperkalemia, and metabolic acidosis due to under-responsiveness to aldosterone, hereafter referred to as secondary pseudo-hypoaldosteronism.
Endogenous Cushing’s syndrome (CS) is caused by chronic and excessive glucocorticoid exposure. This occurs primarily due to adrenocorticotropic hormone (ACTH)-producing pituitary tumors (Cushing’s disease; CD) or cortisol-producing adrenal tumors …
