Adrenal cortex senescence is characterized by an altered output of adrenal cortical hormones, which may be implicated in adverse clinical outcomes, but should it be considered an aging-related pathology?
A unique finding of pheochromocytoma in a young adult with heterotaxy syndrome and a functioning ectopic spleen. The patient remained stable on alpha-blockers having decided not to undergo surgery.
Reninoma should be considered in young people with hypokalemic hypertension when common causes have been excluded. Excision can cure hypertension and prevent morbidity and mortality.
A unique finding of pheochromocytoma in a young adult with heterotaxy syndrome and a functioning ectopic spleen. The patient remained stable on alpha-blockers having decided not to undergo surgery.
Reninoma should be considered in young people with hypokalemic hypertension when common causes have been excluded. Excision can cure hypertension and prevent morbidity and mortality.
A girl with typical signs and symptoms of hypercortisolemia experienced adrenal insufficiency while on oral ketoconazole. Ectopic ACTH syndrome due to a thymic neuroendocrine tumor was diagnosed.
Crinecerfont (CRENESSITY™) is a corticotropin releasing factor type 1 (CRF1) receptor antagonist developed by Neurocrine Biosciences for the treatment of classic congenital adrenal hyperplasia (CAH) in adult and paediatric patients. In patients …
Large adrenal tumors (LATs) defined as more than 5 cm are uncommon, with the incidence rate accounting for 8.6–38.6% of adrenal tumors [ 1 ]. LATs cover a range of different pathologies, from benign lesions to adrenal cortical cancer or metastasis.
The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of several …
Adrenocortical carcinoma is a very rare cancer that commonly presents with hormonal abnormalities or, more rarely, as an incidental finding of an adrenal mass. Following optimal surgical management, ideally in the form of open adrenalectomy …
Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver resources covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.
Adrenal mixed corticomedullary tumors (MCMTs) are rare lesions showing a mixture of two cell populations of cortical and medullary lineage. We describe an MCMT case presented in a 56-year-old woman with a history of arterial hypertension and high …
Cushing’s disease, the most common etiology of endogenous Cushing’s syndrome, is a rare disease characterized by hypercortisolemia resulting from an adrenocorticotropic hormone (ACTH)-producing adenoma [ 1 – 3 ]. Chronic exposure to excess cortisol …
Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear malignant potential based on the histopathological features comprised of the Weiss score. Previous studies reported the …
Adrenal cysts (ACs) are considered rare radiological findings, comprising approximately 1–2% of all adrenal incidentalomas, with an overall incidence ranging between 0.064% and 0.18% [ 1 , 2 ]. They are subdivided into pseudocysts, endothelial …
