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Discover Oncology

Issue 1/2025

Content (2347 Articles)

Integrated bioinformatics analysis identifies ALDH18A1 as a prognostic hub gene in glutamine metabolism in lung adenocarcinoma

  • Open Access
  • Analysis

Hao Ren, Deng-Feng Ge, Zi-Chen Yang, Zhen-Ting Cheng, Shou-Xiang Zhao, Bin Zhang

Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study

Changyu Jin, Zehong Lu, Yuzhan Chen, Huijie Hu, Miao Zhou, Yanli Zhang, Guifang Ouyang, Tongyu Li, Lixia Sheng

The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment

Liangliang Wang, Shanshan Ma, Huiwen Su, Dandan Nie, Lihua Wang

Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian randomization study

Jiaqin Deng, Ming Yu, Yihua Gu, Yeqian Lai, Lihong Qiu

Identification of fatty acid anabolism patterns to predict prognosis and immunotherapy response in gastric cancer

Weijie Sun, Yanhong Xia, Feifan Jin, Jinghao Cao, Gaoping Wu, Keyi Li, Yanhua Yu, Yunyi Wu, Gaoqi Ye, Ke Xu, Dengpan Liu, Weidong Jin

Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study

  • Open Access
  • NSCLC
  • Research

Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

The incidence of and risk factors for axillary web syndrome with limited shoulder movement after surgery for breast cancer, and the effect of early physical therapy intervention

Ya-Hui Chou, Su-Fen Liao, Dar-Ren Chen, Shou-Tung Chen, Wei-Te Wang

Circular RNAs in cancer: roles, mechanisms, and therapeutic potential across colorectal, gastric, liver, and lung carcinomas

Ayushi Malviya, Rajabrata Bhuyan

Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in breast cancer

Xiaozhou Yang, Xiaojun Yang, Haili Tang, Xin Chen, Jiangang Wang, Huadong Zhao

Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects

Hesti Lina Wiraswati, Ilma Fauziah Ma’ruf, Nur Akmalia Hidayati, Julia Ramadhanti, Daniela Calina, Javad Sharifi-Rad

Single-cell RNA-sequencing and genome-wide Mendelian randomisation along with abundant machine learning methods identify a novel B cells signature in gastric cancer

Qi Ma, Jie Gao, Yuan Hui, Zhi-Ming Zhang, Yu-Jie Qiao, Bin-Feng Yang, Ting Gong, Duo-Ming Zhao, Bang-Rong Huang

Hyperprogressive disease induced by PD-1 inhibitor monotherapy in lung adenocarcinoma with HER2 exon 20 insertion: report of two cases and review of literature

  • Open Access
  • NSCLC
  • Case Report

Guangjian Yang, Linyan Tian, Yan Wang

Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer

Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

Comparative efficacy of uterine artery embolization versus laparoscopic myomectomy in treating uterine fibroids: a propensity score matched analysis

  • Open Access
  • Research

Cunbao Wei, Xingwei Sun, Shenzhi Li, Xuming Bai, Yong Jin

Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy

Minni Zhang, Kailin Huang, Qiushi Yin, Xueqin Wu, Mingyue Zhu, Mengsen Li

Vitamin A and its influence on tumour extracellular matrix

Guoqing Xie, Shun Cao, Guangchun Wang, Xianzhong Zhang, Yu Zhang, Haofan Wu, Shuxian Shen, Jiandong Le, Keqiang Li, Zhenlin Huang

Histologically confirmed pediatric extracardiac rhabdomyoma: case series

Gashaw Arega, Abdulkadir Mohamedsaid, Getasew Fikad, Mulualem Nigusie, Tihitena Nigusie, Abrehet Zeray, Fathia Omer, Yodit Abraham, Alemayehu Tsega, Amanuel Damie, Tseganesh Mekonnen Hailemariam, Mesfin Asefa

Bioinformation study of immune microenvironment characteristics of disulfidptosis-related subtypes in ovarian cancer and prognostic model construction

Ying Zhou, Yuhong Zhang, Yang Zhou, Yanzheng Gu, Youguo Chen, Juan Wang

Stathmin 1 expression in neuroendocrine and proliferating prostate cancer

Yingli Shi, Yunshin A. Yeh, Siyuan Cheng, Xin Gu, Shu Yang, Lin Li, Nazih P. Khater, Susan Kasper, Xiuping Yu

Anti-tumor role and molecular mechanism of vanillic acid

  • Open Access
  • Review

Xunxing Hao, Zhixiao Gao, Mingzhe Hu

Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases

Punita Kalia, Rohini Ravindran Nair, Suresh Singh Yadav

Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/GSK3β/β-catenin pathway

Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

Targeting protein synthesis pathways in MYC-amplified medulloblastoma

Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi

Surgical treatment can provide the opportunity for in-vitro fertilization (IVF) in a shorter period of time for patients with early-stage endometrial cancer

Qianhua Xu, Hedong Lu, Xiaolei Wang, Min Li, Weiwei Zou

Environmental factors inducing gastric cancer: insights into risk and prevention strategies

Puyi He, Xiaomei Li, Dan Zou, Futian Tang, Hao chen, Yumin Li

Metastatic pancreatic cancer now in remission: a case report and literature review

Charles W. Shi, Thomas J. VanderMeer, Anita Pudusseri

MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway

  • Open Access
  • Research

Hongming Wang

Bioinformatics analysis of mitochondrial metabolism-related genes demonstrates their importance in renal cell carcinoma

Mohsen Ahmadi, Maryam Motallebinezhad, Pegah Mousavi, Amir Hossein Miladipour, Shamim Fooladgar, Soudeh Ghafouri-Fard, Seyed Amirhossein Fazeli

The role of histone lactylation genes in hepatocellular carcinoma prognostic models and their immune cell infiltration features: a comprehensive analysis of single-cell, spatial transcriptome, Mendelian randomization and experiment

Shanjie Luan

Locally advanced nasopharyngeal follicular dendritic cell sarcoma misdiagnosed as meningioma

Yoldez Houcine, Abir Rais, Salma Kamoun, Sawssen Dhambri, Souhaeil Jebali, Maha Driss

A novel necroptosis-related gene signature predicts the prognosis and immunotherapeutic response in breast cancer through immune infiltration

Dezhi Lu, Sifang Qiu, Zhiqiang Zeng

High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients

Hongyang Zhao, Beiwu Lan, Zenghui Zhao, Peining Zhu, Chong Wang, Yufei Gao

Global research trends and emerging hotspots in nano-drug delivery systems for lung cancer: a comprehensive bibliometric analysis (1998–2024)

Cao Yu, Chong-Qi Fan, Yao-Xuan Chen, Feng Guo, Hao-Han Rao, Peng-Yu Che, Chun-Jian Zuo, Huan-Wen Chen

Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024

Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database

Hanzhang Yuan, Jingsheng Cheng, Jun Xia, Zeng Yang, Lixin Xu

Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway

Yaqiong Zhang, Bo Li, Wanhong Gu, Linna Fan, Xiaofan Wang, Meifen Xu, Minqi Zhu, Chong Jin

A comprehensive pan-cancer analysis of RNF187 in human tumors

  • Open Access
  • Analysis

Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme

Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer

Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

LncRNA MANCR is downregulated in non-small cell lung cancer and predicts poor survival

  • Open Access
  • NSCLC
  • Research

Yunming Tao, Jie Liu, Wenxiao Qiu, Yuanyuan Li

Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach

Haoyun Zhou, Yongbo Wang, Fang Wang, Runtang Meng, Yong Yu, Su Han, Yu Zhang, Yu Wu, Xiaoxue Liu

Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study

  • Open Access
  • Research

Ruoya Lv, Jiabin Chen, Xiaoyu Wu, Kequn Chai, Jiadong Yan, Sheng Wang

Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD

Wei Du, Xiao-Wei Wu, Qing-Feng Li, Bing-Yu Zhang, Jing Wu, Ya-Ping Xu, Xue Yi

A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data

  • Open Access
  • Analysis

Xiaoqiong Li, Kejiang Wang, Jiaxin Liu, Yan Li

RNA modification writer-based immunological profile and genomic landscape of tumor microenvironment in lung adenocarcinoma

  • Open Access
  • Analysis

Qiang Xu, Lingyu Kong, Zhezhu Han, Xiuying Jin, Mingyan Ding, Zhengri Piao, Songnan Zhang

Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies

Zhongqiu Yang, Yuquan Chen, Yaping Miao, Haisheng Yan, Kexin Chen, Yaoqin Xu, Lanqian Su, Lanyue Zhang, Yalan Yan, Hao Chi, Jin Fu, Lexin Wang

Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation

Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

Potential and development of cellular vesicle vaccines in cancer immunotherapy

  • Open Access
  • Review

Wenxi Zhao, Xianjun Li, Jialu Guan, Shuai Yan, Lizhi Teng, Xitong Sun, Yuhan Dong, Hongyue Wang, Weiyang Tao

CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management

Joseph Norton, Patrick Stiff

Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma

Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li

Combination of inflammatory proteins in serum can be used to diagnose papillary thyroid carcinoma with lymph node metastasis

Yongqin Pan, Guanghao Wang, Delin Chen, Zhihui Wu, Yimwing Kei, Mingxi Xu

Combination therapy of low-dose radiotherapy and immunotherapy in advanced metastatic nasopharyngeal carcinoma: a case report and literature review

Chun-Qiao Chen, Hui Huang, Min Pan, Zhe Jia, Jing Zhang, Qiu-Qiu Chen

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

Chieko Niwata, Takayuki Nakagawa, Takako Naruse, Miyuki Sakuma, Nao Yamakado, Misaki Akagi, Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa

Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study

Zheng Wang, Mengshu Pan, Jie Zhu, Changhong Liu

Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy

Nie Zhang, Zhuoying He, Xuejin Qin, Ke Han, Zhengchun Zhu, Fei Zhong

Efficacy of preoperative pulmonary rehabilitation in lung cancer patients: a systematic review and meta-analysis of randomized controlled trials

Yalun Guo, Mengdie Pan, Meidi Xiong, Miao Liu, Na Zhu, Haoxu Dong, Chunhua Zhang

Integrative single-cell and multi-omics analyses reveal ferroptosis-associated gene expression and immune microenvironment heterogeneity in gastric cancer

Shupeng Zhang, Zhaojin Li, Gang Hu, Hekai Chen

FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression

Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

FHL1 as a prognostic biomarker and therapeutic target in acute promyelocytic leukaemia

Bo Luo, Wei Li, Jingyuan Zeng, Yingyu Mao, Shuang He, Nan Hu, Qulian Guo, Xiaoli Zheng

Overexpressed RPS6KA1 and its potential diagnostic value in head and neck squamous cell carcinoma

  • Open Access
  • Research

Chengjun Hu, Jiaheng Xie, Xiyun Fei, Yuming Sun, Shaorong Lei, Xi Yan, Cheng Ran

Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance

  • Open Access
  • Review

Xinni Xue, Zhiwei Li, Jiahui Zhao, Ziyi Zhao, Zhihang Li, Yong Li, Yawen Liu, Huan He

Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets

Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p

Biao Wang, Nianjie Zhang, Lin Dai, Yuanwei Zhang, Shuo Yin, Xuefeng Yang

A risk signature constructed by Tregs-related genes predict the clinical outcomes and immune therapeutic response in kidney cancer

Gang Li, Jingmin Cui, Tao Li, Wenhan Li, Peilin Chen

Revolutionizing ESCC prognosis: the efficiency of tumor-infiltrating immune cells (TIIC) signature score

  • Open Access
  • Analysis

Haixia Wang, Shaowei Ma, Zixin Yang, Ren Niu, Haiyong Zhu, Shujun Li, Shaolin Gao, Zhirong Li, Yanhua Tian

Silymarin: a promising modulator of apoptosis and survival signaling in cancer

  • Open Access
  • Review

Ujjawal Sharma, Praveen Kumar Sahni, Bunty Sharma, Madhu Gupta, Damandeep Kaur, Darin Mansor Mathkor, Shafiul Haque, Sabiha Khatoon, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

Causal role of ischemic heart disease in ovarian cancer subtypes

Jianhai Chen, Huabin He, Ling Gao

Aging and tumors: a dynamic interaction

  • Open Access
  • Review

Yudi Zhang, Siqiang Zhu, Zhaodong Liu, Yonghao Hu, Yongjian Zhang, Liang Shang, Leping Li

NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma

Qiucheng Lei, Yingchun Huang, Feiwen Deng, Huazhen Zheng, Xitao Hong, Peng Wang, Jin Lv, Huanwei Chen, Zhenling Ji

Machine learning-based prognostic model for patients with anaplastic thyroid carcinoma

Yihan Sun, Da Lin, Xiangyang Deng, Yinlong Zhang

A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma

Xiuyun Chen, SenLin Li, Lixue Cao, Shaoxian Chen, Qiuxiong Lin, Shilong Zhong

Anti-cancer effect of midazolam via downregulating YWHAH in papillary thyroid cancer cells

Yang Li, Ai-Ping Tan, Yu-Shan Zhong

Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems

Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications

  • Open Access
  • NSCLC
  • Research

Yue Gu, Miaosen Zheng, Jing Xie

Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma

Chaoqun Zhang, Dianxing Sun, Huifang Zhou, Chao Liu, Jie Ruan, Jiwen Kang, Ying Xie

A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer

Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu

Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review

Manjusha Bhange, Darshan Telange

Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining

Wen-jian Liu, Jia-pan Shen, Ren-quan Zhang, Xiao-yun Fan

Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024

  • Open Access
  • Research

Zhuheng Wei, Anxia Li, Ling Su, Bo Zhang, Yuanyuan Yan

Association between serum levels of 12 different cytokines and short-term efficacy of chemoradiotherapy in esophageal squamous cell carcinoma

Yaping Zhang, Qiufeng Qi, Ming Zhu, Yun Peng, Yanqing Bao, Jun Liu, Yanzhi Bi, Min Xiao, Shaohua Chi, Yongping Liu

Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC

  • Open Access
  • Analysis

Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

Survival outcomes of surgery and adjuvant chemotherapy in early-stage small cell and large cell lung cancer: a novel focus on tumors less than 1 cm

  • Open Access
  • SCLC
  • Research

Jorge Raul Vazquez-Urrutia, Junjia Zhu, Shinkichi Takamori, Max Greenberg, Priyanka Bhatia, Takefumi Komiya

Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma

Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang

Upregulation of CD19 by low‐dose chidamide promotes CAR T cells functionality in B-cell non-Hodgkin lymphoma

Ying Ni, Qun Zhang, Xiaochen Tang, Xiuchun Li, Shiguang Ye, Yan Lu, Aibin Liang, Ping Li

Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis

Qian Guo, Xinxin Zhong, Zihan Dang, Baiquan Zhang, Zixin Yang

The predictive value of radiomics and deep learning for synchronous distant metastasis in clear cell renal cell carcinoma

Wan-Bin He, Chuan Zhou, Zhi-Jun Yang, Yun-Feng Zhang, Wen-Bo Zhang, Han He, Jia Wang, Feng-Hai Zhou

Machine learning-assisted cancer diagnosis in patients with paraneoplastic autoantibodies

Alireza Maleki, Mohammad Mahdi Mirza Ali Mohammadi, Shahab Gholizadeh, Behnaz Dalvandi, Mohammad Rahimi, Aidin Tarokhian

A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets

Lin Li, Xin Zhang, Jiayao Yan, Jingyi Guo, Fangcen Liu, Xiao Wei, Qin Liu, Kongcheng Wang, Baorui Liu

Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies

Ugochi Ebinama, Binsah George

Correction: Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis

Wenjuan Li, Hong Gao, Jianjun Liu

AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism

Yang Yang, Dan Li, Zhigang Liu, Kai Zhou, Wenxing Li, Yanqi Yang, Ruifang Sun, Yulong Li

Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization

Sibo Xu, Yiguo Li, Wei Chen, Ke Wang

To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics

Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response

Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study

Perttu Saarinen, Otto Jokelainen, Liida Ruotsalainen, Essi Ikonen, Timo K. Nykopp

Improving molecular subtypes and prognosis of pancreatic cancer through multi group analysis and machine learning

Xue-Jian Zhang, Fang-Fang Lin, Ya-Qing Wen, Kun-Ping Guan

RASGRF2 as a potential pathogenic gene mediating the progression of alcoholic hepatitis to alcohol-related cirrhosis and hepatocellular carcinoma

Zhengyuan Chen, Danfeng Fan, Tianyi Hang, Xiaoqing Yue

The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family

  • Open Access
  • Research

Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

Developing a novel model for predicting overall survival in late-onset colon adenocarcinoma patients based on LODDS: a study based on the SEER database and external validation

Chen Chen, Heng-Bo Xia, Wei-Wei Yuan, Meng-Ci Zhou, Xue Zhang, A.-Man Xu

The hype around ctDNA guiding an informed perioperative therapeutic strategy in early-stage non-small cell lung cancer

  • Open Access
  • NSCLC
  • Review

Gaia Passarella, Stefania Canova, Maria Ida Abbate, Giulia Caspani, Luca Sala, Alessandro Russo, Paola Muscolino, Francesca Colonese, Diego Luigi Cortinovis

Immunological characterization and prognostic of colon cancer evaluated by angiogenesis-related features: a computational analysis and in vitro experiments

Fei Liu, Yi Wang, Leiming Xia, Chen Sun, Yun Li, Yunhong Xia

FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma

Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

Correction: HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway

Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li

Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology

  • Open Access
  • Research

Laiyi Wan, Wentao Hao, Leilei Li, Lin Wang, Yanzheng Song

A prognostic model of 8-T/B cell receptor-related signatures for hepatocellular carcinoma

Xuan Zuo, Hui Li, Shi Xie, Mengfen Shi, Yujuan Guan, Huiyuan Liu, Rong Yan, Anqi Zheng, Xueying Li, Jiabang Liu, Yifan Gan, Haiyan Shi, Keng Chen, Shijie Jia, Guanmei Chen, Min Liao, Zhanhui Wang, Yanyan Han, Baolin Liao

Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer

Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite

Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies

Ujjawal Sharma, Anidrisha Sahu, Himanshu Shekhar, Bunty Sharma, Shafiul Haque, Damandeep Kaur, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation

Qinmin Wu, Feng Li, Yunlong Zhang, Siying Li, Chuan Xiang

Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk

Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization

Haihui Jiang, Xijie Wang, Xiaodong Chen, Shouzan Zhang, Qingsen Ren, Mingxiao Li, Ming Li, Xiaohui Ren, Song Lin, Yong Cui

Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis: an update

Yuejia Zhao, Simeng Zhao, Zhe Fan, Yongfu Zhao, Guangzhi Wang

Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma

  • Open Access
  • Research

Wei Peng, Yali Zhao, Ningning Yang, Yan Fang, Yintong Wu, Zhenzhong Feng, Qiang Wu, Xian Wang

Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and bulk RNA-seq

Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun

Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers

Aidi Lin, Feifei Xue, Chenxiang Pan, Lijiao Li

Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression

Liqin Ruan, Ningbo Fang, Xinhua Zhao, Weili Chen, Zhaoping Wu, Xiaoyong Wu

Evolving prognostic paradigms in lung adenocarcinoma with brain metastases: a web-based predictive model enhanced by machine learning

Min Liang, Zhiwen Zhang, Langming Wu, Mafeng Chen, Shifan Tan, Jian Huang

Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4

Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning

Junbo Liao, Yingxing Duan, Xiangwang Xu, Yaxue Liu, Chaohong Zhan, Gelei Xiao

Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study

  • Open Access
  • Analysis

Wen-Hao Hu, Jia-An Sun, Chang Liu

Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma

JinSong Li, GuanBo Zhang, Gang Li, Jie Zhang, Zhi Yang, Lin Yang, ShiJie Jiang, JiaXing Wang

Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review

Nazia Afroze, Madhumitha K. Sundaram, Shafiul Haque, Arif Hussain

A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma

  • Open Access
  • Research

Yonglin Luo, Wenyang Wei, Yaxuan Huang, Jun Li, Weiling Qin, Quanxiang Hao, Jiemei Ye, Zhe Zhang, Yushan Liang, Xue Xiao, Yonglin Cai

Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimental tools

Alireza Sadeghipour, Fahimeh Fattahi, Zahra Madjd, Fatemeh Tajik, Farnoosh Sedaghati, Leili Saeednejad Zanjani

SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer

Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma

Wei-Ting Kuo, Yi-Chen Lee, Jia-Bin Liao, Ching-Jiunn Tseng, Yi-Fang Yang

Genetic advancements in breast cancer treatment: a review

Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

Prediction of biochemical prostate cancer recurrence from any Gleason score using robust tissue structure and clinically available information

Laura E. Marin, Daniel I. Zavaleta-Guzman, Jessyca I. Gutierrez-Garcia, Daniel Racoceanu, Fanny L. Casado

GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2

Junbo He, Liangzhi Wang, Mengjia Lv, Yiming Yuan

KLF5 promotes esophageal squamous cell carcinoma radioresistance by targeting the Keap1-Nrf2 pathway

Yang Wang, Yue-ying Yang, Abulajiang Kamili, Dilimulati Aishanjiang, Yi Liu

LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis

Zhenxiang Zhao, Haiying Liu, Yingzi Liu, Junpeng Wen, Jiangwei Yuan

Pathological features and immunohistochemical characteristics of clear cell (glycogen-rich) urothelial carcinoma: a case report and systematic review of the literature

Weiming Wang, Baogang Zhang, Zhangli Wu, Chuanling Hou, Mengyao Li, Tianyi Zhang

Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets

Xuedan Lai, Ling Wu, Peihong Lin, Lijiao You, Jianwen Ye

Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer

Xiaoyu Qin, Wenjuan Xu, Jinxiu Wu, Ming Li

Harnessing artificial intelligence for predicting breast cancer recurrence: a systematic review of clinical and imaging data

Jaqueline Alvarenga Silveira, Alexandre Ray da Silva, Mariana Zuliani Theodoro de Lima

Multivariate Cox regression analysis of prognostic genes and therapeutic mechanisms of gastric cancer

Yangyang Xiao, Zhiru Zhong, Chunli Yang, Zhiying Lin

Innovative laboratory techniques shaping cancer diagnosis and treatment in developing countries

Azeez Okikiola Lawal, Tolutope Joseph Ogunniyi, Oriire Idunnuoluwa Oludele, Oluwaloseyi Ayomipo Olorunfemi, Olalekan John Okesanya, Jerico Bautista Ogaya, Emery Manirambona, Mohamed Mustaf Ahmed, Don Eliseo Lucero-Prisno III

Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis

Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing

Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

Identification of mitophagy-related genes impacting patient survival in glioma

Qiang Zhao, Guangxin Li

Impact of magnetic resonance imaging-defined sarcopenia on prognosis in patients with locally advanced nasopharyngeal carcinoma

Yuanling Yang, Yang Gao, Yingyi Luo, Weiyi Liu, Peizhen Xie, Lixuan Huang, Zisan Zeng

The promise of mitochondria in the treatment of glioblastoma: a brief review

Zhuo Liang, Songyun Zhao, Yuankun Liu, Chao Cheng

Bone marrow mesenchymal stem cells-derived exosomes deliver microRNA-142-3p to disturb glioma progression by down-regulating GFI1

Huahui Chen, Lixiong Xue, Xiaolong Wang, Li Han, Xinmin Ding

Development of a novel prognostic signature based on cytotoxic T lymphocyte-evasion genes for hepatocellular carcinoma patient management

Qinmei Zhu, Shiping Liao, Ting Wei, Suya Liu, Chunqian Yang, Jingsong Tang

Driver mutation detected in cerebrospinal fluid despite negative liquid biopsy results

Kei Kunimasa, Daisuke Aohara, Kazumi Nishino

A bibliometric analysis of immune response in oral cancer

Rongrong Zhang, Runying Guo, Yuqi Xin, Qingkun Jiang, Jiaxuan Qiu

Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism

Jiayi Yu, Kai Hong, Lingli Yao, Dongbo Shi, Jiabo Zhang

Exploration of telomere-related biomarkers for lung adenocarcinoma and targeted drug prediction

Jixing Zhao, Lirong Ye, Wu Yan, Wencong Huang, Guangsuo Wang

DPH2 is a biomarker associated with cell death, immunity and prognosis based on pan-cancer analysis

Maolin Xiao, Shuai Su, Xiangbiao He, Liangdong Song, Delin Wang

LncRNA MSTO2P affects the proliferation, invasion and migration of non-small cell lung cancer by regulating the Wnt/β-catenin pathway

  • Open Access
  • NSCLC
  • Research

Yunfeng Chen, Hai Shi, Yuan Dong, Wenjie Cui

Single-cell pseudotime and intercellular communication analysis reveals heterogeneity and immune microenvironment in oral cancer

Hanjun Liu, Lian Xie, Xuemin Xing, Lili Hou, Jinfeng Zhang, Ling Yang

A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer

Jiaxin Shi, Linyou Zhang

Advances in understanding ferroptosis mechanisms and their impact on immune cell regulation and tumour immunotherapy

Zengjun Zhu, Xuanxuan Wu, Jian Zhang, Minghui Zhu, Maojin Tian, Peiqing Zhao

Identification of inflammation-related genes signature to establish a prognostic model in MGMT unmethylated glioblastoma patients

Yunzhao Mo, Dandan Fan, Wei Wang, Shenchuan Wang, Yingyu Yan, Zhenyu Zhao

Machine learning model reveals the risk, prognosis, and drug response of histamine-related signatures in pancreatic cancer

  • Open Access
  • Analysis

Chang-Lei Li, Zhi-Yuan Yao, Chao Qu, Guan-Ming Shao, Yu-Kun Liu, Xiang-Yu Pei, Jing-Yu Cao, Zu-Sen Wang

Identification of HES4 as a novel prognostic marker and therapeutic target in hepatocellular carcinoma

Yungang Liu, Ying Shen, Peipei Luo, Shaoxian Wu, Yue Wang, Jianzhong Deng, Linghui Deng, Fang Wang, Jianhua Jin, Jingting Jiang

Brain metastases from lung cancer: recent advances and novel therapeutic opportunities

  • Open Access
  • NSCLC
  • Review

Stephen C. Layng, Alexis Betsock, Alireza Mansouri, Takefumi Komiya, Joseph A. Miccio, Sean S. Mahase, Jonathan P. S. Knisely

miR-124-3p inhibits CRC proliferation, migration, and invasion by targeting ITGB1

Jing Li, Lisi Liu

Exploring lung cancer microenvironment: pathways and nanoparticle-based therapies

Arunabh Arandhara, Pallabi Bhuyan, Bhrigu Kumar Das

A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma

Wei Yu, Zizi Jing, Jialin Tang, Jianbin Chen

PGAM1: a potential therapeutic target mediating Wnt/β-catenin signaling drives breast cancer progression

Yongxuan Wang, Wei Liu, Xudong Lai, Haixiong Miao, Xifeng Xiong

MiRNA-21 promotes the migration and proliferation of prostate cancer cells via activating the JAK/STAT pathway

Xin Han, Chenjun Lv

Identification of T cell dysfunction molecular subtypes and exploration of potential immunotherapy targets in BRAF V600E-mutant colorectal cancer

Tiefeng Gu, Haonan Qi, Jiaqi Wang, Liangwei Sun, Yongqi Su, Hanqing Hu

Construction and interpretation of weight-balanced enhanced machine learning models for predicting liver metastasis risk in colorectal cancer patients

Qunzhe Ding, Chenyang Li, Chendong Wang, Qunzhe Ding

A deep learning model to predict dose distributions for breast cancer radiotherapy

Xiaorong Hou, Weishi Cheng, Jing Shen, Hui Guan, Yimeng Zhang, Lu Bai, Shaobin Wang, Zhikai Liu

Deciphering the risk of developing liver cancer following gastric cancer diagnosis with genetic evidence: a Mendelian randomization analysis in an East Asian population

Jiansheng Chen, Aiming Zeng, Yunzhe Yu, Liqun Liao, Siwei Huang, Sida Sun, Weijie Wu

Dynamic changes in peripheral blood immunophenotyping and its prognostic value in cervical cancer patients undergoing immune checkpoint blockade therapy

Wenjian Gong, Zhi Wang, Yongqiang Wei, Maomao Wang, Kuina Li, Xiaoqi Chen, Xiaoling Huang, Lu Zhou, Qiuting Gan, Xiaoying Xu, Zhijiong Huang, Hongyu Yao, Nengxian Wu, Lu Huang, Bingbing Yan, Bingbing Zhao, Zhijun Yang

Inhibition of hemangioma development by regulating the VEGF/VEGFR autocrine loop via the miR-494/PTEN pathway

Jingyu Peng, Feifei Li, Mingke Qiu, Xinjie Xu, Guanghua Liu, Jingmin Ou

Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review

Jie Yang, Yi Luo, Zuhuan Yao, Zhaokai Wang, Ke Jiang

Primary capicua transcriptional repressor-rearranged sarcoma in the thyroid gland with cervical lymph node and lung metastases: a case report and literature review

Li Wang, WangWang Liu, Wen Tang, Yan Ma, Xi Bo Liu, Fang Liu

Identification and characterization of cuproptosis related gene subtypes through multi-omics bioinformatics analysis in breast cancer

Dalang Fang, Yu Zhou, Fengqing Liao, Bimin Lu, Yanghong Li, Mian Lv, Zhizhai Luo, Yanfei Ma

Identification of differentially expressed MiRNA clusters in cervical cancer

S. Sriharikrishnaa, Padacherri Vethil Jishnu, Vinay Koshy Varghese, Vaibhav Shukla, Sandeep Mallya, Sanjiban Chakrabarty, Krishna Sharan, Deeksha Pandey, Shama Prasada Kabekkodu

Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance

Yawen Chen, Jian Yang, Yadan Du, Zaihua Yan, Jieyun Gao, Haoyang Zhang, Qiong Wu, Bowen Nian, Xiujuan Huang, Mingxu Da

Oral cancer driver gene mutations in oral potentially malignant disorders: clinical significance and diagnostic implications

Sayaka Kojima, Nobuyuki Kuribayashi, Hiroyuki Goda, Koh-ichi Nakashiro, Daisuke Uchida

The effectiveness and reliability of autologous hematopoietic stem cell transplantation following chemotherapy in managing malignant lymphoma: a meta-analysis

Hend Ahmed, Ahmed S. Shafiey, Mohamed E. A. Abdelrahim

YRNAs: biosynthesis, structure, functions and involvment in cancer development

  • Open Access
  • Review

Adele Campo, Federica Aliquò, Tania Velletri, Salvatore Campo

Analysis of microarray and single-cell RNA-seq identifies gene co-expression, cell–cell communication, and tumor environment associated with metabolite interconversion enzyme in prostate cancer

Danial Hashemi Karoii, Ali Shakeri Abroudi, Nadia Forghani, Sobhan Bavandi, Melika Djamali, Hamoon Baghaei, Sana Shafaeitilaki, Ehsan HasanZadeh

Construction of regulatory T cells specific genes predictive models of prostate cancer patients based on machine learning: a computational analysis and in vitro experiments

Zhengrong Zhou, Chaozhao Liang

Analysis of ABCC3 in glioma progression: implications for prognosis, immunotherapy, and drug resistance

Liang Shen, Haitao Shen, Tong Wang, Gang Chen, Zhengquan Yu, Fang Liu

Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules

  • Open Access
  • Research

Rirong Qu, Yang Zhang, Shenghui Qin, Jing Xiong, Xiangning Fu, Lequn Li, Dehao Tu, Yixin Cai

Improving access to chimeric antigen receptor T-cells for refractory or relapsing diffuse large B cell lymphoma therapy in Asia

Ya Hwee Tan, Dok Hyun Yoon, Andrew J. Davies, Christian Buske, Yang Liang Boo, Nagavalli Somasundaram, Francesca Lim, Shin Yeu Ong, Anand Jeyasekharan, Koji Izutsu, Won Seog Kim, Jason Yongsheng Chan

High-ammonia microenvironment promotes stemness and metastatic potential in hepatocellular carcinoma through metabolic reprogramming

Renchao Zou, Sicong Jiang, Jiaqi Mei, Chen Chen, Jia Yu, Yanqiu Fu, Siyu Chen

CCR7 in esophageal squamous cell carcinoma: an identification from single-cell and bulk transcriptome sequencing

  • Open Access
  • Analysis

Yang Yu, Qian Zhao, Hongguang Cui, Liang Song

Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review

Ayenew Berhan, Andargachew Almaw, Shewaneh Damtie, Yenealem Solomon

Potential application and prospects of ROS-sensitive biomaterials in cancer therapy: a immune microenvironment triggered nanomaterial

Weiming Huang, Pengju Zhang, Eryong Zhao, Jian Xiong, Shaokun Wang, Zi Lv

Advances in the study of disulfidptosis in digestive tract tumors

Yue Chen, Dachuan Zhang, Haonan Yang, Jun Wu, Wenting He

Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling

  • Open Access
  • NSCLC
  • Research

Guohao Wei, Lingyao Fan, Xiaoyan Song, Wenzheng Zhou, Min Sun, Yan Sun, Yuhui Yao, Huihui Zhao, Fangfang Chen, Chuandong Zhu

Association between SOX gene family expression, DNA methylation, and miRNA regulation in lung adenocarcinoma progression

  • Open Access
  • Analysis

Haidao Wang, Yiming Hu, Haibin Lu, Zhijie Wu, Yixiang Zhang

Anti-tumor potential of Harmine and its derivatives: recent trends and advancements

Hemant Joshi, Sakshi Bhushan, Tanisha Dimri, Deepak Sharma, Katrin Sak, Abhishek Chauhan, Ritu Chauhan, Shafiul Haque, Faraz Ahmad, Manoj Kumar, Hardeep Singh Tuli, Damandeep Kaur

Comprehensive pan-cancer analysis of ENOPH1 in human tumors

Xuezhong Zhang, Ning Li, Tingting Chu, Haijun Zhao, Tonggang Liu

Characterization of hepatocarcinoma cells: lymphatic metastasis potential through enhanced production, expression, and secretion along the VEGF-C/D-VEGFR-3/NRP-2 axis

Jingwen Wang, Xuejiao Qian, Zhiqi Yin, Dan Tong, Caihong Wang, Zhandong Hu, Wenjuan Cai, Jianwu Tang

Identification of exosome-related genes associated with prognosis and immune infiltration features in pancreatic cancer

Jie Wang, Ming Qing, Jie Gui, Pingyong Zhong, Hao Hua

Purine metabolism-associated key genes depict the immune landscape in gout patients

  • Open Access
  • Gout
  • Analysis

Lin-na Li, Hao Wang, Lu-shan Xiao, Wei-nan Lai

Analysis of fatty acid metabolism in prostate cancer and discovery of a new programmed cell death-associated luminal cell subpopulation

Yan Zeng, Zhaolin Jiang

Comprehensive analysis of basement membrane-related genes showed that NELL2 is a new therapeutic target for colorectal cancer

Weiguo Wang, Zhengxing Dai, Chen Ge, Xitian Zhou, Yi Zhan, Chaobo Chen

Benchmarking histopathology foundation models for ovarian cancer bevacizumab treatment response prediction from whole slide images

Mayur Mallya, Ali Khajegili Mirabadi, David Farnell, Hossein Farahani, Ali Bashashati

Molecular subtyping combined with multiomics analysis to study correlation between TACE refractoriness and tumor stemness in hepatocellular carcinoma

Qifan He, Yue Xiong, Xiaoyu Yang, Yihui Yu, Zhonghua Chen

Genetic insights into the shared molecular mechanisms of Crohn’s disease and breast cancer: a Mendelian randomization and deep learning approach

Zhuang Zhuang Wang, Ju Lin Yang, Zong Yao Zhang, Pei Bin Wang

Viral IL-10 can promote the proliferation, migration and invasion of nasopharyngeal carcinoma cells and inhibit their apoptosis

Qin Qiu, Xingyu Yang, Xiaojiang Li, Yanxin Ren, Ning Huang

Study of an N6-methyladenosine- and ferroptosis-related prognostic model and the mechanisms underlying the molecular network in neuroblastoma based on multiple datasets

Jing Chu

Glutathiones’ life in multi-cancers: especially their potential micropetides in liver hepatocellular carcinoma

Didi Ma, Zhenguo Wu, Mengying Zhang, Jian Mao, Wenqin Xu, Lan Jiang, Zuzhen Wang

Plasma proteins mediate the effects of the gut microbiota on the development of head and neck cancer: a two-sample and mediated Mendelian randomized study

Jin-Hui Rao, Wen-Da Zhang, Cheng-Peng Zha, Min-Yue Zhang, Yu-Jie Xing, Zai-Hui Wang, Jun-Xian Yu, Dong-Yan He, Chuan-Zheng Sun, Lei Li

Targeting autophagy in platinum-sensitive relapsed ovarian cancer: randomized phase II trial of hydroxychloroquine with chemotherapy with biomarker correlation

Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Medha Rajappa, Prabhu Manivannan, Sunitha Vellathussery Chakkalakkoombil, Debasis Gochhait, Latha Chaturvedula, S. Pradeep, Annuja Anandaradje, Alladi Charanraj Goud, Prasanth Ganesan

Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study

Ping Qi, Liyun Chen, Aiwei Ma, Yiwen Zhang, Hai Lin, Wenqi Shi, Zijian Huang, Zixuan Tang, Wenshi Jiang, Mengjing Xu, Wancong Zhang, Shijie Tang

Mendelian randomization study identifying immune cell phenotypes associated with breast cancer risk

Zhiqin Zhang, Junfeng Zhao, Ying Li, Huijuan Zhang, Yunsong Chen, Linke Yang, Yanhui Zhang, Yang Li, Jiamao Lin

Comprehensive single-cell analysis of triple-negative breast cancer based on cDC1 immune-related genes: prognostic model construction and immunotherapy potential

Linan Huang, Yiran Liu, Yulin Shi, Qi Sun, Huayao Li, Changgang Sun

The prognosis of ciRS-7 and circHIPK3 in pan-cancer: a mini-review and meta-analysis

Xiangji Li, Tong Wu, Ruihan Dong, Xiaoying Wu

Multidimensional analysis reveals gene expression, cell interactions, and signaling networks in glioma and Alzheimer’s disease

Meiyi Wang, Jie Yu, Dongfang Ge, Zhiwen Geng, Chengqun Wei, Dan Xu

Sample size required for prognostic genes analysis in colorectal cancer

Chuanhua Zhao, Xiao Lou, Weilu Jia, Zhiyi Wan, Xin Lu, Yuxuan Qiu, Qianru Xu, Kaiyu Jian, Hongyan Zhang, Feng Liang

Exploring modifiable risk factors: insights from Mendelian randomization analyses of gastric cancer in East Asian populations

Wenjun He, Xin Tan, Weihao Yang, Donghua Huang, Hengyi Zhang, Hao Liu

Analysis of clinicopathological characteristics in rhabdomyosarcoma and identification of risk factors for metastasis to the lung, bone, liver, and brain: a population-based cohort study

QiaoRong Hao, QiuTing Dai, XueLiang Ding, XueNong Gao, You Zhou

A novel golgi related genes based correlation prognostic index can better predict the prognosis of glioma and responses to immunotherapy

Beichuan Zhao, Ruoheng Xuan, Guitao Yang, Tianyu Hu, Yihong Chen, Lingshan Cai, Bin Hu, Gengqiang Ling, Zhibo Xia

Bibliometric analysis of nanomaterials in hepatocellular carcinoma treatment: research trends, knowledge structures, and emerging insights (2000–2024)

Xu Hou, Xiaohong Jiang, Wei Zhang, Jun Liu

Correction: Overexpressed RPS6KA1 and its potential diagnostic value in head and neck squamous cell carcinoma

  • Open Access
  • Correction

Chengjun Hu, Jiaheng Xie, Xiyun Fei, Yuming Sun, Shaorong Lei, Xi Yan, Cheng Ran

The molecular pathogenesis of SOX2 in prostate cancer

Shixue Liu, Honglian Yu, Zhankui Zhao

Genetically predicted inflammatory proteins mediate the association between gut microbiota and renal cell carcinoma

Xinyun Zou, Dong Li, Ling Zhang, Jinlan Shen

Myelodysplastic syndromes with del(20q) transformed into B-lineage acute lymphoblastic leukemia remaining with del(20q): a case report with literature review

Wenyi Zhang, Xiaomei Hu, Peilei Zhang, Dongxia Wang, Yali Yang, Hongliang Li

Association of DBNDD1 with prognostic and immune biomarkers in invasive breast cancer

Xinzhu Huang, Yiyang Wang, Junyi Wang, Yubo Jing, Elihamu Dilraba, Yongxiang Li, Chenming Guo

The preliminary multicenter retrospective study on the efficacy and safety of thermal ablation for follicular thyroid neoplasms ≤ 3 cm

Yu-tong Liu, Bo-Qiang Fan, Jun-feng He, Ying Zhou, Song-song Wu, Shu-rong Wang, Gang Dong, Jian-qin Guo, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-an Yu

Causal relationship between circulating immune cells and the risk of esophageal cancer: a Mendelian randomization study

Shangren Wang, Ruizhen Wang, Aiqiao Zhang, Xiaofeng Duan, Xiaobin Shang, Hongjing Jiang

Tissue levels of regulatory T cell related lncRNAs in lung cancer: evidence for dysregulation of immune responses

Farbod Esfandi, Bashdar Mahmud Hussen, Ali Shakeri Abroudi, Melika Djamali, Solat Eslami, Fatemeh Sadat Feghahati, Arezou Sayad, Soudeh Ghafouri-Fard

Plasma treatment can efficiently increase the attachment of pancreatic circulatory tumor cells to the surface

Seyed Mohammad Amin Mahdian, Azam Mahmoudi-Aznaveh, Seyed Mojtaba Mousavi, Bagher Larijani, Zahra Azizi, Hamid Akbari Javar

Reduced-dose chemotherapy followed by blinatumomab for newly diagnosed philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia: a propensity-matched comparison with hyper-CVAD

Jing Lu, Yu Zhu, Huiying Qiu, Ying Wang, Xin Zhou, Haiping Dai, Xuzhang Lu, Bin Gu, Ming Hong, Miao Miao, Ruinan Lu, Jun Wang, Qian Wu, Mengxing Xue, Yun Wang, Ailing Deng, Yaoyao Shen, Yin Liu, Xueqing Dou, Yutian Lei, Xiaofei Yang, Suning Chen

Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer

Hao Chen, Baojuan Gao, Jiezhuang Li, Liehui Liu, Yufang Zhang, Mengting Shuai, Yuran Ji

Prognostic implications of ERLncRNAs in ccRCC: a novel risk score model and its association with tumor mutation burden and immune microenvironment

  • Open Access
  • Analysis

Kunlun Feng, Jingxiang Li, Jianye Li, Zhichao Li, Yahui Li

Anoikis-related PLCB4 is linked to immunotherapy response in osteosarcoma

Guo Liu, Yu Fang, Jiamiao Li, Zhaofei Chen

Identification and validation of an m5C-related lncRNA signature for predicting prognosis and immune response in clear cell renal cell carcinoma

Shan Ao, Leqi Liang, Lei Peng, Riwei Yang, Zugen Chen, Tuo Deng

Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics

Jianping Ma, PinYi Liu, Lili Pan

Downregulation of solute carrier family 4 members 4 as a biomarker for colorectal cancer

Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker Lal Kothari

Construction of a novel disulfidptosis and cuproptosis-related lncRNA signature for predicting the clinical outcome and immune response in stomach adenocarcinoma

Caihao Qu, Xin Yan, Futian Tang, Yumin Li

Multifaceted role of heparin in oncology: from anticoagulation to anticancer mechanisms and clinical implications

Niranjan Koirala, Melina Poudel, Amit Kumar Shrivastava, Romit Kumar Subba, Mamata Panthi, Samrat Paudel, Zainab M. Almarhoon, Javad Sharifi-Rad, Daniela Calina

Pingxiao pian attenuate invasiveness and proliferation of lung adenocarcinoma through regulating miR-29b-3p/TGF-β1/Smad/EMT pathway

Jie-Ni Feng, Pei-Rui Chen, Shao-Fei Yuan, Qiang Dai, Wei-E. Zheng, Hua-Long Lin

A preliminary investigation into the potential, pitfalls, and limitations of large language models for mammography interpretation

Filippo Pesapane, Luca Nicosia, Anna Rotili, Silvia Penco, Valeria Dominelli, Chiara Trentin, Federica Ferrari, Giulia Signorelli, Serena Carriero, Enrico Cassano

Pan‑cancer analysis of the oncogenic role of telomeric repeat binding factor 2 (TERF2) in human tumors and in vitro validation in gastric cancer by TERF2 knockdown

Qiang Ma, Wen Xu, Xiaolan Guo

IGF2BP3 prefers to regulate alternative splicing of genes associated with the progression of gastric cancer in AGS cells

Xiangyue Zeng, Yu Zhang, Tiannake Shapaer, Abulajiang Abudoukelimu, Zeliang Zhao, Binlin Ma

Identification of KCNJ5 gene an adverse prognosis associated novel onco-ionchannel in Indian pancreatic cancer cohort

Akash Bararia, Arunima Maiti, Gourav Ghosh, Deepyaman Das, Debabrata Ghosh Dastidar, Sumit Mukherjee, Shibajyoti Ghosh, Bitan K. Chattopadhay, Sudeep Banerjee, Supriyo Ghatak, Nilabja Sikdar

Identification and validation of cholesterol metabolism-related gene GNB3 as prognosis biomarker for pancreatic adenocarcinoma

Shiwei Wu, Haibo Lei, Can Xiao, Ting Gong, Qun Zhou, Xiuli Xi, Xiang Liu

Tumor microenvironment and drug resistance in lung adenocarcinoma: molecular mechanisms, prognostic implications, and therapeutic strategies

Qianqian Cao, Chenxuan Li, Ying Li, Xiangjing Kong, Shoushi Wang, Jun Ma

Identification of a novel signature based on RNA methylation-associated anoikis-related genes for predicting prognosis and characterizing immune landscape in colorectal cancer

Liye Zhu, Xinze Qiu, Shengmei Liang, Shanpei Huang, Qiting Ning, Xingmei Chen, Ni Chen, longjie Qin, Jiean Huang, Shiquan Liu

Exploring BIRC family genes as prognostic biomarkers and therapeutic targets in prostate cancer

Xiao-xiang Yu, Yi Liu, Zeng-mi Mo, Rong-jiang Luo, Wen-kai Chen

Genomic and micro-environmental insights into drug resistance in colorectal cancer liver metastases

Junjie Kuang, Jun Li, Siwei Zhou, Yi Li, Jinbo Lin, Weizhen Huang, Xia Yuan

Exploring the role of oral bacteria in oral cancer: a narrative review

Hassan Mivehchi, Aisan Eskandari-Yaghbastlo, Parnian Pour Bahrami, Anis Elhami, Farbod Faghihinia, Seyedeh Tabasom Nejati, Kimia Sadat Kazemi, Mohsen Nabi Afjadi

Correction: Metabolism: an important player in glioma survival and development

  • Open Access
  • Glioma
  • Correction

Ning Wang, Yiru Yuan, Tianhao Hu, Huizhe Xu, Haozhe Piao

Wogonoside alleviates the proliferation and promotes the apoptosis in liver cancer cells by regulating PI3K/Akt signaling pathway

  • Open Access
  • Research

Xinfang Li, Yitong Huang, Yibo He, Angzhi Ye

Unveiling the effects of GSK126 on osteosarcoma cells implications for apoptosis, autophagy, and cellular migration

Xifeng Xiong, Yulin Liu, Yanli Du, Xudong Lai, Chunming Si, Haixiong Miao

CDKN2A, a key gene in copper-induced cell death model, influencing melanoma invasion and apoptosis

Jing Li, Xi Yang, Cunli Yin, Siru Li, Yan Xu, Bin Liu

Association of skeletal muscle quantity and quality with mortality in women with nonmetastatic breast cancer

Mirele Savegnago Mialich, Bruna Ramos da Silva, Barbara Toledo Amstalden, Jorge Elias Jr., Alceu Afonso Jordao

TRIM44 facilitates aggressive behaviors in multiple myeloma through promoting ZEB1 deubiquitination

Hui Qi, Jing Wang, Lixia Cao

EFNB1 drives glioma progression and shapes the immune microenvironment: a potential prognostic biomarker

Yungui Zheng, Jiasong Shi

Survival differences in malignant meningiomas: a latent class analysis using SEER data

Bo Zhong, Yan Zhang

EMR-C is safe and efficient for rectal neuroendocrine tumor, and easily manageable for novice endoscopists of digestive endoscopy center

Zefeng Zhang, Chao Liu

IL-1β and associated molecules as prognostic biomarkers linked with immune cell infiltration in colorectal cancer: an integrated statistical and machine learning approach

Karishma Sahoo, Vino Sundararajan

Survival expectations in melanoma patients: a molecular prognostic model associated with aging

Nenghua Zhang, Xinyi Qiu, Xingying Chen, Cheng Du, Jingyi Dong, Xiaohong Li, Bing Chen, Lin Zhang, Yuyan Zhang

The research progress on meningeal metastasis in solid tumors

Yi Yue, Yuqing Ren, Chunya Lu, Nan Jiang, Sihui Wang, Junkai Fu, Mengrui Kong, Guojun Zhang

A 10-year bibliometric analysis in the field of osteosarcoma treatment from 2014 to 2023

Yiguo Shen, Xiaobo Shao, Jiansong Chen, Xin Tang

Transformative insights in breast cancer: review of atomic force microscopy applications

Jiamin Ma, Yuanyuan Zhai, Xiaoyi Ren, Huifang Wu, Mengjie Yang, Lijun Chai, Jianzhong Chen

Distant metastasis of oral squamous cell carcinoma: immune escape mechanism and new perspectives on treatment

Lin He, Meixuan Wan, Xinxin Yang, Hongxue Meng

Targeting obesity, metabolic syndrome, and prostate cancer: GLP-1 agonists as emerging therapeutic agents

Azura Murphy, Ritis Kumar Shyanti, Manoj Mishra

Unveiling tumor-infiltrating immune cell-driven immune-mediated drug resistance in clear cell renal cell carcinoma: prognostic insights and therapeutic strategies

Jifeng Yang, Yixuan Xing, Jiusong Luan, Wenbo Yang, Xin Zhang, Yanhua Tian, Haisong Zhang

Mechanistic insights into Uc001kfo-induced hepatocellular carcinoma metastasis

Yanfeng Pan, Qin Liu, Qingqing Li, Zhenjun Ren

Single cell transcriptomic analysis reveals tumor immune infiltration by macrophage cells gene signature in lung adenocarcinoma

  • Open Access
  • NSCLC
  • Research

Xiaotong Guo, Youjun Deng, Wenjun Jiang, Heng Li, Yisheng Luo, Huachuan Zhang, Hao Wu

Global trends and emerging research in nanotechnology for esophageal cancer: a comprehensive bibliometric analysis

Chun-Jian Zuo, Jie Tian

STMN1 regulates the stemness of gastric cancer cells by binding to HN1L to activate the STAT3 signaling pathway

Chunyang Wei, Xing Zhang, Hao Li, Jianzhong Gu, Fei Xue, Wenna Xie, Gang Ji

Pan-cancer characterization of C–C motif chemokine ligand 5 (CCL5) identifies its role as biomarker and therapeutic target

Wenming Zhao, Jirui Sun, Bingjuan Zhou, Haizhi Qiao, Jinku Zhang

The interplay between angiogenesis-associated genes and molecular, clinical, and immune features in bladder cancer

Xiaoxiao Guo, Jingxin Yang, Rui Cao, Gangyue Hao

The causal relationship between hepatitis B, immunophenotypes and liver cancer: a Mendelian randomization study

Zhili Cao, Chunyu Zhang, Shan Chen, Jie Jiang, Xuejiao Bai, Yan Wang, Wenshuang Zhang

lncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p

Tianshi Qin, Chengqiang Lei, Henghua Xiao, Jun Yang, Qiong Luo, Lingli Hu, Fang Chen, Manlong Long, Huayi Zhang

Molecular characterization of colorectal cancer (CRC) using next generation sequencing (NGS) in bridging the gap between research and clinical practice: from biomarker discovery to clinical implementation

Hafeez Abiola Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch’ng Ewe Seng, Siti Norasikin Mohd Nafi, Ahmad Aizat Bin Abdul Aziz, Wan Mohd Nazri Wan Zainon, Ahmad Adebayo Irekola, Yusuf Wada, Sameer Badri Al-Mhanna, Rashidat Folashade Elesho

Global trends and research hotspots in nanodrug delivery systems for breast cancer therapy: a bibliometric analysis (2013–2023)

Yang Li, Pingping Liu, Bo Zhang, Juan Chen, Yuanyuan Yan

The role and mechanism of CHMP4C in poor prognosis and drug sensitivity of lung adenocarcinoma

Chuan Xu, Mingshan Liu, Yang Li, Xiaoyue Peng, Wei Zhou, Wan Zhang, Jingtao Zhang, Bentong Yu

Beyond traditional biopsies: the emerging role of ctDNA and MRD on breast cancer diagnosis and treatment

Hussein Sabit, Manar G. Attia, Nouran Mohamed, Pancé S. Taha, Nehal Ahmed, Salma Osama, Shaimaa Abdel-Ghany

CAT and CXCL8 are crucial cofactors for the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma, the immune infiltration and prognosis of hepatocellular carcinoma

Liang Yang, Peiping Li, JiaLi Zhao, Zirui Bai, Guifang Zeng, Xialei Liu, Baojia Zou, Jian Li

Prognostic modeling of disulfidptosis gene-associated lncRNAs aids in identifying the tumor microenvironment and guiding the selection of therapy

Ying Jiang, Xueping Huang, Rong Huang, Kaihan Deng, Lin Dai, Bin Wang

Multi-gene panel sequencing reveals the relationship between driver gene mutation and clinical characteristics in lung adenocarcinoma

  • Open Access
  • Research

Jinmao Li, Xianyun Li, Hao Guo, Shuni Zhou, Hua Ding, Bo Li, Wei Li, Bo Zhang, Yi Zou

Deciphering the metabolic landscape of colorectal cancer through the lens of AhR-mediated intestinal inflammation

Jasmine Swain, Preeti, Chandana Mohanty, Atul Anand Bajoria, Srinivas Patnaik, Aoife Ward Gahlawat, Kumar Nikhil, Soumya R. Mohapatra

Comprehensive analysis of TMEM9 in human tumors

Xuezhong Zhang, Lele Zhou, Shumin Wei, Xuebin Zhang

Unraveling the causal relationship and underlying mechanisms between cathepsins on liver cancer: findings from mendelian randomization and bioinformatics analysis

Xiaoxue Wang, Zexin Zhu

A preliminary follow-up study on irreversible electroporation therapy in older patients with prostate cancer

Zhi-Yu Xia, Jun Yang, Fan Xiao, Jin-Zhou Xu, Xing-Yu Zhong, Shao-Gang Wang, Qi-Dong Xia

Unravelling the association between metformin and pan-cancers: Mendelian randomization combined with NHANES database analysis

Jia-Cheng Xiang, Ye An, Jian-Xuan Sun, Jin-Zhou Xu, Yi-Fan Xiong, Shao-Gang Wang, Qi-Dong Xia

Prognostic risk modeling of endometrial cancer using programmed cell death-related genes: a comprehensive machine learning approach

Tianshu Chen, Yuhan Yang, Zhizhong Huang, Feng Pan, Zhendi Xiao, Kunxue Gong, Wenguang Huang, Liu Xu, Xueqin Liu, Caiyun Fang

Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma

Long-Bin Jeng, Wen-Ling Chan, Chiao-Fang Teng

Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis

Mohsen Yari, Milad Eidi, Mohammad-Amin Omrani, Zahra Fazeli, Mohammad Rahmanian, Soudeh Ghafouri-Fard

Mitochondrial autophagy-related lncRNAs as prognostic biomarkers and therapeutic targets in gastric adenocarcinoma

  • Open Access
  • Analysis

Rongbo Han, Jinxin Wei, Benxin Zhao, Rongchang Zhao

Profilin 1 induces drug resistance by downregulating CD138 expression via autophagy in multiple myeloma

Ya Wang, ZiYu Dai, Shengying Xiao, Furen Zeng, YiChen Lu

Association between leukocyte telomere length and renal cell carcinoma: insight from Mendelian randomization study

Xiao-bin Chen, Li Wang, Ping-yu Zhu

Real world experience with MET inhibitors in MET exon 14 skipping mutated non-small cell lung cancer: largest Indian perspective

  • Open Access
  • NSCLC
  • Research

Ullas Batra, Ajay Kumar Singh, Shrinidhi Nathany, Abhinav Dewan, Mansi Sharma, B. P. Amrith, Anurag Mehta, Vanshika Batra, Vanita Noronha, Kumar Prabhash

Advances in S100 protein family for gynecological malignancies

Shenglong Wu, Junfen Xu

Unveiling novel susceptibility genes and drug targets for basal cell carcinoma by a cross-tissue transcriptome-wide association study

Hong Sun, Ling Li, Xiu Xin, Jingchao Yan, Taomin Huang

The influence of RAD51 (rs1801320) on breast cancer risk: an updated meta-analysis

Najeeb Ullah Khan, Sana S. Alqarni, Amjad Yousuf, Iqra Shehzad, Waqas Khan, Wei Gu, Tianhui Chen

ZNF385A was identified as a novel colorectal cancer-related functional gene by analysis of the interaction and immune characteristics of oxidative stress and the inflammatory response

Yaqi Guo, Shipeng Shang, Leilei Liang, Enrui Liu

Olaparib increases chemosensitivity by upregulating miR-125a-3p in ovarian cancer cells

Zehua Wang, Tao Pu, Weiwei Miao, Yi Gao, Jianwen Gao, Xinyan Zhang

Research trends and highlights in PD-1/PD-L1 inhibitor immunotherapy in lung cancer: a bibliometric analysis

Zheng Gu, Erle Deng, Jing Ai, Fei Wu, Qiang Su, Junxian Yu

MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance

Madhura Chatterjee, Sayoni Nag, Saurabh Gupta, Tanmoy Mukherjee, Prem Shankar, Deepak Parashar, Arindam Maitra, Kaushik Das

PLOD3 as a novel oncogene in prognostic and immune infiltration risk model based on multi-machine learning in cervical cancer

Lingling Qiu, Xiuchai Qiu, Xiaoyi Yang

The causal relationship between eosinophil counts and hepatocellular carcinoma in East Asians: evidence from a Mendelian randomization study

Dong Liu, Jinju Xia, Ruilin He, Ronghua Zhu

Mendelian randomization analysis of environmental pollution factors and head and neck cancer risk: a causal inference study integrating autophagy-related genes

  • Open Access
  • Analysis

Xuejin Xu, Zhen Wang

RBIS as a prognostic biomarker for progression-free survival in prostate cancer: insights from bioinformatics and immune infiltration analysis

Zexiao Chen, Yutong Fang, Jianhua Zhang

Chito-oligosaccharide impairs the proliferation, invasion and migration of pancreatic cancer cells

Han Liu, Siyuan Ding, Weiyan Lyu, Shengyan Lu, Xu Liu

Leveraging microbiome signatures to predict tumor immune microenvironment and prognosis of patients with endometrial carcinoma

Yuting Yang, Yuchen Meng, Ziyang Xu, Qin Zhang, Miaomiao Li, Fanbing Kong, Suping Zhang, Xinling Li, Yihua Zhu

Simultaneous integrated dose reduction intensity-modulated radiotherapy improves survival in patients with locally advanced non-small cell lung cancer by reducing cardiac irradiation exposure

Chang Xu, Jiehan Wu, Bingxin Liu, Hanheng Meng, Lujun Zhao, Ping Wang, Jifeng Sun, Jun Wang, Ningbo Liu

The causal relationships between inflammatory cytokines, blood metabolites, and thyroid cancer: a two-step Mendelian randomization analysis

Weihao Liu, Yuxiao Sun, Yifei Zhang, Detao Yin

Mapping glioma progression: single-cell RNA sequencing illuminates cell–cell interactions and immune response variability

Xia Li, Shenbo Chen, Ming Ding, Hui Ding, Kun Yang

Mechanisms of action of intestinal microorganisms and advances in head and neck tumors

Su Xialu, Ma Faqiang

Causal relationship and potential common pathogenic mechanisms between hidradenitis suppurativa and related cancer

Zexin Zhu, Xiaoxue Wang

LST1 expression correlates with immune infiltration and predicts poor prognosis in acute myeloid leukemia

Haitao Xu, Dangui Chen, Jia Lu, Lihong Wang, Fei Chen, Long Zhong

Analysis of expression characteristics of ferroptosis-related lncRNAs in gastrointestinal cancer patients in Asia

Ning Ding, Ying Kang, Xiaoxiao Tan, Yanbo Tang, Yingjie Zhang, Yongheng He

The role of PD-L1 in EGFR-mutant non-small cell lung cancer

  • Open Access
  • NSCLC
  • Review

Wentao Gao, Lingling Wang, Yanyan Zhao, Lucheng Zhu

Disulfidptosis: a novel gene-based signature predicts prognosis and immunotherapy efficacy of pancreatic adenocarcinoma

  • Open Access
  • Research

Jingyang Yin, Jian Li, Huaizhi Wang

Transcription factor networks and novel immune biomarkers reveal key prognostic and therapeutic insights in ovarian cancer

Aiqin Zhao, Sufang Zhou, Xiaoyi Yang, Haiying Lu, Dan Zou, Xuan Zhang, Li Liu

EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics

Zheng Liu, Shu Huang, Rui Luo, Xiaomin Shi, Mingzhu Xiu, Yizhou Wang, Ruiyu Wang, Wei Zhang, Muhan Lv, Xiaowei Tang

Exploring novel biomarkers and immunotherapeutic targets for biofeedback therapies to reveal the tumor-associated immune microenvironment through a multimetric analysis of kidney renal clear cell carcinoma

  • Open Access
  • Analysis

Guobing Wang, Jinbang Huang, Haiqing Chen, Chenglu Jiang, Lai Jiang, Wenqi Feng, Gang Tian

USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC

Shujiao Zhang, Feihu Ding, Fuxin Jia, Xiubo Lu

AI-driven biomarker discovery: enhancing precision in cancer diagnosis and prognosis

Esther Ugo Alum

Artificial intelligence-driven integration of single-cell RNA sequencing and transcriptome analysis to decipher APOE’s role in gastric cancer prognosis and therapy

Ni Li, Jinquan Lin, Chunyu Wang, Xiao Ran, Zhi Zhao

Causal effect between circulating metabolic markers and glioma: a bidirectional, two-sample, Bayesian weighted Mendelian randomization

Jiachen Wang, Chengzhuo Wang, Shenglan Li, Mengqian Huang, Rong Zhang, Yuxiao Chen, Zhuang Kang, Wenbin Li

Efficacy and safety of immunotherapy plus chemotherapy in advanced or metastatic pulmonary large-cell neuroendocrine carcinoma

Ruyue Li, Huanle Zhang, Ying Li, Xiujing Yao, Xue Dong, Yali Xu, Yintao Li

The prognostic role of systemic immune-inflammation index, SII, in Metastatic Castration-Resistant Prostate Cancer patients

Mehmet Uzun, Savas Gokcek, Erhan Kaya, Huseyin Salih Semiz

Integrated bulk and single-cell transcriptomic analysis unveiled a novel cuproptosis-related lipid metabolism gene molecular pattern and a risk index for predicting prognosis and antitumor drug sensitivity in breast cancer

Cheng Zeng, Chang Xu, Shuning Liu, Yuanyi Wang, Yuhan Wei, Yalong Qi, Yue Wang, Jiani Wang, Fei Ma

Biological roles and clinical applications of EpCAM in HCC

Peng Liu, Qun Zhang, Fengchao Liu

Pan-cancer bioinformatics analysis of TIPRL in human tumors

Xuezhong Zhang, Hao Xue, Yuanyuan Lv, Yuntao Zhou, Kaihui Sha, Tonggang Liu

Research trends of neoadjuvant therapy in lung cancer: a bibliometric analysis

Xiaoru Geng, Youqin Jiang, Yichun Zeng, Wenmiao Cao, Yao Lu, Yichen Liang, Juan J. Gu, Buhai Wang

Pan-cancer analysis predicts MBOAT2 as a potential new ferroptosis related gene immune checkpoint

  • Open Access
  • Analysis

Yuhan Xie, Shichao Zhang, Yu Wu, Yuanjiong Qi, Shiyong Qi, Xiuju Chen, Bing Chen

A pan-cancer analysis reveals the oncogenic and immunological role of insulin-like growth factor 2 mRNA-binding protein family members

Fuling Zeng, Liuyan Chen, Jing Li, Wenna Yu, Niya Sa, Keke Zhang, Chen Qu, Daolin Wen

SIGLEC1 has the potential to be an immune-related prognostic indicator in colon adenocarcinoma: a study based on transcriptomic data and Mendelian randomization analysis

Jue Gu, Yaxuan Wang, Hui Zhang, Haijuan Gu, Haixia Zhu

Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis

Dongliang Shi, Liang Chen, Chenhao Li, Meng Yang, Wenhua Yang, Guozhong Cui, Jinzhao Liu, Qianqian Chen

Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation

Yinhua Xia, Guanqun Wan, Simin Li, Shaonan Hu, Guohui Wu

ESM1 suppresses LncRNA GAS5/miR-23a-3p/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K/AKT pathway

Hui Li, Tingyu Fan, Mei Qin, Shuanghua Chen, Wenchao Zhou, Peiting Wu, Yuwei Yuan, Xing Tang, Tian Zeng, Jiawen Fang, Ting Yi, Juan Zhang, Juan Zou, Yukun Li

Multi-omics analysis identifies OSGEPL1 as an oncogene in hepatocellular carcinoma

Sintim Mui, Juanyi Shi, Kai Wen, Yongcong Yan, Huoming Li, Weidong Wang, Zhenyu Zhou, Zhiyu Xiao

The SLC26A4-AS1/NTRK2 axis in breast cancer: insights into the ceRNA network and implications for prognosis and immune microenvironment

Mengqiu Lan, Shuang Qin, Jingjing Wei, Lihong Wu, Zhenni Lu, Wenjie Huang

Pan-cancer analysis and experimental verification of cytochrome B561 as a prognostic and therapeutic biomarker in breast cancer

Xiaoting Qiu, Peizhang Liu, Hongxiang Lin, Zeyi Peng, Xinhao Sun, Guanting Dong, Yuanyuan Han, Zhijian Huang

Genetic association of lipids and lipid-lowering drug target genes with breast cancer

Tianhua Wang, Yan Yao, Xinhai Gao, Hao Luan, Xue Wang, Lijuan Liu, Changgang Sun

A novel prognostic signature based on m5C‑related LncRNAs and its immunological characteristics in colon adenocarcinoma

Zihe Liu, Sheng Chang, Shouguo Chen, Rong Gu, Shaoyong Guo

Establishment of nomogram of early death in elderly pancreatic cancer patients with liver metastasis

Yang Wu, Tian Li, Runbing Zhang, Tingting Shi, Shunna Wang, Lingling Zhu, Yani Zhang, Xiaofeng Zheng, Xiaohui Yu, Jiucong Zhang

Advanced machine learning framework for enhancing breast cancer diagnostics through transcriptomic profiling

Mohamed J. Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Anupam Yadav, Subbulakshmi Ganesan, Aman Shankhyan, Girish Chandra Sharma, K. Satyam Naidu, Akmal Rakhmatullaev, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil, Bagher Farhood

Pyrotinib monotherapy for advanced HER2-positive esophageal adenocarcinoma with trastuzumab resistance and chemotherapy intolerance: a case report and literature review

Tao Wang, Mingyuan He, Wei Guan

Enhanced lung cancer subtype classification using attention-integrated DeepCNN and radiomic features from CT images: a focus on feature reproducibility

Muna Alsallal, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Anupam Yadav, Subbulakshmi Ganesan, Aman Shankhyan, Sofia Gupta, Kamal Kant Joshi, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil, Bagher Farhood

Exploring the combined roles of GALNT1 and GALNT2 in hepatocellular carcinoma malignancy and EGFR modulation

Tagwa E. Osman, Yanru Guo, Shijun Li

Development and validation of a disulfidptosis-related prognostic model for colorectal cancer using multi-omics analysis

Lei Shi, Huimei Wang, Yongxiao Sun, Na Xu, Aiyue Pei, Nan Zhang

Identification of GJC1 as a novel diagnostic marker for papillary thyroid carcinoma using weighted gene co-expression network analysis and machine learning algorithm

Jingshu Zhang, Ping Sun

From cell lines to animal models: “plant- derived chemotherapeutics unlocking new frontiers against oral squamous cell carcinoma”—a comprehensive systematic review

Saranya Ramsridhar, Chandini Rajkumar, Vishnu Priya Veeraraghavan, Arul Prakash Francis, Murali Balasubramaniam, Indu Bharkavi

Nomogram for predicting postoperative clinical remission of hypertension in patients with adrenal tumors

YuanJian Liao, MingShun Zuo, YongPan Zhu, Te Xu, JiaJia Tang, LongMei Fan, Neng Zhang

97 Machine learning algorithms in the prognosis of cutaneous melanoma: a population-based study

Tongtong Jin, Donggang Yao, Yan Xu, Xiaopeng Zhang, Xu Dong, Haiya Bai

Downregulated STAT3 and STAT5B are prognostic biomarkers for colorectal cancer and are associated with immune infiltration

Qier Li, Jingzhi Wang, Qingqing Liu, Min Gan, Jianing Yan, Xuan Yu, Yongfu Shao

3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis

  • Open Access
  • NSCLC
  • Research

Lin Guo, Jia Zhang, Yuqiang Li, Yuehong Gao, Jiali Huang, Mengru Liu, Jing Li, Wenshu Chai, Yubin Li

Pan-cancer analysis of the prognosis and immune infiltration of NSUN7 and its potential function in renal clear cell carcinoma

  • Open Access
  • Research

Jinwei Cui, Shiye Ruan, Zhongyan Zhang, Hailiang Wang, Qian Yan, Yubin Chen, Jiayu Yang, Jike Fang, Qianlong Wu, Sheng Chen, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou

The role of fructose-1,6-bisphosphatase 1 on regulating the cancer progression and drug resistance

  • Open Access
  • Review

Mengmeng Wang, Xiaoju Huang, Dan Zhang, Yisan Liu, Pian Liu

Correction: LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis

  • Open Access
  • Glioma
  • Correction

Zhenxiang Zhao, Haiying Liu, Yingzi Liu, Junpeng Wen, Jiangwei Yuan

Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit

Toshiaki Tsurui, Masahiro Hosonuma, Aya Sasaki, Yuuki Maruyama, Yasunobu Amari, Eiji Funayama, Kohei Tajima, Hitoshi Toyoda, Junya Isobe, Yoshitaka Yamazaki, Yuta Baba, Midori Shida, Yuko Udaka, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Atsuo Kuramasu, Mayumi Tsuji, Yuji Kiuchi, Takuya Tsunoda, Kiyoshi Yoshimura

Targeting malignant adenomyoepithelioma of the breast: clinical insights on multimodal therapy and disease-free survival

Hung-Liang Pai, Wei-Ting Hsu, Chia-Chi Chang, Ming-Hsin Yeh

Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis

Hania Shah, Khushbukhat Khan, Yasmin Badshah, Janeen H. Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Dara Aldisi, Dilawer Khan, Suhail Razak

Nomogram construction for overall survival in breast angiosarcoma based on clinicopathological features: a population-based cohort study

  • Open Access
  • Analysis

Peikai Ding, Luxiao Zhang, Shengbin Pei, Zheng Qu, Xiangyi Kong, Zhongzhao Wang, Jing Wang, Yi Fang

Development and validation of M2 macrophage-related genes in a prognostic model of lung adenocarcinoma based on bulk RNA and ScRNA datasets

  • Open Access
  • Analysis

Bolin Wang, Xiaofeng Zhou, Di Wu, Lu Gao, Zhihua Wan, Ruifeng Wu

Gastroesophageal reflux disease as a risk factor for oral cavity and pharyngeal cancer: a Mendelian randomization study

Zixiong Shen, Chuanlei Wang, Chunli Cao, Guangyi Wang, Zhiqin Li

Disulfidptosis-based molecular clustering and prognostic signatures predict patient survival and the immune landscape in patients with colon cancer

Liang Wen, Yongli Ma, Jinghui Li, Dengzhuo Chen, Chengzhi Huang, Ping Wang, Suqi Wen, Gexin Wen, Jizhen Guo, Guosheng Zhang, Junjiang Wang, Xueqing Yao

Serum CDC42 level change during abiraterone plus prednisone treatment and its association with prognosis in metastatic castration-resistant prostate cancer patients

Yong Ma, Zhihua Cao, Jiacheng Zhang, Xu Zhu, Zhonghao Zhao, Jinguo Xiong

Bioinformatic analysis of serpina1 expression in papillary thyroid carcinoma and its potential association with Hashimoto's thyroiditis

Xiuyuan Du, Wanjun Chen

Expression profiles of FABP4 and FABP5 in breast cancer: clinical implications and perspectives

Xingshan Jiang, Yiqin Xiong, Jianyu Yu, Anthony Avellino, Shanshan Liu, Xiaochun Han, Zhaohua Wang, Jonathan S. Shilyansky, Melissa A. Curry, Jiaqing Hao, Edward R. Sauter, Yi Huang, Sonia L. Sugg, Bing Li

Influence of the lncRNA SLC9A3-AS1 on colon cancer and the biological activities of colon cancer cells

Xiulian Xu, Hongyi Qing, Chunyan Jiang, Xiaofeng Zhao, Jinlai Wei

Real-world comparison of the efficacy of first-line therapies and the influence of risk factors in advanced renal cell carcinoma

Maximilian Haack, Stephanie Neuberger, Jan Hendrik Boerner, Stefanie Ziewers, Gregor Duwe, Robert Dotzauer, Axel Haferkamp, Rene Mager

Decoding male breast cancer: epidemiological insights, cutting-edge treatments, and future perspectives

Lei Zhao, Huijuan Cheng, Dongqiang He, Yalan Zhang, Yahui Chai, Ailin Song, Guodong Sun

Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms

Chao Guo, Jiaqin Deng, Tianhua Wen, Jinzhou Li, Peilin Zeng, Chao Liang

PRSS53 is a potential novel biomarker related to prognosis and immunity in clear cell renal cell carcinoma

Jiajun Zhang, Guocheng Liu, Wei Wang

Classification of lung adenocarcinoma based on senescence-related genes identifies a cluster with immunotherapy resistance and poor prognosis

  • Open Access
  • Analysis

Xinrui Gao, Xiang Shen, Shasha Huang, Shangke Huang

A novel PAK1/TCF1 regulatory axis promotes non-small cell lung cancer progression

  • Open Access
  • NSCLC
  • Research

Chuangang Lu, Yuncong Su, Youzhong Xu, Siyuan Sheng, Taiting Chen, Juan Li

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin

Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio

Analyzing research trends in the relationship between immunosuppressants and cancer following organ transplantation: a bibliometric study from 2001 to 2023

Xing Liu, Ren-Chun Du, Jing-Yuan Xu, Yu-Xin Hu, Xun Xie, Qing-Yang Lan, Liaoliao Hu

Microplastics: a cancer-causing agent for humans and prospects for identification using AI and modern approaches

Anshika, Amulya Jindal, Deepak Tomar, Mainuddin, Anoop Kumar

An innovative glutamine metabolism-related gene signature for predicting prognosis and immune landscape in cervical cancer

Hai-Ya Fang, Li-Mei Ji, Cui-Hua Hong

Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway

Fangjun Chen, Wenqiong Xiang, Guangliang Qiang

Expression and prognosis of NR3C1 in uterine corpus endometrial carcinoma based on multiple datasets

Yahui Shen, Peihan Yang, Yanping Lu

Progress in ubiquitination and hepatocellular carcinoma: a bibliometric analysis

Ming Li, Zhiliang Xu, Siqin Liang, Qiaoli Lv, Xiaoxiang You, Tinghao Yuan, Jun He, Qiang Tu

Causal role of immune cells in head and neck squamous cell carcinoma

  • Open Access
  • Analysis

Panshu Xu, Zhenxing Zhang, Haoran Zhu, Conglin Hu, Yukang Ying

Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations

  • Open Access
  • Review

Joseph Nhyira Obisi, Abike Ndidiamaka Josephine Abimbola, Oluwasegun Adesina Babaleye, Peter Kwame Atidoglo, Saviour God’swealth Usin, Eudora Obioma Nwanaforo, Faith Sutu Patrick-Inezi, Ilemobayo Victor Fasogbon, Joseph Chimezie, Christianah Adebimpe Dare, Oluwadoyinsayemi Oluwadamilare Kuti, Daniel Ejim Uti, Humphrey Chukwudi Omeoga

Lower cytoplasmic expression of DDIT4 is associated with poor prognosis in gastric cancer patients

Masoumeh Dehghan Manshadi, Fatemeh Tajik, Leili Saeednejad Zanjani, Farideh Hashemi, Mandana Rahimi, Fahimeh Fattahi, Sadegh Safaei, Zahra Madjd, Roya Ghods

Gut microbiome, dietary habits, and prostate cancer: a two-step Mendelian randomization revealing the causal associations

Junhua Guo, Ting Huang, Heran Zhou

Cardiotoxicity induced by chemotherapy and immunotherapy in cancer treatment: a bibliometric analysis

Xi Zhang, Yanfeng Xue, Mingyan Hao

Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker

Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

Long-term survival in a patient with ruptured advanced hepatocellular carcinoma treated with nutritional therapy combined with apatinib and camrelizumab: a case report

Yaohao Liang, Tianyu Ruan, Jiaqian He, Ketuan Huang, Min Wei, Shengqiang Tan

WGCNA and ferroptosis genes in OSCC: unraveling prognostic biomarkers and therapeutic targets

Ke Liu, Jiannan Yu, Xuanxi Huang, Hongyan Gao, Jing Wang

Protective role of gout against colorectal cancer: a Mendelian randomization study

  • Open Access
  • Gout
  • Analysis

Xia Pan, Yong’an Liu, Xiaoming Zhang, Yan Meng

Exploration of the clinicopathological and prognostic significance of BRCA1 in gastric cancer

Hongrong Zhang, Qi Xu, Hongxing Kan, Yinfeng Yang, Yunquan Cai

Identification of autophagy-related immune targets for enhancing immunotherapy in pancreatic cancer aggressiveness

Qianxi Deng, Linju Wu, Jin He, Fan Wu, Zheng Jiang

Evaluation of the efficacy of totally implantable venous access port in breast cancer patients undergoing chemotherapy

Yujuan Guo, Xiaoping Wang, Yaping Huang, Xiong Wu, Yueqiong Wang

Identification of CCNB1 as a biomarker for cellular senescence in hepatocellular carcinoma: a bioinformatics and experimental validation study

Zhilan Zhang, Jie Zhou, Ruiru Huang, Xingxing Zhuang, Shoudong Ni

Histiocyte-rich rhabdomyoblastic tumor easily misdiagnosed as rhabdomyosarcoma: a case report

Ting Xu, Shuai Luo

Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types

Akhila Balakrishna Rai, Jalaluddin Akbar Kandel Codi, Giridhara Prema Suchitha, Kadabagere Narayanaswamy Hemavathi, Shobha Dagamajalu, Chandran S. Abhinand, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad

Tislelizumab plus anlotinib with or without radiotherapy as first-line therapy in advanced hepatocellular carcinoma: a single center, non-randomized retrospective case–control study

Guishu Wu, Yuhong Liu, Huaxi Fan, Mingyue Rao, Jing Zhang, Jianwen Zhang

Plasma proteomes and metabolism with genome-wide association data for causal effect identification in ovarian cancer

Lin Qi, Cheng Zhang, Yinuo Liu, Wenshu Li, Jingjing Ren, Manyin Zhao

Applying integrated transcriptome and single-cell sequencing analysis to develop a prognostic signature based on M2-like tumor-associated macrophages for breast cancer

Yanghaochen Xu, Peiyan Lin, Ye Zhu, Qing Zhang, Jinhong Zhou

Prognosis model of patients with breast cancer based on metabolism-related LncRNAs

Dan Zhang, Shiwei Ma, Liling Yang, Hongyuan Liu, Han Jiang, Yan Wang

Comparison of treatment outcomes between combined chemotherapy-radiation therapy (chemo-RT) and radiation therapy alone (RT) for intracranial germ cell tumors in adolescent and young adult patients (AYA)

Warissara Rongthong, Nan Suntornpong, Kullathorn Thephamongkhol, Teeradon Treechairusame

Identification of m6A-modified gene signatures in lung adenocarcinoma tumorigenesis and their potential role in drug resistance

  • Open Access
  • Research

Xiaomin Han, Qiang Ma, Ruyi Chang, Siyuan Xin, Guojun Zhang, Ruilong Wang, Yukun Wang

Alterations of the microenvironment of hepatocellular carcinoma in different unfolded protein response activity states

Yao Wang, Xiao Fei Zhu, Wan Jian Gu, Gui Hong Zhang

Albumin-bilirubin grade as an alternative to Child–Pugh class for evaluating liver function within staging systems for hepatocellular carcinoma

Ming-Cheng Guan, Qian Ding, Qian Zhao, Na Li, Ren-Xia Zhang, Shi-Yu Zhang, Ji Wang, Hong Zhu

Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives

Chenyi Zhao

Repurposing of nervous system drugs for cancer treatment: recent advances, challenges, and future perspectives

Zixun Wang, Chen Xu, Qi Wang, Yudong Wang

Risk of secondary myeloid neoplasms following treatment in patients with grade I–II follicular lymphoma: a retrospective cohort study

Yuebo Wang, Yanan Cai

Global trends in esophageal cancer and metabolic syndrome research: bibliometric analysis and visualization from 1995 to 2024

Peng-Yu Che, Chun-Jian Zuo, Jie Tian

Hypoxia signaling in cancer: HIF-1α stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC)

Negar Eghbalifard, Nikta Nouri, Shiva Rouzbahani, Maryam Bakhshi, Negin Ghasemi Kahrizsangi, Faraz Golafshan, Fatemeh Abbasi

A case of onychopapilloma presenting as longitudinal erythronychia

  • Open Access
  • Case Report

Liwei Feng, Guohua Huang, Xiaolin Bu

Successful rapid desensitization to zoledronic acid in a multiple myeloma patient

Federico Spataro, Antonio Giovanni Solimando, Vanessa Desantis, Angelo Vacca, Roberto Ria

Progress of immune senescence in multiple myeloma treatment resistance

Yanan Jia, Lixiang Yan, Chenyang Fan, Hui Sun, Xinli Zhou, Zhexin Shi

Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization

Siqi Chen, Jinfeng Yang, Guangying Qi, Jiawei Zhao, Yujing Chen, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Zhiyuan Jian, Jiamin Jin

In vitro study of effect of gold nanoparticles conjugated with triptorelin peptide on the radiosensitivity of breast cancer cells (MCF-7)

Elham Tavakkoli, Seyyed Mohammad Hashemi, Alireza Montazerabadi, Sara Khademi, Farzaneh Ghorbani, Sheyda Mohammadzadeh, Hosein Azimian

Causal associations between liver function biomarkers and prostate cancer risk in European and East Asian populations: a univariate, multivariable, and bidirectional Mendelian Randomization study

Xinyu Xu, Wenjing Zhu, Yu Peng

Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges

Djilali Seghir Morsli, Hadja Fatima Tbahriti, Fouzia Rahli, Fatima Zohra Mahammi, Andrey Nagdalian, Hassan A. Hemeg, Muhammad Imran, Abdur Rauf, Mohammad Ali Shariati

PD-1/PD-L1 blockade therapy with atezolizumab: a new paradigm in the treatment of non-small cell lung cancer (NSCLC)

  • Open Access
  • NSCLC
  • Review

Samaneh Moradi, Pedram Sarikhani, Rafid Jihad Albadr, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Hiba Mushtaq, Niyousha Vakilzadehian

Analysis of long-term trends and 15-year predictions of smoking-related bladder cancer burden in china across different age and sex groups from 1990 to 2021

Jieming Zuo, Junhao Chen, Zhiyong Tan, Xingcheng Zhu, Haifeng Wang, Shi Fu, Jiansong Wang

Comprehensive identification of a migrasomes-associated long non-coding RNA signature to predict the prognosis and treatment options in colon adenocarcinoma

Zhen Zheng, Hui Liu, Quan Xu, Wei Cui, Kaitai Liu

Identification of tumor immune infiltration-associated VPS72 and prognostic significance of VPS72 and CD8A in hepatocellular carcinoma

Zhou Yang, Xiao Feng, Haoyuan Yu, Lei Lv, Chengli Gao, Wei Liu, Shuhong Yi, Changchang Jia, Binsheng Fu

Evaluating ΔMTV%, ΔDmax%, and %ΔSUVmax of 18F-FDG PET/CT for mid-treatment efficacy and prognosis in diffuse large B-cell lymphoma

Yali Cui, Yao Li, Wenhao Hu, Zhifang Wu, Sijin Li, Hongliang Wang

The development and validation of a column chart for predicting the regression risk of CIN2

Jingjing Ren, Hui Wang, Xiu Zhang, Min Hao

Systematically investigate the mechanism underlying the therapeutic effect of emodin in treatment of prostate cancer

Gang Yuan, Jingxin Mao, Zheng Li

Early-stage small cell carcinoma of the ovary hypercalcemic type: autologous stem cell transplantation as standard primary treatment

Teresa Lopes Bruno, Catarina Cardoso, Joana Ferreira, Fátima Vaz

Expression and mechanism of PRDXs family in oral squamous cell carcinoma

  • Open Access
  • Research

Zhou Zhang, Quan Zheng, Ping Li, Xiaopeng Xu, Yanzhou Zhou, Chen Qian

The hidden pathway: biological aging as a mediator between diabetes and breast cancer risk: a Mendelian randomized study

Yipang Zhao, Jingzhi Zhang, Dong Chen, Sixuan Xing, Shuhan Zhang, Qing Zhang

NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/β-catenin signaling pathway in colorectal cancer

Facai Cui, Yu Chen, Xiaoyu Wu, Weifeng Zhao

Construction and validation of a reliable disulfidptosis-related lncRNAs signature of the subtype, prognostic, and immune landscape in bladder cancer

Xiaoping Leng, Han Chen, Gang Chen

ERCC3 serves as a prognostic biomarker for hepatocellular carcinoma and positively regulates cell proliferation and migration

Chen Yang, Jiahui Du, Xiuqin Qiu, Changhong Jia, Cunbao Ding, Yijie Wu, Chaoxu Gao, Weijie Wang, Xiaojun Wang, Song-Bai Liu

The value of predicting breast cancer with a DBT 2.5D deep learning model

Huandong Niu, Li Li, Ximing Wang, Han Xu

Cytokine biomarkers for independent prediction of hepatocellular carcinoma prognosis

Long-Bin Jeng, Fu-Ying Shih, Wen-Ling Chan, Chiao-Fang Teng

Nanotechnology-based drug delivery system for the diagnosis and treatment of ovarian cancer

Rajeswari Saripilli, Dinesh Kumar Sharma

ANAPC10 expression predicts poor prognosis in oral squamous cell carcinoma and promotes tumor growth via the PI3K/AKT/mTOR pathway

  • Open Access
  • Research

Jing Fang, Yanhao Duan, Yongle Qiu, Shanshan Liu, Xue Bai, Hong Cai, Meijie Zhang, Wei Liu

Review of recent molecular pathology of bladder urothelial carcinoma

Peng Su, Ying Yang, Hong Zheng

Intratumor heterogeneity related signature for clinical outcome and immunotherapy advantages in lung adenocarcinoma

Yanhua Zuo, Li Lin, Libo Sun

Pan-cancer analysis reveal that m6A writer WTAP involve in tumor cell cycle regulation and tumor immunity

Jingwei Shi, Gongyi Xie, Sijing Ye, Xiaoqiong Weng, Qingmei Zhou

Quantifying CD73 expression after chemotherapy or chemoradiotherapy in esophageal squamous cell carcinoma

Zachary A. Cooper, Ying Wang, Philip L. Martin, Kosho Murayama, Rakesh Kumar, Ken Kato, Shun Yamamoto, Shigeki Sekine

Emerging strategies and translational advancements of DDR1 in oncology

Yuxi Luo, Tianxin Liu, Jinli Pei, Shengnan Xu, Jie Liu, Jinming Yu

Anticancer activity of Stemona tuberosa (wild asparagus) against type-II human lung adenocarcinoma (A549) cells and identification of SRC inhibitor using integrated network pharmacology and molecular dynamic simulation

  • Open Access
  • Research

C. Lalmuansangi, Lalfakawmi, Fanai Nghakliana, Hmingremhlua Sailo, Lalchhandami Tochhawng, Amit Kumar Trivedi, Kiran R. Kharat, Balachandar Vellingiri, Nachimuthu Senthil Kumar, Zothan Siama

Prognostic implications of alternative splicing events and key splicing factors in head and neck squamous cell carcinoma

  • Open Access
  • Research

Siyi He, Jiali Meng, Chunyan Liang, Yiru Wang, Xinling Qin, Lulu Huang, Rensheng Wang, Weimei Huang

Visualization analysis of breast cancer-related ubiquitination modifications over the past two decades

Yongxiang Li, Yiyang Wang, Yubo Jing, Youseng Zhu, Xinzhu Huang, JunYi Wang, Elihamu Dilraba, Chenming Guo

Identification of a long non-coding RNA signature associated with cuproptosis for prognosis and immunotherapy response prediction in patients with lung adenocarcinoma

  • Open Access
  • Research

Jie Zeng, Zhenyu Wu, Meijuan Luo, Zhibo Chen, Xie Xu, Guijing Xie, Quhai Chen, Wenjie Bai, Gang Xiao, Jianjiang Xie

Research progress on the signaling pathway mechanism of terpenoids against breast cancer

Sheng-nan Tu, Fen Hu, Juan Zhang, Haifeng Cai, Junquan Yang

Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis

Jingzhi Wang, Simin Peng

Appraising the causal role of cathepsins in genitourinary carcinoma: a two-sample mendelian randomization and prospective study based on 36,225 individuals

Qiyu Zhu, Dingbang Liu, Haoyang Liu, Xiaohui Pan, Yifu Shi, Jingjing Guo, Nanwei Tong, Junru Chen, Hao Zeng

Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics

Samira Tabaei, Mohammadrasul Zareinejad, Mohammad Reza Haghshenas, Nasser Shakhssalim, Kambiz Gilany, Allan Stensballe, Abbas Ghaderi

Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis

Lijuan Wei, Enci Ding, Dongyan Lu, Zhongying Rui, Jie Shen, Guoju Fan

The current landscape of artificial intelligence in computational histopathology for cancer diagnosis

Aaditya Tiwari, Aruni Ghose, Maryam Hasanova, Sara Socorro Faria, Srishti Mohapatra, Sola Adeleke, Stergios Boussios

Circulating tumor DNA in colorectal cancer: biology, methods and applications

Han Chen, Yang An, Chentong Wang, Jiaolin Zhou

Identification of cellular senescence-associated genes for predicting the diagnosis, prognosis and immunotherapy response in lung adenocarcinoma via a 113-combination machine learning framework

  • Open Access
  • Analysis

Ting Ge, Guixin He, Qian Cui, Shuangcui Wang, Zekun Wang, Yingying Xie, Yuanyuan Tian, Juyue Zhou, Jianchun Yu, Jinmin Hu, Wentao Li

A two-decade bibliometric analysis of drug resistance in oral cancer research: patterns, trends, and future directions

Xuejin Xu, Zhen Wang

Decoding colorectal cancer targeted therapy: a bibliometric journey of the last decade (2015–2024)

Linpo Zhou, Xuanwei Huang, Jing Shi, Yebin Yang, Fanhe Dong, Haoran Wei, Chenghao Ji, Yuqiang Shan

Unveiling the key roles in esophageal cancer drug resistance from a genetic perspective: the interplay between cytokines and immune cell phenotypes

Huishen Yan, Zhiwu Lin, Jieying Zhang, Peiquan Zhu, Yuquan Chen, Jingyuan Liao

Transcription factor NFKB1 mediates TUBB6 to promote the proliferation and suppress apoptosis in glioma via Wnt/β-catenin signaling pathway

Yan Li, Ziyu Shao, Jun Jiang, Hongyan Wang, Mei Zhang

miR-221 is a prognostic marker and promotes the proliferation and migration of esophageal squamous cell carcinoma by inhibiting autophagy

  • Open Access
  • Research

Kun Mei, Zilu Chen, Foxing Tan, YuHeng Zhou, Haolin Du, Renjun Gu, Yan Huang

A mendelian randomization study on the association between type 2 diabetes and the risk of bladder cancer

Yuan He, Yu Chen, Chang Gao

A novel gene signature associated with anoikis predicts prognosis and unveils immune infiltration in breast cancer patients

Yangchi Jiao, Fuqing Ji, Lan Hou, Juliang Zhang

Identification of CCDC58 as a potential predictive biomarker of immune cell infiltration in hepatocellular carcinoma

Zishen Liu, Xiaotong Lin, Tingting Tan, Guozhu Xie, Ying Chen

Bioinformatics exploration of the S1PR1 receptor in various human cancers and its clinical relevance

Xing Xiong, Li Zeng, Fanhui Zeng, Yu Huang, Linghua Jia

The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study

Chenfei Qian, Ganwei Xiong, Shihao Hong, Linzhe Miao, Yitao Guo

Nanotechnology in prostate cancer: a bibliometric analysis from 2004 to 2023

Hui Zhang, Hongpeng Chen, Gaowei Guo, Jinming Lin, Xiaosheng Chen, Peidong Huang, Chuqi Lin, Huirong Lin, Yong Lu, Jieming Lin, Xinji Li, Wei Zhang

Evaluating the predictive value of log odds of positive lymph nodes on postoperative survival in patients with laryngeal cancer: a SEER population-based study

Jiahui Zhang, Wenjun Su, Yue Wang, Peiji Zeng, Wei Wang, Wenjie Fu, Chengfu Cai

Role of metabolic transformation in cancer immunotherapy resistance: molecular mechanisms and therapeutic implications

Sandesh Shende, Jaishriram Rathored, Tanushree Budhbaware

Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival

Yu-fu Li, Hui-wei Wang, Huan-yan Peng, Zhen-ying Zhang, Zhi-jia Yao, Yuan Meng, Dong-ye Yang

Radiotherapy-immunity lncRNA model predicts lung adenocarcinoma prognosis and treatment outcome and distinguishes between hot and cold tumors

Lingfan Xiong, Jing Guo, Jingjun Lv, Wenhao Guo, Tingting Qiu

Identification of ferroptosis-related gene signatures as a novel prognostic model for clear cell renal cell carcinoma

Xiaoxiao Du, Haoyuan Cao, Yu-Jie Zhou, Qingli Kong, Xulong Zhang

Oxidative stress as a catalyst in prostate cancer progression: unraveling molecular mechanisms and exploring therapeutic interventions

Yawen Song, Zheng Hou, Longting Zhu, Yan Chen, Jingyu Li

Blocking lncRNA NOP14-AS1 overcomes 5-Fu resistance of colon cancer cells by modulating miR-30a-5p-LDHA-glucose metabolism pathway

Ya-nan Lu

Gut Escherichia coli promotes lung cancer by increasing circulating STAMBP production

Xinpei Li, You Mo, Shijie Shang, Meng Wu, Shuling Ma, Zijun Zhai, Qian Song, Dawei Chen

Constructing a prognostic model based on MPT-related genes and investigate the characteristics of immune infiltration in bladder cancer

Lei Yang, Zhiqiang Zhang, Mengfan Xu, Muhan Shang, Haibing Wang, Zhiqi Liu

Identification of necroptosis & mitophagy-related key genes and their prognostic value in colorectal cancer

Xiuling Zhang, Li Meng, Tingjian Zu, Qian Zhou

Flavonoid GL-V9 suppresses development of human hepatocellular cancer cells by inhibiting Wnt/β-Cantenin signaling pathway

Ye Gu, Qiaoxian He, Lu Xie, Fangfang Chen, Hangbin Jin, Lilan Lou, Xiaofeng Zhang

The application of mendelian randomization in cancer research: a bibliometric analysis

  • Open Access
  • Research

Zhongtao Bai, Genlong Zhang

Prediction of potential targets of aloe-emodin in the treatment of hepatocellular carcinoma using network pharmacology combined with bioinformatics

Jinlong Wei, Haosong Chen, Maoqi Xu, Zhenglin Zhang, Jin Wang, Wen Jiang, Weiguo Zhou, Maoming Xiong

Integrative analysis of mitochondrial-related gene profiling identifies prognostic clusters and drug resistance mechanisms in low-grade glioma

Xiaozan Chang, Yingxuan Huang, Ying Qu, Yu Guo, Wenwen Fan, Haining Zhen

Expression of REV7 has prognostic significance in cervical cancer treated with intensity-modulated radiation therapy

Ling Chen, Wei Liu, Meihua Wang, Yang Feng, Tiechen Xiao, Yuxing Yang, Xue Huang

Multi-omics analysis identifies DLX4 as a novel biomarker for diagnosis, prognosis, and immune infiltration: from pan-cancer to renal cancer

Zengshun Kou, Shuaizhi Zhu, Jiaxi Zhu, Shufei Wang, Yu Zheng, Shengjie Zhou, Zi’ang Si, Hai Zhu

Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective

Falak Thakral, Bhairav Prasad, Rippin Sehgal, Saurabh Gupta, Ujjawal Sharma, Bikram Jit Singh, Bunty Sharma, Hardeep Singh Tuli, Shafiul Haque, Faraz Ahmad

Isorhamnetin inhibits cholangiocarcinoma proliferation and metastasis via PI3K/AKT signaling pathway

Zhiguo Tan, Jie Liu, Min Hou, Jia Zhou, Yu chen, Xu Chen, Yufang Leng

Integrative analysis and prognostication in gastric cancer: unveiling the role of mitochondrial genomics with the MLRScore model

Yiru Wen, Peng Chen, Yong Wang, Chunyan Lu, Cao Li, Liu Peng, Xiaohong Cheng, Yulan Guo, Jun Quan, Yue Wen, Lie Yang

Multi-omics insights into the roles of CCNB1, PLK1, and HPSE in breast cancer progression: implications for prognosis and immunotherapy

Qisheng Su, Leiming Fang, Chaofan Li, Liang Yue, Zhimin Yun, Huiqiang Zhang, Qi Liu, Ruilin Ma, Pengfei Zhong, He Liu, Zhangrong Lou, Zhi Chen, Yingxia Tan, Xiaopeng Hao, Chengjun Wu

Developing a prognostic nomogram for primary thyroid lymphoma: insights from a large retrospective study

Ying Gao, Jinmiao Wang, Weijie Tao, Shoujun Wang, Hai Xie, Ran Duan, Jie Hao, Ming Gao

Variation in perioperative practice in elective colorectal cancer surgery: opportunities for quality improvement

John C. Taylor, Hannah Rossington, Rina George, Sarah L. Alderson, Philip Quirke, Caroline Thomas, Simon Howell

The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review

  • Open Access
  • Review

Rui-Ting Zhou, Xiao-Jie Luo, Xiao-Xin-Ran Zhang, Jiang-Feng Wu, Yi-Ran Ni

FADS1, a lipid metabolism-related diagnostic biomarker in KIRC

Tianmin Yang, Kai Sun, Fan Peng, Yuhu Hao, Qingjie Bai, Hanpu Yu, Qinghua Xia

The role of UPK1B in gastric cancer: multi-omics analysis and experimental validation

Haixing Zhu, Wen Jiang, Qian Zhang, Changjun Yu

A novel molecular classification system for head and neck squamous cell carcinoma: predicting treatment response and metastatic potential through multi-omics analysis

XinYu Liu, YuJun Liu, XuTengYue Tian, Yue Xi, MiaoMiao Lu, Xin Zou, WanTao Chen

Comprehensive bioinformatics analysis identified HMGB3 as a promising immunotherapy target for glioblastoma multiforme

Libin Wang, Peizhi Xu, Xinglong Li, Qinghua Zhang

A retrospective study of pembrolizumab plus chemotherapy for head and neck cancer patients: influence of response in combination phase on subsequent maintenance phase

Ken Saijo, Hiroo Imai, Yuki Kasahara, Ryunosuke Numakura, Reio Ueta, Keiju Sasaki, Yuya Yoshida, Sho Umegaki, Sakura Taniguchi, Kota Ouchi, Keigo Komine, Hidekazu Shirota, Masanobu Takahashi, Chikashi Ishioka

Multi-omics analysis of copper metabolism-related molecular subtypes and risk stratification for osteosarcoma

Yang Zhang, Wen Liu, Dayong Liu, Xiaopeng Li, Qingshan Zhuang, Quan Sun, Xiaolin Wu, Feng Li

Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study

Shurong Wang, Zhouyu Fang, Wenjin Xiao, Ying Xie, Yueyue Zhang, Zhihua Liu

Development and validation of a prognostic nomogram for ovarian clear cell carcinoma: a study based on the SEER database and a Chinese cohort

Yao Shen, Fei Xi, Pingge Zhao, Yuhang Zhang, Guanlin Guo, Xueyuan Jia, Jie Wu, Ye Kuang

SEPT9 and PAI-1 are immunohistochemical biomarkers of the hepatocellular carcinoma immune microenvironment

Eundong Park, Xin Wang, Nusret Bekir Subasi, Michel Kmeid, Paul J. Higgins, Anne Chen, Hwajeong Lee

Insights into the history and trends of nanotechnology for the treatment of hepatocellular carcinoma: a bibliometric-based visual analysis

Yulei Zhao, Xingxin Wang, Xiaoman Yang, Jiaheng Li, Bingbing Han

A causal inference study exploring the impact of iron status on the risk of thyroid cancer based on two-sample mendelian randomization

Yihan Shi, Wenlian Zheng, Guanglun Yang, Hong Liu, Lei Xing

CLDN9 and hsa-miR-4496 as non-invasive biomarkers for gastric cancer detection

Qiongxia Hu, Lu Han, Jinglin Wang, Fei Li, Hongfei Pu, Yue Shi

Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression

Yufeng Chen, Anjing Zhang, Li Lei, Kangping Xiao, Wenchao Mao

Efficacy analysis of brain radiotherapy in EGFR mutation non-small cell lung cancer with brain metastasis: a retrospective study

Kaicheng Pan, Bing Wang, Xiao Xu, Yi Tang, Jiafeng Liang, Shenglin Ma, Bing Xia, Lucheng Zhu

Acinar cells modulate the tumor microenvironment through the promotion of M1 macrophage polarization via macrophage endocytosis in pancreatic cancer

Congjia Ma, Wenbo Zhu, Xiulin Hu, Deli Wu, Xintong Zhao, Yiqi Du, Xiangyu Kong

Application of machine learning models to explore prognosis and cause of death in advanced intrahepatic cholangiocarcinoma patients undergoing chemotherapy

Qin Zeng, Xin Wang, Jun Liu, Yiqing Jiang, Guili Cao, Ke Su, Xiaoqin Liu

Identification of DNA damage and repair gene-related markers in pancreatic ductal adenocarcinoma by single-cell and bulk RNA sequencing

  • Open Access
  • Research

Chaoyi Zhang, Rong Tang, Jianhui Yang, Yueyue Chen, Yangyi Li, Cong Zhou, Wei Wang, Xian-Jun Yu, Jin Xu

Causal relationship between breast cancer and acute myeloid leukemia based on two-sample bidirectional Mendelian randomization and transcriptome overlap analysis

Xin’an Pan, Cuihan Huang, Xinyi Bai, Fei Li

MUC3A promotes the progression of cholangiocarcinoma through the MAPK/ERK pathway

Baijie Feng, Wei Su, Lina Hu, Minghua Yu

Plasmablastic lymphoma mimicking primary ovarian, tubal or peritoneal cancer: a case report and literature review

I-Ning Cheng, Chen Chang, Hong-Ming Tsai, Ya-Ting Hsu, Yu-Fang Huang

CSF2 promotes chemoresistance in colorectal cancer by regulating Notch pathway

Hairong Zhou, Zhenyuan Gao, Xiao Wu, Yaping Wang, Lu Zhang

A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting

Fenglin Li, Yao Chen, Haihui Zhuang, Renzhi Pei, Yuyu Lu, Dong chen, Shuangyue Li, Peipei Ye, Jiaying lian, Ying Lu

Predicting immune status and gene mutations in stomach adenocarcinoma patients based on inflammatory response-related prognostic features

  • Open Access
  • Analysis

Huanjun Li, Jingtang Chen, Zhiliang Chen, Jingsheng Liao

An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells

Akiya Ibe, Masako Nakanishi, Kurumi Higashimoto, Yasuteru Muragaki, Shogo Ehata

ATF6 activation promotes tumorigenesis and drug resistance in diffuse large B-cell lymphoma (DLBCL) by regulating the mTOR/S6K signaling pathway

Shuang Su, Lili Wu, Chen Huang, Cuiying He, Lianjing Wang, Weijing Li, Wei Liu, Lihong Liu

A single-cell atlas of bladder cancer unveils dynamic cellular composition and endothelial functional shifts during progression

Hongjian Song, Guixiang Xie, Yaowei Li, Xiaowei Hu, Zongzheng Yang, Yubo Zhao, Qing Shi, Haonan Li, Ziyi Liu, Zhihao Yin, Ziqi Wang, Zhichao Tong, Wanhai Xu

Relationships among immune cells, metabolites, and non-small cell lung cancer: a mediation Mendelian randomization study

  • Open Access
  • NSCLC
  • Analysis

Yunxiang Chen, Xinlong Wan, Na Zhang, Liping Zhang, Jing Jiao, Zhigang Sun

CCL26 as a prognostic biomarker in hepatocellular carcinoma: integrating bioinformatics analysis, clinical validation, and radiomics score

Junjun Yan, Qiangming Liao, Yong Xie, Sihai Chen

Intrahepatic cholangiocarcinoma patient with epidermal growth factor receptor exon 19 deletion unresponsive to Afatinib monotherapy: a case report

Caijiu Deng, Junming Huang, Qian Yu, Jianjun Han, Yuanxue Jiang, Liping Lin, Xiaolong Cao

Comparison of liver injury and inflammatory response following conventional and drug-eluting bead transcatheter chemoembolization in hepatocellular carcinoma

Ran You, Bin Leng, Chendong Wang, Zeyu Yu, Lingfeng Diao, Ya Lu, Qingyu Xu, Guowen Yin

Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts

Sima Nobari, Ali Shojaeian, Farid Azizi Jalilian, Gholamreza Kalvandi, Razieh Amini

Reconstructing the hepatocellular carcinoma microenvironment: the current status and challenges of 3D culture technology

Ting Xiong, Kai Wang

Sophorolipids as anticancer agents: progress and challenges

  • Open Access
  • Review

Salam Bhopen Singh, Kanupriya Kuniyal, Ananya Rawat, Ananya Bisht, Vijendra Shah, Achlesh Daverey

Unveiling the therapeutic potential of ferroptosis in lung cancer: a comprehensive bibliometric analysis and future therapeutic insights

Wenhuan Song, Peipei Sun, Tongzhen Zhao, Yunxue Zang, Pengpeng Dong, Qi Tang, Wenyu Chen, Wenyi Chen, Zhenqing Wang, QinHeng Zhang, Yinglin Wang, Chunhui Yin, Mingkun Yu

Identification and validation of pyroptosis patterns in AML via comprehensive bioinformatics analysis

Zeyu Deng, Hongkai Zhu, Zhao Cheng, Ruijuan Li, Hongling Peng

Identification of a deubiquitinating gene-related signature in ovarian cancer using integrated transcriptomic analysis and machine learning framework

Suwan Hu, Mengting Wang

Machine learning-based prognostic modeling integrating PANoptosis in head and neck squamous cell carcinoma

  • Open Access
  • Research

Chen Li, Jiajing Lu, Jialin Zhu, Tao Zhou, Qijie Shen, Bikun Huang, Qingsong Li

Single-cell profiling uncovers the intricate pathological niche diversity in brain, lymph node, bone, and adrenal metastases of lung cancer

Le Liu, Yuan Zhou, Zhenjun Ye, Zhiyong Chen, Benchao Yuan, Liyi Guo, Haiyan Zhang, Yuanyuan Xu

Relationship between retinol metabolism and hepatocellular carcinoma: a comprehensive analysis of Mendelian randomization, prognostic characteristic and experiment

Fuqing Chen, Yifan Cai, Jianyin Zhou

Evaluating the immune effector functions induced by humanized anti-CD99 antibody in eliminating T lymphoblastic leukemia/lymphoma cells

Kamonporn Kotemul, Ratthakorn Chaiwut, Chaochetdhapada Putpim, Supansa Pata, Witida Laopajon, Chatchai Tayapiwatana, Watchara Kasinrerk, Nuchjira Takheaw

Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis

Zhiwu Lin, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Jiudong Jiang, Yang Gao, Rulin Li, Jiangang Fan, Yang Yu, Liang Wu, Yanchun Yang

Identification of telomere maintenance-driven molecular subtypes in hepatocellular carcinoma: implications for prognosis and targeted therapy via KPNA2

Zhicheng Xu, Hanyu Wang, Haixia Tian, Weijing Wang, Dong Hua

Mitochondria in cancer: a comprehensive review, bibliometric analysis, and future perspectives

  • Open Access
  • Research

Abeer El Wakil, Patrick Devos, Heba Abdelmegeed, Alaa Kamel

Exploring the role of EBV ZEBRA antibody levels in papillary thyroid cancer risk and drug resistance

Jiaqin Deng, Yeqian Lai, Ming Yu, Yihua Gu, Lihong Qiu, Yuedong Wang

Efficacy of maintenance or consolidation therapy for multiple myeloma based on proteasome inhibitors: a meta-analysis

Dan Wu, Feiqing Wang, Xu Yang, Bo Yang, Juan Chen, Jinyang Cheng, Bo Wei, Xiaoshuang Yuan, Tingting Tian, Zhenhua Liu, Zhixu He, Yang Liu, Yanju Li

Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma

Yuxuan Li, Fengguang Zhai, Lili Kong, Jie Zhu, Hong Li, Xiaofeng Jin

Reevaluating the role of surgery in lung cancer with liver metastases: a propensity score-matched survival analysis

Yongfei Fan, Qiyong Wu, Ming Lou

Pan-cancer analysis of ITGB3 as a potential prognostic and immunological biomarker

Changshun Chen, Lei Wen, Ge Chen, Fei Yang, Zhong Chen, Jianhua Ji, Jinyi Gu

Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating cytochrome P450 family 1 subfamily A member 1 expression

Min Chen, Ming Cheng, Chenchen Shao, Wenwen Liang, Yi Tang, Fangjun Ding

Molecular landscape of clear cell renal cell carcinoma: targeting the Wnt/β-catenin signaling pathway

Judyta Górka, Katarzyna Miękus

Microbiome landscapes of the bladder, intestine, and vagina in bladder cancer: a systematic review

Jonathan Surber, Marie Semmler, Dominik Enderlin, Andres Affentranger, Thomas Scherer, Silvan Sigg, Ernest Kaufmann, Jana Gadient, Luca Truscello, Michael Scharl, Yasser Morsy, Daniel Eberli, Cédric Poyet, Uwe Bieri

Genetic variants in m6A regulator genes confer susceptibility and progression of HCC in a Northern Chinese population

Guohua Ji, Cize Gao, Yi Yang, Yuli Ding, Ruining Liu, Shuang Wu, Xuelong Zhang, Xiao Liang, Songbin Fu, Xiaobo Cui

Predicting survival and immune status of breast cancer patients based on prognostic features related to PANoptosis

Juanjuan Cui, Dapeng Wu, Da Lv

Research trends in essential thrombocythemia from 2001 to 2024: a bibliometric analysis

  • Open Access
  • Research

Yiming Pan, Lingyan Chen, Qun Jiang, Dejian Chen, Yanqin Wu, Li Hou, Haiyan Lang, Jun Yan

Multi-objective deep learning for lung cancer detection in CT images: enhancements in tumor classification, localization, and diagnostic efficiency

Abdulqader Faris Abdulqader, S. Abdulameer, Ashok Kumar Bishoyi, Anupam Yadav, M. M. Rekha, Mayank Kundlas, V. Kavitha, Zafar Aminov, Zahraa Saad Abdulali, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq, Bagher Farhood

Comprehensive pan-cancer analysis of PPP1R3G reveals its diagnostic, prognostic, and immunotherapeutic implications

  • Open Access
  • Analysis

Nie Zhang, Jiaoyu Li, Yanzhi Ren, Yahui Xu

The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study

Chaojia Ou, Yufan Zhou, You Tang, Zhiguo Tan, Chuang Peng, Xu Chen, Ou Li

Immune microenvironment and molecular mechanisms in endometrial cancer: implications for resistance and innovative treatments

Yijia Chen, Lai Jiang, Lanyue Zhang, Hao Chi, Qin Wang

miR-126-5p suppresses HeLa and Ishikawa cell proliferation and migration via the RICTOR/AKT pathway

Xuan Zhang, Yanjing Yang, Yaqin Li, Wei Zhang, Xianfang Song

Clinical benefit loss in myeloma patients declining autologous stem cell transplantation: a real-world study

Yue Wang, Yaqin Xiong, Shiyang Gu, Wenjing Wang, Yang Yang, Peng Liu

Clinical significance and immune infiltration analyses of the coagulation factor V gene in brain lower grade glioma

Yu Wang, Haiyue Zhang, Yuanyuan Zhan, Zhuoran Li, Sujing Li, Changxu Deng, Shubin Guo

Use of consensus clustering to identify subtypes of clinical early-stage non-small cell lung cancer and its association with lymph node metastasis

  • Open Access
  • NSCLC
  • Research

Yi Qin, Yang Wo, Fengyi Han, Yandong Zhao, Yawei Wang

Artificial intelligence-assisted multimodal imaging for the clinical applications of breast cancer: a bibliometric analysis

Chenke Hou, Ting Huang, Keke Hu, Zhifeng Ye, Junhua Guo, Heran Zhou

Synthesis of AgInS2 quantum dots loaded with celastrol for induction of apoptosis and autophagy in hepatocellular carcinoma cells

Qineng Gong, Tianyu Zhu, Linlin Zhang, Hui Wu, Yang Miao, Ye Hu

Utilizing multi-omics analysis, a new signature has been identified and validated for predicting prognosis and response to immunotherapy in lung squamous cell carcinoma, which is based on tumor mutation burden

  • Open Access
  • NSCLC
  • Analysis

Dongguang Wang, Yan Wang, Yiqun Peng, Liang Peng

Dietary factors and oral cancer risk: a comprehensive Mendelian randomization analysis in a European population

Shiyang Zhao, Xichen Liu, Qingsen Wang, Shudong Xiao, Wanting Wang, Xinyue Dong, Yourong Jiang, Wen Wu

Dual-radiomics based on SHapley additive explanations for predicting hematologic toxicity in concurrent chemoradiotherapy patients

Luqiao Chen, Zhipeng He, Qianxi Ni, Qionghui Zhou, Xizi Long, Wenbin Yan, Qian Sui, Jiheng Liu

Predictive biomarkers and molecular subtypes in DLBCL: insights from PCD gene expression and machine learning

Tiantian He, Jie Geng, Chuandong Hou, Hongyi Li, Hong Zhang, Peng Zhao, Peifeng He, Xuechun Lu

Multiple machine learning algorithms identified SLC6A8 as a diagnostic biomarker of the late stage of Hepatocellular carcinoma

Linlin Song, Hongli Zhang, Wang Yang

Based on disulfidptosis, unveiling the prognostic and immunological signatures of Asian hepatocellular carcinoma and identifying the potential therapeutic target ZNF337-AS1

Duo Shen, Ling Sha, Ling Yang, Xuefeng Gu

The impact of the COVID-19 pandemic on the diagnosis, treatment, and prognosis of ovarian cancer in the United States: a retrospective cohort study based on the SEER database

Yuqin Wang, Lele Chang, Haixin He, Xuemei Zhang, Jing Liu, Lele Zang, Li Li, Tongyu Liu, Qin Xu

miR-130a-5p/TFPI2 axis promotes invasion of hepatocellular carcinoma by altering epithelial-to-mesenchymal transition

Xiaoyuan Gu, Hongmin Lu, Wei Wang, Zijun Zhao, Weiqiang Zhang, Xinyuan Lu

A comprehensive review on targeted therapies for triple negative breast cancer: an evidence-based treatment guideline

Hadir M. Emara, Nageh K. Allam, Rana A. Youness

Unraveling the oncogenic role of LINC00504 and its interaction with miR-545-3p and ARIHI in hepatocellular carcinoma: novel insights for molecular therapy

E. Ke, Kai Yang, Qin Zhang, Cheng Luo, Zhiyong Hu, Jing Wang, Hai Zhang

Association between type 2 diabetes and gastric cancer in Europeans and East Asians based on two sample Mendelian randomization

Xiaoyan Wang, Luyu Zhu, Ziyan Liu, Changfeng Man, Zhenjun Gao, Dandan Gong, Yu Fan

Inhibiting glycolysis facilitated checkpoint blockade therapy for triple-negative breast cancer

Chong Li, Yu Tang, Ruizhi Zhang, Liang Shi, Jianying Chen, Peng Zhang, Ning Zhang, Wei Li

Uncovering the anti-cancer mechanism of cucurbitacin D against colorectal cancer through network pharmacology and molecular docking

Hae-In Lim, Ga Yoon Kim, Yu-Jeong Choi, Kangwook Lee, Seong-Gyu Ko

Integrative genomic pan-cancer analysis reveals the prognostic significance of DEFB1 in tumors

Li Wang, Hongyu Yang, Lu Cao, Yang Yang, Ran Ding

The safety and efficacy of atezolizumab for recurrent primary liver cancer after liver transplantation

Rong-Rong Yao, Quan-Bao Zhang, Meng-Xi Ge, Li Li, Jing Li, Xin-Li Zhou, Zheng-Xin Wang, Xiao-Hua Liang

Clinical diagnosis and treatment of abdominal inflammatory myofibroblastic tumors

Qiang Zhang, Zhi-wei Zhang, Jing Fan, Zhuo-Ma Ji, Chun-Yan Wang, Feng Liu

Higher density of compact B cell clusters in invasive front may contribute to better prognosis in pancreatic ductal adenocarcinoma

  • Open Access
  • Research

Junwen Zhou, Kunping Yang, Mei Lu, Peiling Fu, Yupeng Chen, Linying Chen

Gene expression profiling and pathway analysis in head and neck squamous cell carcinoma: focus on disulfidptosis

  • Open Access
  • Analysis

Yajun Tong, Site Bai, Ludi Ou, Qiang Zhou, Songlian Liu, Leilan Yin, Kewei Tang, Ling Long, Qinghua Yin

Machine learning developed immune-related exosome signature for prognosis and immunotherapy benefit in bladder cancer

Xiaoting Luo, Yi Luo

Efficacy and safety of RC48 in combination with PD-1 inhibitors for the treatment of locally advanced or metastatic urothelial carcinoma: a single-center, real-world study

Tiantian Zhang, Shuo He, Lu Tao, Mengting Shi, Yue Wu, Yuanyuan Guo, Rui Wang

The m6A methyltransferase METTL3 affects ferroptosis in non-small cell lung cancer by regulating the PTEN/PI3K/AKT pathway

  • Open Access
  • NSCLC
  • Research

Bin Wu, Danhong Li, Yu Wang, Tingting Pan, Jieru Xu, Lihong Li

The mechanisms and effects of lactylation modification in different kinds of cancers

Yixun Sun, Xiaxia Yang, Feifei Kong, Feng yun Dong, Na Li, Sen Wang

CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling

Genwang Wang, Yu Pang, Nan Li, Yongfeng Hui, Dong Jin

Development and validation of nomogram model predicting overall survival and cancer specific survival in glioblastoma patients

Yingming Mu, Junchi Luo, Tao Xiong, Junheng Zhang, Jinhai Lan, Jiqin Zhang, Ying Tan, Sha Yang

ZNF280A promotes malignant melanoma development through regulating cell proliferation, apoptosis, and cell cycle

Wenjun Zheng, Zhuren Ruan, Yuanyuan Chen, Xianghui Li, Zhijian Yao, Gao Wei

Purinosomes as a therapeutic target in hepatocellular carcinoma: insights and opportunities

Zhen Lin, Jia-Wei Long, Ming-chun Zhao, Pin Guo, Jin Wen, Guang-Liang Chen

HEX-1 reduces colitis-driven colorectal cancer via inactivating the prolyl isomerase PIN1 sensitization and remodeling the gut microbiota

Yanhui Ma, Yunlan Zhou, Guohua Xie, Hui Chen, Yuchan Huangfu, Lisong Shen, Yi Liu, Ping Wang

Research progress on ADAM28 in malignant tumors

Lanlan Zhao, Wei Liu, Fei Wang

Plasma protein levels and hepatocellular carcinoma: a Mendelian randomization study with drug screening implications

Longhui Xie, Dekun Song, Jianwei Lan, Pengpeng Liu, Shuang Qin, Yinkuan Ning, Quanyan Liu

Advances in the roles and molecular mechanisms of exosomal circular RNAs in regulating the pre-metastatic niche of tumors

Wei Xu, Luyu Zhu, Shiqi Zhang, Xiaoyan Wang, Dandan Gong, Yu Fan

Glycosphingolipids as emerging attack points in bladder cancer

Inês B. Moreira, Falk F. R. Buettner

ADAMTSL2 is an independent predictor for the prognosis of gastric cancer

Xiuling Zhu, Zhongyuan Cui, Shasha Li, Yingzhen She, Zhixian Wu

Prognostic value of combined nutritional and inflammatory markers in NSCLC patients receiving ICIs

  • Open Access
  • NSCLC
  • Research

Jianying Liu, Jiaxin Liu, Haiyan Chen, Qingwei Zhang, Peihong Zhang, Zhisheng Chen, Xuefeng Lu, Yijiao Xu

Histopathological biomarkers in squamous cell carcinoma of the vulva: the prognostic relevance of tumor-infiltrating lymphocytes (TILs)—a retrospective study of 157 cases

Gilbert Georg Klamminger, Meletios P. Nigdelis, Yaman Degirmenci, Bashar Haj Hamoud, Erich Franz Solomayer, Laura Schnöder, Bernd Holleczek, Marcus Schmidt, Annette Hasenburg, Mathias Wagner

Single-cell RNA sequencing reveals key signaling pathways and biological functions in giant cell tumors of bone

Zuozhuan Lin, Zuoxi Chen

LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress

Bei Feng, Hai-Ying Guo, Yu Ning, Yu-Ying Zhao, Xiang Wang, Rui Cui

P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells

PeiYao Gao, HengJin Tian, KunPeng Ge, FeiFan Wang, YanMing Zhao, JiWen Sun, Qiang Zhang

Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy

  • Open Access
  • Research

Yixuan Zhu, Kaizhi Cai, Lijuan Guo, Huan Zhang, Li Guan, Zongyao Zhang, Pengcheng Huang, Sen Yang

Machine learning-based prognostic modelling of NK cells in PAAD for immunotherapy guidance

Li Li, Zu-Tao Wu, Wen-Hong Duan, Jiang Liu, Yin-Rong Zhu

Next-generation sequencing in cancer diagnosis and treatment: clinical applications and future directions

Nima Ghoreyshi, Reza Heidari, Arezoo Farhadi, Mohsen Chamanara, Nastaran Farahani, Mahmood Vahidi, Javad Behroozi

Interactions between long non-coding RNAs and m6 A modification in cancer

Han Zhang, Junjie Wang, Chunyi Liu, Kaiqin Yan, Xiaomeng Wang, Xiumei Sheng

Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis

ShengYao Zheng, HongYi Wang, Yingyi Wang

MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type

  • Open Access
  • NSCLC
  • Research

Sha Yao, Omar Elakad, Xiang Hui Yang, Adnan Raza Altaf, Wen Tao Yu, Hanibal Bohnenberger, Luo Gen Peng

Comprehensive analysis of mRNA expression of Piezo1 and Piezo2 in tumor samples and their prognostic implications in gastric cancer

Tong Liang, Junhong Wang, Zhong Yang, Ronglong Zhang

Mapping the landscape of metabolic reprogramming research in lung cancer: a bibliometric and visualized analysis

Song Han, Jialu Li, Feng Jiang, Qingtong Shi

Research progress on cuproptosis and copper related anti-tumor therapy

  • Open Access
  • Review

Yichen Li, Lifei Han, Haolin Hu

A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000–2024)

Wenli Gu

The genetic associations of lipidome on bladder cancer: a Mendelian randomization study

Jing Jin, Weihao Wang, Keyuan Zhao, Gang Xu, Chao Peng, Jiajun Chen, Yulei Li, Shouhua Pan

Identification of novel biomarkers and prognostic model for neuroblastoma using Mendelian randomization and transcriptomic analysis

Yongcheng Fu, Nan Zhang, Jian Cheng, Xiaohan Qin, Xing Zhou, Xiaoran Du, Yuanyuan Wang, Jingyue Wang, Da Zhang

Mendelian randomization study on the causal relationships among fasting blood glucose, plasma proteins, and squamous cell lung cancer

Ronglin Li, Zhenniu Lei, Zhaoke Wen, Yifan Zhou, Yunzhi Ma, Junqi Qin, Xiaoyan Huang, Shuping Huang, Shucong Peng, Shengjing Liang, Yonglong Zhong

Disulfidptosis, a novel regulated cell death to predict survival and therapeutic response in kidney renal clear cell carcinoma

  • Open Access
  • Analysis

Xiaofen Wen, Jiaxin Shen, Hui Lin, Danxia Lin, Minna Chen, Leonardo Antonio Sechi, Maria Rosaria De Miglio, De Zeng

A network-based analysis to identify a piRNA-target signature related to colorectal cancer prognosis: in silico and in vitro study

Fatemeh Khavari, Rezvan Najafi, Saeed Afshar, Akram Jalali, Mehrdad Hashemi, Alireza Soltanian, Fatemeh Nouri

Targeting miR-103a-3p/IGFBP5 axis: a potential therapeutic strategy for gastric cancer progression

Junrui Zhang, Yue Qiu, Fubin Ma, Xingdong Niu, Pengwei Bai, Mingxu Da, Junfeng Ma

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma

Federica Michetti, Mara Cirone, Raffaele Strippoli, Gabriella D’Orazi, Marco Cordani

ADCYAP1 as a pan-solid cancer biomarker: predictor of immunotherapy efficacy in bladder cancer and prognostic potential across solid tumors

Xiaoyu Jing, Ying Deng

TM9SF4 is a potential prognostic biomarker in hepatocellular carcinoma

Yahui Ma, Lingling Guo, Bo Zhang, Ting Wang, Qingchun Feng

Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy

Bhagyalakshmi Nair, Anjana Menon, M. Rithwik Kalidas, Lekshmi R. Nath, Daniela Calina, Javad Sharifi-Rad

Efficacy of CRISPR-Cas9 gene editing for targeting KRAS mutations in pancreatic cancer: a systematic review

Hashim Talib Hashim, Ahmed Qasim Mohammed Alhatemi, Tehreem Fatima, Tahmina Haque, Fatimah Abdullah Sulaiman, Mohammed Ganim, Muhanned Ahmed Abdullah, Rawaa Awad Kadhum, Ahmed Dheyaa Al-Obaidi, Ammar Al-Obaidi

Risk prediction of second primary malignancies in patients with primary gastric neuroendocrine neoplasms: a population-based study

  • Open Access
  • Analysis

Peipei Yang, Yuanyuan Xu, Wenjie Huang, Qiurong Li, Peng Shu

Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway

Xin Wang, Siyuan Li, Dong Fan, Yuyou Luo, Huitong Chen, Zhongyu Wang, Xingyi Yuan, Jing Liu, Zongming Wang

RNA-binding proteins and autophagy in lung cancer: mechanistic insights and therapeutic perspectives

Xiao Lei, Yuexin Zheng, Wenmei SU

A global bibliometric map of Mendelian randomization in lung cancer research: trends, themes, and emerging risks

Chong-Qi Fan, Yao-Xuan Chen, Feng Guo, Hao-Han Rao, Chun-Jian Zuo, Peng-Yu Che, Cao Yu, Huan-Wen Chen

Association between kidney stones and urological cancers: results from the NHANES 2007–2020 and Mendelian randomization study

Jinghua Zhong, Jiahao Cheng, Zhijian Zhao, Houmeng Yang, Yongda Liu, Xiaolu Duan, Guohua Zeng

Mendelian randomization analysis reveals potential causal relationships between serum lipid metabolites and prostate cancer risk

Chuanmin Guo, Lejun Wu, Lintang Xu

Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming

  • Open Access
  • Research

Rongrong Zhang, Jinjing Guo, Yicong Lin

Integration of single-cell sequencing and mendelian randomization reveals novel causal pathways between monocytes and hepatocellular carcinoma

Jiang Yu, Jing Yu, Zhou Kang, Yong Peng

Modeling of cancer stem cells and the tumor microenvironment Via NT2/D1 cells to probe pathology and treatment for cancer and beyond

Mia C. Borlongan, Thomas Rodriguez, Napasiri Putthanbut, Hongbin Wang, Jea-Young Lee

Multiple data sets to explore the key molecules and mechanism of lymph node metastasis in gastric cancer

Yijun Zheng, Yawu Zhang, Zheyuan Wang, Xiaohu Guo, Lingyi Zhang, Youcheng Zhang

Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy

Aasma Zafar, Summaiya Khatoon, Muhammad Jawad Khan, Junaid Abu, Aisha Naeem

Development of a machine learning-derived programmed cell death index for prognostic prediction and immune insights in colorectal cancer

Jinping Li, Yan Jiang, Shengbin Nong, Liudan Liang, Liangchao Chen, Qiming Gong

Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis

Rulin Li, Yanchun Yang, Yang Gao, Jing Lv, Chuanqiang Dai, Yuanwei Zhai, Chirong Mao, Jiudong Jiang, Jiangang Fan, Yang Yu, Liang Wu, Zhiwu Lin

S100A7 as a predictive biomarker in malignant transformation of oral epithelial dysplastic lesions

  • Open Access
  • Research

Jeffrey Soparlo, Lachlan McLean, Christina McCord, Linda Jackson-Boeters, Michael Shimizu, Michael Robinson, Wanninayake M. Tilakaratne, Mark R. Darling

Evaluation of the diagnostic value of a three-miRNA panel in prostate cancer: a discovery and validation study

Xutai Li, Chen Sun, Zhenjian Ge, Yingqi Li, Huimei Zhou, Yutong Wu, Shengjie Lin, Pengwu Zhang, Xionghui Wu, Yongqing Lai

The regulatory role of PTTG1 in proliferation and migration of thyroid cancer

Jianjun Wang, Chenjun Guo, Junyu Cao, Li Li

Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization

Peizan Ni, Lilin Li, KunPeng Du, Pengkhun Nov, Duanyu Wang, Changqian Wang, Qianzi Kou, Ying Li, Yangfeng Zhang, Chongyang Zheng, Wen Fu, Jiqiang Li

DeepOmicsSurv: a deep learning-based model for survival prediction of oral cancer

Deepali, Neelam Goel, Padmavati Khandnor

Research progress on N6-methyladenosine and non-coding RNA in multiple myeloma

Xiaoqi Sun, Yongming Zhou, Wenwei Zhu, Hailin Chen

ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target

Lei Tang, Xiyue Wang, Zhengzheng Xia, Jiayu Yan, Shanshan Lin

Immune-related gene expression with colorectal cancer risk: a Mendelian randomization analysis

Xin Tan, Wenjun He, Tao Chen, Weihao Yang, Donghua Huang, Hengyi Zhang, Yangyang Luo, Mengting Lu, Zhenzhan Zhang, Jianguang Ji, Hao Liu

Predictive role of inflammatory markers for the efficacy of first-line immunotherapy plus chemotherapy in advanced gastric cancer

Chenming Zhong, Ying Yuan, Yue Jiang, Guanglei Qiao, Zhoufeng Deng, Zimei Liu, Liping Yu, Hongjian Lin, Jiuang Mao, Lijun Ma, Jianjun Zhang

Adherence to chemotherapy and associated factors among adult patients with cancer in the Amhara region, Ethiopia, 2022

Sewunet Ademe, Tariku Mohammed, Afework Edmealem, Belachew Tegegne, Bekalu Bewket, Atsedemariam Andualem, Abebaw Bires

In silico-based analysis and in vitro experiments identify SIGMAR1 as a potential marker of putative lung cancer stem cells

Tetsuhiro Horie, Ayane Kuwano, Takuya Sakamoto, Yuka Nakamura, Kayoko Yamaguchi, Ikuhiro Tanida, Satoshi Osawa, Kazuo Yasumoto, Yasuhito Ishigaki

Safety of bronchial artery infusion immunotherapy: from comparative analysis in beagle canines to clinical validation

  • Open Access
  • NSCLC
  • Research

Bin Liu, Jia Zhou, Wei He, Bo Xie, Rui Zhang, Xiaocheng Cheng, Yueming Zhang, Li Xu, Shuliang Guo

Low-grade intracranial solitary fibrous tumor with early metastasis to lumbar spine and recurrence twice: case report

Huan Qian, Pan Zheng, Sanjun Guo, Yulin He, Yue Yang, Huajun Sun

Laparoscopic curative resection following perioperative chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel and its influence on Claudin18.2 expression in advanced gastric or gastroesophageal junction adenocarcinoma: a two-case report

Tohru Takahashi, Takahiro Ishii, Taku Maejima, Eriko Aimono, Dai Miyazaki, Susumu Fukahori, Taichi Kimura, Mitsuru Yanai, Yusuke Ono, Masahiro Hagiwara, Yusuke Mizukami

Gene mutations and differentiation in laryngeal and pharyngeal squamous cell carcinoma

  • Open Access
  • Research

Gaofei Yin, Nuan Li, Xiaohong Chen, Yang Zhang, Jugao Fang, Qi Zhong, Zhigang Huang, Wei Guo

Mapping immune cell dynamics and macrophage plasticity in breast cancer tumor microenvironment through single-cell analysis

Wang Chen, Siyu Zeng, Junyong Zhong, Jian Zou, Yanli Lei, Xiaohan Chen, Qinghua Mei, Qianhua Luo

FOXM1 could serve as a bridge mediating prognosis and immunity for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing

Jianhua Zhou, Zhuxian Xu, Yang Yu, Bingye Zhu, Qianwei Xing

Spheroid morphology of lung cancer cell lines correlates with oncological profiles

Kaido Oishi, Keitaro Matsumoto, Shintaro Hashimoto, Fumitake Uchida, Ryosuke Hara, Masato Nishimuta, Takamune Matsumoto, Mayumi Iwatake, Koichi Tomoshige, Ryoichiro Doi, Ryusuke Machino, Tomohiro Obata, Takeshi Nagayasu

Serine metabolism in tumor progression and immunotherapy

  • Open Access
  • Review

Dong Huang, Hui Cai, HaiYu Huang

From chronic obstructive pulmonary disease (COPD) to lung cancer: a Mendelian randomization study revealing mediation pathways through plasma metabolomics, proteomics, and immunophenotyping

Tianjian Ding, Qiaoming Lin, Xiaohan Qu

Gene expression profiling of lncRNA-HOTAIR and lncRNA-MALAT1 in esophageal cancer: uncovering links to lifestyle factors and diagnostic significance

Vahid Ghorbani, Saeid Ghorbian

The management of multiple myeloma patients accompanied with disseminated intravascular coagulation before receiving LCAR-B38M therapy

Ruijun Dong, Rui Liu, Rui Yang, Yun Yang, Yan Xu, Bo Lei, Wanhong Zhao, Wanggang Zhang, Gongzhizi Gao, Aili He, Ju Bai

Identifying candidate biomarkers for detecting bronchogenic carcinoma stages using metaheuristic algorithms based on information fusion theory

Bagher Khalvati, Kaveh Kavousi, Amir Hosein Keyhanipour, Masoud Arabfard

Cervical metastasis of breast cancer: a case report and review of the literature

Yuping Shan, Feng Hou, Yan Wang, Yi Han, Zhumei Cui, Guangjie Yin

Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis

Changwen Li, Tao Chen, Yuanyuan Li, Chunyan Zhou, Jing Du, Xiaoxin Li, Chuangang Tang, Cheng Ma, Na Deng, Huaixin Cui

Mendelian randomization reveals immune cell composition as a key determinant of cervical cancer prognosis

Yangyang Chen, Dongdong Zhong

Based on single-cell and transcriptome data, ferroptosis and the immunological landscape in osteosarcoma were discovered

Yingcun Jiang, Chao Song, Jiyuan Yan, Liang Luo, Silong Gao, Feng Jiang, Zhangchao Wei, Jinwen Chen, Zongchao Liu, Jianhua Ge

Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets

Akhmed Aslam, Bassem Refaat, Riyad A. Almaimani, Ahmad A. Obaid, Abdulrahman Mujalli, Wesam F. Farrash, Mohamed E. Elzubier, Shakir Idris, Afnan Salaka, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Mohammad A. Baqassi, Ali M. Alhanash, Othman M. Hakmi, Faisal Minshawi

Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis

Wei Jiang, You Zheng, Huiying Fang

Effects of anlotinib hydrochloride on the expression of immunogenic cell death-related molecules in Cal27 tongue cancer cells

  • Open Access
  • Research

Pengcheng Huang, Jitao Zhu, Lijuan Guo, Zong Yao Zhang, Li Guan, Sen Yang

LINC00704 facilitates cell proliferation, migration, and invasion via miR-323a-3p/SLC44A1 axis in epithelial ovarian cancer

Xiaojuan Kong, Lei Lei, Zhengjiao Ma

Anti-tumor immune modulation and favorable survival outcomes in uterine corpus endometrial carcinoma: insights from PIK3CA/ARID1A co-mutation analysis

Dongmei Han, Caihong Wu, Hao Jin

The causal association between ankylosing spondylitis and endometrial cancer: a two-sample mendelian randomization study

Yanpin Gu, Yupei Shao

Clinical characteristics and prognosis of non-metastatic multiple gastrointestinal stromal tumors: a population-based study

Liang Chen, Ye Lu, Jiawei Qian, Jie Qiu, Chuanfu Wu, Zhenguo Qiao, Yimin Ma, Feng Yu

The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells

Tingting Liu, Hua Liang, Yang Li, Wenxin Liao, Juexiao Deng, Lanyue Zhang, Fujin Shen

Automatic melanoma and non-melanoma skin cancer diagnosis using advanced adaptive fine-tuned convolution neural networks

Muhammad Amir Khan, Tehseen Mazhar, Muhammad Danish Ali, Umar Farooq Khattak, Tariq Shahzad, Mamoon M. Saeed, Habib Hamam

Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment

Esther Ugo Alum, Daniel Ejim Uti, Okechukwu Paul-Chima Ugwu, Benedict Nnachi Alum, Friday Ogbu Edeh, Christine Ainebyoona

Research progress on cholesterol metabolism and tumor therapy

  • Open Access
  • Review

Zewen Chu, Lei Fang, Yanwei Xiang, Yue Ding

Prognostic role and tumor-suppressive effects of CADM family members and the potential molecular mechanisms of CADM1 in neuroblastoma

Yu Wang, Lingling Zheng, Jun Liu, Mingyu Zhang, Ying Kan, Wei Wang, Jigang Yang

Integrative multi-omic analysis of NLRP3 inflammasome dysregulation and subtyping for personalized treatment in acute myeloid leukemia

Hong Zhang, Linlin Yang, Yukexin Liu, Dongju Wang, Liming Shi, Changyu Tian

Causal associations between iron deficiency anemia and digestive system cancers: evidence from a bidirectional two-sample Mendelian randomization study

Yan Qin, Rong Zhou

Urolithins’ interaction with hepatocyte growth factor receptor: a mechanistic basis for anticancer activity in gastric adenocarcinoma cells

  • Open Access
  • Research

Fatemehsadat Hosseini, Abdolreza Ahmadi, Zahra Nasiri Sarvi, Milad Iranshahy, Fatemeh B. Rassouli

TMCO1, as a potential biomarker of prognosis and immunotherapy response, regulates head and neck squamous cell carcinoma proliferation and migration

Ting Li, Lu Chen, Guangkai Zhou, Yuhan Deng, Meng Zhou, Mingze Yan, Shuyan Dong, Kaixun Xing, Shan Yu, Hongjiang He

Survival benefits of postoperative adjuvant chemotherapy in adults aged ≥ 80 years with locally advanced gastric cancer: insights from a population-based study

Fuhai Ma, Yangyang Zheng, Jian Cui, Zijian Li, Jinxin Shi, Tianming Ma, Xianglong Cao, Tao Yu, Guoju Wu, Gang Zhao, Jinghai Song, Qi An

Mushroom-derived bioactive compounds pharmacological properties and cancer targeting: a holistic assessment

  • Open Access
  • Review

Sakshi Zade, Tarun Kumar Upadhyay, Safia Obaidur Rab, Amit Baran Sharangi, Sorabh Lakhanpal, Nadiyah M. Alabdallah, Mohd Saeed

LINC00534 promotes breast cancer progression by targeting the miR-139-5p/HMGB2 axis

Qiaomei Liu, Wei Xiong

Associations between lipids and lung cancer subtypes

  • Open Access
  • NSCLC
  • Analysis

Jiayu Wen, Jian-Qing He

Lactic acid metabolism: gynecological cancer's Achilles’ heel

Ting Zhang, Wenchao Zhou, Tingyu Fan, Yuwei Yuan, Xing Tang, Qunfeng Zhang, Juan Zou, Yukun Li

A Mendelian randomization study investigating the causal associations of 35 blood and urinary metabolite biomarkers with breast cancer development

Ting Lin, Yimin Liu, Zixuan Liu, Ao Liu, Runtong Liu, Qianchao Wang

Multi-center strain elastography radiomics for breast cancer diagnosis: integrating intratumoral and peritumoral regions

Guoqiu Li, Qiaoying Li, Huaiyu Wu, Zhibin Huang, Hongtian Tian, Keen Yang, Jing Chen, Jinfeng Xu, Lijun Yuan, Fajin Dong

Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer

Jinlong Cao, Siyu Chen, Jirong Wang, Xinpeng Fan, Shanhui Liu, Jiaqi Shan, Xiaoran Li, Li Yang

Constructing a mitochondrial-related genes model based on machine learning for predicting the prognosis and therapeutic effect in colorectal cancer

Shaoke Wang, Yien Li, Zhihui Wang, Changhui Geng, Peng Chen, Zhengang Li, Chenxu Li, Xuefeng Bai

A coagulation-related long non-coding RNA signature to predict prognosis and immune features of breast cancer

Yetao Han, Mengsi Hu, Yanzhong Wang, Shoufang Xu, Feiyu Jiang, Yingjian Wang, Zhiwei Liu

Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning

Yaoming Yang, Xinbao Wang, Liuqing Wu, Shihua Zhao, Ran Chen, Guoyong Yu

The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment

H. G. Zhang, W. R. Yao, Z. Y. Zhou, L. Liu

The periphery of pituitary macroadenoma expressed higher invasive capability: the importance of clinical implication

Cheng-Chi Lee, Yin-Cheng Huang, Ping-Ching Pai, Shih-Ming Jung, Peng-Wei Hsu, Yu-Chi Wang, Chi-Cheng Chuang

Regulation of iodide transportation by a plant secondary metabolite in SW1736 anaplastic thyroid cancer cell line

Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

Molecular and immune landscape of melanoma: a risk stratification model for precision oncology

Miao Sun, Junliang Wu

Synergistic bioinformatics and sophisticated machine learning unveil ferroptosis-driven regulatory pathways and immunotherapy potential in breast carcinoma

Lei Xia, Zhen Ye, Man Zheng, Zhaofeng Tan

Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

  • Open Access
  • Review

Neda Hedayati, Mohamad Hosein Safari, Yaser Eshaghi Milasi, Samaneh Kahkesh, Najma Farahani, Seyedeh Mahdieh Khoshnazar, Zahra Dorostgou, Elmira Alaei, Mina Alimohammadi, Payman Rahimzadeh, Afshin Taheriazam, Mehrdad Hashemi

Evaluating the safety and efficacy of combination immune checkpoint inhibitors and chemotherapy treatment in extensive-stage small cell lung cancer

Yalin Xie, Xiang Li, Hongxu Lu, An Lei, Lei Li, Yun Jin, Yanyang Li, Wenchang Cen, Weifeng Zou, Ning Su, Jizhen Liang

Global trends and research status in clonal hematopoiesis: a bibliometric analysis of the last 10 years

  • Open Access
  • Research

QingQing Luo, Li Yu

Effectiveness of chemotherapy with/without radiotherapy for stage IVb esophageal squamous cell carcinoma: a population-based target trial emulation study

Yao-Hung Kuo, Chen-Yuan Lin, Yao-Ching Wang, Yo-Liang Lai, Yu-Cheng Kuo, Ji-An Liang, Chia-Chin Li, Chun-Ru Chien

Advances in mRNA vaccine therapy for breast cancer research

Jia-ying Li, Rui-yuan Jiang, Jia Wang, Xiao-jia Wang

BEND4: a novel prognostic biomarker in diffuse large B-cell lymphoma

Yanfang Wang, Zhenhao Zhang, Lianyong Xi, Hua Wang, Fei Dong

Integrating machine learning and genetic evidence to uncover novel gene biomarkers for colorectal cancer diagnosis

Li Zhou, Lihua Yu, Mingjing Liao, Tingting Peng, Leilei Zhang, Chengyun Han, Yuan Li, Jiwang Zhang

Human papilloma virus infection drives unique metabolic and immune profiles in head and neck and cervical cancers: implications for targeted therapies and prognostic markers

Saira Hamid, Mohd Shahnawaz Khan, Meraj Alam Khan, Naoshad Muhammad, Mayank Singh, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha

Lactylation-related risk model for prognostication and therapeutic responsiveness in uterine corpus endometrial carcinoma

Yupeng Yin, Min Luo

Progress of the application of spatially fractionated radiation therapy in palliative treatment of tumors

  • Open Access
  • Review

Hongfu Zhao

Intrathoracic migration of I-125 seed marker following ultrasound-guided lymph node localization in locally advanced breast cancer: a case report

Coco Smit, Thomas E. van der Krieken, Maikel T. H. Brauer, Fleur J. W. Mauritz, Thomas Schok

LINC00313 promotes the aggressiveness and tumorigenesis of cholangiocarcinoma through targeting miR-320b and MITF

Ziyu Wang, Jiao Li, Jing Xu, Tingqiu Wan, Yunjin Ya, Xi Li, Xi Wang, Yan Jin

Exploring the role of CD13 and inflammatory factors in radiation enteritis: insights from high-throughput proteomics and Mendelian randomization analysis

  • Open Access
  • Research

Xue Ren, Feng Shang, Defu Yang, Ying Xu, Ying Yan

Exploring the association between chemotherapy and prognosis among patients less than 50 years old with hepatocellular carcinoma: a retrospective cohort study based on the SEER database

Qiyu Zhang, Qiongyu Liang, Chi Xu

Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential

Asmita Rayamajhi, Nisha Gyawali, Deepa Karki, Luis E. Pérez-Caltzontzin, Sheila I. Peña-Corona, Hernán Cortés, Achyut Adhikari, Gerardo Leyva-Gómez, Yadav Uprety, Solomon Habtemariam, Lashyn Kiyekbayeva, Javad Sharifi-Rad

Prediction model for the early recurrence of stage IA–IIA non-small cell lung cancer based on hematological indexes and imaging features

  • Open Access
  • NSCLC
  • Research

Wei Zhao, Yiyuan Sun, Xin Liu, Mingxiang Zhang, Bohui Zhu

Combination treatment with Phloretin enhances the anti-tumor efficacy of radiotherapy in lung cancer models

Juan Tang, Weijie Xiong, Xianguo Liu, Yuhui Shi, Yanxin Yu, Maolin Shi, Hongyu Xu

Expression patterns, prognostic significance, and immune correlations of the TNFAIP8 family in acute myeloid leukemia: a comprehensive bioinformatics analysis

Xuezhong Zhang, Min Qu, Lei Bi, Xiaolei Wang, Tonggang Liu

Inhibition of ATG5-mediated autophagy maintains PMAIP1 stability to promote cell apoptosis and suppress triple-negative breast cancer progression

Fangjian Shang, Hongfeng Nie, Liyan Du, Jin Shang, Xiangquan Song, Ya Chen, Hui Li, Zhuo Wang, Yixin Qi, Liyan Zhao

Development of a nomogram for predicting the risk of carcinoma in chronic atrophic gastritis

Jia-Yi Zhang, Ding Li, Guo-Jie Hu

Identification of PD-L1-related biomarkers for selecting gastric adenocarcinoma patients for PD-1/PD-L1 inhibitor therapy

Bo-Ya Li, Hui-Ling Li, Fei-Er Zeng, Xuan-Yu Luan, Bi-Qing Liu, Zhi-Zhou Wang, Lan Zhang, Xian-Zhe Dong

F-α-DDB-derivative, a novel synthetic of bifendate, plus epirubicin improves antitumor efficacy against triple negative breast cancer without additional cardiotoxicity

Hai-yi Huang, Lisa Zong Yong Lin, Xin-yi Lu, Ying Jiang

New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis

  • Open Access
  • Analysis

Jianxiong Xu, Chen Gao

Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells

Ying Chen, Zhenhua Zhang, Xue Luo, Meini Cen, Peng Dai, Xiaoyan Zhu

Single-cell and bulk transcriptome sequencing identifies circadian rhythm disruption and cluster-specific clinical insights in colorectal tumorigenesis

Chen Liu, Jingyang Liu, Jing Shao, Xiaoman Zhao, Lin Xie, Mengyao Shang, Ying Li, Weiming Li

Evaluating the safety and feasibility of allogeneic NK cell infusion in high-risk lymphoma patients post-autologous stem cell transplantation

Shirin Tavakoli, Maryam Samareh-Salavatipour, Amirhossein Mardi, Hossein Salehi-Shadkami, Mohammad Vaezi, Maryam Barkhordar, Mohammad Ahmadvand

Correlation between HMGB1 expression and drug resistance and prognosis in patients with bladder urothelial carcinoma

Min Xu, Liang Hu, Zhang Chen, Tianyu Liang, Juanjuan Li

Preoperative total bile acid can be used as a prognostic biomarker in patients with operable biliary tract cancers

Shanshan Fan, Kexin Zhao, Jiabao Lei, Yang Ge

The role of nanomedicine and artificial intelligence in cancer health care: individual applications and emerging integrations—a narrative review

Prasanthi Samathoti, Rajasekhar Komarla Kumarachari, Sarad Pawar Naik Bukke, Eashwar Sai Komarla Rajasekhar, Ashish Ashokkumar Jaiswal, Zohre Eftekhari

Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data

Maomao Guo, Sudong Liang, Zhenghui Guan, Jingcheng Mao, Zhibin Xu, Wenchao Zhao, Hao Bian, Jianfeng Zhu, Jiangping Wang, Xin Jin, Yuan Xia

The relationship between cathepsins and nasopharyngeal carcinoma: a Mendelian randomization analysis

Jiaxiang Hu, Keyun Lin, Mei Jiang, Guanying Qiao

A global bibliometric and visualized analysis of the status and trends of lung metastasis in breast cancer research from 2000 to 2024

Baoyi Huang, Shengchao Huang, Zeming Yan, Jialun Li, Yuanqi Zhang

A study on the microbiome within oropharyngeal cancer tissues

Ran Sun, Lu Xing, Wenqing Wang, Xinhua Cui, Ying Guo, Fangfang Gao, Bo Geng, Hongxia Cheng, Hui Liang

A bibliometric analysis of nucleic acid probe and its applications in oncology: towards more precise molecular medicine

  • Open Access
  • Review

Xingyu Zhong, Haodong He, Yifan Xiong, Jianxuan Sun, Na Zeng, Shaogang Wang, Qidong Xia

Efficacy and safety of cinobufacin-based combination therapy for advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials

Yongling Zou, Yang Zhang

Construction of risk prediction model of sentinel lymph node metastasis in breast cancer patients based on machine learning algorithm

Qianmei Yang, Cuifang Liu, Yongyue Wang, Guifang Dong, Jinghuan Sun

The prognostic value of the central location of pulmonary nodules in osteosarcoma patients

Gehad Ahmed, Maged Elshafiey, Marwa Romeih, Ahmed Kamel, Ahmed Elgammal, Asmaa Salama, Yomna AboTabl, Mohammad Taher

Aberrant expression of CNTRL was associated with poor prognosis, immune response and progression in glioma

Xiaoping Mei, Deyuan Qin, Min Zou, Hongli Teng, Yang Zhai

Cathepsin B in urological tumors: unraveling its role and therapeutic potential

Zhaojie Yan, Guansong Zheng, Junrong Zou, Xiaofeng Zou, Keqiang Chai, Guoxi Zhang

PWRN1 low expression facilitates cancer progression and is an unfavorable prognosis factor in breast cancer

Hubao Yuan, Yuanwei Liu, Yong Jia, Xiaodong Yang, Dezhen Yang, Ming Dong, Xin Tang

Mendelian randomization analysis of immune cell traits and their association with cervical cancer risk

Jie Yu, Yamei Zhang

CEG-0598, a novel dual inhibitor of EGFR and C5aR demonstrates in vitro anticancer and antimetastatic activity in prostate cancer cells

Ayed A. Dera, Majed Al Fayi

Global research trends in tumor-associated macrophage studies: a bibliometric analysis

  • Open Access
  • Research

Aina Luan, Yipeng Zhang, Lu Yang, Guojing Zhao, Xin Yang

Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites

Siyuan Zhao, Jinghao Jiang, Jianwu Zhang, Xiaoqing Jin

Identification of programmed cell death-related genes and construction of a prognostic model in oral squamous cell carcinoma using single-cell and transcriptome analysis

  • Open Access
  • Analysis

Yongheng Li, Yang Yu, Shaonan Hu, Simin Li

City scale related to epidermal growth factor receptor mutations status in Chinese non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Guang-Gui Ding, Jie-Lun Wen, Rui Gong, Jiao-Jiao Yang, Wen-Jian Cen, Ling Deng, Fang Wang, Li-Yue Sun

Exploring the cancerous nexus: the pivotal and diverse roles of USP39 in cancer development

Yujing Chen, Jingyi Zhang, Jinfeng Yang, Jiawei Zhao, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Weijia Zhao, Siqi Chen, Xinwen Zhang, Yi Lin, Jiamin Jin

Effects of albumin-bound paclitaxel combined with Sophora subprostrate polysaccharide on inflammatory factors and immune function in breast cancer rats

Changli Ding, Zhuolin Li, Ying Zheng, Kaichun Li, Wenyan Yu, Lingzhijie Kong, Zhiyong Zhang

Radiotherapy, tyrosine kinase inhibitors, immune checkpoint inhibitors combined with hepatic arterial infusion chemotherapy of RALOX versus FOLFOX for hepatocellular carcinoma with portal vein tumor thrombus: a propensity score-matching cohort study

Hao-yang Tan, Shuang-quan Liu, Yan-han Liu, Guo-hua Dai, Jiu-ling Zheng, Hua-guo Feng

Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature

Keyuan Zhao, Gang Xu, Jing Jin, Chao Peng, Jiajun Chen, Yulei Li, Weihao Wang, Shouhua Pan

Multidisciplinary collaborative treatment of a giant malignant peripheral nerve sheath tumor on the top of the head: a case report

Eryang Zhao, Mantao Chen, Hu Yang, Xiaoqun Ba, Ligong Xu

Comparative analysis of tissue damage and inflammatory response for transoral laser microsurgery versus open surgery in the management of early-stage laryngeal cancer

Jingchun Ge, Jiawei Gui, Hui Xiao

Blood metabolites, protein regulatory networks and their roles in pan-cancer: a mendelian randomisation study

  • Open Access
  • Research

Shenglong Xia, Zhengyang Xu, Cheng Cheng, Rui An, Wenci Chen, Daopo Lin, Yuzhen Gao, Liangjing Wang, Xinyou Xie, Jun Zhang

The roles, signalling pathways and therapeutic implications of Apoc1 in cancer

Hao-Han Guo, Qiang Guo, Qun-Xian Zhang, Dan Li, Yan Lv

Novel cuproptosis-related lncRNAs risk model to predicting prognosis and guiding immunotherapy for OSCC patients

  • Open Access
  • Research

Lingbo Kong, Chenfei Wang, Xiaohui Lu, Qianqi Zhu, Yihua Song, Xingmei Feng

Nomograms predicting cancer-specific survival and overall survival of advanced salivary gland malignancy patients: a study based on the SEER database

Congzhi Ma, Xiaolin Nong

Tumour-infiltrating immune cells as a novel prognostic model for bladder cancer

Can Liu, Chaoyu Liao, Bishao Sun, Zhen Guo, Sihao Chen, Shixue Liu, Xiaoyu Yuan, Zeyu Huang, Jingui Liu, Min Deng, Kui Wang, Ruixin Wu, Jiang Zhao, Xingyou Dong

Combination of RNA-sequencing data analysis, network pharmacology, molecular docking techniques to investigate the mechanism of Prunella vulgaris L. in the treatment of non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Yanggang Dan, Yangli Jin, Jing Wang, Lu Wang, Dawei Zheng

Efficacy and safety of mitoxantrone hydrochloride liposome-containing regimens in treating refractory/relapsed acute myeloid leukemia

Ni Lu, Li Liu, Yigeng Cao, Rongli Zhang, Weihua Zhai, Xin Chen, Qiaoling Ma, Donglin Yang, Aiming Pang, Jialin Wei, Yi He, Sizhou Feng, Mingzhe Han, Erlie Jiang

Identification of novel potential biomarkers using bulk RNA and single cells to build a neural network model for diagnosis of liver cancer

Yingzheng Gao, Jiahao Chen, Weidong Du

Application of accommodated jejunal interposition double tract reconstruction after total gastrectomy for gastric cancer: a retrospective study

Cankun He, Huangming Zhou, Guobao He, Weixin Zhang, Huizhong Chen

PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells

Liang Tian, Liyun Liu, Chunlou Wang, Yan Kong, Zhigang Miao, Qing Yao, He Zhang, Yuehong Li

Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance

Jianlin Pu, Kai Yuan, Jian Tao, Yuliang Qin, Yongxin Li, Jing Fu, Zhong Li, Haimei Zhou, Zhengxiu Tang, Li Li, Xuesong Gai, Dongdong Qin

Meningeal malignant solitary fibrous tumor with multiple recurrence, extracranial extension, cervical lymph node metastases: case report and review of the literature

Rong He, Peng Zhong, Juntao Hu, Guangkuo Guo, He Xiao, Lin Lei, Yun Liu, Mingying Geng, Jungang Ma

Synergistic effects of Aurora A and AKT inhibitors combined with radiation in colon cancer cells

Qiuxia Peng, Wei Zhou, Jie Li, Danqing Liu

Global trends and research hotspots in autophagy and tumor drug resistance: a bibliometric analysis

Long Zhao, Jiao Zeng, Junfeng Wen, Zhaoyang Li, Jianguo Xu, Jinxiang Wang, Xiaoping Tang, Lingmi Hou

Pan-cancer predictive survival model development and evaluation using electronic health record and genetic data across 10 cancer types

Jurgita Gammall, Alvina G. Lai

Application of ultrasound-guided microwave ablation combined with polidocanol injection in benign cystic-solid thyroid nodules and recurrence analysis

Sichen Yang, Dali Huang

Research trends and hotspots of single nucleotide polymorphisms in endometrial cancer: a bibliometric analysis

Renjie Wang, Zhihong Jia, Liang Peng, Jinghui Xu, Qiying Zhu, Yinghong Wu

Construction of a novel CD8T cell-related index for predicting clinical outcomes and immune landscape in ovarian cancer by combined single-cell and RNA-sequencing analysis

Yu Zhang, Peng Wan, Liangliang Wang, Ruiping Ren

Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia

Xiaoyun Feng, Yufeng Qin, Yulong Feng, Yingquan Zhuo

Multi-omics identify ribosome related causal genes methylation, splicing, and expression in prostate cancer

Chengcheng Wei, Jingke He, Yunfan Li, Yu Luo, Liangdong Song, Kun Han, Jindong Zhang, Shuai Su, Delin Wang

Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs

Xiaopeng Hu, Yanhua Li, Xisheng Wang, Xingkui Xue

An integrative analysis combining bioinformatics, network pharmacology and experimental methods identified key genes of EGCG targets in Nasopharyngeal Carcinoma

  • Open Access
  • Research

Yuhang Yang, Wenqi Luo, Zhang Feng, Xiaoyu Chen, Jinqing Li, Long Zuo, Meijiao Duan, Xiaosong He, Wenhua Wang, Feng He, Fangxian Liu

Machine learning predicts prognosis in patients with gastroenteropancreatic neuroendocrine tumors with liver metastases

Fuli Gao, Jian Chen, Xiaodan Xu

Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer

Zhenwei Wang, Zhihong Dai, Yuren Gao, Zhongxiang Zhao, Zhen Li, Liang Wang, Xiang Gao, Qiuqiu Qiu, Xiaofu Qiu, Zhiyu Liu

Causal links between plasma lipidome and ovarian cancer risk: evidence from Mendelian randomization

Huke Dong, Chen Zhang, Hua Wang, Ying Dai

Genetic insights into BRCA1/2 associated breast cancer in Türkiye: focus on early-onset and aggressive subtypes

Betul Celik Demirbas, Seda Kilic Erciyas, Ozge Sukruoglu Erdogan, Ozge Pasin, Zubeyde Yalniz Kayim, Merve Çiğdem Özgel, Seref Bugra Tuncer

Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study

Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge

Fatty acid metabolism-related risk signature revealing the immune landscape of neuroblastoma and predicting overall survival in pediatric neuroblastoma patients

Shizun Wang, Dan Zhang, Ming Ge, Nijia Zhang, Wei Yang, Yuqin Liu

USP39 promote post-translational modifiers to stimulate the progress of cancer

Yuli Zhou, Fang Wang, Siren Feng, Mengsen Li, Mingyue Zhu

Development of macrophage M2 relate signature for predicting prognosis and immunotherapy response in ovarian cancer

Yifei Xiong, Yan Tong

Exploring miR-301a-3p and osteosarcoma: from expression differences to mechanism of action

Tianying Liu, Mintao Ma

Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma

Xu Zhang, Chenglei Zhao, Tianyi Liu

FANCI is involved in the malignant progression of glioma cells by regulating the Akt/Bcl-2 signaling pathway

Hanyun Li, Yinrui Liu, Mingyao Wang, Shaoshao Xu, Jilan Liu, Xianyun Qin, Banban Li, Jikui Sun, Yan Liu, Feng Jin

Expression of insulinoma-associated protein 1 (INSM1) in gastric neuroendocrine and non-neuroendocrine neoplasms

Sujeong Kim, Jisu Seo, Youjung Shin, Moonsik Kim

Machine learning in ovarian cancer: a bibliometric and visual analysis from 2004 to 2024

Xian Zeng, Zude Li, Lilin Dai, Jiang Li, Luqin Liao, Wei Chen

Arginine methylation modulates tumor fate and prognosis in clear cell renal cell carcinoma

Jiahao Wang, Dan Bao, Xiaochao Chen, Zijie Yu, Weiyu Kong, Chen Xu, Songtao Li, Yulin Yue

Periungual pigmented Bowen’s disease infected with human papillomavirus 73 and healed with secondary intention healing

Guangdong Wen, Xiaojie Wang, Yuxin Wang, Dandan Mao

Primary pancreatic signet ring cell carcinoma: a case series from China and literature review

  • Open Access
  • Case Report

Dongming Zhang, Tianyu Li, Bo Chen, Georgios Antonios Margonis, Jaeyun Jane Wang, Jiashu Han, Kaiqi Ma, Rilige Chaomu, Chen Lin, Weibin Wang

A-to-I RNA edited POLA2 attains carcinogenesis in prostatic cancer by impeding immune infiltration and upregulating BTBD7

Shengyi Lin, Hang Huang, Yeping Li, Yongyong Lu, Tingyu Ye

Activated platelets stimulate effector CD8+ T cells to enhance HNSCC immunotherapy efficacy

  • Open Access
  • Research

Zhennan Yuan, Lunhua Guo, Yuheng Pang, Wenjing Wang, Yuefeng Shang, Chufei Xie, Cheng Qian, Ji Sun, Xiaohong Wu

Polydatin inhibits the stemness and angiogenesis of gastric cancer cells by targeting down-regulation of HDAC7

Jialin Zhou, Fucun Zheng, Peng Dai

Development of a prognostic model for breast cancer patients based on intratumoral tumor-infiltrating lymphocytes using machine learning algorithms

Xinyi Wu, Chun Li

Research on the developments of artificial intelligence in radiomics for oncology over the past decade: a bibliometric and visualized analysis

Pengyu Zhang, Lili Wei, Zonglong Nie, Pengcheng Hu, Jilu Zheng, Ji Lv, Tao Cui, Chunlei Liu, Xiaopeng Lan

Enhancement of radiation effects by Plantago major in MCF-7 human breast cancer: an animal study

Hongliang Zhao, Hongxiang Gao, Jing Kang, Jiexin Chen, Huiling Ouyang, Peiyao Chen, Hussain Shaik Althaf, Turki Mayudh Alrubie, Maddu Narendra, Kai Wang

Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985–2024)

Yao-Xuan Chen, Feng Guo, Hao-Han Rao, Chong-Qi Fan, Chun-Jian Zuo, Peng-Yu Che, Cao Yu, Huan-Wen Chen

Prognostic and immunological role of RHEBL1 in pan-cancer: a target for survival and immunotherapy

Yue Chen, Xiao Feng, Xindong Yin, Nan Yi, Ya Zhao, Qian Wang, Wenya Xing, Chaoqun Ma, Dexuan Chen

Emerging trends and hotspots of tRNA-derived small RNAs in tumours: a bibliometric analysis via VOSviewer and CiteSpace

  • Open Access
  • Research

Junhong Wang, E-ling Shao, Zhenhua Gao

Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation

  • Open Access
  • Review

Sara De Domenico, Veronica La Banca, Silvia D’Amico, Sara Nicolai, Angelo Peschiaroli

Overexpression of MAFG-AS1 in ovarian cancer promotes glucose metabolism reprogramming and malignant biological behavior of ovarian cancer cells by regulating HIF-1α

Liu Jia, Fei Yu

Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway

Danping Li, Limei Li, Shu Wu, Jun Zhao, Haishan Zhang, Qiaoli Chen, Yingxi Mo, Liudmila Matskova, Ping Li, Xiaoying Zhou

Exploring non-coding RNA expression profiles of AKR1B10P1, RP11-465B22.3, WASH8P, and NPM1P25 as a predictive model for hepatocellular carcinoma patient survival

Khatereh Firouzi-Farsani, Mina Dehghani-Samani, Razieh Gerami, Reihaneh Sadat Moosavi, Marzieh Gerami, Mohammad Mahdevar

Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway

Sheng-Ping Lin, Feng-Ying Huang, Ri-Hong Wu, Wei-Jing Xie, Ming-Hui Chen, Shu-Zhen Dai, Wen-Tian Xu, Wu-Ping Zheng, Guang-Hong Tan

Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agent

Bharti S. Fegade, Somadatta Y. Chaudhari, Rupali V. Likhar, Ritesh P. Bhole, Pravin S. Uttekar, Sandeep S. Pathare, Swastika Maitra, Daniel Ejim Uti, Magdi E. A. Zaki, Esther Ugo Alum

Deciphering the role of acetylation-related gene NAT10 in colon cancer progression and immune evasion: implications for overcoming drug resistance

Xuancheng Zhou, Xun Sang, Lai Jiang, Shengke Zhang, Chenglu Jiang, Yuheng Gu, Yipin Fu, Guanhu Yang, Jieyin Zhang, Hao Chi, Binbin Wang, Xiaolin Zhong

Hepatic arterial infusion chemotherapy (HAIC) plus Lenvatinib and PD-1 inhibitors versus systemic chemotherapy for unresectable intrahepatic cholangiocarcinoma

Qingyu Xu, Chendong Wang, Ran You, Bin Leng, Zeyu Yu, Ya Lu, Lingfeng Diao, Hao Jiang, Bei Wu, Guowen Yin

Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies

  • Open Access
  • Review

Chengpeng Sun, Jiawei Gui, Yilei Sheng, Le Huang, Xingen Zhu, Kai Huang

Integrating multi-omics data to identify the role of Aggrephagy-related genes in tumor microenvironment and key tumorigenesis factors of GB from the perspective of single-cell sequencing

Zipei Chen, Shengke Zhang, Chenglu Jiang, Lai Jiang, Haiqing Chen, Jinbang Huang, Jie Liu, Guanhu Yang, Xiufang Luo, Hao Chi, Jiangping Fu

Novel technique in intraoperative localisation of skin cancer metastasis using ultrasound guidance: a case report

Nadin Hawwash, Amr Fadel, Niranjan Bista, Damian Mullan, Damir Kosutic

Progress of antibody–drug conjugates in the treatment of locally advanced or metastatic urothelial carcinoma: opportunities and challenges

Fanhao Zeng, Qingjie Han, Tao Ding, Chao Tian, Maolin Jiang

Integrating radiomics features and CT semantic characteristics for predicting visceral pleural invasion in clinical stage Ia peripheral lung adenocarcinoma

Fengnian Zhao, Yunqing Zhao, Zhaoxiang Ye, Qingna Yan, Haoran Sun, Guiming Zhou

Identification of M0 macrophage associated lipid metabolism genes for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma

Huanjie Zhou, Ming Lao, Zhengui Liang, Huiliu Zhao, Ying Wang, Qiongqing Huang, Chao Ou

Deciphering the interaction between the expression of LRP2 served as a mitochondrial metabolism-related gene and prognosis in colon cancer integrating multi-omics analysis

Jie Zhang, Ziyun Liu, Xiaoqing Ma, Zhenyu Shi, Jing Zhao, Yongjie Xie, Xiaobin Shang, Xia Zhang

Survival outcomes in trial defined high-risk hormone receptor-positive/human epidermal growth factor receptor II-negative early breast cancer: impact of adjuvant chemotherapy

Ta-Chung Chao, Deanna Gracia, Chan-Heng Ho, Hao-Yang Chen, Chi-Cheng Huang, Ling-Ming Tseng

The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer

Xinhai Gao, Tianhua Wang, Cun Liu, Ye Li, Wenfeng Zhang, Minpu Zhang, Yan Yao, Chundi Gao, Ruijuan Liu, Changgang Sun

Sialyltransferase gene signature as a predictor of prognosis and therapeutic response in kidney renal clear cell carcinoma

Huiyu Liu, Changwei Zhou, Zaichun Yan, Hairong Yang, Yun Zhao, Rui Tian, Xuejun Bo, Leizuo Zhao, Wei Ren

Drug-induced second tumors: a disproportionality analysis of the FAERS database

Shupeng Chen, Yuzhe Zhang, Xiaojian Li, Nana Tang, Yingjian Zeng

Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway

Juexiao Deng, Yang Li, Lanyue Zhang, Wenxin Liao, Tingting Liu, Fujin Shen

Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy

Xiaoxue Wang, Weiwei Zhong, Qin Wang, Peng Song, Xia Lin, Bohan Li, Yancun Yin, Chunyan Yang, Minjing Li

Research hotspots and emerging trends in targeted therapy for colorectal cancer: a bibliometric analysis (2000–2023)

Xiangnv Meng, Zhongting Lu, Fu Mi, Sha Sha, Tao Li

Exploring the potential role of ADRB1 as a tumor suppressor gene and prognostic biomarker in pan-cancer analysis

Shenghan Xu, Xinlei Wang, Yani Wang, Min Liu, Hao Chen

Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis

Xu-Chu Li, Bangqi Wang, Yu Tang

Advancing cancer therapy: the role of silver(I) phosphine complexes in overcoming resistance and toxicity

Reinout Meijboom, Austine Ofondu Chinomso Iroegbu, Suprakas Sinha Ray

Segmental bronchi radiation dose affected the progression of radiation pneumonitis in lung cancer patients

Gai Liang, RuiJie Chang, Qu Zhang, Yan Luo, Yi Peng, Bo Luo

Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets

Song Wang, Xin Yao, Shenshen Li, Shanshan Wang, Xuyu Huang, Jing Zhou, Xiao Li, Jieying Wen, Weixuan Lan, Yunsi Huang, Hao Li, Yunlong Sun, Xiaoqian Zhao, Qiaoling Chen, Xuedong Han, Ziming Zhu, Xinyue Zhang, Tao Zhang

Effects of ER-phagy regulatory genes on the microenvironment of hepatocellular carcinoma: a comprehensive analysis

Rongchang Zhao, Dan Ding, Minhui Bao, Yan Ding, Rongjie Ding, Jun Liu, Yu Li, Chunrong Zhu

Lesson from a metastatic male breast cancer case: CDK4/6 plus aromatase inhibitors could not exceed tamoxifen

Tala Najdi, Samah Seif, Nahed Damaj, Joseph Kattan

Nebulized inhalation of extracellular vesicles containing SPOCK2 suppresses lung adenocarcinoma progression via MAPK inhibition

Ying Wang, Ningning Liu, Chuanqin Xu, Jing Wang, Liyang Dong, Shuang Yang, Junhong Jiang

Silencing hnRNPD inhibits gastric cancer growth by increasing TXNIP-mediated oxidative stress

Xuan Zou, Jin Li, Junshuo Zhou, Qiulei Ren, Kelong Wang, Xiaoyan Wang

Mendelian randomization analysis reveals potential association between allergic rhinitis and nasopharyngeal carcinoma

Qingfu Bao, Jianjun Zou, Changyang Wang, Haiying Wang

Potential prognostic value of HER2/CEP17 FISH ratio in HER2-positive non-metastatic breast cancer: a real-world study

Fangchao Zheng, Feng Du, Zixuan Yang, Xue Wang, Jian Yue, Yun Ling, Peng Yuan

Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study

Taichuan Xu, Wentao Xiao, Wenjie Li, Xianfa Xu, Haiwen Zhang, Xian Zhang

Bibliometric analysis of current trends and emerging patterns in the application of nanomaterials for non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Shanshan Cai, Weichang Yang, Hongquan Xing, Jiale Yang, Hongdan Luo, Xiaoqun Ye

Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes

Yuepei Liu, Songshan Liu

Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis

Kailin Qu, Jingyan Gu, Zhi Xu, Yixiang Hepeng, Qi Ning, Xu Wu

Modelling the cost-effectiveness of cervical cancer screening with HPV self-sampling and molecular triage for women aged 60–69 years

Jasmine Fridljung, Lovisa Bergengren, Linda Ryen, Gabriella Lillsunde Larsson

An energy metabolism-related signature relevant to the tumor immune microenvironment in HNSCC

  • Open Access
  • Research

Kaiyu Zhu, Yang Bai, Changwei Lin, Guilin Song, Yifei Chen

Revealing the prognostic potential of natural killer cell-related genes in hepatocellular carcinoma: the key role of NRAS

Ruixi Li, Guangquan Zhang, Qiang Tao, Ziyun Wu, Xiaoping Liu, Rongrong Wang, Lei Liu, Yiran Niu, Kaile Du, Runpeng Wu, Fei Du, Xiyan Zheng, Yingliang Li, Xianjie Shi

Identification of benign from malignant small renal tumors: is there a possible role of T1 mapping?

Lianting Zhong, Danlan Lian, Ying Zhang, Yuqin Ding, Shengxiang Rao, Jiefeng Guo, Weifeng Lin, Xiaobo Qu, Jianjun Zhou

Bibliometric visualization of hepatocellular carcinoma and metabolic syndrome research: trends and emerging areas

Kang Chen, Qianye Feng, Haipeng Liu

XGBoost model for predicting erectile dysfunction risk after radical prostatectomy: development and validation using machine learning

Hesong Jiang, Lu Ji, Leilei Zhu, Hengbing Wang, Fei Mao

Pediatic intracranial synovial sarcoma: a case report

Ming Liu, Menglei Fan, Dejiong Li, Guoping Zhang, Qunwu Li

Glioma raises periodontitis risk via CD8 upregulation on NKT cells: a Mendelian randomization study

Shanmu Jin, Ningrui Zhao, Kaiming Wang, Xuedong Wang, Yu Wang, Wenbin Ma

Evaluating the role of consolidative chest radiotherapy after chemo-immunotherapy in extensive-stage small cell lung cancer: a retrospective study

  • Open Access
  • SCLC
  • Research

Jorge Raul azquez-Urrutia, Natasha Venugopal, Junjia Zhu, Joseph A. Miccio, Mitchell Machtay, Takefumi Komiya

Mucinous breast cancer organoids: an in vitro research model

Dongyi Zhao, Shida Zhu, Xue Bai, Xuelu Li, Zuowei Zhao

Rare rectal elastofibroma: diagnostic challenges and case report

Chen-Xin Xiang, Yu Long, Yi-Ning Xiang, Fei Huang, Yun Ke, Yi-Ran Yao, Yun-Huan Zhen

Effects of Coronin 2A on prognosis and immune microenvironment in tumor patients: a knowledge map of the novel biomarker via bioinformatics analysis

Minghe Lv, Jingping Yu, Hongwei Zeng, Ruping Zhao

5,7,2’,6’- Tetrahydroxyflavone affects the progression of ovarian cancer via hsa-miR-495-3p-ACTB/HSP90AA1 pathway

Mengjie Chen, Huihui Jia, Xuyang Tao, Yani Jin, Zuorong Shi

Single-cell transcriptomic landscape reveals complex cellular heterogeneity and dysregulated signaling pathways in nasopharyngeal carcinoma

Xiaoyan Zhang, Zuojia Guan, Zhan Xu

The causal association between psoriasis and 32 types of cancer: a mendelian randomization study

Guangyao Li, Jiahe Tian, Jingyu Xu, Kun Li

Safranal-loaded gold nanoparticles alleviate hepatocellular carcinoma via targeting the Wnt/β-catenin pathway

Yara A. Samra, Al Shaima G. Abd El Salam, Amr M. Abdelghany, Mamdouh M. El-Shishtawy

Current trends and landscape of drug resistance in renal cell carcinoma: a bibliometric analysis

Kenan Zhang, Shixu Chen, Zhenzhen Zhou, Shuanbao Yu, Yonghao Zhan, Xuepei Zhang

The antineoplastic effects of nuciferine on hepatocellular carcinoma are associated with suppression of the HER2-AKT/ERK1/2 signaling pathway

Tiantian Li, Weidong Wang, Mingwei Zhu, Tianxiu Dong, Jian Jiang, Zizhuo Li, Tingting An, Xi Chen, Yingxuan Mao, Yaodong Chen, Xiuhua Yang

Novel marker genes and small molecule drugs for radiotherapy resistance in cervical cancer identified based on single-cell multi-omics analysis

Yang Liu, Xin Pan, Xu Zhang, Bo Tan, Rui Ran, Li Liu, Lin Yang, Zhiliang Wang

Changes in pulmonary function of CT-guided microwave ablation for patients with pulmonary ground-glass nodules after lobectomy: a retrospective, observation study

Ruoyu Deng, Chunyan Li, Jialing Lv, Huan Luo, Lin Wang, Tengfei Zhang, Feineng Liu, Yudong Fu, Zhipeng Wang, Wen Zhang, Chao Zhang

Survival outcomes and prognostic factors of breast cancer spinal metastases: a retrospective study

Panpan Hu, Xin Wu, Yan Li, Feng Wei, Shengxin Zeng, Yu Xiao, Xiaoguang Liu, Zhongjun Liu

Visfatin promotes multiple myeloma cell proliferation and inhibits apoptosis by inducing IL-6 production via NF-κB pathways

Wenting Tie, Tao Ma, Jia Liu, Zhigang Yi, Hao Xiong, Jun Bai, Yanhong Li, Lijuan Li, Liansheng Zhang

Interaction between Dectin-1 gene polymorphisms and low weight on the risk of invasive pulmonary aspergillosis in patients with lung cancer undergoing surgery

Wenfang Jin, Yu Yao, Yanling Lv

HOX gene dysregulation in glioblastoma: a narrative review of current advances

Suleyman Hekim, Severa Bunda, Shaliman Dilibaerguli, Maierdan Palihati, Yasin Mamatjan

Mutational spectrum and profile of breast and ovarian cancer patients in Saudi Arabia’s western region: single center experience

Samar N. Ekram, Omima Elemam, Munzir Alandonisi, Arwa Flemban, Jamil Samkari, Hassan H. Zainuddin, Zohor Azher, Emad Tashkandi, Ahmad Mufti, Asim Khogeer

The expression and prognostic value of CCL19 in breast cancer

Zonghao Ding, Lei Yang, Xinyu Wang, Yong Wang, Xiao Chen

Development of a clinical prediction model for sensitivity to combination therapy of Bcl-2 inhibitors and hypomethylating agents in elderly/unfit patients with acute myeloid leukemia

Yufeng Du, Chunhong Li, Yonghong Chen, Fang Xie, Jinsong Yan

Unraveling the immunomodulatory role of TIM-3 in head and neck squamous cell carcinoma: implications for targeted therapy

Shuang Xu, Yang Luo, Yuzhu He, Yuxiang Chen, Fengfeng Qin, Wenjian Hu

Matrix Remodeling Associated Genes (MXRAs): structural diversity, functional significance, and therapeutic potential in tumor microenvironments

  • Open Access
  • Review

Chao Zeng, Xiao Lv, Feng Wang, Yaomin Huang, Yanxian Ren, Hengwei Zhang

Pyroptosis drives tumor progression and immune evasion in Hepatocellular Carcinoma: a single-cell and spatial transcriptomic study

Siyu Tao, Yunhao Yang

Proteomics and succinylation modification characterization in clear cell renal cell carcinoma

Dong Yue, Miao Zheng

Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia

Yaobin Lin, Shenghong Shi, Jianyuan Song, Shan Liu

SUMOylation-regulated genes in colon cancer: expression patterns and clinical implications

Wen Peng, Zirong Yang, Ru Yan, Lan Mu, Lan Li, Shan Jin, Shisheng Tan

Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer

Junzuo Lin, Qian Xu, Zhengfei Zhao

Synchronous triple primary colorectal cancer: a rare case report from a rural tibetan population

Qing Zhou, Jin-ke Kang, Yong-fa Zhi, Ming-jie Ma, Xiao-de Ren, Zheng-ning Gan, Jie Niu

Study on the molecular mechanism of UBA52 and BARD1 regulating hepatocellular carcinoma through the PI3 K/AKT signaling pathway

Chenrui Yang, Yanzhong Zhang, Yajuan Liu, Xiaoyong Wu, Fangyuan Sun

Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study

Xujia Li, Lingli Huang, Yue Yan, Yuming Rong, Xuxian Chen, Mengge Gao, Jinsheng Huang

Molecular mechanisms of arecoline-induced oral cancer: a network toxicology and molecular docking techniques integrated analysis

Linghan Leng, Xin Wang, Hao Wang, Yingchun Hu, Yaxing Deng, Chenglin Wang

Multidimensional investigation of thyroid hormones and prostate cancer: insights from NHANES, Mendelian randomization, genetic markers, and bioinformatics analyses

Jinhai Wu, Sian Chen, Ran Xu, Yanfei Chen, Jiadin Guo, Jing Li, Xiheng Zeng, Bin Wang, Xuejin Zhu

Plasma fibrinogen levels towards cancer incidence: a systematic review and meta-analysis of epidemiological studies

Yuexin Luo, Furong Lu, Lihua Luo, Yuting Li

Clinical characteristics and survival of breast cancer patients with extramammary malignancies in a single Asian center over the past 23 years

Bei Sun, Yaoyao Jing, Yang Wang, Haiyan Wang, Xinyue Zhang, Jin Zhang, Feng He

SELP can affect the immune microenvironment of gastric cancer and is associated with poor prognosis

Yue Wu, Jingyu Liu, Tong Yin, Xiaoxiao Li, Xian Liu, Xiaobo Peng, Xianbao Zhan

Role of the “inflammation-immunity-metabolism” network in non-small cell lung cancer: a multi-omics analysis

  • Open Access
  • NSCLC
  • Analysis

Jingqi Zhang, Liping Lin, Wenyuan Li, Jing Guo

Computational analysis of DEHP’s oncogenic role in colorectal cancer

Zhou Zhu, Jian Qin, Chungang He, Shuangyou Wang, Yaolin Lu, Shuai Wang, Xiaogang Zhong

Interfered long non-coding RNA HELLPAR or up-regulated microRNA-448 inhibits nasopharyngeal carcinoma progression via suppression of ADAM10

  • Open Access
  • Research

Wenjuan Zhu, Qi Yang, Huijun Yang, Mingtao Qian, Yan Ji, Jianyong Liu

Metabolic reprogramming and immune microenvironment profiling in clear cell renal cell carcinoma: implications for prognosis, targeted therapy, and drug resistance

Xiao Zheng, Yongqiang Liu, Zixin Yang, Yanhua Tian

Therapy-related second malignant neoplasms on top of neuroblastoma: frequency, types and risk factors

Mohamed Fawzy, Nihal Abdelfattah, Menna Alaa, Inas Mohsen, Sonya Soliman, Sherine Salem, Wael Zekri, Omar Arafah

Investigation of mRNA expression levels of DNA damage response genes in Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma: a pilot study

Sara Passerini, Matteo Fracella, Amedeo Ferlosio, Ugo Moens, Carolina Scagnolari, Guido Antonelli, Marco Ciotti, Valeria Pietropaolo

Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy

Qianyun Shen, Yijie Yang, Maoying Guan, Hegen Li

Dynamic conditional survival nomogram for primary hepatocellular carcinoma: a population-based analysis

Junling Zhao, Jing Gao, Wei Liu, Jianye Sun

Role of N6-methyladenosine methyltransferase component RBM15 in cancer progression and its therapeutic potential

  • Open Access
  • Review

Wenxiang Shen, Yulong Ma, Chunwang Yang, Shishun Yan, Kaishan Ye

Establishment of a m6 A-associated lncRNAs-derived risk model for enhanced patient prognosis stratification and personalized therapy approaches in bladder cancer

Renhu Chen, Yuqing Ye, Yuxuan Zheng

T-DM1 with concurrent radiotherapy in HER2-positive breast cancer: preclinical evaluation and mechanisms, prediction, and exploration of adverse effects

Guangmin Wan, Lu Yang, Quan Wang, Gang Xu

Treatment strategies and prognostic insights for lacrimal gland adenoid cystic carcinoma: a review

Xinyun Wang, Huiling Ma, Ying Chen, Menghui Zhang, Sisi Liu, Huiyan Li, Xiawei Wang, Hongguang Cui

Comprehensive analysis Neddylation-related genes identified UBB as a prognostic biomarker for clear cell renal cell carcinoma

Shengren Cen, Yingpeng Li, Xinhao Xiong, Zihong Ma, Yongsheng Wang, Xingcheng Gao

Advances in the role of baicalin and baicalein in colon cancer: mechanisms and therapeutic potential

Lexin Li, Xuyang Cui, Zhanyu Lin, Yiming Chen, Xiaoyu Zhang, Yong Zhu

Identification of metabolic reprogramming-related key genes in hepatocellular carcinoma after transcatheter arterial chemoembolization treatment

Tongfei Li, Shujuan Liu, Shengjun Wang, Shan Sun, Feng Ji, Mingliang Li, Yong Zhang

Identification and Validation of a Novel Lactylation-related Gene Signature to Predict the Prognosis of Endometrial Cancer

Linna Chen, Meng Xia, Weijia Wen, Li Yuan, Yan Jia, Xueyuan Zhao, Haolin Fan, Songlin Liu, Tianyu Liu, Pan Liu, Hongye Jiang, Wei Wang, Yuandong Liao, Chunyu Zhang, Shuzhong Yao

RAP1GAP is a prognostic biomarker and correlates with immune infiltrates in bladder cancer

Zehua Shu, Xinyi Liu, Xiaoyan Li, Siming Fu, Sheng Li, Gaolei Liu, Zhouting Tuo, Weihua Lan, Baohua Lan, Yao Zhang

Integrating Mendelian randomization and multi-transcriptomic analyses to unveil the genetic association risk of regulatory T cell-mediated free cholesterol and gastric cancer

Fanyu Peng, Haitao Liu, Yesong Guo, Jing Wen, Yizhi Ge, Yanhong Luo

The role of TLR-4 in chemoresistance of cancer

Yuhua Li, Tianle Tang, Yang Sun, Gui’e Chen, Xinrong Yuan, De Cai

Construction of lung adenocarcinoma subtype and prognosis model based on fatty acid metabolism-related genes

  • Open Access
  • Research

Jing Chen, Jinyu Huang, Liangfang Shen

Relationship between red cell distribution width and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey

Yongli Liu, Jiajia Qu, Chenyang Hu, Wei Zhao, Yuxin Zhang, Yuchen Luo, Yiqing Qu

Exploring the genetic causal inference between plasma lipidome and lung carcinoma: a bidirectional mendelian randomization study

Hongyu Pan, Jinyu Hu, Shanshan Gong, Yuchang Fei

Association of metformin with risk of digestive tract cancers from a drug target mendelian randomization and cell experiments

Yifei Wang, Xirong Cao, Jie Ren, Rui Chen, Xing Zhang, Chang Liu, Yifan Jia, Ting Lin

Comparative analysis of the performance of the large language models ChatGPT-3.5, ChatGPT-4 and Open AI-o1 in the field of Programmed Cell Death in myeloma

Wu Kun, Tao Bo, Li Yuntao, Cheng Shenju, Li Yanhong, Luo Shan, Zeng Yun, Nie Bo, Shi Mingxia

Single-cell RNA sequencing and traditional RNA sequencing reveals the role of cancer-associated fibroblasts in head and neck squamous cell carcinomas cohort

Ling Zhong, Yixin Qiao, Shasha He, Yangju Fu, Jian Zou

Characteristic genes and immune infiltration analysis of gastric cancer based on bioinformatics analysis and machine learning

Chengwei Xia, Yini Liu, Xin Qing

Unveiling the role of IL7R in metabolism-associated fatty liver disease leading to hepatocellular carcinoma through transcriptomic and machine learning approaches

Priyadharshini Annadurai, Arnold Emerson Isaac

Alterations of drug-resistant proteins in nasopharyngeal carcinoma after intensity-modulated radiation therapy with or without chemotherapy and correlation with clinicopathologic features and short-term prognosis

GaoFeng Wang, Yuan Li

Molecular subtype characteristics and development of prognostic model based on inflammation-related gene in lung adenocarcinoma

  • Open Access
  • Research

Xuelei Hu, Tengfei Jiang, Jinxiang Wang

A nomogram for predicting overall survival in young triple-negative breast cancer patients: a population-based study

Guangwen Zhang, Xinle Wang, Chen Cheng, Shiming Wang, Yujun Guo

Circulating metabolic biomarkers mediated causal relationship between gut microbiota and bladder cancer: a two-step mendelian randomization study

Fa-Ye Wei, Qi-Huan He, Bin-Tong Yin, Jia-Wen Zhao, Yu-Tong Zhao, Zheng-Shu Wei, Yu-Jian Li, Hai-Qi Liang, Min Qin, Ji-Wen Cheng

Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression

Dongping Wu, Qing Xia, Xinming Su, Yunan Mao, Jiwei Mao, Qiannan Ding, Jianjiang Liu, Wangyan Zhong, Xiaoyu Zhang, Hanbing Li, Shiwei Duan

Prognostic value of circ_0000043/miR-590-5p in cervical cancer and regulation of tumor progression

Yue Zhu, Xi Shi, Shanshan Zhang, Hongyin Cui, Baohua Wu

Recent advances in understanding the role of Wnt5a in prostate cancer and bone metastasis

Qian-Yu Xie, Guang-Quan Zhao, Hao Tang, Qing-De Wa

Process management method in head and neck cancer patient care

Francesca De Felice, Valentino Valentini, Francesca Casarano, Chiara Gaudino, Cira Rosaria Tiziana Di Gioia, Gianluca Tenore, Marco Della Monaca, Andrea Cassoni, Alessio Cirillo, Alessandro Corsi, Andrea Botticelli, Bruna Cerbelli, Andrea Battisti, Edoardo Brauner, Daniela Messineo, Armando De Virgilio, Antonio Greco, Daniele Santini, Carlo Catalano, Umberto Romeo, Carlo Della Rocca, Antonella Polimeni, Marco de Vincentiis

Methuosis key gene ARF6 as a diagnostic, prognostic and immunotherapeutic marker for prostate cancer: based on a comprehensive pan-cancer multi-omics analysis

Yongjin Yang, Liangliang Qing, Chengyu You, Qingchao Li, Wenbo Xu, Zhilong Dong

Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC

Keh-Sen Liu, Yen-Hsiang Chang, Hsing-Ju Wu, Hung-Yu Lin

Comprehensive analysis of the prognosis and tumor immune microenvironment of ubiquitin-conjugating enzyme transport-related gene UBE2C in hepatocellular carcinoma

Yang Xu, Fei Lan, Qiang Bi, Xinyi Li, Zhiyu Wang, Ying Li, Pengfei Li, Haichen Long, Li Du

Integration of cuproptosis-related gene signatures in stomach adenocarcinoma: implications for prognostic prediction and therapeutic strategies in cancer drug resistance

  • Open Access
  • Analysis

Xin Zuo, Youchun Lei, Shan Ou, Xiu Yuan, Peng Shi, Qian Li, Yun Xu

Integrative machine learning model for subtype identification and prognostic prediction in lung squamous cell carcinoma

Guangliang Duan, Qi Huo, Wei Ni, Fei Ding, Yuefang Ye, Tingting Tang, Huiping Dai

Inhibition of PDK modulates radiotherapy resistance in gastric cancer

Qi Zhang, Wanjia Qiao, Xiaoyu Liu, Jun Lu, Farooq Benish, Shuping Li, Xiaojun Liu

From exposure to innovation: decoding aromatic amines’ role in bladder cancer mechanisms

Haoyu Xu, Junwu Li, Senlin Peng, Yuanyuan Bai, Wei Tang

The role of programmed cell death in renal cancer: a bibliometric perspective (1998–2024)

Liang Hong, Chun Zhao, Tingping Wu, Xiaorong Hu, Xueyao Li, Lu Li

Impact of tumor-to-nipple distance on outcomes in robotic nipple-sparing mastectomy and reconstruction

Joon Suk Moon, Young Jin Lee, Tae Kyung Yoo, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sae Byul Lee

HER2 prognostic values in non-muscle-invasive bladder cancer: a step towards personalized treatment for BCG instillation

Xinpei Deng, Runhao Zheng, Xingliang Tan, Kai Yao

Predictive value of combined DCE-MRI perfusion parameters and clinical features nomogram for microsatellite instability in colorectal cancer

Leping Peng, Wenting Ma, Xiuling Zhang, Fan Zhang, Fang Ma, Kai Ai, Xiaomei Ma, Yingmei Jia, Hong Ou-Yang, Shengting Pei, Tao Wang, Yuanhui Zhu, Lili Wang

Inhibition of colorectal carcinogenesis by sunitinib malate: disruption of the IL-6/STAT3/c-MYC/TWIST/MMP2 autocrine signaling axis

Ling Qian, Yi Yang, Bin Zhao, Pan Xu, Ziyan Hu, Liangwang Zhong, Qi Dai, Youbao Zhong, Chao Yang, Qinglong Shu, Ray P. S. Han, Yang Guan, Zhiming Li, Lai Chen

Timosaponin B-II suppresses gastric cancer cell proliferation and induces apoptosis via the Nrf2/miR-455-3p/KLF6 pathway

Qiaoyan Cui, Ruijie Zhang, Shiqiao Zhao, Jian Wang, Yafen Dong, Xuesong Bai, Ye Chen, Yan Qiu

Analysis of immune infiltration in basal cell carcinoma based on transcriptome sequencing and experimental validation of diagnostic biomarkers

Pengfei Fan, Yun Liu, Tengxiao Ma, Qiaoxing Wang, Lei Li

*Mechanisms of circular RNA in drug resistance of lung cancer: therapeutic targets, biomarkers, and future research directions

Xuanlin Tao, Xixian Ke, Gang Xu

Role of fructose in renal cell carcinoma progression

Jixuan Miao, Di Wang, Ruochong Pang, Hao Zhang, Yuyun Wu, Xingwei Sun, Yong Jin

Endoscopic thyroidectomy for central lymph node dissection—is there a difference in the number of lymph node dissections performed through different surgical approaches? A retrospective cohort study and pooled data research

Zheng Wang, Han Yan, Jun Yu, Rui Sha, Zhao cai Yin, Bin Chen, Ya bing Wang, Chang sheng Yu

MiR-493-5p functions as a tumour suppressor in head and neck squamous cell carcinoma progression by targeting HIF-1α

  • Open Access
  • Research

Liu Jiahui, Tian Ruxian, Chen Xi, Song Qing, Sun Caiyu, Li Dongxian, Fang Yuhui, Lv Shijun, Yumei Li, Xicheng Song

Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning approaches

Wang Liu, Liangjing Xia, Yuan peng, Qiang Cao, Ke Xu, Huiyan Luo, Yongjun Peng, Yanping Zhang

miR-1246 enhances chemo-resistance of polyploid giant cancer cells in H1299 cells by targeting GSK3β/β-catenin

  • Open Access
  • NSCLC
  • Research

Lili Wang, Zien Yang, Sining Xing, Song Zhao, Mingyue Ouyang, Huiying Yu

CD155 as a prognostic and predictive biomarker in acute myeloid leukemia

Ashraf Zeidan Abdalla, Salah Mabrouk Khallaf, Asmaa Mohammed Zahran, Nehal Adel Rayan, Ahmed Refaat Abd Elzaher

Risk factors and prediction models for severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing chemoradiotherapy

Yi Liang, XiaoQin Wang, XunRen Shi, XinXiong Fei

Efficacy and mechanisms of Angelica sinensis in treating endometrial cancer: an integrated study

Zhenyi Li, Congchao Jia, Yiqian Zhou, Qin Wang

Prognostic model identification of ribosome biogenesis-related genes in pancreatic cancer based on multiple machine learning analyses

Yuan Sun, Yan Li, Anlan Zhang, Tao Hu, Ming Li

Potential associations between gut and skin microbiota and lung cancer: a bidirectional Mendelian randomization analysis

Zishun Guo, Shifei Liu, Zhuozheng Hu, Xiaojie Pan, Wenxiong Zhang, Zhenlong Zhang

Genomic and clinical insights into ovarian cancer: subtype-specific alterations and predictors of metastasis and relapse

Feng Cheng, Feng Shao, Yiping Tian, Shujun Chen

Estimate hazard ratios in small clinical trials without reported hazard ratios

  • Open Access
  • Tick
  • Analysis

Shuyuan Wang, Ziwei Song, Mingjie Wu, Yuanjian Huang

Prognostic and therapeutic insights from lactate metabolism and tumor immune microenvironment in head and neck squamous cell carcinoma

Huanyu Jiang, Lijuan Zhou, Haidong Zhang, Shanchun Gong, Zhenkun Yu

Clostridium difficile as a potent trigger of colorectal carcinogenesis

Javad Nezhadi, Masoud Lahouty, Mohammad Ahangarzadeh Rezaee, Manouchehr Fadaee

Global research trends on the links between prostate cancer and postoperative urinary incontinence between 2014 and 2024: a bibliometrics and visualized study

FuQiang Li, DeSheng Zhu, QingHong Li, ZhiLong Zhong, WenTao Fan, Zekun Xu

Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets

  • Open Access
  • Analysis

Lin Xiao, Tianen Wu

Big data-driven machine learning: transforming multi-omics lung cancer research

Yanqi Zhang, Mingyu Liu, Jinhua Luo, Zhongqing Xu

Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights

Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

Identification of circulating tumor cells marker genes as prognostic signature in triple-negative breast cancer

Jia Hu, Kai-Ming Zhang, Xi Wang

Identification of key ferroptosis genes in hepatocellular carcinoma and type 2 diabetes mellitus through bioinformatics analysis

Jinjin Zhou, Yage Shi, Yulun Jian, Yuhan Li, Wenya Yu, Wei Mu, Yang Ge

Leveraging multiple cell-death patterns based on machine learning to decipher the prognosis, immune, and immune therapeutic response of soft tissue sarcoma

Binfeng Liu, Shasha He, Chenbei Li, Zijian Xiong, Zhaoqi Li, Chengyao Feng, Hua Wang, Chao Tu, Zhihong Li

Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures

Misbah Ullah Khan, Humaira Aslam, Jehanzeb Sohail, Ali Umar, Aman Ullah, Hayat Ullah

GTV delineating for patients with postoperative glioma based on enhanced T2-FLAIR sequence instead of enhanced T1-TFE sequence: a feasibility study

Yuanyuan Li, Qingqing Yuan, Hengbing Jiang, Yin Zhang, Xingru Sun

Reciprocal regulation between m6 A modifications and non-coding RNAs: emerging roles in cancer therapeutic resistance

  • Open Access
  • Review

Dan Fan, Yan Shang, Yating Cong, Yanlin Jiao, Na Li, Hailong Zhao

The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database

Yaxing Deng, Chenglin Wang, Rui Yang, Qingqiang Yang

The role and diagnostic value of deregulated miRNAs in cervical cancer

Masoumeh Parvizi, Maryam Vaezi, Farhad Jeddi, Masoumeh Bakhshandeh, Reza Eghdam-Zamiri, Noushin Mobaraki-Asl, Ebrahim Esmati, Abbas Karimi

A four gene risk score model for prognosis and immune microenvironment insights in small cell lung cancer based on CAF functional-related genes

  • Open Access
  • SCLC
  • Analysis

Yunfei Chen, Yunfeng Tong, Xinyuan Ye, Yehao Yang, Hui Li, Haicheng Wu, Wanchen Zhai, Yuwei Li, Qian Zhang, Linjing Zhou, Jing Sun, Yun Fan

Bladder cancer biomarker analysis and drugtarget prediction based on pyroptosis-related genes

Ping Li, Xuexi Yang, Qin Liu, Hanchao Zhang, Zhumei Luo

A comparison of the survival outcome of paclitaxel liposome-based chemoradiotherapy with or without rhEndostatin for unresectable esophageal squamous cell carcinoma: a retrospective study

Mengyuan Zhu, Jiehao Liao, Min Wei, Shan Huang, Junjie Xu, Qun Li, Xiaofen Pan

Identification of metabolic biomarkers and therapeutic targets in the thymoma-associated myasthenia gravis treated with methylprednisolone

Shanshan Gu, Xu Wang, Hongxia Yang, Yaxuan Wang, Congya Yan, Xiaoting Lin, Peng Liu, Lu Liu, Li Meng, Guoyan Qi

Application of bioinformatics analysis to construct the prognostic model and immune-related gene characteristics of low-grade glioma

Peng Liao, Xiaocui Zhang, Ruyan Yuan, Tingjun Tang, Feng Wang, Baowei Geng

Disclosing the development and focus of sequencing and omics studies in kidney neoplasm research

Yifan Liu, Bingnan Lu, Xinyue Yang, Jinming Cui, Tianyue Yang, Haoyu Zhang, Zihui Zhao, Donghao Lyu, Yuanan Li, Yuntao Yao, Runzhi Huang, Xiuwu Pan

Post-translational modifications and the reprogramming of tumor metabolism

  • Open Access
  • Review

Yuqing Hu, Wenxia Xu, Lin Chen

Cinobufagin inhibits hepatocellular carcinoma EMT-like stemness via VEGF/VEGFR2 autocrine signaling

Mingjun Ye, Shujun Chen, Chen Lu, Yangpei Wu, Jiaming Tian, Anqi Han, Jimin Zhu, Baikun Li, Qinglin Li

IGLC1 is an independent prognostic marker and potent therapeutic target in osteosarcoma

Zhenjie Wu, Xinlian Xie, Guangfu Shi, Kebin Ning, Jinmin Zhao

A rare case of an elderly male patient with primary pulmonary rhabdomyosarcoma

Chen Xie, Zhengqiong Chen, Chen Sun, Yunhong Xia, Shuomin Wang

A prognostic model for head and neck squamous cell carcinoma based on radiotherapy sensitivity insights from nasopharyngeal carcinoma

Yinjiao Fei, Zhen Liu, Jinling Yuan, Lei Qiu, Yuchen Zhu, Kexin Shi, Jinyan Luo, Mengxing Wu, Weilin Xu, Shu Zhou

DNA methylation expression patterns predict outcome of clear cell renal cell carcinoma

Xuwen Li, Haoxi Wang, Yajian Li, Yihao Zhu, Yabo Zhai, Nianzeng Xing, Xiongjun Ye, Feiya Yang

Butyrate confers colorectal cancer cell resistance to anti-PD-1 therapy by promoting CPT1A-mediated fatty acid oxidation

Ran Zhu, Shujiang Gu, Yuan Tao, Yan Zhang

Systematic analysis of the aberrances and functional implications of epigenetic genes in hepatocellular carcinoma

Jiehua Zheng, Weixun Lin, Jing Tang, Bo Xu

Elevated CEP72 expression facilitates the progression of hepatocellular carcinoma and is associated with unfavorable outcomes

Nengren Tan, Qiuxia Wei

High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation

Jing Shi, Fuxing Zhao, Tianlei Qiu, Dengfeng Ren, Zitao Li, Junli Ma, Jiuda Zhao

Molecular genetic analysis of pulmonary benign metastasizing leiomyoma and intravenous leiomyomatosis: a comparative study using whole exome sequencing

Jin Li, Jiafei Zeng, Shuai Luo, Jinjing Wang

Exploring program-cell death patterns to predict prognosis and sensitivity of cervical cancer immunotherapy via multi-omics analysis and clinical samples

Chunhong Pang, Xianfeng Long, Yongjin Luo, Ying Luo

Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation

Yilong Chen, Qiuying Wang, Shuixiu Bian, Jing Dong, Jie Xiong, Jiamei Le

RNA methylated long non-coding RNAs as potential biomarkers for prognosis prediction in patients with lung adenocarcinoma: development of a risk assessment model

  • Open Access
  • Research

Xin Lin, Jialin Cui, Yangyang Cheng, Huimin Xu, Wanlin Xie, Jingya Zeng, Yihua Sun

VSV-CHIKV activates antitumor immunity by inducing pyroptosis in a melanoma model

Fan Wu, Ying Zhan, Siyu Wang, Xiaoke Wang, Min Hui, Jian Zhang, Jing Zhang, Hongxu Yang, Yingfeng Lei, Shibin Yu

Mendelian randomization reveals limited causal effects of genetic variants on cervical cancer risk: insights from immune cell populations

Zhang Zhang, FuRong Fu, ShaoLi Zhuang

To explore the molecular mechanisms and shared genetic characteristics of rheumatoid arthritis and cervical cancer based on multiple omics and clinical samples

Xifeng Xu, Yujie Huang, Wu Wei, Zhong Lin, Yongjin Luo, Kaiyi Meng

Impact of preoperative comorbidities on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis

Kexun Li, Simiao Lu, Changding Li, Jie Mao, Huan Zhang, Kangning Wang, Guangyuan Liu, Yongtao Han, Lin Peng, Xuefeng Leng

From infection to tumor: genetic evidence of viral antibody immune response’ role in urologic cancer development

Chen Wang, Qifa Zhang, Qiang Li, Yelong Wang, Xin Chen

HOTAIR, a ferroptosis-related gene, promotes malignant behavior of breast cancer via sponging miR-206

Wei Wu, Zhihan Yao, Yongxing Chen, Rongxuan Xu, Chenxin Jin, Xiaofeng Li

Fumarate hydratase in cancer research: scientific trends and findings over 22 years

  • Open Access
  • Analysis

Cem Yalaza, Serife Efsun Antmen

Pneumocystis jirovecii pneumonia in patients with lung cancer receiving immune checkpoint inhibitors: a retrospective nationwide population-based cohort study from South Korea

Jiyun Jung, Seong Yeon Park, Hee Bum Jo, Jae Yoon Park, Dalyong Kim, Kyoungmin Lee, Sungim Choi

Unraveling the TEC-associated landscape in hepatocellular carcinoma: a comprehensive study based on multi-omics analyses

Jianwei Lan, Longhui Xie, Dekun Song, Pengpeng Liu, Quanyan Liu

Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance

Cuiping Sun, Zhiyong Du, Wenhui Yang, Qing Wang

hsa-let-7b-5p/TMPO-AS1-mediated ceRNA networks are linked to poor prognosis for lung cancer patients with FOXM1/MAD2L1 axis

Chainsee Saini, Prerna Vats, Bhavika Baweja, Sakshi Nirmal, Rajeev Nema

Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics

Subhayan Das, Shayeri Chatterjee Ganguly, Shiuli Bera, Moumita Kundu

NCAPD3 is involved in papillary thyroid carcinoma proliferation, metastasis, and aerobic glycolytic pathway

Liubing Zhang, Aiping Peng, Yue Qin

Assessing the value of artificial intelligence-based image analysis for pre-operative surgical planning of neck dissections and iENE detection in head and neck cancer patients

Benedikt Schmidl, Cosima C. Hoch, Robert Walter, Markus Wirth, Barbara Wollenberg, Timon Hussain

Development of an immune scoring system based on exosome-related gene expression for prognosis and treatment response prediction in breast cancer

Xiaocang Ren, Yanyan Ma, Jing Li, Yuee Liu, Xuankai Liao, Rubing Lin, Zhihong Qiu

Prognostic and immunological characterization of osteosarcoma patients evaluated by liquid–liquid phase separation related genes

Jieyang Zhu, Sihui Chen, Jiang Yi, Xu Zhuang, Yun Li, Zhenqi Lou, Jinyu Zhu

Modern therapeutic approaches for hepatic tumors: progress, limitations, and future directions

Shayan Sadrinasab, Sadaf Saket, Nadia Pourmohammadi, Fatemeh Khosravi, Masoud Saadat Fakhr

Exploring the use of traditional Chinese medicine exercises for cancer patients from the perspective of bibliometrics

  • Open Access
  • Research

Ying Qu, Yuting Yang, Yan Huang, Yukun He, Jingqi Gao, Chunju Deng, Lei Gu

A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors

Fangsheng Chen, Yuan Zhou, Xinwen Mao, Ronggui Lin, Heguang Huang

Enhanced magnetic resonance imaging-based radiomics predicts CD40LG expression and survival in high-grade gliomas: a retrospective study

Jie He, Nan Liu, Lin Li, Hongjie Hu

Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer

Donghui Liu, Mingzhu Liu, Juan Du

Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study

Ting Xiao, Ge Hu, Tian Li, Xiao Zhu, Hui Wang, Zhenhua Zhu

CK2 in the spotlight: decoding its role in hematological malignancies and therapeutic applications

Zhaoyi Cai, Qiang Luo, Yuqun Zhang, Rui Meng, Ming Tian

A review of enhanced biosignature immunotherapy tools for predicting lung cancer immune phenotypes using deep learning

A. Sheryl Oliver, Md Shohel Sayeed, Siti Fatimah Abdul Razak

NEIL3 promotes the carcinogenesis of prostate cancer by activating PI3K/Akt/mTOR signaling

Wei Zhang, Zihao Liu, Simeng Wen, Yuan Shao, Zhen Yang, Yong Wang

NCAPG2 is a diagnostic biomarker associated with immune infiltration in cholangiocarcinoma

Zhaojun Huang, Xiaohang Niu, Mingjin Zhang, Xiaoming Wei

Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis

Bing Zhou, Jialing Zhang, Mingfeng Guo

Ki-67 and 21-gene recurrence score assay in decision making for adjuvant chemotherapy in breast cancer patients

Mohammad Aghebati, Reza Hossieni, Afsaneh Sadat Makeh, Alireza Shirzadi, Mohammad Esmaeil Akbari

Unlocking new horizons: advances in treating IDH-mutant, 1p/19q-codeleted oligodendrogliomas

Jing Bao, Zhenjiang Pan, Shepeng Wei

Special status of iron transfer proteins in the serum of breast cancer patients

Lama Alhaddad, Maher Saifo, Ranwa Alsayed

Modulatory effect of metformin and its transporters on immune infiltration in tumor microenvironment: a bioinformatic study with experimental validation

Ahmed A. Rashad, Mohamed F. Elshafie, Safwat A. Mangoura, El-Sayed Akool

Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization

Shuyi Qian, Yuting Gong, Ying Chen

Unveiling GBE1 as a hypoxia-related prognostic gene with significant impact on immune cell infiltration in HER2-enriched breast cancer

Farkhonde Hasannejad, Mohammad Darzi, Mehrdad Yasaei

Prediction of pathological grade of oral squamous cell carcinoma and construction of prognostic model based on deep learning algorithm

  • Open Access
  • Analysis

Tingru Shao, Peirong Ni, Chun Wang, Jiahui Li, Xiaozhi Lv

Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer

Yi Chen, Munawar Anwar, Xiaoli Wang, Boxiang Zhang, Binlin Ma

Global trends and characteristics of metal–organic frameworks in cancer research: a machine-learning-based bibliometric analysis

  • Open Access
  • Research

Heyuan Niu, Haipeng Du, Zhe Ji, Xiaoping Li, Wanyi Xiao, Anqi He, Ping Yu, Gang Liu

Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study

Yanmei Yang, Yongjin He, Ping Zhang, Chunyan Wang

Research progress on the development and progression of long non-coding RNA in upper gastrointestinal adenocarcinoma

Haitao Wei, Xiaojin Lin, Ruirui Fang, Sa Zhang, Li Li

CB5712809, a novel Keap1 inhibitor upregulates SQSTM1/p62 mediated Nrf2 activation to induce cell death in colon cancer cells

Ayed A. Dera, Majed Al Fayi

Should CDK4/6 inhibitors replace chemotherapy in HR+ /HER2− metastatic breast cancer with visceral crisis? Evaluating the emerging evidence

Armando Orlandi

Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway

Hua-Tao Liang, Feng-Ying Huang, Wei-Jing Xie, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Wen-Tian Xu, Wu-Ping Zheng, Guang-Hong Tan

Novel nomograms for predicting overall survival and cancer-specific survival in invasive lobular carcinoma of the breast

Xia Qiu, Baoxing Tian, Yifan Gu, Kai Yin, Ji Zhao, Jie Wang

Hotspots and frontiers of extracellular vesicles and lung cancer: a bibliometric and visualization analysis from 2002 to 2024

Zelin Yang, Jie Tian

Identification and validation of T cell senescence-related prognostic genes in gastric carcinoma and investigation of their potential regulatory mechanisms

Jing Liu, Huiyu Wang, Fang Huang, Zhiqiang Hang, Pan Xu, Runjie Wang, Junying Xu

Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study

Dianzhe Tian, Shitao Jiang, Yaoge Liu, Han Zheng, Lei Zhang, Yiyao Xu, Xin Lu

Radiotherapy improves the clinical outcomes of recurrent or metastatic head and neck cancers treated with immunotherapy

Yanshuang Cheng, Juan Wang, Ji Sun, Yahua Zhong, Qiuji Wu

Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015–2024)

  • Open Access
  • Research

Huihui Zhang, Ying Shen, Peijian Bai, Xiaorui Wu, Ping Li, Ting Wang

Cytological features of invasive stratified mucin-producing carcinoma of the uterine cervix and literature review

AnChun Liu, MaiQing Yang, Hao Zou, XiaoLin Gong, Tao Cao, LongYun Wu, Li Ge

Multi-omics analysis reveals cancer stemness function and establishes a predictive model for thyroid cancer prognosis and immunotherapy

Zhanrong Feng, Yue Xu, Ying Ding, Xiaoxiao Sun, Qian Zhao, Jingjing Zhu, Qiang Chen, Yang Zhang, Yilai Zhang

Identification of novel susceptibility loci for testicular germ cell tumors through multi-omics analysis

Yuangao Xu, Hua Shi, Jieyu Xiong, Yikun Wu, Xiaoyu Wu, Yuanbo Xu, Yuanlin Wang, Shuxiong Xu

The role of immune cells phenotype in neuroendocrine tumors development

Jie Qiao, Yi-Wen Wu, Yuan-You Wang, Jing-Jing Huang, Peng-Fei Shan

Causal relationship between gut microbiota and hepatocellular carcinoma: a two-sample Mendelian randomization and case–control study

Liu Yang, Wei Wei, Yuekui Wang, Wentao Kuai, Liang Xu

Prophylactic transarterial chemoembolization after R0 resection is beneficial to improve the prognosis in hepatocellular carcinoma patients with microvascular invasion

Wenjie Sun, Yafang Li, Haozhe Fu, Jiangze Li, Jinbao Li

The safety and efficacy of dabrafenib plus trametinib for patients with brain metastatic melanoma: a systematic review and meta-analysis

Mohammad Amin Habibi, Mohammad Sina Mirjani, Bardia Hajikarimloo, Mohsen Dashti, Afsaneh Ghasemzadeh, Seyed Hesam Hojjat, Mohammad Shahir Eftekhar, Kosar Doraghi, Yalda Ghazizadeh, Fateme Aghaei, Shaghayegh Karami, Mehrshad Edalat, Farhang Rashidi, Sajjad Ahmadpour, Sina Ahmadi

TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis

Ning Ding, Yujiao Li, Xiaohui Yu

The genetic landscape of CYP24A1 polymorphisms in cancer risk: evidence from a systematic review

Ssarvinna Haran Manoharan, Vithiya Dewarajan, Sau Har Lee, Yin Sim Tor

Exploring the relationship between hypoxia in lung adenocarcinoma and tumor microenvironment immune cell infiltration

  • Open Access
  • Analysis

Changcong Gu, Shuai Guo, Haoxiang Li

Identification and validation of a thirteen-gene signature based on ubiquitin related genes in cervical cancer

Wenxiu Ding, Shu Liu, Huiai Zhang, Hongxia Ding, Shaobing Zhou, Hongxun Ye

Nomograms for predicting prognosis in postoperative lip squamous cell carcinoma patients

Hao Cheng, Xue-Lian Xu

miR-17-5p is highly expressed in patients with lung cancer and promoted lung cancer by targeting SIK1

Xiaoyan Chen, Shanna Su, Jingyi Liu, Dong Zhang, Guangliang Qiang

Research progress of galectins in glioma

Xin-Li Feng, Gang Su, Qiong-Hui Wu, Qi Jia, Zhen-Chang Zhang

Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines

Sahar Khojastehpour, Azarmidokht Aminazad, Shahrokh Abdolahi, Shirin Tavakoli, Maryam Samareh-Salavati, Nasrin Momeni, Mohammad Vaezi, Mohammad Ahmadvand

Connection between circulating inflammatory cytokines and non-small cell lung cancer: integrated Mendelian randomization and gene function analysis

  • Open Access
  • NSCLC
  • Analysis

Ke Niu, Jing Tang, Jianxin Zhong, Lin Zheng, Yayu Zhu, Huijuan Ling, Yu Liu, Qing Xu, Ping Qiu, Liwen Chen

Multi-omics exploration of CAV1+ tumor epithelial subcelltype in oral squamous cell carcinoma and its impact on the immune microenvironment

  • Open Access
  • Analysis

Yan’an Shi, Yiting Shao, Bin Xia, Wenying Yang, Yan Wang, Lifu Yu, Yonghui Zhang

Intratumoral and peritumoral ultrasound radiomics analysis for predicting HER2-low expression in HER2-negative breast cancer patients: a retrospective analysis of dual-central study

Jiajia Wang, Yunxin Gu, Yunyun Zhan, Rubing Li, Yu Bi, Lan Gao, Xiabi Wu, Jiaqi Shao, Yilin Chen, Lei Ye, Mei Peng

Gender-based differences in survival outcomes of rectal neuroendocrine tumors: a population-based analysis

Tianbao Chen, Yao Liu, Xianxiao Ding, Xiao Xu, Zhenguo Qiao, Rencheng Cai, Shaojun Hu

Glutamate promotes triple-negative breast cancer development through IRE1α/XBP1-mediated macrophage polarization: mechanism insights and therapy

Hao Wang, Jifeng Sun, Zhansheng Jiang, Zhongsheng Tong, Chen Wang

Intervention of machine learning in bladder cancer research using multi-omics datasets: systematic review on biomarker identification

Blessy Kiruba, P. S. Athul Narayan, Badhari Raj, S. Rohieth Raj, Sam George Mathew, Sudhakaran Sajitha Lulu, Vino Sundararajan

Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review

Xiaodan Shao, Na Wang, Ke Tang, Kunning Wang, Zhangyan Tan, Jiangxiu Xie, Zhiwei Shen, Yuting Jiang, Yan Zhang

Lactate metabolism-related genes serve as potential biomarkers for predicting gastric cancer progression and immunotherapy

Mingjie Yuan, Xuekai Li, Xuanli Song, Xiaowei Chen, Yunshan Wang, Shuyi Han, Yang Ni, Duanrui Liu

Deciphering the dual role of autophagy in gastric cancer and gastroesophageal junction cancer: from tumor suppression to cancer progression

Lili Lei, Junling Zhang, Ran Wei, Bingqi Dong, Xin Wang, Ying Zhou

Causal relationships between immune cell subtypes and risk of Pneumocystis pneumonia and lung cancer: a Mendelian randomization study

Zhongqiu Tian, Wenfang Tang, Long Wen, Zhixiong He, Yanyan Fang, Yubin Fan, Yan Peng, Linyan Xu, Bin Li, Xuelian Chen

Plasma NLRC4 and NLRP3 as potential diagnostic biomarkers for non-small cell lung cancer in pulmonary tuberculosis

  • Open Access
  • NSCLC
  • Research

Mengting Xiong, Shuanshuan Xie, Chenlei Cai, Jun Ma, Jiawei Yang, Yunlu Gu, Jian Ni, Haiyan Cui, Wei Sha

Unveiling the mechanisms of Tianjihuang in hepatocellular carcinoma: a network pharmacology and molecular docking study

Bixing Liang, Wenyu Wu, Fan He, Bing Yang, Dongxin Tang

Comprehensive analysis of m7G-related genes METTL1 and WDR4 for predicting prognosis and oncogenic functions in prostate cancer

Degeng Kong, Juanyi Shi, Cong Lai, Jintao Hu, Yelisudan Mulati, Jiawen Luo, Junjie Wang, Yunfei Xiao, Cheng Liu, Kewei Xu

Integrated analysis unraveling the immunologic and clinical prognostic values of synaptotagmin like 4 in pan-cancer

  • Open Access
  • Analysis

Yuehan Ren, Xiangbin Wu, Jinlei Li, Zhenhua Zhou, Shichang Ni, Jianhui Cai

Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study

Wenhuan Li, Yonggang Yang, Rong Xie, Xinyu Su, Pengfei Shi, Lin Chen, Bo Hu

Obese patients with malignant tumor: a case series and literature review

Ping Liang, Meng-yuan Zhu, Ruixia Yang, Xin Wang, Hongyu Yue, Ying Zheng, Jiang Liu, Ya-lei Lv, Bin Shan

The expression and prognosis for Aurora kinases in human non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Yue Wang, Juan Liu, Jiaxue Xu, Zhaodong Ji

Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics

Alessandra Glovi, Panagiota M. Kalligosfyri, Antonella Miglione, Sima Singh, Gabriella Iula, Antonio Giordano, Michelino De Laurentiis, Stefano Cinti

The effect of radiotherapy on patients with EGFR-driven lung cancer brain metastasis: a systematic review and meta-analysis

Mohammad Amin Habibi, Farhang Rashidi, Pourya Delbari, Bardia Hajikarimloo, Seyed Hesam Hojjat, Sana Kazemivand, Sahar Fathi Tavani, Amirmohammad Bahri, Mohammad Shahir Eftekhar, Hossein Gandomkar, Ibrahim Mohammadzadeh

Analysis of immune status and prognostic model incorporating lactate metabolism and immune-related genes in clear cell renal cell carcinoma

Jun Wu, Yuqian Wu, Yefeng Sun, Jianhang You, Wenjie Zhang, Tao Zhao

Drug treatment of breast cancer brain metastases: progress and challenges

Jialing Luo, Aixiong Ren, Dikun Si, Jixin Yang, Dongdong Xu, Nanlin Li

Global research landscape on active surveillance for papillary thyroid microcarcinoma: a bibliometric analysis

Dong-Shu Kang, Yu-Hao Lin, Jian-Qing Tian

Mechanisms of Jisheng-Wumei tablet in laryngeal cancer treatment: a network pharmacology analysis of baicalein’s targeting of cytochrome C for laryngeal cancer inhibition

Quanwei Ren, Xiaoli Luo, Chao Yu, Yilin Xiang, Di Wu, Yanli Zhao, Zhongwan Li

Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics

  • Open Access
  • Analysis

Yue Li, Keru Ma, Hao Wang, Zongying Liu, Zhuying Li

Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review

Parmar Keshri Nandan, Jayanthi Sivaraman

SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis

Chen Fu, Yanyun Hu, Lei Yang, Weifeng Sun

Establishment of M2 macrophage-related prognostic signature in pancreatic ductal adenocarcinoma

Hui Chen, Jingyang Yin, Xianxing Wang, Renpei Xia, Fanbo Qin, Zhuo Li, Jiali Yang, Changjiang Liu, Shixiang Guo, Huaizhi Wang

Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes

Mona Rady, Albert Ashraf, Hesham Abdelaziz, Mohamed El-Azizi

Analysis of the differences in immune indexes of common gene mutations and 5q- chromosome karyotype mutations in MDS

Hanxue Zheng, Zilu Meng, Liansheng Zhang, Lijuan Li

Outcomes of secondary primary malignancies among patients with diffuse large B-cell lymphoma

Peng Xu, Yan Lin, Weiying Gu, Zhenyu Li

Shared hub genes in membranous nephropathy and kidney renal clear cell carcinoma: investigating molecular overlap and tumor progression

  • Open Access
  • Research

Peng Hui, Zhang Shuwen

Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma

  • Open Access
  • Research

Xue Xu, Meng-Yu Zhang, Jia-Qi Fan, Guo-Dong Li, Jun-Yi Li, Xiao Chen

The impact of the COVID-19 pandemic on the small cell lung cancer epidemiology

  • Open Access
  • SCLC
  • Analysis

Xuemei Zhang, Lele Chang, Wansu Xu

Integrated bioinformatics and functional studies identify CDK9 as a potential prognostic biomarker and therapeutic target in AML

Zhibin Xie, Yang Xia, Zhongyu Li, Mengmeng Zhang, Yuanyuan Tan, Yuqing Han, Meng Wang, Pingping Zhang, Jiajia Li

Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma

  • Open Access
  • Analysis

Qian Chengqun, Wang Xijun, Fan Yangyang, Yang Xiaoqin, Cheng Min, Xu Jun

Transfer learning for accurate brain tumor classification in MRI: a step forward in medical diagnostics

Muhammad Adnan Khan, Muhammad Zahid Hussain, Shahid Mehmood, Muhammad Farhan Khan, Munir Ahmad, Tehseen Mazhar, Tariq Shahzad, Mamoon M. Saeed

Suppression of MRPL23 induces cellular senescence in hepatocellular carcinoma by targeting HMGB1

Ya-Bin Huang, Shi-meng Xu, Min Li, Jin Chen, Cui-Hua Lu, Qing-qing Liu

Endobronchial lipoma: a rare cause of bronchial obstruction—case report and literature review

  • Open Access
  • Lipoma
  • Case Report

Shujun Bao, Yang Chen, Caiming Zhong, Jing Zhang, Hao Tang

Causality of genetically predicted solid cancers on risk of sepsis: insights from Mendelian randomization

Linjie Qiu, Shiyu Chen, Jia Zhong, Yan Zhang, Kai Zhang

Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia

Tianping Chen, Nan Wei, Wenxiu Lv, Lijun Qu, Qian Qu, Chaohong Wu, Yuan Ling, Haipeng Liu, Hongjun Liu

Multi-omics analysis of tumor necrosis factor superfamily 4 reveals its prognostic value with T cell exhaustion feature in cancer

Kai Lei, Weiqing Chen, Anqi Wang, Anyu Zeng, Yun Ding, Tianqi Luo, Qi Zhou

LncRNA ZFAS1 promotes the transformation from prostatitis to prostate cancer via myddosome assembly-mediated activation of NF-κB signaling

Tao Feng, Hao Shen, Shenglan Ye

TCF19 expression and significance analysis in breast cancer: integrated bioinformatics analysis and histological validation

Haiyang Yu, Jingjing Wei, Qinhao Chen, Yueyin Pan, Xiaojun Qian, Jing Pan, Yubei Sun

Assessing the influence of metabolic syndrome on thyroid cancer: insights from a Mendelian randomization approach

Xiaosong Ru, Ziying Su, Yong Guo

Advancement in tumor treating fields of mechanism, clinical applications, and future directions

Meiqi Zang, Song Zhu, Qiang Niu

LncRNA MIR99AHG serves as a diagnostic marker for early lung cancer and regulates cancer cell growth and metastasis via miR-194-5p

  • Open Access
  • NSCLC
  • Research

Wenhui Li, Wenhan Li, Zhen Xu

Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in intrahepatic cholangiocarcinoma carcinoma

Xuan Zhou, Bai Wei, Yan Wang, Mingjie Liu, Xiangru Guo, Yuting Duan

Enhancer RNAs profiling in colorectal cancer liver metastases reveals novel molecular subtypes with prognostic and therapeutic relevance

Xiaoyun Bu, Dongsheng Wen, Tiejun Zhou, Lei Xiao, Zhiqing Zhang, Xingshuai Zhao, Yingbin Hu

Ropivacaine combined with esketamine in ultrasound-guided thoracic paravertebral nerve block in lung cancer patients undergoing thoracoscopic radical surgery

Jian Wen, Gao Zhou, Yong Bin, Yan Zeng, Dianxiang Tan, Juan Zhang

Immunoregulatory role of pulmonary microbiota in lung cancer: a bibliometric analysis

Huijun Jia, Yifan Gong, Hongyu Wei, Chengguang Zhao, Qiwei Zang, Constance Sat Lin Liew

Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis

Ziqian Wang, Xiaodu Xie, Ze Wang, Peng Tang, Jian Chen, Jing Xu, Junying Zhang, Haiyang Xiao, Chongliang Zheng, Jun Jiang, Qiuli Liu, Weihua Lan

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie

Trends and visualization analysis of research on MASLD-Related hepatocellular carcinoma: a bibliometric analysis

Hongkun Yin, Xusheng Zhang, Qi Wang

IGF1/IGF1R signaling promotes the expansion of liver CSCs and serves as a potential therapeutic target in HCC

Qiuju Tian, Qun Zhang, Bin Wang, Yanzhi Qian, Fengchao Liu

Prognostic role of eIF2α protein in metastatic renal cell cancer patients

Ferhat Ekinci, Hanife Seda Mavili, Nalan Neşe, Atike Pınar Erdoğan, Bilgin Demir, Esin Oktay, Nil Çulhacı, Mehmet Uzun, Aziz Karaoğlu, Kutsal Yörükoğlu, Emine Burçin Tuna, Ahmet Dirican

Circulating chemokines and leukocytes and their impact on breast cancer prognosis

Rogério Agenor de Araújo, Felipe Andrés Cordero da Luz, Eduarda da Costa Marinho, Camila Piqui Nascimento, Ana Cristina Araújo Lemos da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Marcelo José Barbosa Silva

SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications

  • Open Access
  • Analysis

Dali Wu, Guanghui Zhong, Yufeng Liu, Cuilian Li, Lingfei Yan, Yang Luo, Qing Li, Dawei Liu, Tao Wang

Midkine (MDK) in cancer and drug resistance: from inflammation to therapy

Berna Yıldırım, Kudret Kulak, Ayhan Bilir

The role of non-coding RNAs in the regulation of cell death pathways in melanoma

Yekta Metanat, Maria Sviridova, Bareq N. Al-Nuaimi, Fateme Janbazi, Mahtab Jalali, Nogol Ghalamkarpour, Elnaz Khodabandehloo, Ehsan Ahmadi

Efficacy and safety analysis of DEB-TACE for hepatocellular carcinoma with portal vein tumor thrombosis

Yan Zhang, Yu-Yu Hua, Li-Zhou Wang

Genetically predicted immune cells mediates the association between hepatocellular carcinoma and inflammatory proteins: a Mendelian randomization study

Yunlan Wang, Zijia Tao, Ying Cheng, Shaokun Wang, Dehui Yi

Differential expression of capecitabine-related metabolic enzymes in hepatocellular carcinoma and its clinical value: a retrospective cohort study

Jianing Lu, Zhiqi Yin, Yan Zhuang, Zhenglu Wang, Hong Zheng, Lei Cao, Dejun Kong, Jinliang Duan, Shaofeng Chen, Tao Chen

Integrating transcriptomics and hybrid machine learning enables high-accuracy diagnostic modeling for nasopharyngeal carcinoma

Hehe Wang, Junge Zhang, Peng Cheng, Lujie Yu, Chunlin Li, Yaowen Wang

Investigating laryngeal squamous cell carcinoma: clinical features and the role of TAS2R16 polymorphisms and its protein levels

Enrika Pileckaite, Alvita Vilkeviciute, Vykintas Liutkevicius, Rasa Liutkeviciene

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer

Li Cheng, Mingyue Guo, Ammad Ahmad Farooqi, Linlin Wang, Yuxi Zhang, Hanlin Ye, Gan Qiao, Xiukun Lin

Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma

Chenlie Ni, Qiwen Sun, Haibo Yin

Impact of differential detection of TM6SF2 rs58542926 mutation in circulating tumor DNA versus peripheral blood cells on hepatocellular carcinoma patients

Samar Samir Youssef, Eman Abd El Razek Abbas, Mohamed Hassany, Aya Shaaban Ragheb Shaaban, Eman Elsayed Abass Mohammed, Tamer Elbaz

Histone demethylase JMJD2D emerges as a novel prognostic biomarker and exhibits correlation with immune infiltration in lung adenocarcinoma

Bona Liu, Hui Hao, Zhen Wang, Yingchun Li, Cheng Du, Jian Ming, Shuang Zhang, Lin Zhou, Dazhi Liu

Comprehensive analysis of SELPLG as a potential immunotherapy target and prognostic biomarker in oncology

Ranran Shi, Ling Ran, Beibei Li, Yuan Tian, Wei Guo, Shaoju Jin, Wenshan Zhao

Comprehensive conditional survival analysis of pancreatic signet ring cell carcinoma: chemotherapy’s role and predictive model development using the SEER database

Mingxu Yu, Xiaodong Chen, Zihao Zheng

miR-146a-5p suppresses migration and downregulates vimentin and MMP-9 expression in gastric cancer cells

Amir Baghbanzadeh, Shima Rahmani, Sahand Eslami, Mahya Ahmadpour Youshanlui, Nadia Shafiee, Atefe Shafiee, Amirreza Khalaji, Behzad Baradaran

The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis

Zeyu Tian, Qi Liu, Jihui Luo, Ning Ning, Jing Qu

Multi-omics integration of TPX2 in prognostic prediction in resectable hepatocellular carcinoma

Haoran Zhao, Weiwei Duan, Tong Qu, Xu Tong, Chao Zhan, Yubao Zhang

A nomogram to predict cancer-specific survival of ocular melanoma

Ruisheng Huang, Jian Chen, Limin Lin, Jun Lyu, Qing Zhou

Evaluation of the efficacy of laparoscopic hepatolobectomy for primary liver cancer with early combined enteral and parenteral nutritional support

  • Open Access
  • Research

Zhouxia Wei, Yingxian Li, Suyan Jiang

Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms

Mohamed Y. Zaky, Hadeer M. Morsy, Adel Abdel-Moneim, Khairy M. A. Zoheir, Anthony Bragoli, Mostafa A. Abdel-Maksoud, Abdulaziz Alamri, Osama M. Ahmed

Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma

Ke Xu, Tao Gu, Ke Su, Xin Liu, Bingsheng He, Jie He, Hao Chi, Xuancheng Zhou, Hanlin Liu, Rui Xiao, Xue Tang, Qinni Ye, Xue Zhou, Yingpeng Liu, Jie Xiong, Pan Wang, Han Li, Kun He, Lu Guo, Yunwei Han

Glutamate activates the MAPK pathway by inhibiting LPAR1 expression and promotes anlotinib resistance in thyroid cancer

Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Liansheng Cha, Ruochuan Cheng

Gambogic acid suppresses osteosarcoma progression through upregulation of FOXO3a

Yawei Hu, Jiawen Wu, Songqing Ye, Hao Zhang, Zengfeng Guo, Xiaohong Han, Jianhua Zhou

A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis

Wen Zhang, Rui Xiang, Wang Gu, Qiang Zhang, Lei Liu, Chenglin Wang, Muhu Chen, Yingchun Hu, Guihong Chen

MASP1 in stomach adenocarcinoma: linking diagnosis, prognosis, and tumor immunity

  • Open Access
  • Research

Chuyu Xiao, Fuyang Hong, Guanzi Chen, Wenli Xu, Yusheng Jie

Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment

Jialong Yu, Wei Luo, Guangwei Xu, Mei Tao, Yuqi Wang, Qiman Dong, Linfei Hu, Xiukun Hou, Jingzhu Zhao, Dapeng Li, Songfeng Wei, Xianhui Ruan, Xiangqian Zheng

Global bone cancer incidence and death rate analysis at 40 years

Peiran Liu, Hang Lv, Yongji Li, Zelin Liu, Xiangjun Yang, Hai Hu

Unraveling the interrelationship between breast cancer and endometriosis based on multi-omics analysis

Jie Yang, Ping-Ting Li, Sheng-Ying Xi

A novel cuproptosis-associated LncRNA model predicting prognostic and immunotherapy response for glioma

Bo Lei, Ao zhan, Guoliang You, Honggang Wu, Shu Chen, Daobao Zhang, Zhiye Liu, Niandong Zheng

Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival

Qizhou Yang, Tian Zhao, Yuying Han, Zhengguo Ji, Haihong Ye

Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study

Santosh Chokkakula, Siomui Chong, Yu-Yen Yang, Liying Huang, Yanan Qian, Qixiang Sun, Sijian Xia, Xiaoxi Zhang, Jiang Yong, Balaji Pathakumari, D. S. Prabakaran, In-Cheong Si, Yuyi Ou, Chengliang Yin

Identification of biomarkers associated with exhausted CD8 + T cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis

LiuXing Feng, Quan Yuan, Hao Yu, RongJie Ye, ZhenHao Xie, JiaHuan Xu, XiuDong Li, ShuangJia Wang

Mendelian randomization analysis of immune cell characteristics and genetic variants in cervical cancer risk: a genome-wide association study

Yu Zhang, Limei Ji, Shuo Yang

RNA m6A methylation patterns in hepatocellular carcinoma and their association with characteristics of the tumor microenvironment and prognosis

Zongcai Yan, Meiling He, Lifeng He, Liuxia Wei, Yumei Zhang

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis

Xinjun Li, Jie Qi, Ren Xu, Shuo Xu, Shengpu Wang, Chunxiao Wang, Sufen Zhao

Single cell analysis and bioinformatics reveal pyroptosis mechanisms in hepatocellular carcinoma

Wei Luo, JunxiaWang, Hongfei Wang, Fei Liu, Taiwei Yang, Zhongjun Wu, Wubin Guo

The impact of SRRM2-AS1 in ovarian cancer: a comprehensive analysis based on pan-cancer and in vitro validation

Jiaojiao Lu, Xia Zheng, Xu Li

Amplified TPM1 suppresses non-small cell lung cancer cells proliferation and metastasis

  • Open Access
  • NSCLC
  • Research

Fengling Xu, Jiangfeng Lv, Shuang Qin, Lijuan Liu, Yuguo Ren

Single-cell transcriptomics identify a chemotherapy-resistance related cluster overexpressed CLIC3 in ovarian cancer

Zhefeng Li, Jie Li, Yue Li, Junjie Yi, Xiaoting Zhao, Wentao Yue

Beyond BCL2 (B cell lymphoma) and BTK (Bruton tyrosine kinase) inhibitors: novel agents and resistance mechanisms for chronic lymphocytic leukemia

Priya Hays

Misdiagnosis of bilateral breast metastases as primary benign tumors secondary to lung large-cell neuroendocrine carcinoma: a case report

Yu Zheng, Tingting Ding, Rong Wang

Prediction of lung adenocarcinoma prognosis and clinical treatment efficacy by telomere-associated gene risk model

Yan Jiang, Jun Liu, Bi Pan, Siping Yu, Chunyan Hu, Qiancheng Li, Hong Cheng, Ling Chen, Min Jiang, Die Xu, Chuanhui Wang, Jie Yan

LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway

Shaoda Meng, Sicheng Liu, Chunsheng Liu, Kunxian Yang, Minghua Lai

Syndecan-4 promotes gastric cancer progression through activating TGF-β1 induced lipid reprogramming and contributes positive loop circuits

Guangjie Liu, Ru Jia, Heng Deng, Xiaoshan Wang

Exploration of the current status and trends of pancreatic cancer immune cells in the past 30 years: a bibliometric analysis

Yang Hu, Simeng Lei, Zihan Zhang, Kexin Wang, Zhili Ji

Single-cell and bulk RNA analysis identifies EMT-associated CAF signatures and prognostic model in lung adenocarcinoma

  • Open Access
  • Analysis

He An, Ping An

Response to crizotinib in advanced intrahepatic cholangiocarcinoma with ZKSCAN1-MET fusion and MET amplification: case reports and literature review

Jian-Hui Wu, Yu-ze Fan, Jing Sun, Xue-Zhang Duan

Pulmonary metastasis of giant cell tumor of bone 29 years after local recurrence resection: implications for Long-Term surveillance

Qiushi Bai, Xiao Chang, Xiongfei Zou, Baozhong Zhang

Marjolin ulcer: a rare clinical entity that every health professional should be informed about: a narrative review

Berna Aksoy, Hasan Mete Aksoy

Pan-cancer analysis reveals dual roles of HES6 in cancer immunity and prognosis

Ying Sun, Peiru Liu, Dongyang Lv, Defu Yang, Shiyu Qiao, Jing Liu, Ying Yan, Wenping Wang

Unraveling the role of blood cell perturbation responses in lung cancer by Mendelian randomization

Yichao Huang, Xinjing Lou, Ziqing Han, Linyu Wu, Chen Gao

Mechanism of dexmedetomidine in inhibiting proliferation, migration, and invasion of esophageal squamous cell carcinoma cell through coagulation factor II receptor

Jianli Cui, Xiang Liu, Yanqin Liu, Lei Shi

Elevated CD14 in B cells associates with reduced ovarian cancer risk via CD80 + dendritic cell interaction: a multi-omics study

Mengyu Zheng

Construction and validation of a chemokine-related gene signature associated with prognosis, clinical significance, and immune microenvironment characteristics in cervical cancer

Tianjiao Huang, Renshuang Cao, Cong Gao, Jie Luo, Zhiyu Zhou, Kun Ma

Identification of CWH43 as a novel prognostic biomarker and therapeutic target in clear cell renal cell carcinoma by a multi-omics approach and correlation with autophagy progression

Ailian Wu, Peng Bai, Hui Qu, Tao Zhang

Hypoxia-related signatures predicts survival, immunosuppression and PARP inhibitor resistance in HCC

Min Su, Haibo Duan, Yu Gu, Jianfu Zhao

Shared chromatin remodeling mutations drive concurrent rhabdomyosarcoma and leukemia in a pediatric patient

Ji’ou Zhao, Huimin Li, Yongren Wang, Xiaoyan Sun, Yongjun Fang, Yao Xue

A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma

Chunyang Wu

Identification of DCAF5 as a novel cancer prognostic and immunotherapy biomarker through pan-cancer analysis and renal clear cell carcinoma clinical data validation

Huaqing Yan, Liqi Zhang, Fan Xu, Tieding Chen, Rubing Li

Development and validation of machine learning models for distant metastasis of primary hepatic carcinoma: a population-based study

Cong Lu, Ying He, Chun-Ru Chen, Lun Wu, Dan Song, Chen-Hong Wang, Le-Qing Zhang, Jing-Yi Miao, Yong-Bin Zheng, Wei Wang

The heterogeneous expression patterns of serum tumor markers in non-small cell lung cancer patients are predictive factors for progression-free survival

  • Open Access
  • NSCLC
  • Research

Siqi Li, Zihang Zeng, Zixi Hong, Jiali Li, Conghua Xie

Identification of novel HER2 ınhibitors: potential therapeutics for breast cancer

Cem Yalaza, Serife Efsun Antmen, Saliha Ece Acuner, Hasan Oz, Ecem Bulut, Necmiye Canacankatan

Mendelian randomization analysis of modifiable risk factors for breast cancer

Diabate Ousmane, Jie Liu, Ziyu Liu, Zongjiang Zhou, Liu Liu, Junpu Wang

To reveal the key mechanism of Citri Reticulatae Pericarpium–Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect with network pharmacology, molecular docking and bioinformatics

Chen Lin, Yujie Wang, Xiao Lin, Chufan Ren, Yifeng Wang, Yizhong Ma, Jiahao Zhou, Chuyu Gu, Jianyi Wang

Paraptosis-related classification and risk signature for prognosis prediction and immunotherapy assessment in gastric cancer

Kai Zhou, Ruyue Chen

Prognostic value of LncRNA SH3BP5-AS1 in non-small cell lung cancer and its regulatory effect on tumor progression

  • Open Access
  • NSCLC
  • Research

Cong Meng, Aihua Zang, Fengcai Du

Identification of TMEM100’s role in immune infiltration regulation and construction of an endogenous RNA network in prostate cancer through pan-cancer analysis

Yinfeng Jiang, Tingan Pan, Zhenglin Zhang

Exploring genetic causal relationships between spinal cord injury and glioma: a Mendelian randomization study

Guangbiao Li, Jingquan Li, Chaoen Hua, Dachuan Pan, Yonghong Li, Huafang Hu, Gang Wu

RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway

Zijian Da, Yadan Du, Yawen Chen, Mingxu Da, Fenghai Zhou

Comprehensive analysis of the role of NEDD4 in pan-cancer and experimental verification of its role in KIRC progression

Yanjiong Chen, Lifan Lin, Qiqi Tao, Weizhi Zhang, Jianjian Zheng, Siqi Wang

SUMO2 inhibits ACSL3 protein degradation to antagonize erastin-induced ferroptosis in hepatocellular carcinoma

Yanxi Shen, Bin Ye, Chuanfei Li

Prognostic and immunological landscape of DDX17 in pan-cancer analysis: a comprehensive study

Yu Lei, Xin He, Peng Chen, Yiping Qin, Bin Ge, Yan Liu, Pu Li, Xing Wei

Treatment of a newly diagnosed glioblastoma harboring MET amplification with vebreltinib in combination with radiotherapy: a case report

Xinliang Liu, Xin Wang, Pengwei Yan, Dan Zong, Wenjie Guo, Xia He

Machine learning-based identification of exosome-related biomarkers and drugs prediction in nasopharyngeal carcinoma

  • Open Access
  • Analysis

Zhengyu Wei, Guoli Wang, Yanghao Hu, Chongchang Zhou, Yuna Zhang, Yi Shen, Yaowen Wang

PARP14-mediated glycolysis enhances Tamoxifen resistance in estrogen receptor + breast cancer cells

Wenju Mo, Fanrong Zhang, Chen Wang, Xiaowen Ding, Lili Ren

Multidimensional bioinformatics analysis of chondrosarcoma subtypes and TGF-β signaling networks using big data approaches

Shengke Li, Junteng Chen, Fuping He, Maosheng Wang, Jun Liu, Hui Xie

Identification of intracranial solitary fibrous tumor and atypical meningioma by multi-parameter MRI-based radiomics model

Yanghua Fan, Panpan Liu, Junting Zhang, Liang Wang, Zhen Wu

Identification of CENPW as a prognostic biomarker and potential therapeutic target for clear cell renal cell carcinoma

Haibing Xiao, Qili Xu, Yu Gao, Weikang Wu, Baojun Wang, Haolin Li, Mintian Fei

Integrative stemness- and EMT-related gene signatures associated with prognosis and the immune microenvironment in lung adenocarcinoma

  • Open Access
  • Analysis

Fei Lu, Lan Li, Li Wang, Sisong Shu, Jingyan Gao, Li Chang, Hui Yu, Wenhui Li, Yaoxiong Xia

An explainable machine learning model for predicting the risk of distant metastasis in intrahepatic cholangiocarcinoma: a population-based cohort study

Jinzhe Bi, Yaqun Yu

PXMP2 inhibits tumor stemness and immune infiltration in hepatocellular carcinoma based on stemness risk

Dingde Ye, Jiaqing Chen, Jian Wang, Qing Ge, Xianzhong He, Jiamu Qu, Ting Fang, Runze Wang, Shuai Mao, Qiang Wang, Qingxiang Xu, Beicheng Sun

The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer

Yeuni Yu, Sun Park, Jaewan Jeon, Se-Hui Lee, Hyeyun Kim, Dongju Seo, Minwoo Park, Eunho Park, Ji Young Kim, Seong-Jun Cho, Sunmi Jo, Geumju Park, Jin-Young Yang

Inhibition of LINC01048 decreases cell proliferation and induces the apoptosis in gastric cancer

Jinxi Huang, Weiwei Yuan, Gaofeng Li, Beibei Chen, Lihong Wang, Yulong Chen, Hai Huang

Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance

Kezhen Shen, Xiaozhe Li, Sihan Zhao, Xinyu Zhang, Le Yu, Jun Li, Lei Cai

LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells

Mei Li, Yuan Cheng, Fakai Qiu, Xudong Mu, Pengtao Zhai, Zhubin Li, Qunyi Liu, Qianjin Li

Assessing causal associations between TNF-related apoptosis-inducing ligand, vascular endothelial growth factor and colon cancer: a Mendelian-randomization study

Chaoyang Zhang, Fangfang Zhang, Xiaofei Zheng, Chunhui Cao, Bei Qian, Chu Zhang, Jingyu Wu, Xiaoyu Shi, Jian Chen

A novel perspective on dissemination: somatic metastasis of germ cell tumors from the central nervous system

Shao-Pei Qi, Chuan Zhao, Jing-Jing Ge, Cheng Li, Feng-Jun Xue, Chi Zhao, Chen-Chen Kong, Hui-Jie Sun, Jing-Jing Zhang, Ya-Qi Zhang, Jun-Ping Zhang

Overcoming therapeutic resistance in driver-negative NSCLC: Immunomodulatory mechanisms and clinical efficacy of Camrelizumab-chemotherapy combination in a real-world cohort

  • Open Access
  • NSCLC
  • Research

Yan Ge, Yang Zhao

Identification of prostate cancer potential therapeutic targets and virtual drug screening through combined Mendelian randomization study, Bayesian colocalization and molecular docking

Zilong Liang, Conglei Hu, Haofeng Pang, Yongxiang Shao, Lingchen Kong, Meng Cheng, Haiyang Du, Tianxi Feng, Zudu Fan, Liping Yao, Fei Liu

How chronic inflammation fuels carcinogenesis as an environmental epimutagen

Yu-Yu Liu, Yui Ohashi, Toshikazu Ushijima

Publication trends and hotspots for cervical cancer screening biomarker: a bibliometric analysis

Jia Xu, Wen Yang, Liangying Liu, Shuting Zhou, Xiangshu Jin, Min Zhao, Miao Liu, Yuanguang Meng

Optimized YOLOv8 for enhanced breast tumor segmentation in ultrasound imaging

Ayman Mohamed Mostafa, Alaa S. Alaerjan, Bader Aldughayfiq, Hisham Allahem, Alshimaa Abdelraof Mahmoud, Wael Said, Hosameldeen Shabana, Mohamed Ezz

Prognostic related signature predicts the benefits of immunotherapy for kidney renal clear cell carcinoma

Feng Xiong, Bowen Wang, Haoxun Zhang, Guoling Zhang, Boju Tao, Yiwen Liu, Chunyang Wang

Visualization of research trend of neoadjuvant chemotherapy for breast cancer treatment: a bibliometric analysis

Tian Tian, Chao Li, Chao Hu, Xiandong Liu, Pingming Gong, Ming Li, Nan Jiang

Should follow-up cystoscopy be performed in upper-tract urothelial carcinoma patients managed with radical nephroureterectomy after a five-year bladder tumor-free period?

Guoli Wang, Bao Guan, Yicong Du, Qi Tang, Chunru Xu, Qian Yang, Hanzhen Ren, Huifeng Zhang, Chao Cao, Kaishun Luo, Zhihua Li, Liqun Zhou, Kai Zhang, Xuesong Li

EZH2 expression in colorectal carcinoma: an evaluation of clinicopathological and prognostic value

Diren Vuslat Cagatay, Mecdi Gurhan Balci, Gizem Issin, Fatih Demir

The causal relationship between circulating inflammatory proteins, gut microbiotas, immune cells and leukemia: a bidirectional Mendelian randomization study

Linying Zhu, Xiaoyi Ruan, Yilun Zou, Shuikang Ye, Liangzhen Xie

PTX3 as a diagnostic and prognostic biomarker in lung adenocarcinoma: a comprehensive analysis

Shaobo Zhou, Na Li, Dina Haishaer, Hongmei Zhao

ALOX15B-based efferocytosis clusters: prognostic implications and immune cell infiltration in breast cancer

Juan Chen, Chang Zheng, Fei Zhang, Shiyao Sun, Guowen Liu, Guo Huang

FAM64A silencing inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition in ovarian cancer cells via activating Hippo pathway

Jianxiu Luo, Ruiyang Li

Integrating multi-omics data to optimize immunotherapy in endometrial cancer: a comprehensive study

Xin Guan, Rongchuan Cao, Longbi Liu, Lin Ma, Ning Gao, Yanfei Yang, Mingyue Xiao, Rui Du, Yuzhe Su, Zhen Wang, Xiaofeng Liu, Lu Han

Mendelian randomization studies of gastric cancer reveal potential risk factors, promising biomarkers and therapeutic targets

Maowei He, Yanting Duan, Yuanyan Zhang, Chao Qian, Jiawei Jin

Prognostic significance of preoperative abdominal fat thickness for pancreatic ductal adenocarcinoma

Shengqiang Zhang, Longjie Xu, Dekang Gao, Hongbo Zhang, Shaohua Wei

Clinicopathological features and prognostic significance of site-specific metastasis in gastric cancer: a population-based, propensity score-matched analysis

Xingbiao Huang, Zhe Li, Qiuyan Weng

Vitamin D and risk of thyroid cancer: a two-sample Mendelian randomization study

Yunbin Shi, Lihui Qian, Tao Ma, Juntao Huang

Dietary saturated fatty acids and prostate cancer: insights into NF-κB pathway and lipid metabolism mechanisms

Jia Wei He, Zi Xuan Huang, Yan Feng Su, Yang Qi Mo

Effect and mechanism of PYCR1 on biological function of hepatocellular carcinoma cells under hypoxia

Jiayi Guo, Xinxin Jin, Junli Zhang, Yuming Zhang, Wenjuan Wu

Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma

  • Open Access
  • Research

Hui Zhao, Kunpeng Yang, Yuejiao Lan, Mingda Wu, Lei Wang, Chenglun Cai, Peiyun Lv, Wenjuan Sun, Xiaodan Lu, Bao Wang

Unusual phenomenon in advanced hepatocellular carcinoma: declining alpha-fetoprotein levels despite disease progression

Haoran Shi, Xing Gao, Pan Liu, Lulu Xing, Zhixuan Qin, Yanfeng Pan

Genomic and immunological profiling reveals novel prognostic biomarkers for limited-stage small cell lung cancer

  • Open Access
  • SCLC
  • Research

Ye Li, Xiaolong Ma, Zhiyi Wan, Pengfei Bao, Enli Zhang, Lihua Liu, Shunchang Jiao, Shengjie Sun

Global research trends on Chinese patent drugs inducing programmed cell death in cancer: a bibliometric analysis (1998–2024)

  • Open Access
  • Research

Min Song, Chunyan Teng, Xiaodong Zheng, Shizhen Tan, Yipeng Guo

Nanotechnology in oncology: advances in biosynthesis, drug delivery, and theranostics

Mohamed M. Ammar, Rania Ali, Naira Ali Abd Elaziz, Heba Habib, Fatima M. Abbas, Mohamed Taha Yassin, Khalid Maniah, Rewan Abdelaziz

Cutting-edge dynamics and research hotspots on boswellic acid in cancer: a bibliometrics analysis from 1994 to 2024

  • Open Access
  • Research

Minghe Lv, Lei Tang, Yue feng, Su Zeng, Hongwei Zeng, Jingping Yu, Qing Ji, Ruping Zhao

Targeting inflammatory pathways in hepatocellular carcinoma: recent developments

Fulufhelo Tabitha Ramaite, Sanah Malomile Nkadimeng

Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization

Weisheng Li, Baoguo Xia, Weixin Chu, Likui Lu, Xuedong Liu

Identification and characterization of survival-dependent genes in esophageal cancer via the DepMap database: unraveling their association with immune infiltration

Xiangrong Yao, Junyan He, Wentao Xiao, Limou Chen, Fangzhu Xiao

MicroRNA- 103 as a novel potential biomarker of poor prognosis and durg resistance in solid tumours

Xiaoping Xia, Xiuping Weng, Tianyu Liang, Mingxia Xu, Chao Zhang

Machine learning-based detoxification enzymes-related genes prognosis model in breast cancer: immune landscape and clinical significance

Jingdi Zhang, Wendi Zhan, Haihong Hu, Hongxia Zhu, Bo Hao, Siyu Wang, Zhuo Li, Zhiming Zhang, Taolan Zhang

The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway

Dandan Xu, Chenyang Hou, Jianliang Chang, Shuaibo Yang, Zhicong Yang, Zelong Yuan, Jingqi Li, Shuqin Liu, Yaqun Liu, Yingpeng Su, Peng Gao, Xiaojuan Liu

Identification and validation of the fibrosis-related molecular subtypes of hepatocellular carcinoma by bioinformatics

Ling-li Liu, Wei-lin Cao, Jian-sheng Chen, Jian-ping Wang

Precision medicine research progress based on colorectal cancer organoids

Xiyou Pang, Yuqing Hu, Zhihui Dai, Qiuwen Lou, Wenxia Xu, Lin Chen

Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis

Kexun Li, Simiao Lu, Changding Li, Jie Mao, Huan Zhang, Kangning Wang, Guangyuan Liu, Yunchao Huang, Yongtao Han, Xuefeng Leng, Lin Peng

Diagnostic value of CD138 and GATA3 in benign prostatic hyperplasia and prostate cancer

Yang Hu, Luo Dan, Yang Shikun, Lian Junbo, Huo Shuangjie, Dong Liru

Real-time survival assessment in breast cancer with liver metastasis

Shu Fang, Guohua Ren, Qiuyue Liu, Ling Qiang

A case of angioimmunoblastic T-cell lymphoma mimicking angioedema

He Zhao, Yun Xia, Fei Su, Liuqing Chen, Bin Hu

Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for thyroid cancer

Peng Zhang, Meizhong Qin, Fen Li, Kunpeng Hu, He Huang, Cuicui Li

Mechanistic role of miR-375 in regulating PDPK1 to promote progression of small bowel neuroendocrine tumors: a silico analysis

Tao Ren, Lu Zhou, Zhenlong Li, Mingmei Pan, Xueqiong Han

Thyroid nodule size and risk of malignancy: a systematic review

  • Open Access
  • Analysis

Aine Cotter, Marcel Jinih

Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis

Cong Fu, Lin Sun, Lili Zhang, Tong Zhou, Yanzhi Bi

The multi-omics analysis identifies a novel endoplasmic reticulum stress and immune related genes signature in lung adenocarcinoma

  • Open Access
  • Research

Danhe Huang, Yuying Liu, Mingyu Yuan, Xiongwei Wang, Lianqing Hong

PDS5B positively regulates PTEN by binding to YTHDC1 to inhibit the malignant progression of endometrial carcinoma

Hanyi Wang, Yaping Qian, Jie Li, Qianyun Gao

Malignant phyllodes tumor of the breast with osteosarcoma component: a diagnostic dilemma - a case report

Yuki Muroyama, Minoru Miyashita, Tsuyoshi Miura, Satoko Sato, Mika Watanabe, Takashi Suzuki

Systematic review of transarterial chemoembolization for desmoid tumors: a promising locoregional treatment for challenging tumor

  • Open Access
  • Review

Abdulrahman Alaseem, Naif Alsaikhan, Abdulaziz M. AlSudairi, Yazeed A. Alsehibani, Mohammed N. Alhuqbani, Zyad A. Aldosari, Omar A. Aldosari, Abdulaziz Almuhanna, Ibrahim S. Alshaygy

Identification and validation of NEIL2 as a prognostic biomarker and potential therapeutic target in cervical cancer

Yan Li, Jiayuan Du, Lingjia Wei, Tianmeng Tan, Liyi Bao, Jinqiu Su, He Wang

Steroid resistant bullous pemphigoid induced by pembrolizumab in a patient with metastatic lung adenocarcinoma: case report and review of the literature

Elie S. Bterrani, Francois G. Kamar

Tumor-associated macrophages derived exosomal circPLK1 promotes resistance to EGFR inhibitor osimertinib in non-small cell lung cancer

Chuankui Li, Xinyu Sun, Zuyi Wang

Neoadjuvant treatment patterns and biomarker selection in muscle-invasive bladder cancer

Wei He, Jiaxin Xie, Ziwei Wang, Maoyu Wang, Qing Chen, Chen Zhang, Yue Wang, Xufeng Yu, Yi Wang, Hui Zhang, Xuncheng Yang, Zhensheng Zhang, Chuanliang Xu, Shuxiong Zeng

Research trends and visualization analysis of autoimmune disease-related liver cancer from 2004 to 2024: a bibliometric study

Xusheng Zhang, Yannan Xie, Wenyan Zhou, Qi Wang, Bendong Chen

The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis

Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li

Construction of a clinical prediction model for overall survival and cancer-specific survival in malignant phyllode tumor of the breast based on the SEER database

  • Open Access
  • Analysis

Chenggeng Pan, Ruokuo Han, Senzhe Xia, Dingwei Fan, Daqing Yang, Haiguang Ma

The effect of microRNA-145 on proliferation and apoptosis of cutaneous squamous cell carcinoma cells

Gengjian Zhang, Songlian Lei, Kaiyue Zhang

Combination of venetoclax with CHG regimen in refractory/relapsed T-lymphoblastic lymphoma/acute lymphoblastic leukemia: a case series and literature review

Mei Zhou, Yuze Yang, Xiaoyan Zhang, Yijie Jiao, Zhenxing Guo

Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma

Piaopiao Bian, Shaoyan Liu, Qiuping Luo, Zewen Feng, Sanyan Li, Wei Zhang

Prognostic analysis and mechanistic exploration of the autophagy-related exosome genes ITGA3, ITGB4, and PTK6 in pancreatic ductal adenocarcinoma

Lunbing Liang, Pengcheng Guo, Mingming Xiao, Fuqiang Zu, Guoliang Hao, Chaochun Zhang, Qingfeng Liu

Increasing linc00261 expression may predict well cancer prognosis, based on the meta-analysis

  • Open Access
  • Review

Xinyue He, Shixu Fang, Chen Wu, Jintong Na, Liping Zhong, Xiyu Liu

A lactate related signature for predicting prognosis and tumor microenvironment in lung adenocarcinoma

  • Open Access
  • Research

Ying Wang, Huiting Li, Chao Chen, Hui Yu, Lichao Xu

Bibliometric analysis of programmed cell death and immunogenic cell death in hepatocellular carcinoma immunotherapy: global trends and future directions

Shan-Peng Chen, Jie Tian

Cellular and molecular mechanisms of arenobufagin in cancer therapy: a systematic review

Si-Jun Wang, Peng-Xin Wang, Hai-Ling Ding, Yuan-Yuan Qi, Ya-Ru Song, Xiao-Nan Mu

Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies

Xixi Wang, Yifei Fan, Qin Wang, Xiaojun Shu, Junyi Lin, Juqing Guo, Zhi Li, Jun Xu

Causal relationships between immune-related adverse events, immune cell characteristics, and plasma metabolites: insights from Mendelian randomization study

  • Open Access
  • Analysis

Zhiyuan Shi, Zhao Sun, Dingding Zhang, Lin Zhao

Machine learning based obesity and aging related signature for predicting the prognosis and immunotherapy benefit in stomach adenocarcinoma

Yongheng Chen, Xiaoxia Yu, Wencan Xu, Anqi Huang, Zhengbing Li

GFOD1 expression in clear cell renal cell carcinoma and its role in cancer cell proliferation, migration, and invasion

Zhi Liu, Kui Wu, Qian Shu, Xin Chen

The effects of coagulation factors on the risk of lung cancer: a Mendelian randomization study

Heran Zhou, Xinye Mao, Junhua Guo, Xuefei Yang, Ting Huang

Ferulic acid as a promising candidate for developing selective and effective anti-cancer therapies

Abdur Rauf, Rahaf Ajaj, Zuneera Akram, Nabia Hafeez, Maksim Rebezov, Mohammad Ali Shariati, Abdullah S. M. Aljohani, Muhammad Imran, Fahad Tanveer, Hassan A. Hemeg, Mohammad S. Mubarak

Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration

Linlin Wang, Ning Shao, Yaoyu Qu, Huizhen Sun, Jin Zhao

Carboxypeptidase Q(CPQ) promotes glioma progression by inducing M2 macrophage polarization and immunosuppression

Zhihao Qi, Rui Hu, Moyang Qi, JianDong Zuo

Screening and validation of long non-coding RNAs associated with colorectal cancer based on random forest and LASSO regression algorithm

Yujia Zhao, Qian Li, Xintong Cui, Zhiyu Zhang, Yong You, Xiaowen Hou, Yan Wang, Xu Feng

Decoding breast cancer heterogeneity: a novel three-gene signature links intratumoral heterogeneity with tumor microenvironment and patient outcomes

Fangfang Zhu

Rosmarinus officinalis suppresses cancer cell viability and inflammatory mediators in RAW 264.7 cells: in vitro and in silico analysis

Hamza Assaggaf, Naoufal El Hachlafi, Nidal Naceiri Mrabti, Mohamed Taibi, Amine Elbouzidi, Ahmed Qasem, Ammar Attar, Fahad M. Alshabrmi, Long Chiau Ming, Said Moshawih, Chrismawan Ardianto, Hanae Naceiri Mrabti, Abdelhakim Bouyahya

Predictive biomarkers in the gut microbiome and metabolome for severe acute radiation enteritis in cervical cancer radiotherapy

Chen-ying Ma, Jing Zhao, Xiao-ting Xu, Xiao-lan He, Song-bing Qin, Ju-ying Zhou

Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024)

  • Open Access
  • Research

Yu Chen, Yuxuan Dai, Xing Wang, Jian Liu

The impact of vascular endothelial growth factor on oral squamous cell carcinoma through dendritic cell induction and facilitation of tumor immune tolerance

  • Open Access
  • Research

Peng Zhang, Yue Xu, Bolei Cai, Jiaqiang Xu, Tao Wang, Hongyan Xu

A T2 weighted imaging-based radiomics nomogram for the classification of hepatic blood-rich lesions: hepatocellular carcinoma and benign liver lesions

Chen Yang, Boburjon Turgunov, Fandong Zhu, Yang Xia, Jianfeng Zhou, Zhenhua Zhao

Development and validation of a prognostic model for efferocytosis-associated genes in cervical squamous cell carcinoma

Lan-lan Ma, Li-juan Zhao, Ying Zhang, Yan-fen Ma, Qi Shang, Xiao-li Liu

Integrating single-cell sequencing analysis, bioinformatics analysis, and Mendelian randomization analysis to explore FABP4 prediction of prognosis and immune microenvironment in patients with lung squamous cell carcinoma

  • Open Access
  • Analysis

Shun Gao, Xia Long, Jiawei Li, Xialin Zhang, Youhua Wang, Sheng Lin

Systematic benchmarking of large Language models in programmed cell death-oriented gastric cancer research: a comparative analysis of DeepSeek‑V3, DeepSeek‑R1, and Claude 3.5

Yuheng Li, Jiaqi Dong, Dongdong Liu, Yuqing Huang, Yan Jiang, Liangchao Chen, Qiming Gong

Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study

Xiaogen Kuang, Bingquan Wu, Dan Hu, Juliet Matsika, Chunliang Cheng, Jiatong Xiao, Zhiyong Cai, Mingyong Li, Jinbo Chen, Weimin Zhou, Bolong Liu

Single nucleotide polymorphism and expression of P16 gene as a potential biomarker for oral and pre-oral cancer

Kumud Nigam, Yogendra Verma, Manish Raj Kulshrestha, Aditi Singh, Somali Sanyal

Construction of prognostic scoring model for ovarian cancer based on deep learning algorithm

Xiaolin Zhong, Hongyang Xiao, Weihong Lu, Jiayuan Chen, Fan Chao, Ruiqin Tu

Immunometabolism signature derived from on-treatment tumor specimens predicts immune checkpoint blockade response in metastatic melanoma

Shuzhao Chen, Shutong Liu, Jiangtao Song, Xiaojin Li, Huaze Liao, Shuiqin Chen, Yuanbin Song, Yun Wang, Yang Liang, Qianqian Huang, Weiran Lv

LncRNA MALAT1 as a prognostic biomarker in endometrial cancer: a molecular genetics approach

Xinlian Liu, JinBao Xiao, Junqi Ma

A decade of scientific advancements and collaborations on CRISPR-Cas9 application in cancer research: a bibliometric review

Elham Anari, Razieh Anari, Hamidreza Pazoki-Toroudi

Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data

Sixten Harborg, Signe Borgquist

Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study

Guicai Liang, Lyubo Wang, Zhiqiang Wang, Tao Li, Lei Jiang, Yuncheng Bai, Lei Yang, Yi Feng, Yan Li, Meng Yang, Jiling Chang, Haiyue Yang, Xilong Zhou, Lincan Duan, Chunlei Ge

Integrated single-cell and bulk RNA sequencing analysis establishes a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in neuroblastoma

Zhiyao Cao, Qi Wang, Yali Han, Jianwei Lin, Qi Wu, Chencheng Xu, Jingchun Lv, Lei Zhang, Hongxiang Gao, Dapeng Jiang

Pan-cancer analysis and validation of NT5DC2: emphasizing its prognostic significance and immunological role in TNBC

Qing Luo, Xiandong Xie, Luyao Tian, Xiaomin Gao, Shu Li, Jinqiu Zhang, Limei Mo, Xue Zhu, Ke Wang, Yongxiang Yin

Diagnostic performance of contrast-enhanced ultrasonography for predicting therapeutic response to radiofrequency ablation in patients with hepatocellular carcinoma: a meta-analysis

Ji Dong, Xin Hu, Lin Li, Fei-Yan Jing, Jin-Jin Chen, Jun Chen

Applications of sonodynamic therapy combined with nanobiotechnology in the treatment of digestive tract tumors

Menghan Gui, Xinmei Zheng, Hexin Fu, Mingming Cang, Haokai Ma, Jingshu He, Dong Tang

Sequential surgery following Yttrium-90 resin microspheres combined with targeted therapy and immunotherapy for primary hepatocellular carcinoma: a case report

Fang-Yuan Hu, Jun Li, Mo-Yan Xiao, Chang-Yong Chen, Ke Ye, Ge-Wen Zhang

OTUB1 promotes colorectal cancer progression by stabilizing GPX4 and inhibiting ferroptosis

Guofeng Lin, Xi Lin, Qihuang Lin, Jianfeng Zhao

Diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in preoperative staging of locoregional urinary bladder cancer: a systematic review and Meta-Analysis

Ahmed Saad Abdlkadir, Dhuha Al-Adhami, Sudqi Allouzi, Mohannad Badarneh, Mohammed Shahait, Marwa Abdulrahman, Saad Ruzzeh, Serin Moghrabi, Akram Al-Ibraheem

A manganese metabolism-related gene signature stratifies prognosis and immunotherapy efficacy in kidney cancer

Yang Liu, Hao Ye, Ruoxuan Zhang, Xiaolong Liu, Ranlu Liu

Comprehensive characterization of NK cell-related genes in cutaneous melanoma identified a novel prognostic signature for predicting the prognosis, immunotherapy, and chemotherapy efficacy

Haili Ma, Jian Liu, Huan Jin, Min Zhang, Qian Liang, Zhiqiang Guo

Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports

Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang

An in-silico pan-cancer bulk and single-cell profiling of transcription factors in protein autoubiquitination

  • Open Access
  • Analysis

Angela Dong, Ayana Rasteh, Panpan Wang, Hengrui Liu

Rhaponticin inhibits the proliferation, migration, and invasion of head and neck squamous cell carcinoma (HNSCC) cells through modulation of the IL6/STAT3 signaling pathway

  • Open Access
  • Research

Hongcheng Wei, Shanshan Wang, Jiayue Wan, Sicheng Li, Wei Wang, Jiajun Zhu, Lin Jiang, Yisen Shao, Yuan Wu

Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer

Hao Yu, Quan Yuan, Liu-Xing Feng, Jia-Huan Xu, Shen-Yuan Zhan, Zhi-min Li, Shuang-Jia Wang

Knowledge mapping of ultrasound technology and triple-negative breast cancer: a visual and bibliometric analysis

Yonglin Wan, Yan Shen, Jun Wang, Tingting Zhang, Xiaohong Fu

Integrated eQTL-pQTL Mendelian randomization and single-cell sequencing reveal therapeutic targets in ovarian clear cell cancer

Yuwen Qi, Yang Gao, Hongbing Cai

Comprehensive pan-cancer analysis of NLRs family as prognostic and immunity markers based on multi-omics data

Xianhui Wen, Miaomiao Cui, Junhua Zhang, Hai Huang

Aberrant DNA hypermethylation-regulated long non-coding RNA RYR3-DT affects ferroptosis and progression of glioma cell through the CoQ10/FSP1 axis

Yang Cui

Clinical characteristics, treatment patterns, and survival outcomes of 1031 patients with peripheral T cell lymphoma in china: a multicenter, real-world study

Ling Huang, Yong Yang, Zhenyu Zhao, Shengsheng Zhou, Jingsong Wu, Ning Wang, Fen Zhang, Keqian Shi, ChengPing Li, Xiaolei Wei, Hongyu Zhang, Yun Lin, Guowei Li, Hui Zhou, Hanguo Guo, Xinmiao Jiang, Xiaojuan Wei, Feili Chen, Sichu Liu, Caidi Lin, Zhanli Liang, Yilan Huang, Lu Pan, Hui Yang, Yirong Jiang, Yudan Wu, Shuqin Cheng, Huifang Yang, Xiaoqiang Zheng, Xinggui Chen, Xiaoliang Li, GuiNian Huang, Jihao Zhou, Zhigang Peng, Li-e Lin, Tingbo Liu, Wenyu Li

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression

Dan Jian, Nana Hu, Rong He, Le He, He Xiao, Xingqiao Peng, Yang Peng, Yuxin Yang, Xiaoyan Dai, Dong Wang, Yan Feng, Nan Dai, Qian Chen

Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland

Ryo Kawaura, Tomohiko Ishikawa, Hirofumi Shibata, Masashi Kuroki, Kazuhiro Kobayashi, Yuki Hanamatsu, Tatsuhiko Miyazaki, Hiroyuki Tomita, Takuma Ishihara, Hajime Usubuchi, Yayoi Aoyama, Yukinori Asada, Takayuki Imai, Akira Ohkoshi, Akira Hara, Yukio Katori, Toru Furukawa, Takenori Ogawa

Single-cell RNA sequencing reveals the potential role of estrogen in tuberous sclerosis complex related renal angiomyolipoma

Yi Liu, Wenda Wang, Guoyang Zheng, Weifeng Xu, Zhan Wang, Xu Wang, Jiang Liu, Dongxu Qiu, Yanan Li, Yang Zhao, Yushi Zhang

Single‑cell RNA sequencing reveals TMEM71 as an immunomodulatory biomarker predicting immune checkpoint blockade response in breast cancer

Boyang Li, Ruonan Lin, Yibo Hua, Binlin Ma, Yi Chen

Selective targeting of the AKT1 (E17K) mutation: advances in precision oncology and therapeutic design

  • Open Access
  • Comment

Xiaoyan Chen, Danfeng Zhang, Jiapeng Xue, Zhi Li

The role of JPT1 in hepatocellular carcinoma: tumor progression, microtubule dynamics regulation, and potential mechanisms within the immune microenvironment

Yipin Lu, Peng Xu, Sha Li, Jie Yao

Clinical value of the worst pattern of invasion in predicting extranodal extension in oral squamous cell carcinoma

Mirai Higaki, Toshinori Ando, Fumitaka Obayashi, Nanako Ito, Suguru Hirota, Atsuko Hamada, Sachiko Yamasaki, Tomoaki Shintani, Koichi Koizumi, Souichi Yanamoto

Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma

  • Open Access
  • Research

Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang

Integrative analysis of cholesterol homeostasis reveals prognostic subtypes and immune features in clear cell renal cell carcinoma

Jian Zhu, Minghao Deng, Weizhuo Wang, Aijin Peng, Anli Zhu, Rongchao Yang, Zhenhua Jin, Dong Zhang, Xi Zhang

The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors

Xianghong Wang, Xian Yang, Ruxin Wang, Chuanchuan Sun, Hongyun Lu

Simultaneous medullary thyroid carcinoma and primary non-small cell lung cancer: case report and literature review

Zhang Jianyong, An Xiaoxiao, Zheng Yu, Peng Yunsong

Knowledge mapping of micro/nanomotors in cancer treatment: a bibliometric analysis (2006–2025)

  • Open Access
  • Research

Ying Song, Kai Zhao, Yan Yang, Haiming Yu

mRNA vaccines and SiRNAs targeting cancer immunotherapy: challenges and opportunities

Zhen Lv, Yuheng Dai

Mendelian randomization analysis of immune cell populations, serum metabolites and hepatocellular carcinoma risk

Wei Shen, Yuanying Zeng

Bibliometric and visualized analysis of mitophagy in liver cancer from 1998 to 2024

Shanshan Gong, Yuchang Fei

Exploring the causal relationship between obesity, immune cell characteristics and cervical cancer risk using Mendelian randomization

HongYin Cui, Jingjing Zhang, Xiaolin Lang, Changchang Huang, SongQing Yang

Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner

Hong Hu, Yishuai Huang, Jiafeng Li, Ruijie Liu, Honglei Li, Meng Cai, Hao Chen, Ning Wang, Shuo Yang, Kaikai Wang, Lei Teng, Huailei Liu

p53/PD-L1 co-expression predicts poor prognosis in diffuse large B-cell lymphoma

Yaoyao Jing, Ying Yuan, Yong Yu, Haifeng Zhao, Hongliang Yang, Xiaofang Wang

Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy

Haodong He

Efficacy analysis of endostar combined with chemoradiotherapy and immune checkpoint inhibitors in locally advanced non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Bo Li, Yaocheng Yang, Lina Dong, Dunmin Zhuang, Shixiang Pan, Haijun Lu

Demographic and clinical predictors of treatment outcomes in invasive lobular carcinoma breast cancer: insights from Cox regression analysis

Sonia Kaindal, B. Venkataramana

Characterization and treatment of brain metastases from pancreatic cancer: a systematic review

Yuanchi Ma, Hairong He, Boyang Li, Weiqi Lyu, Weikun Qian, Liang Han, Zheng Wang, Kongyuan Wei

Advancing understanding of autoimmune diseases and lung cancer: trends, themes, and future directions

Hao-Han Rao, Wan-Chen Xie, Feng Guo, Huan-Wen Chen

A review on mesenchymal stem cells and their secretome in hepatocellular carcinogenesis and its related signaling pathways: recent update

Jayenth Jayachandran, A. T. Rithi, Abhijit Mitra, Arunkumar Radhakrishnan, Antara Banerjee, Asim K. Duttaroy

Nicotine and tar-multiple targets synergize to alter the immune micro-environment to induce prostate cancer

Lianlin Zeng, Yajie He, Fei Huang, Xiaoqian Jiang, Yang-An Li, Kehui Hu

Multi-omics analysis of the effects of pla2g4a on the prognosis of various cancers and its experimental validation in breast cancer cell lines

Yao Qian, Quan Yuan, Hao Yu, Rongjie Ye, Ming Niu, Feng Liu

Incidence of pulmonary embolism and its risk factors in lung cancer patients: a systematic review and meta-analysis

Chunhong Chen, Ying He, Dongmei Zheng, Chen Chen, Daiying Zhang

Clinical characteristics of duodenal-type follicular lymphoma

Lu Wang, Wenyan Shen, Xiaoyuan Zhang, Ling Xue, Beili Hu

Tumor-secreted RGS17 impairs CD8 + T cell function in lung adenocarcinoma through affecting glucose metabolism mediated by PI3K/AKT pathway

  • Open Access
  • Research

Ming Lou, Ji-Chun Tong, Qi-Yong Wu, Zheng Zhu, Xiao-Liang Mao, Jia-Wei Lu

Progress in the application research of cervical cancer screening developed by artificial intelligence in large populations

Wenxin Liao, Xiaoyan Xu

Targeting WEE1 and asciminib suppresses ABL-tyrosine kinase inhibitor-resistant chronic myeloid leukemia cells

Seiichi Okabe, Mitsuru Moriyama, Akihiko Gotoh, Daigo Akahane

Identification of disulfidptosis-related prognostic biomarkers associated with CD4 + and CD8 + T cells infiltration for sarcoma by integrating bioinformatic analysis and experimental validation

Wenliang Tan, Xi Zhou, Ting Wang, Shuanghua Wu, Ting Mo, Zhiqin Xie, Yang Xie

Machine learning assists regulated cell death crucial biomarker selection in adenocarcinoma of the lung: biological data testing and cell assay determination

Han Ning, Ying Jiang, Mengli Zheng, Gao Yang, Lianjun Ma, Yachao Zhao

An extremely rare case of thymic carcinoma manifesting as a liver metastasis: a case report and literature review

Ikhwan Rinaldi, Muhammad Alifian Remifta Putra, Farida Farah Adibah, Marcello Mikhael Kadharusman, Hanna Farida Rachmat, Mohammad Reynalzi Yugo, Ening Krisnuhoni Sudarmodjo, Lisnawati Rachmadi

Gallbladder metastasis in invasive ductal breast cancer with concurrent gallstones and gallbladder carcinoma

Rujuan Wang, Feng Zhao, Tao Yan, Yongtian Li, Danqing Cheng, Wenping Wang, Chongyue Tian, Hao Yu

Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics

Prashant Chauhan, Pratibha Pandey, Ajay Singh, Sujayaraj Samuel Jayakumar, Sorabh Lakhanpal, Meenakshi Verma, Vijay Jagdish Upadhye, Fahad Khan

Identification of a novel ferroptosis-induced immunogenic cell death related signature based on a machine learning framework in colorectal cancer

Feng Zhu, Xin Liu, Huiyuan Li, Jianfeng Li, Hongzhang Liu, Yusheng Wang

Causal impact of air pollution on head and neck cancer: a Mendelian randomization study

Dong-ling Huang, Bing-shuang Zhao, Hao Wu, Shu-zheng Wang, Hao-sheng Ni

Leveraging machine learning models to evaluate immune infiltration in the ovarian cancer microenvironment: a single-cell analysis approach

Jie Liu, Baoguo Xia, Bingxin Li, Hui Liang

O-prenylchalcones inhibit cell proliferation and activate apoptosis by inducing mitochondrial dysfunction in gastric cancer cells

José C. Espinoza-Hicks, Yarely M. Salinas-Vera, Javier Camarillo-Cisneros, Alejandro A. Camacho-Dávila, Jessica L. Hernández-Rivera, Nadia Flores-Huerta, Eloisa Ibarra-Sierra, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Ángeles C. Tecalco-Cruz, César López-Camarillo

Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo

Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Fumiya Harada, Dedy Ariwansa, Sarita Giri, Jun Sato, Hiroki Nagayasu, Yoshihiro Abiko

Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration

Mian Lv, Huiling Wang, Guanqing Feng, Qingxiao Nong, Shouwen Tao, Yanfei Ma, Dalang Fang

Impact of Nintedanib on tumor angiogenesis and vascular normalization in a mouse model of colorectal cancer

Naita M. Wirsik, Jens M. Seeger, Thomas Schmidt, Frank Hilberg, Hans F. Fuchs, Christiane J. Bruns, Oliver Coutelle, Hamid Kashkar, Lars M. Schiffmann

Cellular senescence and disulfide death-related genes as biological markers of breast cancer prognosis

Yidan Zhang, Yan Ye, Jing Wang, Jintao Liu

Somatostatin receptor expression in multiple hemangiomas

Benjin Liu, Shangjian Li, Yisi Xu, Xuqi Huang, Xudong Guo, Hanbo Wang, Shaobo Jiang

Identification of a novel ferroptosis-related gene signature in hepatocellular carcinoma: clinical significance, tumor microenvironment, drug sensitivity, and gene landscape analysis

Yunzhao Hu, Chenchen Hao, Chengyuan Dong, Ping Tao, Jia Wang, Qun Lu

Radiation-induced acute pericarditis after palliative spine radiation in a non-small cell lung cancer patient on osimertinib: a case report

Chomkwan Decha-umphai, Thitiwan Prachanukul, Nanthida Phattraprayoon, Teerapat Ungtrakul

Serum carnitine and cancer risk: a Mendelian randomization study identifying pancreatic cancer as a modifiable metabolic target

Xiaoqing Zhou, Yujie Zhou, Yingnan Xu, Zhen Wang, Xin Lv

Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses

Zilong Bai, Jiale Liang, Yuanhua Nie, Shilong Wang, Dongmin Chang

Relationship between the effectiveness of pembrolizumab monotherapy and ABO blood type in recurrent and metastatic squamous cell carcinoma of the head and neck

Shogen Boku, Tatsuki Ikoma, Tomoyo Yasuda, Nobuhiro Shibata, Tomofumi Sakagami, Kensuke Suzuki, Takuo Fujisawa, Hiroshi Iwai, Masashi Kanai

Tislelizumab-induced anaphylactic shock: a case report

Haiyu Niu, Feixue Song, Xiaochun Zhou, Qingfang Lv, Qiaoying Jin, Yating Liu, Luxi Yang, Benxin Luo, Hanwen Wei

The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study

Xun Zhang, Hailang Zhou, Qianqian Meng, Weiyi Wang, Lu Zhou, Ying Xu, Haiqin Zhang, Zixu Zhang, Jinnian Cheng, Xiaopeng Zhan, Ji Li, Changping Hu, Fengli Zhou, Daming Yang, Luowei Wang, Yimin Chu, Haixia Peng

Exploring the role of PANoptosis related genes in the prognosis of oral squamous cell carcinoma subtypes based on multi-omics analysis

  • Open Access
  • Research

Yang Liu, Lingdu Wen, Lijuan Yan, Zifeng Cui

SLC3A2 as a key anoikis−related gene for prognosis and tumor microenvironment remodeling in melanoma

Xiaojin Liu, Jiaheng Xie, Yingying Xiao

The state of cancer research and its association with the cancer burden in Ecuador: a bibliometric study

Santiago D. Padilla-Sánchez, Isabel Espinosa, Ivan Sisa

Zwilch kinetochore protein affects the prognosis of cancer patients by participating in cell proliferation, enhancing cell communication, and reshaping the tumor microenvironment

  • Open Access
  • Analysis

Long Yao, Lianpo Liu, Jinsong Wu, Yunlong Huang, Renquan Zhang, Haoxue Zhang

Exploring the potential value of SRC in pan cancer based on bioinformatics methods

  • Open Access
  • Analysis

Liyin Huang, Yanwen Lu, Lei Yi, Yuxin Zhao, Tao Si, Mingmin Zhang

SPDL1 overexpression was associated with poor prognosis and immune status in HCC through in vitro experiment and bioinformatics analysis

Ying-Ming Xu, Bo-Hua You, Ming Chen, Tian-Ping Xiong, Lin Shi, Qin Wei, Zhong-An Wang

Exploring the role of hepsin in prostate cancer: bioinformatics, molecular Docking and molecular dynamics simulations

Hongying Peng, Dan Du, Zhonggui Hu, Zhiliang Xia

Nomogram predicting overall survival in hospitalized cervical cancer patients in Mato Grosso, Brazil

Sancho Pedro Xavier, Audêncio Victor, Noemi Dreyer Galvão, Ageo Mario Cândido da Silva

Development and validation of a prognostic nomogram for gastric GIST patients under 65 years of age

Yifan Cheng, Shuyang Gao, Zhen Tian, Shuai Zhao, Ruiqi Li, Jiajie Zhou, Yayan Fu, Qiannan Sun, Daorong Wang

Molecular classification and construction of the risk signature for diffuse large B-cell lymphoma based on vitamin B6 metabolism

Wen Wei, Dao Xin, Huawei Weng, Le Yu, Lingxi Jiang, Yuxin Man

IPSS-M outperforms IPSS-R in prognostic stratification and guides effective interventions for very High-Risk myelodysplastic syndrome patients undergoing allogeneic hematopoietic stem cell transplantation

Huixian Wu, Shuang Li, Jun Yang, Yu Cai, Huiying Qiu, Chongmei Huang, Yin Tong, Kun Zhou, Jiahua Niu, Xinxin Xia, Ying Zhang, Xiaowei Xu, Chang Shen, Baoxia Dong, Liping Wan, Xianmin Song

PGLS as an immune and prognostic biomarker: from pan-cancer analysis to validation

  • Open Access
  • Research

Shiqiong Lei, Shaobo Hu, Weimin Wang

Hypoxia- and lactate metabolism-associated prognostic and therapeutic signature in pancreatic cancer

Chen-Hui Zhang, An-Qi Huang, Cang-Chang Shi, Zhi-Jia Jiang, Hao Yao, Jin-Jin Sun

Mechanism of crosstalk between Helicobacter pylori and immune stromal cells in the development and occurrence of gastric cancer

Yang Wu, Runbing Zhang, Tian Li, Jiucong Zhang, Xiaohui Yu, Xiaofeng Zheng

Disease burden and trends of bladder cancer in the world and BRICS from 1990 to 2021 and its projection until 2036: analysis based on the global burden of disease study 2021

Yipei Zhang, Huize Zhang, Yan Li, Xiaolan Ma, Hong Tan, Jinghui Gao, Li Li, Ping Yan

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis

Fuchuan Xie, Jian Song, Yunming Tian, Xinyu Zhang, Tanhuan Chen, Meng Xu

Development and validation of a prognostic model for predicting survival and immunotherapy benefits in melanoma based on metabolism-relevant genes

Xiaoru Pan, Shiyao Zhou, Ning Mao, Fengming Yao, Yajun Guo, Wenming Zhou, Shengxiu Liu

Efficacy of astragalus polysaccharides (PG2) in alleviating chemotherapy-induced fatigue in gynecologic cancer: a retrospective cohort study

Chia-Ching Chang, Yi-Liang Lee, Chih-Hsiang Yin, Cheng-Chang Chang, Yi-Hsin Lin

Genetic determinants of head and neck cancer: exploring causality among immune cells and plasma metabolites through two-sample Mendelian randomization and mediation analysis

  • Open Access
  • Analysis

Yuting Lu, Xiangnan Du, Hanlin Liu, Qing He, Xiaolin Cao

Integrative genomic analysis identifies novel causal genes of Hodgkin’s and non-Hodgkin’s lymphoma

Patrick Shi, Ancha Baranova, Hongbao Cao

Integrating bulk and single-cell RNA sequencing reveals intratumor heterogeneity phenotypes and immune infiltration in pancreatic cancer

Li Zhao, Yao Huang, Jiang Li, Rui Xie, Kaiming Li

Machine learning modeling and analysis of prognostic hub genes in cervical adenocarcinoma: a multi target therapy for enhancement in immunosurveillance

  • Open Access
  • Analysis

Madiha Jabeen Abbasi, Rashid Abbasi, ShuPeng Wu, Md Belal Bin Heyat, Ding Xianfeng, Huijie Jia, Aiwen Zheng

Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis

Lina You, WuKui Huang, ShuYing Chen

Nodal metastasis in surgically treated sinonasal squamous cell carcinoma

Jacob E. Hoerter, Si Hao Tang, Jacob G. Eide, Mandy K. Salmon, Ryan M. Carey, Aman Prasad, Jason A. Brant, James N. Palmer, Nithin D. Adappa, Rijul S. Kshirsagar

Causal association between modifiable risk factors and esophageal cancer: A Mendelian randomization study

Xiaoqing Wang, Weiguang Zhang, Tianxin Lin, Renyan Mao, Ye Lin, Jingchuan Yu, Limin Ruan, Jihong Lin, Lei Gao, Peipei Zhang, Zhimin Shen, Mingqiang Kang

Pathological omics prediction of early and advanced colon cancer based on artificial intelligence model

Zhe Wang, Yang Wu, Yingjie Li, Qingwen Wang, Hongfei Yi, Hongyan Shi, Xinyue Sun, Chengxiang Liu, Kuanyu Wang

Dexamethasone, celecoxib, and simvastatin-induced 5-fluorouracil resistance in cancer cells: a possible role of lipid droplet accumulation

Duaa S. Sabbah, Balqis A. Ikhmais, Qasem M. Abdallah, Roger M. Phillips, Nidal A. Qinna

GALNT6 associated with O-GlcNAcylation contributes to the tumorigenesis of oral squamous cell carcinoma

  • Open Access
  • Research

Junfeng Yan, Xuan Tang, Yingying Zhou, Xin Xiong

A machine learning-based screening model for the early detection of prostate cancer developed using serum microRNA data from a mixed cohort of 8,741 participants

Cong Lai, Zhensheng Hu, Zhuohang Li, Zhikai Wu, Kuiqing Li, Lin Li, Hongze Liu, Juanyi Shi, Yi Zhou, Kewei Xu, Cheng Liu

The role of long noncoding RNA SNHG29 in malignant tumors

Tingcheng Bu, Wendong Gu, Yingjie Shao

Pan-cancer analysis and experimental validation revealed the prognostic role of ZNF83 in renal and lung cancer cohorts

Peipei Wu, Yu Lin, Fang Dai, Huming Wang, Hantao Wen, Zihan Xu, Gengyun Sun, Zhaojie Lyu

Altered glycosylation of EVs in cancers: galectin-3-binding protein (LGALS3BP)

Jie-Yi Koh Kok, Bey-Hing Goh, Wai-Leng Lee

Evaluating the efficacy of mind maps and micro-videos in postoperative care education for lung cancer patients

Liang Feng, Wenjun Shen, Chen Zhang, Dandan Liu, Shunyi Huang, Xiaoxin Liu

In silico analysis of the oncogenic role of myoferlin (MYOF) and suggestion of folate as a potential therapeutic for brain cancer in the Caucasian population

Saanvi Muthuchetty

Comparison of differences in hematogenous metastasis among cervical cancer patients by CT-guided three-tube intracavitary brachytherapy and hybrid intracavitary and interstitial brachytherapy

Bo Yang, Yinping Hu, Shuhui Yu, Chunfang Zhao, Zhongyan Dou, Lan Li, Kangming Li, Meiping Jiang, Lan Zhang, Xingrao Wu

A rare case of HER2-positive pure metaplastic squamous cell carcinoma of the breast

Lingping Xie, Tianhai Du, Chao Wang

Calcium ion-binding genes can predict tumor mutation burden and immune checkpoint blockade response in a pan-cancer model

Wan-Yu Lin, Chien-Jung Huang, Yu-Chao Wang

Correlation between CTMP expression levels and resistance to trastuzumab in HER2 + metastatic breast cancer

Mania Makhoul, Maher Saifo, Fariz Ahmad, Jumana Saleh

Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study

Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

Risk factors and prognostic analysis of endometrial cancer with para-aortic lymph node metastasis

Feng Cheng, Li Yang, Qiang Wen, Jianying Xu, Feng Shao

Evolution of glioma exosome research: emerging trends and global collaborations (2005–2025)

Yijun Zeng, Ting Liu, Shixue Jing, Yongfeng Wang, Jihong He, Hui Cao, Xinlian Liu, Lushun Zhang

Advances in the treatment of malignant tumors with neurological drugs

Yongnian Li, Jintong Na, Liping Zhong, Yongxiang Zhao

Mapping the landscape of locally advanced colon cancer research: a 30-year bibliometric perspective

Yanwu Sun, Zhiping Chen, Zihan Tang, Zhenyu Xu, Hongfeng Pan, Pan Chi, Ying Huang

Natural killer cell therapy in hepatocellular carcinoma: a comprehensive review

Shirin Tavakoli, Maryam Samareh-Salavati, Mahshid Akhavan Rahnama, Shahrokh Abdolahi, Ali Hassanzadeh, Zeinab Ghazvinian, Javad Verdi, Nasim Vousooghi, Saba Manoochehrabadi, Bahram Chahardouli, Maryam Barkhordar, Iman Seyhoun, Mohammad Ahmadvand

Small nuclear ribonucleoprotein polypeptide B2 regulated by SNHG4/miR-204-5p axis inhibits ferroptosis to aggravate the progression of hepatocellular carcinoma

Jiaxing Guo, Lingshu Li, Haiyan Wang, Zhenqin Gao, Chanjuan Shen, Bokang Yan

GPC3: a novel mutated gene in pleuropulmonary blastoma

Jiahang Zeng, Xinying Wang, Yingyi Xu, Qinglin Yang, Junzheng Peng, Fenghua Wang, Jue Tang, Dongmei Huang, Jiachi Liao, Yunyu He, Lin Huang, Jianhua Liang, Le Li, Zefeng Lin

Correction: Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015–2024)

  • Open Access
  • Correction

Huihui Zhang, Ying Shen, Peijian Bai, Xiaorui Wu, Ping Li, Ting Wang

UNC93B1: a novel immune−related prognostic biomarker in breast cancer

Lv Tian, Huifang Zeng, Lin Tian, Huijing Wang, Wei Liu

Expression and prognostic value of SEC13 across multiple tumour types and its association with the regulation by Pulsatilla chinensis: a multi-omics and Mendelian Randomization Study

Huaqing Leng, Xin Luan, Ming Li

High expression of DGKA indicates poor overall survival of nasopharyngeal carcinoma

Hao Chen, Runduan Lin, Qi Yuan, Xiaohang Gao, Lin Zhang, Rong Zhang

Unveiling the predictive role of systemic inflammation marker in mortality outcomes: a nationwide analysis of cancer survivorship in the United States

  • Open Access
  • Analysis

Angshu Cai, Bowen Zha, Chen Zhang, Shuying Guo, Guiqi Wang, Shun He

miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review

Shazia Fathima Jaffer Hussain, Mohammad Fareed, Mohmed Isaqali Karobari

The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy

Yanlin Jiang, Yi Fu, Xinyan Song, Yongjie Xie, Xiaobin Shang, Xi Liang

Global trends in sarcopenia and cancer over the past 10 years: a bibliometric analysis

Ruoshuang Liu, Menghuan Wu, Xia Cheng, Chundi Zhou, Caiqin Cheng, Lijun Feng, Yirong Shen

Cross-tissue transcriptome-wide analysis reveals novel insights into thyroid cancer etiology

Yue Zhu, Yu Luo, Yuye Zhang, Yixuan Wang, Zhangqi Gu, Jinyan Liu, Ancheng Qin, Weifeng Qian

Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD

  • Open Access
  • Research

Shengping Min, Linfeng Pan, Xinyu Zhang, Huili Chen, Lixuan Qiu, Xinyu Wang, Yiluo Xie, Kai Zhang, Qiang Zhang, Chaoqun Lian, Jing Zhang

Therapeutic effect of Chelidonium majus hydro-alcoholic extract alone and in combination with oxaliplatin on ovarian cancer cell line

Zahra Hashempour, Mehdi Noraddini, Majid Nejati, Ameneh Jafari, Mahdi Rafiyan, Amirreza Ostadian, Behrang Alani, Hamed Mirzaei

Recent advances on the role of G0S2

Xin Hua Zhao, Liqin Ruan

Organizing pneumonia in ALK+ non-small cell lung cancer treated with ceritinib: a case report

Xiao Lin, Mengyao Xie, Dandan Ma, Dandan Zheng, Jingjing Liu, Jinyan Ye, Lehe Yang, Yao Lu

Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis

  • Open Access
  • Analysis

Pengjian Zhang, Weizhang Chen, Kai Chen, Yuanhang Ye, Weijun Wu

Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets

  • Open Access
  • NSCLC
  • Review

Mohammadamin Joulani, Nahal Aghajamal, Masoumeh Nouri, Faraz Rahmani Khajeh, Nafiseh Sharifi, Dena Saghafi, Mahan Amiri, Ali Abdollahzadeh, Ehsan Heidari, Amin Mirdamadian, Malihe Sharafi, Samira Masoumi, Reza Morovatshoar, Alireza Azani, Qumars Behfar

Predictive and prognostic value of inflammatory factors (IL-6, IL-8, and TNF-α) in saliva for radiotherapy response in patients with HPV-associated oropharyngeal squamous cell carcinoma

Li Tan, WenJuan Liu, QiChen Sun, Yan Shi

Systemic strategies for osteosarcoma: advances and future directions

Vivek Kumar Morya, Anuja Gajanan Magar, Sin-Hye Park, Kyu-Cheol Noh

A case report of adenoid cystic carcinoma combined with giant renal metastasis treated with robotic surgery

Yongrui Zhang, Shuxin Li, Yueqiu Zhang, Fulin Wang, Tong Yang, Wei Wei

Precision prognostic model for uveal melanoma: nomogram prediction and comparison with AJCC system

Wentao Wu, Jingjing Zhu, Yuzhu Wu, Daning Li, Rong Liu, Yuchen Zheng, Qiuqiong Deng, Yiqiang Yuan

Associations between circulating metabolites and pca: a bidirectional two-sample Mendelian randomization study

Jing Lv, Yonghong Deng

Liraglutide inhibits the development of colorectal cancer by regulating TGF-β/Smad3 signaling pathway and affecting epithelial-mesenchymal transition

Xinjian Li, Minghu Fan, Rong Huang, Keqiang Wang, Hunan Huang

Regulation of GLI2 by LINC02560 and its role in hepatocellular carcinoma

Yunmei Huang, Zhang Qingyun, Chunying Luo

Expression characteristics and biological significance of exosome-related genes in lung cancer

Qixiang Zhong, Yujie Zhao

Genetic evidence for causal relationships between vegetarian biomarkers and esophageal cancer risk

Xinqi Liu, Xu Xu, Zhenglong Jiang, Ning Du, Jiayang Chen, Jinyuan Chang, Lixing Liu, Li Feng

Evaluation of human papillomavirus as a risk factor in prostate cancer pathogenesis

Richard Maliye, Shari Babu, Anna E. Harris, Rodhan Patke, Atara I. Ntekim, Catrin S. Rutland, Victoria James, Nigel P. Mongan, Srinivasan Madhusudan, Jennie N. Jeyapalan, Musalwa Muyangwa Semenova

Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization

Shi Li, Kaijiong Zhang, Guiji Zhang, Min Shi, Xing Yin, Bo Wang

Mediating factors between autoimmune thyroiditis and breast cancer: a bidirectional Mendelian randomization study

Pei Xin, Lei Wang, Xianyang Chen, Huazhi Li, Nan Jiang

Ten-year outcomes of IMRT with chemotherapy versus IMRT alone for stage II–IVa nasopharyngeal carcinoma: a retrospective study

Xiao-li Wang, Da-qing Sun, Hui Yang, Yang Li, Xiu-feng Li, Xiao-long Chang, Xiang-di Meng, Ya-nan Zhang, Yun-xiang Zhang, Fu-rong Hao, Jian-wen Li

C20orf27 promotes hepatocellular carcinoma progression via NT5E

Yu He, Wen Zhang, Ming Chang, Yuanjie Chen, Risheng Lin, Xinyu Ye, Wei Mao, Yubin Lu, Yi Lu, Erbao Chen

Research trends between acquired immune deficiency syndrome and hematological malignancies: a bibliometric analysis

Qiwen Zhou, Hao Sun, Shanshan Fan, Lan Luo, Jianhua Ji, Zejiao Jiang, Haiyan Min

Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation

  • Open Access
  • Research

Tim Lange, Alexandra Renko, Ulrike Flierl, Felix B. Ademmer, Johann Bauersachs, Hans Christiansen, Jochen Tillmanns

A review of synergistic strategies in cancer therapy: resveratrol-loaded hydrogels for targeted and multimodal treatment

Yang Fu, Yuanxin Ge, Shixiong Yi, Qifeng Peng, Heng Jiang, Jie Zhou

The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer

Jiayi Wang, Jiayao Ma, Shiying Lei, Yulei Zhai, Yangjie Liao, Chongrong Hu, Jingbo Li

Global burden of liver cancer attributable to drug use: trends from 1990 to 2021 and projections to 2040

  • Open Access
  • Analysis

Cong Chen, Ying Zhou, Weiwei Gu, Zhuxin Gu, Pengfei Jia, Luyi Si, Suming Zhao, Hui Zhao

Disulfidptosis-related LncRNA signatures in gastric cancer: regulation of MYH10-driven cytoskeletal remodeling and therapeutic implications

Jing Yu, Longkuan Yin, Min Li, Qian Li, Xiangzhi Qin, Long Qin, Yunhong Tian

Yttrium90-TARE with or without chemotherapy may improve survival in patients with locally advanced unresectable intrahepatic cholangiocarcinoma

Esteban Garita, Ammar Sarwar, Mohid Tahir, Santiago Sucre, Juan J. Juarez-Vignon Whaley, Mary L. Peters, Andrea J. Bullock

The role of LAMA5 in breast cancer progression and its potential in immunotherapy

Xiaoli Zhang, Hongfang Yan, Lihan Bie, Zheng Xu, Xiaoyang Yao, Zhilan Li, Chengshan He, Zhouhong Xiang, Xiudi Jiang

Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer

Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia

Sathyanarayan Balaji, Suvitha Anbarasu, Sudha Ramaiah, Anand Anbarasu

Expression of interleukin 1-alpha, interleukin 6 and CD 10 in predicting recurrence of ameloblastoma

Nurhazwani Mohd Danil, Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena, Yet Ching Goh, Wanninayake Mudiyanselage Tilakaratne

A 23-gene multi-omics signature predicts prognosis and treatment response in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Analysis

Yinxu Zhang, Siwang Wang, Xiaoyang Chen, Guangyu Zhang, Yuxi Wang, Xiaomei Liu

Advances in radiotherapy for mouth neoplasms: emerging technologies and future perspectives

Xuhong Liu, Zhuoya Zhang, Xinyu Deng, Zekun Lang, Jianrong Wang

A phase separation-related gene signature for prognosis prediction and immunotherapy response evaluation in gastric cancer with targeted natural compound discovery

Yanjuan Jia, Yuanyuan Ma, Zhenhao Li, Wenze Zhang, Rukun Lu, Wanxia Wang, Chaojun Wei, Chunyan Wei, Yonghong Li, Xiaoling Gao, Tao Qu

RNF213 governs divergent tumor-immune dynamics across human cancers: a prognostic biomarker for immunotherapy stratification

Jinpeng Wen, Zhekuan Lv, Mojiao Lu, Chuanming Zheng, Changtian Yin

Application of ultrasound in liver cancer from 2014 to 2024: bibliometric analysis and global trends

  • Open Access
  • Research

Yaping Zhu, Yanyan Lu, Xinju Chen

Mucinous carcinoma of the breast: epidemiological, clinical, and prognostic characteristics; a single-center experience

Omar Hamdy, Mosab Shetiwy, Mahmoud M. Saber, Basma A. Eldawody, Shorouq A. Kassab, Mariam H. Nabih, Mostafa Abdelhakiem, Mona Zaki, Shaimaa M. Yussif, Saleh Saleh, Khaled Abdelwahab

Identification of cell adhesion related signature for molecular subtyping and prognostic prediction in acute myeloid leukemia

Caifang Zhao, Xiang Weng, Wei He

Sirtuin family in lung adenocarcinoma

  • Open Access
  • Review

Cui Chen, Xiumin Liu, Zhe Xu, Juan Xu, Lei Gong, Xiaobo Wang

Integrating molecular docking and network pharmacology to reveal the molecular mechanisms of Anemarrhena asphodeloides in the treatment of non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Xianshun Xie, Yiling Jiang, Sumei Liu, Changjun Xie

Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking

Yingqiang Fu, Yiyang Liu, Ziqi Sui

Identification of key targets and exploration of therapeutic molecular mechanisms of natural compound tangeretin in osteosarcoma

Ruoping Yanzhang, Zhaojie Yang, Xiangping Li, Yin Yu, Ruifang Shen, Huijun Zhang, Ying Wu, Junyan Teng

Application of Mendelian randomization and bioinformatic analysis to construct a prognostic model for thyroid cancer and perform pan-cancer analysis

Zhenrun Zhan, Zhiyan Weng, Ke Zheng, Jiebin Lin, Sunjie Yan, Ximei Shen

Shared blood gene signature in lung adenocarcinoma and microbial lung infections: a bioinformatic analysis and in silico validation

Milad Sheervalilou, Mostafa Ghanei, Masoud Arabfard

The network map of mucin 1 mediated signaling in cancer progression and immune modulation

  • Open Access
  • Analysis

Akhina Palollathil, Shobha Dagamajalu, Mukhtar Ahmed, Manavalan Vijayakumar, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju

Hypoxia-mediated HES4 promotes the proliferation and motility of hepatocellular carcinoma cell by enhancing COL4A2 transcription

Pingping Zhao, Hong Xu

Targeted therapy for Wilms tumor: a bibliometric study of worldwide scientific activity and collaborative networks

Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang, Xiaohui Wang

The role of mitochondria-related genes in hepatocellular carcinoma prognosis: construction of prognostic models based on machine learning

Fei Gao, Fei Teng, Yuxiang Wan, Qiaoli Zhang, Jinchang Huang

Notch1 and CyclinD1 expression and significance in jaw ameloblastoma: an immunohistochemical analysis

Baoyinbatu Gabiyatu, Wenchao Li, Rihan Wu, Yuan Tian, Senhao Li, Sarnai Tsagaankhuu, Li-dao Bao, Damdindorj Boldbaatar

FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer

Yan Li, Chi Zhang, Jian Chen, Gang Tu, Lingfeng Tang

Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions

Yong Zhang, Wanling Zheng, Rufei Dai, Tianyi Ma, Zonghan Li, Jicheng Li, Jiawei Shen

Deciphering hypoxia’s role in hepatocellular carcinoma prognosis with single-cell approaches

Jun Liang, Di Chen, Huiyu Liang

Association and interaction network analysis of immune cell subgroups in cervical cancer microenvironment based on Mendelian randomization

Yan Cai, Nanxing Jiang, Yan Wang, Min Ji, Wenzhe Shen, Qiming Wang

Bridging molecular insights and clinical application: non-coding RNAs, targeted drug delivery, and metastatic breast cancer therapy

Sohini Chakraborty, Satarupa Banerjee

Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis

Xinping Huang, Hailong Shu, Man Xu, Weixiao Ke, Wanting Chen, Wenbin Huang, Hai Wang, Yifan Zhu, Yongxia Yang

A case of advanced NUTc of the nasal cavity: case report and review of the literature

  • Open Access
  • Case Report

Ningping Xiao, Cheng Lin, Tingjie Yu, Feng Bi, Pingping Tan, Jiahui Tan, Rong Zhang, Fan Lou, Xiaoxue Xie, Zi Xu, Jingru Yang, Hekun Jin, Pei Yang, Yi Jin

Alcohol-related disorders are associated with short-term outcomes in lung cancer patients undergoing VATS lobectomy: a 5-year retrospective analysis

Shanshan Wu, Xianying Zhu, Kangming Pan, Weibin Wu, Yue Chen, Xiaoying He, Hai Li, Hongyu Guan

Metastatic neuroendocrine carcinoma in inguinal region complicated with membranous nephropathy: a case report

  • Open Access
  • Case Report

Xinyun Qiang, Jieyu Lu, Mujie Ye, Ruitong Xu, Qiyun Tang

Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma

Fei Bai, Kexin Zhai, Tiantian Yao, Yuxia Zhou, Yongxiang Zhao, Guanghui Yang

BRD8 inhibits colorectal cancer progression through TGF-β1-mediated tumor-associated macrophage recruitment

Liang Xu, Yejia Mo, Bingqi Yu, Sunfu Fan

TIGAR inhibits glucose-metabolism and cisplatin-chemosensitivity in human lung cancer cells

Yang Feng, Yiling Meng, Meichao Zhang, Yingxia Ying, Yuan Yao, Dong Li

Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization

XueLian Chen, JianRong Zeng, FengYun Cao, Jun Cai, Xin Ma, ChangYu Pu

Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma

An Wang, Yun-ye Mao, Tao Li, Xin Zhou, Yi-bing Bai, Jia-pei Qin, Yi Dong, Ting Wang, Tong Zhang, Zhi-qiang Ma, Yi Hu

MED8 is related to tumor immunity and has predictive value in the prognosis and treatment of glioma

Jingyi Yang, Bin Li, Xinghai Zhang, Yufeng Li, Hao Yuan

Artificial intelligence-driven pathomics in hepatocellular carcinoma: current developments, challenges and perspectives

Wei Ding, Jinxing Zhang, Zhicheng Jin, Hongjin Hua, Qingquan Zu, Shudong Yang, Weidong Wang, Sheng Liu, Haifeng Zhou, Haibin Shi

Interplay between innate-like T-cells and microRNAs in cancer immunity

  • Open Access
  • Review

Mohammad Javad Yousefi, Yashmin Afshar, Amirmohammad Amoozadehsamakoosh, Alma Naseri, Fereshteh Soltani, Niloufar Yazdanpanah, Kiarash Saleki, Nima Rezaei

Knockdown of CSF1R molecules enhances the antitumor effects of CD8+ T lymphocytes in bladder cancer

Jingxuan Peng, Dongjie Li, Boyu Xiang, Zhongyi Li, Zhengyan Tang

Targeting the molecular crosstalk between diabetes and lung cancer for therapeutic intervention

Alireza Azani, Nahal Aghajamal Avval, Mohammad Saeed Soleimani Meigoli, Mahshid Imankhan, Pouya Asgari, Gholamreza Ebrahimisaraj, Reza Morovatshoar, Ahmad Mir Hosseini, Seyedeh Tarlan Mirzohreh, Masoumeh Nouri, Hossein Azari Bostanabad, Qumars Behfar, Fahimeh Bayrami, Malihe Sharafi

Identifying potential therapeutic targets for prostate cancer with mediating role in tumor immunity

  • Open Access
  • Analysis

Zhechun Wu, Sihan Li, Yuqing Li, Zhizhi Wang, Wei Wang

Metabolomic Understanding of variable risk factors for kidney cancer: a two-sample Mendelian randomization study

Yihao Zhu, Ke Wang, Yuan Yu, Xuwen Li, Yabo Zhai, Can Chen, Yajian Li, Mingshuai Wang, Dong Chen, Nianzeng Xing, Feiya Yang, Xiongjun Ye

A comprehensive analysis through Mendelian randomization of immunological markers and sphingolipid metabolism

Dunpeng Yang, Wentian Zhang, Qibin Wang

Managing hepatocellular carcinoma recurrence after liver transplantation: emerging role of immune checkpoint inhibitors

Mohammad Saeid Rezaee-Zavareh, Soo Young Hwang, Naomy Kim, Hasmik Adetyan, Nguyen H. Tran, Ju Dong Yang

A bibliometric analysis reveals a dynamic growth in the use of artificial intelligence in oral cancer research over three decades

Irna Sufiawati, Anisa Insyafiana, Rifat Rahman, Adi Idris

Therapeutic potential of natural compounds in targeting cancer stem cells: a promising approach for cancer treatment

  • Open Access
  • Review

Ishita Debnath, Moumita Kundu

Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials

Nikan Amirkhani, Ehsan Saraee, Mehdi Zeinalizadeh, Alba Fiorentino, Paola Anna Jablonska, Reza Ghalehtaki

Decoding tumor-infiltrating lymphocytes heterogeneity in ductal carcinoma in situ: immune microenvironment dynamics and prognostic insights

Lingzi Wang, Yalong Yang, Yuhang Song, Jiahui Zeng, Hongmei Zheng, Xinhong Wu

Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization

Xiaping Liu, Zhang Jing, Jian Chen, Linhong Su, Jun Lin, Xiaoqu Zhu, Xiaodan Ye

Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma

Yafei Zhang, Xiaofeng Dou, Jianghua Yan, Rongshui Yang, Xinhui Su

A web-based prediction model for brain metastasis in non-small cell lung cancer patients

  • Open Access
  • NSCLC
  • Analysis

Jianing Chen, Li Wang, Li Liu, Qi Wang, Jing Zhao, Xin Yu, Shiji Zhang, Chunxia Su

CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma

  • Open Access
  • Analysis

Hanjing Zhou, Jun Ying, Xuchun Xu, Jian Huang

Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis

Xipeng Wu, Wenda Zou, Ziwei Liu

Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis (2005–2024)

Jiexiang Zhang, Weichen Yuan, Tongtong Zhang, Xuesong Liu, Dongliang Xu

Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing

Zixiong Jiang, Yu Luo, Liangdong Song, Jindong Zhang, Chengcheng Wei, Shuai Su, Delin Wang

The complex role and molecular mechanism of family with sequence similarity genes in cancer: a comprehensive review

Hongyang Deng, Xiaodong Xu, Youcheng Zhang, Yongfang Li

Bibliometric insights into molecular and bioinformatic research trends on ameloblastoma

Yoithapprabhunath Thuckanaickenpalayam Ragunathan, Ramdas Madhavan Nirmal, Supriya Kheur, Kumar Chandan Srivastava, Swetha Pasupuleti, Srichinthu Kenniyan Kumar, Armen A. Muradyan, Artak Heboyan

Alterations in GSH/GSSG and CyS/CySS redox status in small cell lung cancer patients undergoing chemotherapy

  • Open Access
  • SCLC
  • Research

Azra Guzonjić, Milkica Crevar, Ivana Simić, Natalija Samardzić, Vesna Ćeriman Krstić, Jelena Kotur Stevuljević, Dragana Jovanović

Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers

Qiuyu Zhu, Zhaoxuan Li, Changmin Cai, Dongdong Li

TSC2-mutated perivascular epithelioid cell tumor with partial response to mTOR inhibition: a case report and literature review

Xiaopeng Suo, Ruihan Dong, Lingling Zhang, Xiaoying Zhang, Xiangji Li, Mengmeng Xiao

Two-sample Mendelian randomization analysis of the causal association between circulating inflammatory proteins and osteosarcoma

Hong Tang, Na Tang, Yueling Liao, Tao Tan, Hui Xie, Jiong Wang, Xie Hui

Construction of an immune prediction model for osteosarcoma based on coagulation-related genes

Ye Jiang, Huiqi Yuan, Yongping Cao

Prognostic value of FDG PET/CT in special types of breast cancer with non-favorable histology

Mutsumi Fujimoto, Momoko Takaya, Kanako Suzuki, Haruka Ikejiri, Ai Amioka, Emiko Hiraoka, Shinsuke Sasada, Hideo Shigematsu, Morihito Okada

Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway

Xin Ding, Yan Wang, Zhiying Shao, Xin Wen, Bo Wang, Gongzhen Liu, Chang Xu, Luyijie Chai, Hui Qiu, Longzhen Zhang

Analysis of 5 cases of PICC removal difficulty caused by fibroblastic sleeve

Xiajuan Lyu, Man Li

Gross total resection in low-grade and pretreated high-grade invasive growth hormone pituitary adenomas promises favorable outcomes

Ting-Wei Chang, Chun-Chia Tseng, Yu-Chi Wang, Yin-Cheng Huang, Peng-Wei Hsu, Chi-Cheng Chuang, Cheng-Chi Lee

Astragaloside IV represses hepatocellular carcinoma progression by modulating HMGB1-ferroptosis axis

Xingyang Zhao, Ruizhe Liu, Haiyu Zhou, Deqing Wu

Lysosome-derived biomarkers for predicting survival outcome in acute myeloid leukemia

Gongchang Li, Yangyang Miao, Fang Yuan, Weiran Zhang, Yali Wu, Liqiang Zhu

Towards non-invasive diagnosis of glioblastoma: identifying metabolic biomarkers in liquid biopsies using a ROC-based approach

Margareth Borges Coutinho Gallo

Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas

Yongxue Li, Lihao Lin, Wenhui Zhang, Yan Wang, Haoyu Shen, Yi Guan

Smoking and alcohol specific alterations in miRNA expression in head and neck squamous cell carcinoma

Mohd Younis Bhat, Vishalakshi Nanjappa, Mariana Brait, David Sidransky, Aditi Chatterjee, Jayshree Advani

Exploring the prognostic value and immune landscape of EGLN1 in colorectal cancer: insights from bioinformatics analysis

Xiawu Chen, Chengqing Huang, Yingping Liao, Xiaoxun Chen

Identification of hub genes for psoriasis and thyroid cancer using bioinformatics analysis

HaiXia Shi, Yuan Guo, JuPing Chen, HaoChen Yuan, LiYa Wang, Yun Zhang, YanHua Li

Knowledge-map and bibliometric analysis of scientific research on FDA-approved Chimeric Antigen Receptor T cell products (2015–2024)

Moutaz W. Sweileh

Uncovering biomarkers and pathways in oral squamous cell carcinoma through integrated lncRNA-mRNA regulatory network analysis

ShiWei Liu, Jin Li, Qing Shao, JuFeng Chen, Chen Zou, YiLong Ai

Calanquinone A suppresses glioma progression via STAT3-mediated regulation of c-Myc and MMP9

Wen-Chi Hsieh, Chun-Yu Lin, Hsuan‐Cheng Wu, Huang-Wei Lo, Chiung-Yuan Ko, Jian-Ying Chuang, Tsung-I. Hsu, Tsui-Hwa Tseng, Teng-Wei Huang, Shao-Ming Wang

Development and validation of a hypoxia-immune-based microenvironment gene signature for predicting survival in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Analysis

Xiangwu Zhang, Rongxian Zhou, Guangqiang Zhao, Wanling Chen, Ping Zhao, Yunchao Huang, Qiubo Huang, Lianhua Ye

Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions

Hongming Song, Fengqin Gao, Zhaohe Niu, Xiangping Liu, Xingang Wang, Weihong Cao, Haibo Wang

Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease

Mizuki Tagami, Keishiro Isayama, Mizuho Nishio, Atsuko Yoshikawa, Norihiko Misawa, Atsushi Sakai, Yusuke Haruna, Mami Tomita, Yoichi Mizukami, Atsushi Azumi, Shigeru Honda

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation

Xue Mei, Jufen Zhang, Lu Chen, Fang Wang

Relationship between AQP5 and chemotherapy resistance in colorectal cancer cells and its mechanism

Xiaoyun Yang, Chunhua Zhou, Wencheng Kong, Tongfa Ju, Qi Xie, Xinchun Liu

ZNF385B as a potential prognostic and immunotherapy biomarker in ovarian cancer: insights from pan-cancer analysis

Hang Yu, Wei Cheng, Aoshuang Huang, Jing Feng, Dan Zi

Leptomeningeal metastasis in triple-negative breast cancer: a retrospective study

Yun-Yi Wang, Xiao-Han Ying, Kun-Yu Zhang, Li Chen, Qin Xiao, Zhong-Hua Wang

Exploring the interplay between LDHA and ABCC1 in breast cancer using computational approach

Bader Alshehri

Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization

  • Open Access
  • Analysis

Shuai Wang, Shanshan Huang, Xiaohui Ren, Hengheng Zhang, Yuan Tian, Ziqi Luo, Hongbin Wang

A ferroptosis-related risk model for non-coding RNA AC002331.1 in colon cancer: construction via competing endogenous RNA network analysis

Jiahui Liu, Chenning Zhang, Bao Ma, Jie Qi, Xinghai Zhang, Hengli Zhao

Integrative analysis of efferocytosis- and invasion-related genes as potential biomarkers and therapeutic targets in breast cancer

Jing Yang, Rong Zhang, Lamei Sun, Cong Wang, Ming Feng, Bin Su, Lixin Jiang

Causal relationships between immune cell traits and HER2 subtypes in breast cancer: a Mendelian randomization study

Fenfen Gu, Chuling Hu, Chao Li

Leveraging diverse cell-death patterns to predict to predict prognosis and immunotherapy in hepatocellular carcinoma

Xiaoxiang Zhang, Dongxiao Ding, Dianqian Wang, Yunsheng Qin

Development and validation of a machine learning model for predicting pulmonary metastasis in hepatocellular carcinoma patients

Gangfeng Zhu, Qiang Yi, Rui Xu, Yi Xie, Siying Chen, Yipeng Song, Yi Xiang, Xiangcai Wang, Li Huang

Recent advances in calcium peroxide nanomedicines for breast cancer treatment

Sirui Hang, Liu Xu, Ruixue Ma, Huiqin Xu, Xiaojuan Zhang, Chuanchuan He

Collagen gene signature in the tumor microenvironment predicts survival and guides prognosis in bladder cancer

Yi Huang, Shuogui Fang, Weibin Xie, Yitong Zou, Hui Zhuo, Gang Shen, Hua Zhou, ChunPing Mao, Cong Lai, Jianqiu Kong, Xinxiang Fan

Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristics

Yanling Zhang, Qianya Chen, Danna Chen, Guangda Yang

A long-term glioblastoma survivor with Lynch syndrome: a case report of tumor molecular and microenvironment characterization

Yiqiang Zhou, Qianqian Duan, Tiantian Han, Yueshan Piao, Jie Tang

Identification of copper related biomarkers in breast cancer using machine learning

Jing Wang, Haining Wang, Zilan Li, Qi Xu, Yiwei Yang, Run Shi, Feng Liu, Shiyang Jin

WGCNA and single-cell analysis reveal ferroptosis-related gene signatures for hepatocellular carcinoma prognosis and therapy

Can Peng, Fujian Yan, Mingli Xu, Yueyue Zhao, Jiaxing Sun

Promoter methylation correlates with reduced SMAD4 expression in patients with breast cancer

Archana Chaudhary, Manish Kumar, Lalit Mohan, Rizwanul Haque, Pankaj Prabhakar, Mohammad Shamsul Ola, Md. Margoob Ahmad

Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning

Tianchi Lei, Yiwen Jiang, Kexin Yang, Chuqi Meng, Yue An

The role of cellular heterogeneity in thyroid cancer: a multi-modal analysis approach with Mendelian randomization

Yichun Qian, Wei Chen, Xinyuan Chen, Shuai Cheng, Fangzhou Liu

Advances in the regulation of macrophage polarization by the tumor microenvironment

Minzhi Peng, Yuan Zhu, Yi Hu, Jianping Wen, Weiguo Huang

Prognostic and immunotherapeutic response prediction in hepatocellular carcinoma: role of non-histone acetylation/deacetylation scoring

Jizhen Li, Sisi Huang, Fangling Yuan, Xunjun Yang, Qipeng Xie

Mapping thirty years of tumour-microenvironment-driven drug resistance in breast cancer: a global bibliometric analysis

Zuoping Duan, Yonghong Zhou, Yang Wu

Genetic evidence for causal effects of inflammatory protein factors on breast cancer

Xinqi Liu, Xu Xu, Peizhi Ye, Zhenglong Jiang, Le Tian, Yukun Yin, Li Feng

The association between white blood cell count and relative risk of non-small cell lung cancer

  • Open Access
  • NSCLC
  • Analysis

Xiao Yang, Wenyi Liu, Jiaqi Wang, Weifeng Xia, Lanxiang Wu

Machine learning and deep learning in glioblastoma: a systematic review and meta-analysis of diagnosis, prognosis, and treatment

Hadja Fatima Tbahriti, Ali Boukadoum, Meriem Benbernou, Mohamed Belhocine

Long-term survival outcomes and subtype variations between primary breast cancer and liver metastases in 542 patients with advanced breast cancer: insights from a real-world analysis

  • Open Access
  • Research

Ying Yan, Xinyu Gui, Lijun Di, Hanfang Jiang, Xu Liang, Bin Shao, Guohong Song, Huiping Li

PCED1A serves as a potential biomarker for diagnosis and prognosis in colorectal cancer

  • Open Access
  • Analysis

Chun Wang, Dahong Zhang, Yushen Huang

Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential

  • Open Access
  • Research

Rajnikant Raut, Devesh Srivastava, Amit Kumar Chakraborty, Manish V. Bais, Parul Mishra, Ashish Misra

Causal relationship among immune cells, basal cell carcinoma, and gut microbiome: a two-sample Mendelian randomization analysis and mediation analysis

Hequn Li, Liang Chen

Transcriptomic and functional analysis of triphenyl phosphate exposure in prostate cancer progression

Li Cai, Guizhi Du

Ethyl β-carboline-3-carboxylate targets PRDX5/c-Jun axis for novel therapeutic strategy against cervical cancer

Wan-Qiu Xiao, Dong-Hun Lee, Hakjin Kim, Hui-Na Zhang, Yao-Yuan Feng, Ying-Hua Jin, Mei-Hua Jin, Ying-Hao Han, Taeho Kwon, Hu-Nan Sun

Multi-omics dissection of CPNE1 reveals its prognostic value and immune-regulatory function in liver cancer

Liu Liu, He Hong, Weiwei Zhang, Xiang Li, Yuan Yao, Zhengjun Zhang, Guangyao Li

Mendelian randomization analysis of inflammatory biomarkers and hepatocellular carcinoma risk: genetic causality and single-cell transcriptomics

GuangXin Shao, Xiao Yun, Hongyue Xie, Beicheng Sun

Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series

Qingyu Xu, Bin Leng, Ran You, Lingfeng Diao, Chendong Wang, Zeyu Yu, Guowen Yin

Isosilybin B: a potential novel therapeutic agent with hepatoprotective, anticancer and antifibrotic properties

Michal Selc, Kristina Jakic, Radka Macova, Andrea Babelova

Advances and emerging trends in the tumor microenvironment of colorectal cancer liver metastasis: a bibliometric analysis

Qiong Wu, Jie Zhao, Zhongqi Sun, Hao Jiang, Guanzhong Qiao, Kai Zhao, Tingting Fan, Huijie Jiang

Targeting SPATS2 in lung adenocarcinoma: implications for prognosis and immune-based therapy

Maorong Teng, Fangtao Yan, Jingping Shang, Xiaohua Sun, Yahui Wang, Jian Shen

Eosinophilic solid and cystic renal cell carcinoma: a case study of the youngest surgical patient

Zhenfang Qin, Geng Li, Wen Zhang, Fang Yu, Heyun Gao, Shanzhen Yu, Guowei Du, Tao Hu, Yunkai Guo, Yifan Liu, Mingshuang Luo

Identification of potential molecular targets of luteolin in the treatment of hepatocellular carcinoma based on network pharmacology and transcriptome sequencing technology

Yunqi Han, Huijun Wu, Xin Zhang, Wei Lv, Yang Xiong, Xinyuan Tian, Yunfeng Xiao, Hongwei Cui

Multi-omics insights into Palmitoylation-mediated brain network remodeling and glioblastoma risk

Shasha Tan, Jinliang You, Huijun Wang, Long Zhao, Shun Li, Xiaoping Tang, Hongjun Liu

Comprehensive Mendelian randomization analysis of inflammatory networks in diabetic nephropathy and pituitary adenoma: unveiling complex causal relationships

Yi Fu, Yongyong Chen

Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma

  • Open Access
  • Research

Xiaohua Jiang, Liqi Chen, Zixia Xu, Hangzhe Sun, Jing Ye, Ziyi Guo, Mang Xiao

Identifying key genes involved in HBV-related hepatocellular carcinoma: diagnose, prognosis, interaction and immune analysis

Yan Li, Sa-Sa Liu, Hua-Rong Jing, Hong-Wei Qian, Rui-Cheng Li

Identification and validation of LDHA and SLC16A1 for predicting prognosis and diagnosis in lower-grade glioma

Jingyi Huang, Qishun Wang, Zhijun Li, Xuning Huang, Wen Wang, Jiao Liu

Research trends in cervical cancer brachytherapy: a bibliometric analysis

Shuilan Bao, Yiren Wang, Yiheng Hu, Sheng Lin, Youhua Wang, Ke Yuan, Yun Zhou, Ping Zhou, Haowen Pang, Zhengyi Zuo

CYBB as a potential therapeutic target through influencing ferroptosis and macrophage in ovarian cancer

Tian Yi Ye, Su Fang Wu, Xiao Yun Wang

A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin elevation

Manning Li, Sixun Jia, Han Wu, Chunyi Shou, Xiaolu Song, Ye Peng, Huafang Wang, Ying Wang, Xiangmin Tong, Yirui Chen

SPINT1-AS1 promotes oxidative damage and apoptosis of gastric cancer cells via the miR-656-3p/PLCXD3 axis

Duo Xu, Tong Wu, Xin Zhao, ShaoHai Li, XiaoHui Wei

Development and validation of G2M signature-based prognostic model for stratifying colon cancer prognosis

Xin Song, Yan Dou, Xiaoyong Shen

From lab to life: technological innovations in transforming cancer metastasis detection and therapy

Soumya Basu, Satish Sasikumar, Subhayan Sur, Viniti Vaidya, Supriya Kheur, Samir Gupta, Amit Ranjan, Manash Paul, Neelu Nawani, Aditi Bhat, Nikita Adak

Genetically predicted inflammatory protein mediate the association between lipidome and colon cancer

Sun Jiawei, Jiang Yixin, Shen Ting, Guan Yining

Integrative approach for enhanced ovarian cancer diagnosis: cytology and biomarkers

Shuangyan Chen, Lixiu Cai, Daoyin Zhou, Yan Chen

Integrative systems biology and in-vitro analysis of cryptolepine’s therapeutic role in breast cancer

Hina Qayoom, Pankaj Keshari, Manzoor A. Mir

Clinacanthus nutans (Burm.f.) Lindau facilitates cuproptosis and ameliorates colon cancer progression by inhibiting PDE3B-mediated Apelin pathway

Gaoyun Zhou, Xueying Lin, Zhiheng Lai, Dewen Su, Long Lin, Xuewu Chen

Mapping the current research landscape of metformin in cancer based on bibliometric analysis

Yuan Wang, Sike He, Ziqi Li, Nan Jiang, Guangxi Sun

Targeted drug monitoring in oncology for personalized treatment with use of next generation analytics

Wei Li, Chaoling Wen, Bin Ye, Pranjal Gujarathi, Meghraj Suryawanshi, Kuldeep Vinchurkar, Imtiyaz Bagban, Sudarshan Singh, Opeyemi Joshua Olatunji

Knowledge mapping of ferroptosis in sarcoma: a bibliometric and bioinformatics analysis (2012–2023)

Zhen Cao, Chanjuan Qu, Fan Yang, Ning Yao, Wei Zhang, Xiaoguang Cheng, Dong Yan

The role of advanced diagnostics on precision medicine in hemato oncology

Befikad Mandefro, Dereje Mengesha Berta, Amanuel kelem, Bisrat Birke Teketelew, Abateneh Melkamu, Yalew Much, Zewdu Mulatie, Tiruneh Adane

Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status

Jian Yue, Lei Gu, Sheng Chen, Fang Wen, Guoxing Huang

Screening drugs of Anemoside B4 for MFAP4 expression in osteosarcoma in PDTX to increase personalized medicine

Lei Zhang, Lijuan Zeng, Jing Zhang, Zhiwei He, Xiaozhou Liu

Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma

Qin Ding, Wenquan Hong, Guanghao Chen, Ting Lin, Xiaochuan Chen, Hanxuan Yang, Wenqian Xu, Xinyi Hong, Jinghua Lai, Sufang Qiu, Jun Lu

Chemoradiotherapy for recurrent CBTs case report

  • Open Access
  • Case Report

Guangyu Liu, Shuangyan Zhao, Jiankai Wang, Xiaoyu Duan, Hongyi Cai

CRISPR/Cas technologies in pancreatic cancer research and therapeutics: recent advances and future outlook

Hanieh Noormohamadi, Hamed Soleimani Samarkhazan, Maryam kargar, Faezeh Maroufi, Nazli Servatian, Fatemeh Davami

Proteomic insights into early pancreatic ductal adenocarcinoma biology and screening

  • Open Access
  • Analysis

Yue Huang, Chengzhi Sun, Xiangyuan Gao, Siqi Zhai, Guosheng Wang, Fan Zhang

Recent strategies in diagnosis, screening, prevention, and treatment of breast cancer in young women

Dinesh Kumar Sharma, Rajeswari Saripilli

Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization

Kang Ma, Xueyan Mao, Hongkai Zhuang, Cheng Long, Bo Chen

Genetic analysis the causal associations between metal elements and thyroid cancer: a bidirectional Mendelian randomization

Siyi Yan, Ting Huang, Nan Shi, Keke Hu, Junhua Guo, Zhifeng Ye, Yinyan Shao, Heran Zhou

Clinicopathological patterns and treatment outcomes of pediatric germ cell tumors treated at Tikur Anbessa Specialized Hospital, Ethiopia: a single tertiary hospital experience

Mihret Gebrehiwot, Tihitena Negussie Mammo, Michael A. Negussie, Gashaw Arega

Mapping the future: bibliometric analysis of omics research trends in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Yanqian Zhu, Jiawei Chen, Yufei Wang, Jinyang Hu, Chen Gao, Linyu Wu

The outcome of selective delayed sentinel lymph node biopsy following upfront omission of axillary staging in low-risk invasive breast cancers: a retrospective hypothetical simulated analysis

Albin Bengtsson, Karolina Larsson, Kian Chin

Clinical and survival differences between second primary and first primary nasopharyngeal carcinoma in a retrospective study

  • Open Access
  • Research

Xin Huang, Ying Kong, Tianyu Wu, Zhen Meng, Min Kang

Construction and validation of a cell-in-cell related prognostic signature for hepatocellular carcinoma

Hao Zhong, Dong Wang, Yisheng Chen, Danhong Zhan, Chenxi Wang, Rongqi Lin, Wen Li, Qiang Sun, Ruizhi Wang, Meifang He

Investigation of biomarkers and associated molecular mechanism shared between colorectal cancer and lung adenocarcinoma

Kun Gao, Lianyang Yu, Lei Wang, Linlu Gao, Tingting Li, Jing Sun

Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer

Ling Shi, Feng Qiu, Chao Shi, Guohua Zhang, Feng Yu

Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study

Xu Zhang, Li Wang, Xingxing Ruan, Jie Ding, Jing Wan, Chengfang Xu, Xiaomao Li

Nomogram models for predicting lymph node metastasis and prognosis in early gastric cancer 60 or older: a population-based cohort study

Jian Jiao, Kexin Zheng, Hanchen Dong, Guangchuan Wang, Liang Shang, Jin Liu, Leping Li, Chunqing Zhang

Multi-omics-based construction of a palmitoylation-driven prognostic model reveals tumor immune phenotypes in osteosarcoma

Jingyu Chen, Feihu Chen, Haiping Zhang, Yuanlong Hu, Xingyu Zhou, Xijia Weng, Guofeng Bao, Xiaomin Ding

Metallothionein 1X is a tumor suppressor gene and inhibits oxidative stress and metastasis in renal cell carcinoma

Rui Rui, Cong Huang, Yucai Wu, Heng Guo, Yanqing Gong, Xuesong Li, Liqun Zhou, Shiming He

Metabolomics-based liquid biopsy reflects molecular alterations induced by meningioma

Gabriel A. Kurokawa, Pedro T. Hamamoto Filho, Aline F. Galvani, Jeany Delafiori, Arthur N. de Oliveira, Flavia L. Dias-Audibert, Rodrigo R. Catharino, Marco A. Zanini, Adriana C. Ferrasi, Estela O. Lima

Global, regional, and National burden of metabolic dysfunction-associated steatohepatitis-related liver cancer in older adults: trends and cross-national inequality based on the global burden of disease study 2021

Weikang Meng, Jingsheng Hua, Jingyu Sun, Hengfang Liu, Jie Qian, Yating Gu

Comorbidity of hypertension and lung cancer: interplay of genetics and environment

Jingtong Zeng, Difang Shi, Daqian He, Wenxun Dong, Zhenghong Yang, Ying Chen

Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression

  • Open Access
  • Research

Chengcheng Zhao, Tianming Wang, Yingfei Lu, Yu Zhou, Jianquan Chen, Rong Ju

High expression of LIMD2 predicts a poor prognosis and promotes migration of colon cancer cells

Jianjun Wang, Fengjuan Cai, Guodong Liu, Jingtao Zhang, Dongdong Li, Yujie Cai, Yu Wang, Wanjun Xu, Xiaoyan Wang, Xiaomin Li

AKR1B10 as a novel prognostic biomarker linking methylation and immune escape in hepatocellular carcinoma

Muhammad Naveed Khan, Mao Binli, Hu Juan, Shi Mengjia, Wang Shunyao, Xiaosong Li

SARS-CoV-2 infection heightens the risk of developing HPV-related carcinoma in situ and cancer

Yu-Hsiang Shih, Chiao-Yu Yang, Chia-Chi Lung

Competing risk model for prognosis of small cell neuroendocrine lung carcinoma based on SEER database

Dongxu Xia, Jun Fan, Xin Zhou, Fengzhou Li, Fachen Zhou

Diagnostic potential of the B9D2 gene in colorectal cancer based on whole blood gene expression data and machine learning

Zhaorui Wang, Yongcheng Fu, Haozhe Zhang, Na Liu, Ningjing Lei

Research on the regulatory effects and mechanisms of YES1 on apoptosis and autophagy in cervical cancer cells

Na Feng, Lili Liu

A risk model for predicting partial late radiation-induced injuries in T3-4 nasopharyngeal carcinoma based on dosimetric parameters and clinical factors

Qiulu Zhong, Xiangde Li, Qinghua Du, Haiying Yue, Sisi Wu, Yunhui Zhong, Xiaodong Zhu, Jian Li

UBE2C-mediated ubiquitination of ACSL4 inhibits ferroptosis and promotes gastric cancer progression

Lei Yang, Miaomiao Zeng, Bo Li, Qiang Li, Yi Sun, Binsheng Wang, Xiang Cui, Zhiyun He, Chen Chai

A surgical strategy-based nomogram for primary pulmonary mucoepidermoid carcinoma

Lei Yu, Yanling Peng, Shan Lan, Lu Yang

Radiotherapy versus no radiotherapy for rectal neuroendocrine carcinoma patients treated with surgery and chemotherapy: a population-based cohort study

Xiaojun Liu, Jiaying Li, Farooq Benish, Shuping Li, Weisheng Zhang

Construction of a multimodal esophageal cancer prognostic model with screening of key genes and investigation of their biological functions

Zhengsong Chang, Yiru Li, Mengyao Wang, Xin Zhang, Qiang Bai, Huan Luo, Pengyun Deng, Liping Yang, Xiaomei Li

Transcriptomic HEPN1 signatures predict treatment response in low grade glioma

Lei Jiao, Shuhua Fang, Jianbo Zhang

A nomogram integrating mutation signatures and clinical features for prognostic stratification in bladder cancer

Lili Wang, Peng Chen, Huanhuan Liu, Jiayue Qin, Shanbo Cao, Hongzheng Li, Dingkun Hou, Kaibin Wang, Haitao Wang

Radiomics in pediatric brain tumors: from images to insights

Pranjal Rai, Sabha Ahmed, Abhishek Mahajan

Bidirectional Mendelian randomization analysis and systematic meta-analysis of causal relationships between hepatocellular carcinoma and non-alcoholic fatty liver disease

Tielong Zhao, Yanglieguang Lou

A novel prognostic risk score associated with resistance to docetaxel chemotherapy for predicting biochemical recurrence-free survival in patients with prostate cancer

Desheng Zhu, Hongbin Zhu, Ting Huang, Wentao Fan

PTK6 mediated immune signatures revealed by single cell transcriptomic and multi omics big data analysis in cervical cancer

Fen Zhao, Huanxin Zhong, Lifang You, Yi Du, Changchang Huang

Efficacy and safety of platinum-based, anthracycline-free neoadjuvant chemotherapy for triple-negative breast cancer: a systematic review and meta-analysis

Yichao Du, Lu Huang

Diagnosis and treatment outcomes of primary lymphoma of the thyroid gland

Omar Hamdy, Gehad A. Saleh, Ramadan Ayman Selim, Radwa M. Abdelsattar, Maryam M. Dawood, Youssef Y. Abbas, Rana Abdo, Yousef M. Mansour, Jana M. AbuZahra, Mohamed Elsayed, Ahmed E. Eladl, Shaimaa El-Ashwah, Mohamed Ezat

Bibliometric analysis of immunogenic cell death in hepatocellular carcinoma

Jianming Sun, Chun Liu, Dongdong Liu, Xinlian Hu, Shirong Ren, Guoying Jiang, Daizhong Zhang, Shuai Hu, Xiaojing Yuan, Jun Tao

FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges

Peng Wang, Yugeng Gao, Can Chen, Xiaoxin Zhao, Yuying Zhang, Taorui Liu, Haoran Jiang, Zhe Wang, Xiang Zhao, Jianjun Li

Impact of home-based preoperative physical activity on postoperative complications in patients undergoing oncologic surgery: a systematic review and meta-analysis

  • Open Access
  • Research

Takuya Yanagisawa, Noriatsu Tatematsu, Kazuhiro Hayashi

Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis

Hongwang Yuan, Zhanyan Hua, Hua Zhang, Dingwen Xu

T cell redirecting therapy for relapsed multiple myeloma

Melinda S. Y. Tan, Tamer Hellou, David Dingli

CD99 is a potential diagnostic and immunological biomarker in pan-cancer

Juntao Jiang, Zuoxiao Han, Haizhu Zhang, Hao Chen

Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis

Shusen Xia, Lixin Liu, Yi Zhou, Yanbin Zhu, Qian Dai, Hong Peng

An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma

Han Fan, Peng Qiu, Yun Lu, Zhengdong Deng, Li Tian

Identification of glycolysis-related molecular subtypes and prognostic model in intrahepatic cholangiocarcinoma

Yue Wang, Pengxiang Wang, Hui Liu, Haokang Feng, Muzi Cao, Zefan Zhang, Keqiang Rao, Jia Fan, Xiutao Fu, Yunfan Sun

Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression

Yuhui Zhao, Xiaotong Wu, Yi Zheng, Huiming Bai, Zhihang Zhang, Mingzhi Li, Xiaofeng He, Chao Yu

Mitochondrial fission genes MTFP1/MTFP2 as predictive biomarkers in prostate cancer: a mendelian randomization study

Xuejun Huangfu, Zhiqiang Fan, Jia Zheng, Jiabei Xie

Chemotherapy response in primary peritoneal small cell carcinoma

Kholoud Alqasem, Sakhr Alshwayyat, Salsabeel Aljawabrah, Sundus Yahya Nser, Ala’aldin Eqleem, Mohammad Abu Shattal, Maisoon Hajir, Mohammed Al-mahdi Al-kurdi

The value and application of a poorly differentiated cluster-based Ezrin marginal score system in the prognostic assessment of colorectal cancer

Yangyang Jiang, Ling Liu, Yingying Chang, Limei Gu, Yaohui Wang, Ting-Sheng Ling, Xiaolong Zhang

Mendelian randomization identifies genetically predicted calorie dietary preference as causal risk factors for cancer

Kaiyuan Zhang, Jiaheng Lou, Jianbo Huang, Xiaochen Ni, Chuhang Wang, Jianing Guo, Wei Fan, Yuanlin Lv, Guangji Zhang, Tao Jiang

Biproximate ellipsoid formula with transrectal ultrasound: a superior method for PSA density in gray zone prostate cancer detection

Xin Wang, Jinxiao Sun, Dandan Xu, Hao Zhu

Identification of copper metabolism-related subtypes, the development of a prognosis model, and characterization of the immune landscape in colorectal cancer

  • Open Access
  • Research

Geng Peng, Lin Zhong, Nan Lai, Lina Luo, Fu Cheng, Manzhao Ouyang

Oncogene-driven lung cancer in the era of radiogenomics: current evidence and future developments

  • Open Access
  • NSCLC
  • Review

James Ryan, John Kavanagh, Niamh Coleman

A TARGET database-driven nomogram for pediatric osteosarcoma prognosis

Jianfeng Li, Jiayi Li, Jianjun Wang, Bingquan Li

Identifying genes associated with Sorafenib resistance in hepatocellular carcinoma to develop risk model

Kuan He, Hongyan Hui, Fang Zhou, Kai Liu, Xi Zhao, Jun Liu

The role of angiotensinogen, angiotensin II receptor type I and type II receptor polymorphisms (AGTR2 rs11091046, AGT rs699, AGTR1 rs5186, and AGT rs4762) in multiple myeloma

Istemi Serin, Yasemin Oyaci, Sacide Pehlivan, Elif Ertas, Fatma Ceren Tuncel, Mustafa Pehlivan

Integrating network pharmacology and molecular modeling to decipher the anti-esophageal squamous cell carcinoma mechanisms of Bidens pilosa L

  • Open Access
  • Research

Zhenzhen Yang, Cheng Chang, Na Gao, Pan Gao, Yinsen Song, Ruiting Feng, Jingjie Meng, Chen Wang, Haozhe Zhang, Tianli Fan

METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells

Bo Tang, LianMin Wang, Dong Wei, Tao Wang, Renchao Zou, Kun Su, Tao Wu, Dongyun Cun, Qiuhong Wang

Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis

Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

The causal relationship between inflammatory cytokines and lung cancer: a two-sample bidirectional mendelian randomization study

Kaiyang Zhao, Ning Wang, Peiyan He, Wenhan Shi, Rongke Fan, Shengxian Peng

CAR-T cell therapy in china: innovations, challenges, and strategic pathways

Lihui Yan, Boshi Duan, Peng Sun, Tianzuo Wang, Tianyou Wang, Shuang Jiang, Yue Wang

Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis

Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

KYNU is a potential metabolic-related biomarker for nasopharyngeal carcinoma by Raman spectroscopy, metabolomics, and transcriptomics analysis

Ziman Wu, Haiyan Yang, Yafei Xu, Xiang Ji, Dayang Chen, Chuang Zhang, Mingjie Liang, Xinying Li, Xiuming Zhang, Dan Xiong

Bioinformatics mining and experimental validation of prognostic biomarkers in colorectal cancer

Feng Huang, Salah A. Alshehade, Wei Guo Zhao, Zhuo Ya Li, Jung Yin Fong, Chin Tat Ng, Li Chen, Sasikala Chinnappan, Mohammed Abdullah Alshawsh, Karthikkumar Venkatachalam, Malarvili Selvaraja

The landscape of research on B cell and immunotherapy in solid tumors over the past 20 years

Shuman Kuang, Mingjian Piao, Chengjie Li, Nan Zhang, Jiongyuan Li, Shuofeng Li, Binhe Tian, Lijin Zhao, Haitao Zhao

Quantitative assessment of the associations between MTR and MTRR gene polymorphisms and glioma risk

Xu Chen, Yanping Yao, Xi Wang, Jun Qiu

Breast cancer as the first primary malignancy: clinical pathological characteristics of common cancer combinations

Yaping Ma, Hui Guo, Yuchen Hao, Bin Song

Exploring the multifaceted roles of glutamate oxaloacetate transaminase 1 as a biomarker and therapeutic target in colorectal cancer and pan-cancer analyses

Xi Wang, Longquan Pi, Yuning Chen, Jiangyu Tan, Yingying Wang, Kaiyan Xia, Xianchun Zhou

Genetically predicted interleukin 7 levels and neuroblastoma risk combined with analysis of radiation therapy timing effects

Gang Rui, Ying Cheng, Qun Gao

Emerging trends and global collaboration in Paclitaxel resistance research for breast cancer: a comprehensive bibliometric study

Yuxuan Meng, Chenshan Zhang, Huan Feng, Pinjun Lu, Wenjun Wang, Sakorn Pornprasert, Tao He, Yan Lin

Global research trends on the association between gastric cancer and chronic atrophic gastritis: a bibliometric analysis

Qingyue Miao, Bingyang Qin, Songlan Piao, Changchun Ma

Identification of diabetes-related signatures as prognostic and therapeutic biomarkers in colon cancer

Ming Yao, Rongzhong Wang, Ronghai Cui, Fan Lou, Zelian Chen

Machine learning-based characterization of a PANoptosis-associated model for enhancing prognosis and immunotherapy response in lung adenocarcinoma patients

  • Open Access
  • Analysis

Ziqiao Fu, Jia Zeng, Xiaomin Xiong, Weimin Zhong

SFRP2 and RPRM as methylation based serum biomarkers for the detection of gastric cancer

Serap Dede, Çağrı Şakalar, Barış Yılmaz, Gamze Çubukcı, Muradiye Acar, Aydın Yavuz, Gizem Aksu, Saygın Altıner, Osman Yüksel, Furkan Ayaz, Esra Aydemir

A novel immune-metabolic prognostic model stratifies survival and personalizes therapy in hepatocellular carcinoma

Zejin Lin, Jiaheng Wang, Yiping Li, Taijun Yi, Xiaoyue Huang, Chengrui Zhong, Zhiping Chen, Zeyu Lin

Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity

Xi-Xi Li, Pei Shi, Fei-Fei Wu, Dai Li

A high-grade glioma metastasis to the thoracic spine: illustrative case and a brief review

Nenad Koruga, Ivan Hećimović, Alen Rončević, Tajana Turk, Tatjana Rotim, Domagoj Kretić, Vedran Farkaš, Tomislav Ištvanić, Branko Dmitrović, Anamarija Soldo Koruga

Efficacy of integrative non-pharmacological traditional Chinese medicine approaches in enhancing gastrointestinal function and quality of life in patients undergoing chemotherapy: a systematic review and network meta-analysis

Ai-Yun Huang, Jing Liang, Li-Ya Tian, Yang Yang

Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression

Xiaohui Wang, Mumtaz Hussain, Qurat ul Ain, Madiha Zaynab, Mostafa A. Abdel-Maksoud, Taghreed N. Almana, Saeedah Almutair, Abdulaziz Alamri, Ibrahim A. Saleh, Naser Zomot, Wahidah H. Al-Qahtani, Faisal Siddique, Yasir Hameed

The instrumental role of lipids in governing the sensitivity of multiple myeloma to ferroptosis

Ali Habib, Oliver G. Best, Charlotte E. Toomes, Craig T. Wallington-Gates

Lipid homeostasis dysregulation in oral cancer drives metabolic reprogramming and offers novel diagnostic and therapeutic opportunities

Liang Liang, Chen Luo, Shuo Dong, Zhe Jia, Linyu Zhao, Jingchao Tang, Min Li, Xiaoren Zong, Simin Li, Zuryati Ab Ghani

Global research trends in PARP inhibitors for ovarian cancer: a bibliometric analysis

Xiaodong Wang, Gouping Ding, Jing He, Yiping Huang, Qianqian Wang

Investigating the interaction of ACKR1 and c-Myc in the breast carcinoma tumor microenvironment modulation

Joyeeta Talukdar, Arnab Nayek, Gayatri Gogoi, Tryambak P. Srivastava, Isha Goel, Om Saswat Sahoo, Ruby Dhar, Subhradip Karmakar

Targeting the CD47-SIRPalpha checkpoint in multiple myeloma

Tao Ming Sim, Wee Joo Chng, Haiyan Liu, Sanjay de Mel

The roles of non-coding RNAs (ncRNAs) in the function of leukemic stem cells (LSCs): a comprehensive review

Mehran Sharifi, Shahram Nekoeian, Reza Eshraghi, Ehsan Behzadi, Ali Rajabi

Integrated single-cell and bulk RNA-sequencing data reveal prognosis and therapeutic response in low-grade glioma based on hypoxia-lactylation related genes

Hongyu Tang, Ruijie Zhang, Ying Xu, Xu Wang, Jingyan Gu, Lianping Gu, Yaohua Liu

Mendelian randomization study of breast cancer-related genes and their association with inflammatory signaling pathways

Yongjing Long, Runze Huang, Wei Li

Mendelian randomization and single-cell analysis reveal causal relationships between renal clear cell carcinoma, kidney fibrosis, and inflammatory factors

  • Open Access
  • Analysis

Xian Chen, Hui Wang, Qianqian Li, Haiping Jia, Tingting Ding, Wentao Liu, Jiansong Shen

Identification of potential drug targets and possible drugs for esophageal carcinoma from genetic insights: a comprehensive two-sample Mendelian randomization study

Juan Wang, Ji Sun, Chen Liang, Haibin Ou, Jiong Liu, Aoqing Ye, Qiuji Wu, Yu Liu

High mobility group A2 (HMGA2) protein tissue levels and its association with clinicopathological features in bladder cancer patients

Feras Alsoufi, Almoutassem Billah Zetoune

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace

  • Open Access
  • Review

Ruijun Guo, Jiajun Xu, Chunxia Li, Chune Mo, Minglin Ou

DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target

  • Open Access
  • Research

Huimin Guo, Guiwen Zheng, Jia Li, Shuzhan Yao, Qiang Jia, Jian Tan, Zhaowei Meng

Application of artificial intelligence in medical imaging for tumor diagnosis and treatment: a comprehensive approach

Junyan Huang, Yizhen Xiang, Shengqi Gan, Linrong Wu, Jiangyu Yan, Dong Ye, Junjun Zhang

PCK1 and ALDH1A1 are identified as biomarkers for inherent drug resistance in hepatocellular carcinoma

Wei Chen, Cheng Zhou, Gao Liu, Xinyu Wang, Yong Yi, Yang Xu, ShuangJian Qiu

Whole-exome sequencing in a patient with a history of esophageal squamous cell carcinoma to discriminate recurrent disease from a second primary tumor

Guoqing Zhang, Kaiyuan Li, Zheng Ding, Jia Zhao, Xue Pan, Xiangnan Li

Analysis of mortality trends and projected burden of digestive system cancer in China: a nationwide longitudinal analysis (2006–2020) with mortality forecasts to 2045

Yajing Feng, Junhui Chai, Jichun Zhu, Yuehua Zhang, Kaijuan Wang, Fujiao Duan

Granular acute lymphocytic leukemia : a case report and literature review

Yike Tian, Ping Huang, Mi Jiang, Jing Wu, Wei Cai

Neoadjuvant therapy demonstrates both safety and clinical feasibility for renal cell carcinoma patients with tumor thrombus

Le Yu, Kewei Chen, Liyuan Ge, Fan Zhang, Shaohui Deng, Jianfei Ye, Ye Yan, Guoliang Wang, Shudong Zhang

Neutrophil extracellular traps in tumor metastasis: mechanisms, and therapeutic implications

Ni Li, Changmei Yin, Jing Tao

A bibliometric analysis of trends and hotspots in autophagy in gastric cancer

Jianfang Zhu, Liuyang Shu

Real world feasibility of combining pembrolizumab with radiotherapy in early triple negative breast cancer

Riccardo Ray Colciago, Daniele Presti, Carlotta Giandini, Eliana La Rocca, Maria Grazia Carnevale, Anna Cavallo, Emanuele Pignoli, Riccardo Lobefaro, Chiara Listorti, Laura Lozza, Serena Di Cosimo, Maria Carmen De Santis

Folate-modified liposomes for co-delivery of schisandrin A and oxaliplatin to enhance colorectal cancer cell death

Bo Zhou, WanRu Dong, Yuhan Fu, Qianqian Jiang

Tissue-specific profiling of human protein phosphatases identifies G6PC1 as a liver cancer–selective biomarker

Adil R. Sarhan

Construction of a prognostic risk-scoring model based on SASP-related genes in patients with skin cutaneous melanoma

Ming-Feng Li, Jing Du, Gang Wang, Wei Feng, Ju-Gao Chen, Chao Zhang

Potential role of DKK3 and WIF1 in prostate cancer: bioinformatics and clinical analysis

Zhiliang Xia, Zhonggui Hu, Dan Du, Zhi Zhang, Zonglai Liu, Xinyu Li, Xiong Guo, Ziqiu He

CAF-derived exosomal LncRNA ANRIL promotes glycolytic metabolism and proliferation in non-small cell lung cancer via the miR-186-5p/HIF-1α axis

  • Open Access
  • NSCLC
  • Research

Baofan Zhang, Ruiyan Huang, Zhongjie Tang, Yufeng Hu

Bibliometric analysis of research on cervical cancer and miRNAs from 2010 to 2024: research trends, hotspots, and prospects

Cong Xu, Yonghong Xu, Guangming Wang

Microsurgical resection of a giant thoracolumbosacral Schwannoma in an adolescent with intraoperative neuromonitoring and anatomical laminoplasty reconstruction

Wenhua Zhang, Yaxiong Li, Honglei Liu, Jianfeng Liu

Aberrant DNA methylation and overexpression of NR0B1 are prognostic biomarkers in KEAP1-mutant lung adenocarcinomas

Mohamed Elshaer, Ahmed Hammad, Yang Gao, Xiu Jun Wang, Xiuwen Tang

A 40-year bibliometric analysis of global research on neoadjuvant chemotherapy for oral cancer (1985–2024)

Xu Xiang, Ping Shi, Li Yang, Shumin Ma, Jian Kang

Metabolic genes interaction perturbation network identified and validated CD24 as a novel prognostic gene in hepatocellular carcinoma

Hao Liu, Hongyi Yan, Ying Huang, Xiangkun Meng, Long Liu, Yuyuan Zhang, Hui Xu, Yanchao Hu

Correction : Glutathiones’ life in multi-cancers: especially their potential micropetides in liver hepatocellular carcinoma

Didi Ma, Zhenguo Wu, Mengying Zhang, Jian Mao, Wenqin Xu, Lan Jiang, Zuzhen Wang

Improved brain tumor classification through DenseNet121 based transfer learning

Mehwish Rasheed, Muhammad Arfan Jaffar, Arslan Akram, Javed Rashid, Tagrid Abdullah N. Alshalali, Asma Irshad, Nadeem Sarwar

DNA methylation and transcription factor-driven immune subtypes in ovarian cancer

Jingshu Hu, Mu Su, Zhijun Qin, Jiayu Li, Hengyu Wang, Kexin Chang, Guosheng He, Yan Zhang, Xiuwei Chen

NTRK expression and its clinical significance in pancreatic neuroendocrine tumors

Pingping Yan, Xiaoqin Dai, Fenfen Zhang, Yu Dong, Huijuan Shi, Anjia Han

HADHB mediates 5-fluorouracil sensitivity in colorectal cancer

Xue Zhang, Hui Jin, Dan Li, Jiayin Liu, Jing Han

PTEN defects in cancer, from gene to protein molecular causes and therapeutic targets

  • Open Access
  • Review

Ghaith Khasarah, Darina Al Nabilsi, Odai Madani, Farah Khazem, Ranwa Alsayed

CD44 overexpression as a mediator of drug resistance in oral cancer: a meta-analysis unveiling molecular underpinnings and therapeutic implications

Shushu Miao, Caiqiong Wang, Anqi Zheng

The role of oral microbiota in lung carcinogenesis through the oral-lung axis: a comprehensive review of mechanisms and therapeutic potential

Mingzhu Zhou, Yan Liu, Xin Yin, Jiannan Gong, Jianqiang Li

Current perspectives and global trends of nanotechnology in advanced breast cancer: a bibliometric and visualized analysis

Hanwen Huang, Tingting Ma

Emerging nanotherapeutics for HPV-associated cancers: current advances, challenges, and future directions

Ujjawal Sharma, Himanshu Shekhar, Bunty Sharma, Anidrisha Sahu, Shafiul Haque, Darin Mansor Mathkor, Damandeep Kaur, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

Dietary factors causally affect the risk of kidney cancer: a two-sample Mendelian randomization study

Congcong Zhu, Tonghu Liu, Zhengyi Jiang, Hui Wang, Mengran Zhang, Weibo Sun, Zechen Yan

KLB as a potential prognostic biomarker and therapeutic target in colorectal cancer: insights from multi omics and single cell analyses

Xiaofei Bi, Wenjin Zhang, Meimei Shen, Guicheng Wu, Chengmei Fang, Jian Gao

SNX7 mediates inhibition of autophagy in prostate cancer via activation of CFLIP expression

Liang Qin, Fan Yang, Zhuifeng Guo, Xuwei Lu, Jiawen Wu, Dongzhen Jiang, Ning Yang

Systematic analysis identifies CDKN2A as a prognostic biomarker for hepatocellular carcinoma

Shilin He, Yanling Zhang, Junjie Xu, Xiao Liang

Ferroptosis and non-coding RNAs in breast cancer: insights into CAF and TAM interactions

Mohamed J. Saadh, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Anita Devi, Girish Chandra Sharma, Abdusamat Valiev, K. Satyam Naidu, Pushpa Negi Bhakuni, Fadhil Faez Sead

A preoperative inflammatory score-based nomogram predicts overall survival after curative hepatectomy for hepatocellular carcinoma

Xiaojian He, Xu Peng, Jianliang Duan, Zongyang Li, Yuexiang Niu, Yahui Liu

LncRNA ADAMTS9-AS1 regulates the proliferation, migration, and invasion of esophageal cancer cells via miR-575/ CADM2

  • Open Access
  • Research

Jinhua Wang, Wei Ji, Hongxia Qu, Yingying Sun, Tiesong Zhang

Potential role of immune-related LncRNAs in prognosis of hepatocellular carcinoma: an integrative study

Peidong Miao, Chunxia Pan, Tianyu Li, Ying Li

Predictive value of MHC-related genes in cervical cancer: implications for immunotherapy and prognostic nomogram development

Meili Xi, Xiaoqing Wang, Xiao Xu, Jiarong Zhang, Aimin Ren

From gum inflammation to oral cancers: pyroptosis as the molecular torchbearer in periodontitis-driven carcinogenesis

Shabnam Ghasemzadeh, Farzad Fattah, Sahand Emrahoglu, Seyed Mahdi Madani, Seyedeh Tabasom Nejati, Ava OstovarRavari, Elham Oveili, Shahryar Irannejadrankouhi, Mohsen Nabi Afjadi

Clinical significance of ANXA9 expression in colorectal cancer and its impact on immune evasion and drug resistance

Mingyang Hong, Qian Dong, Huiming Zhu, Xu Huang

TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer

Li-Min Zhu, Hai-Xia Shi, Zhen-Ye Xu, Hai-Bin Deng

Integrated pan-cancer and melanoma-specific analysis of angiopoietin-2: prognostic value, immune microenvironment modulation, and ceRNA network regulation

Xuejun Ni, Xiaofen Wan, Beichen Cai, Hongteng Xie, Lu Chen, Qian Lin, Ruonan Ke, Tao Huang, Heyan Ye, Xiuying Shan, Biao Wang

N(6)-methyladenosine modification of ADGRA3 by ZC3H13 suppresses papillary thyroid cancer cell malignancy by inactivating the PI3K/Akt/mTOR signaling pathway

Li Cai, Linghui Zhang, Zhaodan Yan

Upregulation of EMP3 in acute myeloid leukemia: a study based on data mining, RT-qPCR and immunohistochemistry

Angui Liu, Cong Yu, Xianwei Peng, Jiaodi Liu, Yiting Zhang, Yubing Ma, Kanglai Wei, Yinghui Lai

Diagnostic and management strategies for retroperitoneal leiomyosarcoma invading the inferior vena cava: a case report

Haoxiang Zhu, Huipeng Zhu

Horseshoe kidney with renal parenchymal squamous cell carcinoma: a case report and comprehensive literature review

Peng Su, Ying Yang, Neng Zhang, Hong Zheng

Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis

Bo Liu, Tingting Zhang, Jihua Han, Wen Bi, Chunlei Nie, Jiewu Zhang

Effects of apigenin on the proliferation, migration, and apoptosis of human diffuse large B-cell lymphoma OCI-LY3 cells

Pengyan Wu, E. Li, Chen Wang, Jing Li, Rong Wei

Preliminary study on SIRI dynamic changes for the efficacy prediction and prognosis evaluation of advanced cancer patients treated with immunotherapy

  • Open Access
  • Research

Xiuzhen Wei, Yinghai Liu, Huijuan Wang, Qingqing Yang, Baihong Zhang, Qianyu Liu, Yuan Zhu, Lingling Zhu, Zhengjie Zhang

Long non-coding RNA-based single and combination independent prognostic biomarkers for hepatocellular carcinoma

Long-Bin Jeng, Horng-Ren Yang, Chiao-Fang Teng

SLC38A4 as a prognostic biomarker and correlated with immune infiltration in colorectal liver metastasis

  • Open Access
  • Research

Ying Liu, Xin Wei, Ningning Chen, Weijia Wang

Bibliometric-driven research on chemoresistance in breast cancer: knowledge mapping, hotspot evolution, and emerging insights (1994–2024)

Hao Zhang, Ting Feng, Juntang Lin, Badrul Hisham Yahaya

Advances of androgen receptor in triple-negative breast cancer: from molecular mechanisms to clinical applications

Lange Ma, Hao Xu, Chunyan Wang, Yue Hu, Qinglan Ren, Shengnan Yu

Mechanisms of cancer-induced neurophysiological dysfunction and therapeutic strategies

Regan Mujinya, Elna Owembabazi, Ibe Michael Usman, Victor Bassey Archibong, Patrick Maduabuchi Aja, Daniel Chans Mwandah, Swase Dominic Terkimbi

Vision transformer network discovers the prognostic value of pancreatic cancer pathology sections via interpretable risk scores

Zhiyong Peng, Yue Zhang, Tianchi Zhou, Wenjie Shi, Ya Wang, Maciej Pech, Georg Rose, Maximilian Dölling, Katrin Hippe, Roland S. Croner, Yi Zhu, Ulf D. Kahlert

Identification and verification of exosome-related gene signature to predict the cancer status and prognosis of prostate cancer

Haoxi Wang, Xuwen Li, Liyuan Wu, Yabo Zhai, Yihao Zhu, Wenkuan Wang, Dong Chen, Nianzeng Xing, Xiongjun Ye, Feiya Yang

Impact of preoperative anemia on short- and long-term outcomes of sphincter-preserving rectal cancer surgery

Jung Wook Suh, Min Hyun Kim, Duck-Woo Kim, Min Hyeong Jo, In Jun Yang, Jeehye Lee, Heung-Kwon Oh, Sung-Bum Kang

Analysis of risk factors associated with recurrence of granulomatous lobular mastitis and establishment of a prediction model

Boyu Shang, Tianyi Zhang, Chang Liu, Zonglin Yuan, Yao Wang, Jing Feng, Yi Zhou

Application of Mendelian randomization in the discovery of risk factors for cancer from 2014 to 2024: a bibliometric review

  • Open Access
  • Research

Junchi Yang, Dongyan Wang, Yixiao Han, Xinzhe Tan, Haibin Du

The multifaceted roles of ZIC genes in cancer: from development regulators to cancer modulators

Dina Hesham, Shahenda El-Naggar

The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways

Shymaa Abdullah Mohamed, Toka M. I. Badawy, Menna Allah M. K. Hussein, Mohammed Salama, Yasser M. El Kerm, Mohamed A. Abdel Mohsen

Correction to: Talin1 promotes HCC progression by regulating NRG1/PI3K/AKT pathway

  • Open Access
  • Correction

Jialong Liu, Yao Lu, Bowen Zheng, Deng Huang, Juxian Song, Baolin Wang, Shuguo Zheng

Deciphering and targeting oncogenic pathways through integrated approaches and amino acid metabolism in hematologic malignancies

Farhan Ikhtiar, Adil Jamal, Syed M. Safeer Mehdi Bokhari

Premenstrual sub-occlusive episodes as initial presentation of metastatic breast cancer: a case report of a previously undescribed entity

Wassim Hamadeh, Hassan Kanaan, Hamze El Husseini, Mohammad H. Abbas, Leila Akil, Hammam Farhat

Role of intratumoral heterogeneity in metastatic progression and drug resistance

Neeha Sinai Borker, Jyothilakshmi Sajimon, Seemadri Subhadarshini, Rifat Aara, Mohit Kumar Jolly, Jyothi S. Prabhu, Radhika Nair

KLF4 in cancer chemoresistance: molecular mechanisms and therapeutic implications

  • Open Access
  • Review

Suresh Singh Yadav, Punita Kalia, Navneet Kaur, Sourav Sharma, Shambhavi Thakur, Soni Kumari, Rohini Ravindran Nair

Novel radiation-derived gene blueprint stratifying patients with breast cancer

Hao Zhang, HongHua Lin, Enyi qiu, Wenqi jin, Shi Dong

Mendelian randomization analysis of immune cell traits and oral microbiota in nasopharyngeal carcinoma during radiotherapy

JianLong Wu, Jian Zhang, YuYun Xu, JianDa Sun, XiaoYang Wang, Lang Peng, Jin Weng, YiBiao Chen

Research of SLC7A11 to estimate the prognosis and immune infiltration landscape for breast cancer

Xiangjie Xue, Yicheng Zhi, Lu Wang, Ye Shu, Erhao Zhang, Hao Ding, Jiaxin Chen, Ting Li, Yanyan Hu, Peihong Jin, Qinhao Gu, Chenyang Ye, Ji Wang, Ye Zhao

From texture analysis to artificial intelligence: global research landscape and evolutionary trajectory of radiomics in hepatocellular carcinoma

Xiong Teng, Quan-Neng Luo, Yi-Di Chen, Tao Peng

Selection of tumor invasion-related genes to build a prognostic model and predict immune response and potential drugs for esophageal cancer patients based on WGCNA

Xueqiong Deng, Yiming Liu

Implementation of whole genome sequencing in cancer management: modelling and sensitivity analysis using system dynamics

  • Open Access
  • Research

Hadi Akbarzadeh Khorshidi, Marzieh Soltanolkottabi, Maarten J. IJzerman

Pilot research on predicting the sub-volume with high risk of tumor recurrence inside peritumoral edema using the ratio-maxiADC/meanADC from the advanced MRI

  • Open Access
  • Edema
  • Research

Jinling Zhang, Haobin Liu, Yuxiao Wu, Jian Zhu, Yuting Wang, Yijun Zhou, Mingguang Wang, Quanyu Sun, Fengyuan Che, Baosheng Li

Causal effects of circulating inflammatory proteins on colorectal cancer: a Mendelian randomization and Spatial transcriptomic study

Mei Bai, Bo Wu, Jie Li, Li Zhao, Lingqiong Zhao

SSBP1 is a prognostic biomarker and promotes the progression of lung adenocarcinoma via p53 signaling pathway

Dengrong Hao, Hao Wang

The reduced DLG5 promotes doxorubicin resistance in breast cancer cells MCF-7 through regulating autophagy

Jingmin Che, Xusheng Wang, Bo Chen, Huxia Wang, Qing Feng, Jingying Sun, Cuixiang Xu, Zhangjun Song

Risk factors and prognostic nomogram for distant metastasis in patients with PTMC

Qiaoqiao Liang, Leitao Yu

Single-cell RNA-seq reveals gene expression heterogeneity in NSCLC and its link to the immune microenvironment

  • Open Access
  • NSCLC
  • Analysis

Jinzhuo Ren, Hua Zhang, Haiyong Wu

Decoding the functional roles of circular RNAs linked to NF-κB pathway in carcinogenesis

Wei Wang, Kang Zheng, Zhi Feng, Zhangyi Wang, Bo Wei, Zhenfa Li

Identification of immunosuppressive CD4+ T-cell subtype and construction of prognostic model for hepatocellular carcinoma

Chuxuan Wang, Lianchi Li, Yingrui Lou, Lan Zhang, Feifei Tian, Taoyou Zhou

Integrated single-cell transcriptomics and Mendelian randomization identify neutrophil-associated biomarker genes in colorectal cancer

Hongting Yan, Yingjie Li, Bing Yang, Wenyu Wu, Wenqi Huang, Bin Guo, Dongxin Tang

Prognostic factors and nomogram for intracranial malignant meningeal sarcomatosis: a population-based retrospective surveillance, epidemiology, and end results database analysis

Siyuan Yang, Xiaoyu Ji, Tong Wang, Mingzhe Sun, Xuebo Sun, Dejing Cheng, Chengyuan Ji

Pan-cancer multi-omics profiling reveals ubiquitin D as a novel biomarker for diagnosis, immune microenvironment remodeling and prognostic prediction

Yinxia Su, Yong Wang, Fei Liu, Quan Chen

Identification of immunoheterogeneous key prognostic protein ZC3H12D in OSCC and analysis of prognostic models and drug resistance

Qianqian Wang, Shuai Qi, Jing He, Danyang Li, Taoli Deng

Comparison of random survival forest and Cox regression for long-term prognosis of pediatric Wilms tumor: based on the SEER database and external validation cohort from China

Honggang Fang, Junjun Dong, Qinglin Shi, Guanghui Wei, Xing Liu, Shengde Wu, Yi Hua, Dawei He, Qi Li, Deying Zhang

Potential of circulating miR-6875 and miR-1307 as non-invasive diagnostic biomarkers for pancreatic cancer

Vinit Sharma, Ankita Semwal, Shivangani Lohani, Ankita Arora, Sakshi Bansal, Mayank Sharma, Rajesh Gupta, Harjeet Singh, Anjali Aggarwal

Targeted and epigenetic therapies for acute myeloid leukemia treatment

Marzieh Shokoohi, Mobin Ghaderi, Milad Mokarami, Homaira Arian, Sara Mohammadnabi, Arastoo Farokhi

Hsa_circ_0075451 promotes NSCLC proliferation, metastasis, and glycolysis through interaction with the RNA-binding protein RBM4

  • Open Access
  • NSCLC
  • Research

ChongYu Su, YuXuan Wang, Kang Shi, ZheXin Bai, DaPing Yu, ZhiDong Liu

Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization

Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li

Immunogenic cell death-related macrophage gene model for prognostic prediction in glioblastoma

Yiming Mao, Ting Li, Wenqiang Lu, Chunhong Li, Changjiang Wu

CLEC11A as a potential biomarker for prognosis and response to immunotherapy in colon adenocarcinoma

Yuyang Gu, Yanjun Li, Tingting Qian, Xiaofang Xu

Systematic review of c-met as a prognostic indicator in esophageal cancer patients: a meta-analysis study

Zipu Yu, Guofei Zhang, Gang Shen

Gut microbiota as a hidden modulator of chemotherapy: implications for colorectal cancer treatment

Zahra Sadeghloo, Amir Sadeghi

LncRNA B4GALT 1-AS1/miR-144-3p axis suppresses cytotoxicity of CD8+ T cells in lung adenocarcinoma by modulating PD-L1 expression

  • Open Access
  • Research

Lifei Huang, Jiadong Wu, Yahong Sun, Yi Yang, Zhihao Liu

Early antibiotic exposure does not affect prognosis in patients with advanced gastric cancer treated with PD-1 inhibitors

Ziting Qu, Yuyan Wang, Zhikun Wang, Yiyin Zhang, Yan Zhang, Kangsheng Gu

Antibody-drug conjugates in triple-negative breast cancer (2010–2024): a bibliometric analysis of global trends and clinical translation

Xin-Yu Li, Shan-Qi Li, Si-Lu Xiang, Wan-Chen Xie, Jun-Yi Yang, Xiao-Yi Wang, Xue-Dong Yin

LncRNA DEPDC1-AS1 drives the progression of endometrial carcinoma by regulating miR-508-3p

Rencheng Wang, Jianhua Ji

The effect of thyroid nodule location in ultrasound on the diagnosis of papillary thyroid carcinoma

  • Open Access
  • Research

Jia-fei Hu, Jun Xu, Li-ping Gao, Xiao-lin Shen, Yan-li Wang, Min-juan Wu, Ling Zhang

Computational prediction of diagnostic biomarker candidates and prognostic gene signature from DNA replication-related genes in breast cancer

Ceren Sucularli

Big data analysis reveals miR-874 as a suppressor and therapeutic target in the progression from endometriosis to ovarian cancer

Peihong Lin, Ling Wu, Xuedan Lai, Chenxin Xiao, Jianwen Ye

Integrated multi-omics analysis reveals PTM networks as key regulators of colorectal cancer progression and immune evasion

Guiting Yang, Liu Ji, Chengmei Lv, Chen Zhao, Riliang Ma, Ying Li, Yanyan Hu, Linghui Pan

Renal cell carcinoma unclassified with medullary phenotype: a case report and review of the literature

Mengyao Li, LuLu Zhang, Yulei Li, Bing Wu, Jiajun Chen

Regulation of major histocompatibility complex class-I (MHC-I) gene methylation using DNA methyltransferase inhibitor and PD-L1 inhibitor in triple negative breast cancer

Young Ju Jeong, Na-Rang Lee, Hoon Kyu Oh

EGFL9 regulates the growth and metastasis of hepatocellular carcinoma through EGFR/PI3K/AKT signaling pathway and amino acid modulation

Ziye Li, Jingyang Feng, Longcheng Zhao, Lei Wang, Xiaobao Shen, Wei Yuan, Bailin Wang, Fan Wu

Oesophageal metastasis of prostate cancer: a case report

Yu-Juan Shi, Yu-Sheng Yang, Da-Bing Ren, Wang Jing

Amyloid precursor protein accumulation in glioblastoma is associated with altered synaptic dynamics and immune suppression

Tyrel R. Porter, Mikhail Inyushin, Lilia Kucheryavykh

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

Abhishek Chauhan, Seeta Dewali, Vinay Mohan Pathak, Satpal Singh Bisht, Ritu Chauhan, Damandeep Kaur, Hardeep Singh Tuli, Shafiul Haque, Faraz Ahmad

SLC8A1-AS1 inhibits oral squamous cell carcinoma by regulating the miR-1305/ESRRG axis

  • Open Access
  • Research

Shukuang Pan, Feng Ding, Mengtian Hu, Hongbao Xue

Development of a metabolism-associated prognostic risk model based on immune landscape stratification in prostate cancer

Yuanting Liu, Yixiao Shi, Yujie Cao, Yuchun Zhu

Disulfidptosis OXSM serves as a potential prognostic biomarker and correlates with immune infiltrates in glioma

Jinchao Zhu, Yao Ke, Yijuan Fan, Qingyuan Lin, Weiyao Zhu, Wenhuan Guo, Shengdong Nie

A GRK5 centered prognostic framework for bladder cancer based on palmitoylation and epigenetic regulation

Junpeng Liu, Zeke Zhang, Bin Huang, Yutong Fang, Hao Lin

A new prognostic model for lung adenocarcinoma according propionate metabolism related genes: a comprehensive bioinformatic study

  • Open Access
  • Analysis

Chunmei Liu, Liya He, Zexin Peng, Jianmin Luo

Bibliometric analysis of immune dysregulation and immunotherapy in mismatch repair-deficient colon cancer

Xingtao Jin, Hao Wang, Ye Han, Min Yang, Qianqian Ye, Qingming Wang, De Zheng, Zubing Mei

hsa-miR-21-5p can serve as a standard biomarker in clear cell renal cell carcinoma by promoting tumor progression and influencing immune evasion

Mu-Yang Xu, Xu Wang, Shao-yu Yue, Qing-Wei Meng, Xiao-Xin Bai, Lei Chen, Rong-Rong Li, Ke Zhang, Ling-Fan Xu, Yu Guan, Chao-Zhao Liang

Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer

Xvliang Liu, Zeli Yin, Pengju Xi, Liming Wang, Jiakai Mao

Plasma metabolites and endometrial cancer: elucidating causal associations through Mendelian randomization

Songlin Xue, Kaihua Wu, Qinyuan He, Yanwei Zhang, Minmin Yu

SMPD2 affects the prognosis of cancer patients by mediating lipid metabolism and the immune microenvironment

Qing-Yan Li, Jia-Ming Huang, Xiang Yuan, Hui-Long Guo, Wei Zhang, Yu-Chuan Chen, Yi-yi Li, Ze Song

Identification of prognostic biomarkers associated with T and melanoma cell subpopulations in melanoma through integrating machine learning and multiomics

Huiwen Zheng, Chen Shen, Liming Ma, Jing Li, Wei Li, Sha Zhou, Fang Guo, Gang Yu

Clinicopathological features and prognostic factors of apocrine carcinoma of the breast in a cohort of 63 patients

Ryusei Yoshino, Nozomi Hatanaka, Kengo Takahashi, Akane Ito, Nanami Ujiie, Shunsuke Yasuda, Masahiro Kitada

Multilayered insights into the full spectrum of diffuse gliomas: a novel prognostic evaluation model

Xu Cao, Mingfan Liu, Dongmei Zou, Jing Zhang, Jing Huang, Ke Li

The multifaceted role of RNF213 in oncogenesis: current insights and future research directions

Guicheng Kuang, Hang Ji, Hailan Yang, Haitao Liu, Haogeng Sun, Yi Liu

DNMT3A-R882 mutation promotes acute myeloid leukemia progression by recruiting E2H2 to inhibit circKCNQ5 methylation

Yijian Chen, Xiaodan Zhu, Chuanming Lin, Rong Xu, Pengxiang Xu, Liuyan Xin, Lin Li, Liqun Zhang

Exploring drug repurposing for PAK2 inhibition: a systematic virtual screening of FDA-approved drugs against cancer

  • Open Access
  • Research

Shadma Wahab, Abdulrhman Alsayari, Taghreed A. Majrashi, Mohammad Ali Abdullah Almoyad, Rahaf Abdullah Assiri, Wasim Ahmad, Subhash Chandra

Exploring the genetic determinants of the oral microbiome’s role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population

Wei Jin, ZongYao Zhang, Hang Zhang, Xiaoli Jin, Jun Wang

Deciphering key chemotherapeutic drug targets within tyrosine metabolism for breast cancer and advancing a wide-ranging diagnostic strategy

Dan Lu, Jun Yang, Reng-min Wu, Zi-lu Xie, Shu-hang Cao, Huan-huan Shi, Shaofeng Jiang, Chen Yi, Dong-juan Chen

Firmicutes in gut microbiota: hormonal influence on breast cancer in obese individuals

Jiale Chen, Zicheng Zhang, Manqi Ma, Qianyu Huang, Zijun Ling, Yutong Liu, Zhenjian Gao, Saifeng Wang, Yilin Zhu, Lehong Zhang, Mupeng Li, Minfeng Liu

Case report: metachronous male metastatic breast and colon cancer in a BRCA2 mutation carrier

Emiliana Larionesi, Oana-Nicoleta Pilet, Christos Sotiriou

The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study

Xin He, Yuzhe Zhang, Zhengsheng Yi, Xiaohui Zhao, Yusheng Shi, Shengni Hua

Predictive factors of pathologic good response after neoadjuvant chemoradiotherapy for rectal cancer

Yi-En Lin, Tung-Hao Chang, Tsai-Wei Chou, Jin-Ching Lin, Li-Chung Hung, Chia-Chun Huang, Jhen-Bin Lin, Jie Lee

Single-cell RNA sequencing reveals NFATc1-mediated regulatory mechanisms of vascular smooth muscle cell osteogenic transformation in the osteosarcoma microenvironment

Xuejiao Yi, Shilin Fu, Chunliang Zhang, Tianle Zhao, Huan Feng, Dehui Qian

ATG7-induced autophagy inhibits ferroptosis and promotes the progression of colorectal adenocarcinoma

Minyuan Chen, Ziqi Meng, Limei Zhu, Jieyu Liu

Low pre-treatment neutrophil-to-lymphocyte ratio predicted a better survival in recurrent/metastatic cervical cancer treated with PD-1/PD-L1 inhibitors

Jing Li, Yulu Wang, Jiayu Pei, Min Wang, Dian Wang, Ruixia Guo, Haifeng Qiu

Mechanistic evaluation of hyperoside against non-small cell lung cancer: a combined approach of network pharmacology and in vitro experimental validation

  • Open Access
  • NSCLC
  • Research

Shuang Xu, Yaping Zou, Guangwen Luo, Liu Tang, Haichao Zhan, Lili Huang, Zhaowei Zhang

Effect of body mass index on postoperative lymphedema after breast cancer: a systematic review and meta-analysis

Weiwei Zhang, Zhilin Liu, Jinming Li, Hengheng Zhang, Meijie Wu, Ping Yang, Tao Wu, Guoshuang Shen, Fuxing Zhao, Zhen Liu

Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma

  • Open Access
  • Analysis

Qing Wang, Gang Liu, Jun Zhang, Qinguang Zou, Junfeng Geng

Multidimensional transcriptomic and immune profiling of papillary thyroid cancer: bridging molecular networks, disease stage, survival outcomes, and drug discovery

Haitham Al-Madhagi

Prevalence of GLUT1 overexpression in human cancers a systematic review and meta analysis

Quan Yuan, Hongzhi Liu, Canxu Song, Yan Tian, Waseem Hassan, Ramla Shabbir, Chen Wenjuan, Le Han

Multi-omics analysis of ILF2 reveals its prognostic value and functional roles across pan-cancer

Huan Xiong, Zewei Chen, Junjie Xu, Hailin Tang, Xiaoyan Li, Anli Yang

Identification and prognostic significance of Ki-67-related genes in triple negative breast cancer

Wenhan Li, Dan Chen, Jianhui Li

Pharmacological inhibition of NMDA receptors reduces migration and viability in triple-negative inflammatory breast cancer cell lines

Laura L. Mendez-Santacruz, Xavier S. Bittman-Soto, Alexie Molina-Nieves, Carmen S. Maldonado-Vlaar, Esther Peterson-Peguero

Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms

Yingying Wei, Junlian Li

Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer

Guanlong Wang, Lidan Zhu, Ling Lu, Guangyang Wu, Bangjie Wang, Changjun Yu

Poly(ADP-ribose) polymerase-1 in breast cancers: expression level and its association in various molecular subtypes with a focus in Africa

James J. Yahaya, Advera I. Ngaiza

An integrative bioinformatic and Mendelian randomization study exploring the role of polyunsaturated fatty acid metabolism in laryngeal cancer

Lina Peng, Haibin Ma, Longchao Qin, Qian Zhao, Xueyan Ren, Zihao Wang, Jing Hu, Haiping Han

The management of benign parotid disease

Rui Shi, Shao-ming Li, Ling Gao, Wen-hao Ren, Ke-qian Zhi

Global research trends in CAR-T cell therapy for glioblastoma: a bibliometric and visualized analysis

Jian Li, Lichun Lu, Yu Duan, Guohui Huang, Xuhao Fang, Yao Deng, Feng Tang, Feng Jiang, Dongwei Dai

Benign prostatic hyperplasia and risk of urological cancers: a prospective cohort study based on the UK biobank

Jinjing Guo, Liang Zhou, Jiaming He, Xinkai Pan, Dingwen Liu, Jiaren Li, Qing Zhou, Long Wang

Integrative bioinformatics analysis and elastic network modeling elucidate the role of cellular senescence in meningioma recurrence

Jian-huang Huang, Yao Chen, Yuan-bao Kang, Cai-hou Lin

Unveiling the oncogenic functions of lncRNA PSMG3-AS1: a review of its biological roles in cancer

Hui Zhang, Xin Wang

Mendelian randomization analysis of druggable gene expression in liver cancer risk and autoimmune hepatitis

Mingming Lian, Jun Yao

Integrating single-cell and bulk RNA sequencing data establishes a cuproptosis-related gene predictive signature in breast cancer

Rongrong Peng, Yu Li, Bo Xu

Tumor size in the management of preoperative radiotherapy for locally advanced rectal cancer

Xiaohong Zhong, Huaqin Lin, Qizhen Huang, Lei Wang, Junxin Wu

Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality

  • Open Access
  • Analysis

Zhiguo Wang, Chen Wang, Xiangyu Gao

Genetic risk and clinical implications of BRCA1 and BRCA2 mutations in Turkish triple-negative breast cancer patients

Betul Celik Demirbas, Seda Kilic Erciyas, Ozge Sukruoglu Erdogan, Zubeyde Yalniz Kayim, Ozge Pasin, Merve Cigdem Ozgel, Seref Bugra Tuncer

Cell division cycle 25 C (CDC25C) mediates cell-cycle progression and immune evasion in glioma

Anqi Qiao, QiuYue Zhang, Jiakai He, Fan Song, Tenglu Cui, Yi Liu, Pengfei Sun

Driver gene-specific prevalence and incidence of brain metastases in non-small cell lung cancer: a meta-analysis encompassing all disease stages

  • Open Access
  • NSCLC
  • Analysis

Yu Zhang, Yuxin Wen, Peiyang Fan, Fangfang Li, Muye Li, Zhiyuan Wang, Xiaofang Wang, Zichen Mao, Yanxun Li, Yuchen Yao, Li Bian

TERT links telomere length to cancer risk by integrating genomic instability and immune modulation

  • Open Access
  • Analysis

Jingwei Zhao, Jiayun Zhu, Kangle Zhu, Mingyang Wang, Wei Gong, Jiandong Wang, Shilei Liu

Identification of KIF14 as a ferroptosis biomarker for predicting the prognosis and immunotherapy efficacy of bladder cancer

Xiaocheng Ma, Changyi Quan

Voxel-wise analysis of brain metastasis predilection sites in breast cancer by clinical features

Hairong Wang, Hongyu Chen, Haoqun Xie, Hao Duan, Lei Lin, Jiangen Chen, Dongping Jiang, Yonggao Mou, Zhongping Chen, Qunying Yang, Maojin Yao, Chengcheng Guo

Genetic and epigenetic contribution to tamoxifen resistance in breast cancer, concepts to drive therapeutic strategies

Rosa Jahangiri

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study

Beian Guo, Zhiyi Zhou, Wanzhe Liao, Yurong Zheng, Yinjie Liao, Ruiqi Zeng

Construction of lactylation-related prognostic signature for glioma

Yi Huang, Shenbao Shi, Qiuchan Yan, Ziwen Qiu, Zhiming Zeng

Prognostic analysis and immunotherapy prediction based on key receptor-ligand pairs of bladder cancer

Yuhang Wang, Tailai Zhou, Chen Hu, Hengxin Chen, Minfeng Chen

Mendelian randomization analyses support causal relationships between unswitched memory B cells and lung squamous cell carcinoma

Hong-Jun Li, Chun-Yu Lin, Dai-Zheng Huang, Zhen-Cheng Chen, Xiao-Jv Chi

Lactylation-related gene signatures for prognosis and treatment response prediction in radiation-resistant non-small cell lung cancer

  • Open Access
  • NSCLC
  • Analysis

Xiangdi Yang, Guanjun Li, Rong Jiang, Yongqin Yang, Huan Zhu, Linxuan Huang, Tingting Li, Jianping Zhou, Zhigang Liu

CDCA5 knockdown potentiates olaparib sensitivity in BRCA1-mutated ovarian cancer through autophagy activation

Wenzong Wu, Huan Wu, Yuqing Song, LiuJun Wu, Jiajia Chen, Minsheng Zhu, Xinchun Wu, Jiawei Wang, Qingsong Zhang

Role of interleukin-6 in resistance to tumor therapy

Yumin Liang, Yingjie Shao, Wendong Gu

Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma

Yi Yin, Xingyu Fu, Shuhua Gong, Yutong Xie, Wenyu Wu, Zhenzhou Li, Shuo Wu, Zhengliang Gao, Ke Hu, Chun Luo, Huan Wang

Isoquercitrin triggers the ferroptosis of ovarian cancer via SLC7A11-dependent manner to repress its tumorigenesis

Xiaolong Zhang, Youzhen Luo, Qiaoling Gao, Zhisheng Huang, Caihong Li

Comparative evaluation of CD34 immunohistochemistry and hematoxylin and eosin staining for detection of lymphovascular emboli in oral squamous cell carcinoma: a retrospective cross-sectional study in a developing country

Kajal Hatgaonkar, Anand Hatgaonkar, Pratibha Dawande, Shweta Sonkusale, Shruti Deshpande

Mapping research hotspots and trends in hepatocellular carcinoma nanomedicine: a bibliometric analysis

Lu Yang, Lei Yu, Qiang Zhou, Li Liu, Shimin Tang, Yong Li, Na Li

Drug repurposing in cancer research: a bibliometric analysis

Uche Samuel Ndidi, Israel Ogwuche Ogra, Emohchonne Utos Jonathan, Okechukwu Kalu Iroha

Comparing the diagnostic accuracy of pre-operative genetic testing for thyroid cancer on fine needle aspiration cytology specimens: a systematic review and meta-analysis of diagnostic accuracy

Xin Liao, Klaas Van Den Heede, Bruno Lapauw, Wouter Huvenne, Dirk Ysebaert, Vanessa Meert, Ying Fang, Jing Li, Sam Van Slycke, Nele Brusselaers

Identification of key biomarkers and immune microenvironment features in gliomas based on single-cell analysis combined with bioinformatics

Yang Zhang, Lisha Liu, Chao Peng, Lu Wang, Jun Yang, Yingjiang Gu, Yu Cai

Gut microbiota and urological cancers: from microecological imbalance to potential for precision therapy

Junfeng Cui, Hong Chen, Fengming Dong, Qianqian Zheng, Jinge Wu, Bo Feng, Dongsheng Guo, Shaohui Jiang, Meng Li, Jingyu Li

Expression of FoxP3 in oral squamous cell carcinoma and its biological significance

  • Open Access
  • Research

Lina Jiang, Yangxiao Zhang, Chenchen Zhu, Luwen Song, Zhenghao Ma, Hongsheng Liu, Zhenxing Su, Mingxun Xia, Jiancheng Li

Comprehensive bioinformatics evaluation uncovers the possible oncogenic contribution of acrylamide to endometrial cancer

Yiting Zou, Shan Lu, Shiqiang Han, Renfeng Zhao

Deep learning-based survival prediction model for adult diffuse low-grade glioma: a multi-cohort validation study

Pengfei Xu, Wenxin Liu, Haibo Su, Tang Ye, Guangyuan Wu, Tao Wu, Baodong Chen

Multi-omics-based molecular classification of adrenocortical carcinoma predicts response to immunotherapy and targeted treatments

Xingwei Jin, Xianjin Wang, Zhiyuan Wang, Baoxing Huang, Xuejian Zhou, Boke Liu, Yuan Shao, Guoliang Lu

Gene-edited hematopoietic stem cells for leukemia and lymphoma treatment: a systematic review of preclinical and translational evidence

Hassan Nourmohammadi, Mashallah Babashahi, Mohammad Panji, Safa Radmehr

Evaluating the prognosis of prostate cancer through metabolic pathways

Qiang Su, Yi Hu, Bin Dai

The role of pyroptosis in ovarian cancer

Yingzhi Zhou, Tian Peng, Jiahan Zhang, Ruojia Liang

LncRNA VIM-AS1 is a potential prognostic biomarker and effects on tumor cellular behaviors in breast cancer via impairing miR-29a-3p

Yang Yuan, Meng Wei, Linna Kong, Pengfei Li, Huihui Zhang, Wenqing Bian, Qun Yuan

Overlapping risk factors and pathogenic mechanisms in lung cancer and cardiovascular disease

Yan Liu, Yifei Li, Haiyang Ning, Yujia Xi, Yifan Li, Jinfeng Ma

GlycoRNA, a novel RNA modification

  • Open Access
  • Review

Binbin Hu, Tianyu Ma, Dongli Zhou, Juan Jiao, Xiangwei Xia

Identification and analysis of key transcription factors in esophageal squamous cell carcinoma

  • Open Access
  • Research

Zhe-Ran Chen, Zhi-Yuan Cheng, Si-Wei Zhou, Yan-Hui Zhang, Ye Gao, Chu-Ting Yu, Bo Tian, Xun Zhang, Yan Bian, Mei-Juan Hao, Wei Wang, Lei Xin, Han Lin, Luo-Wei Wang

Research advances of lactylation modification in breast cancer

Pu Shen, Meng Yang

The role of LncRNA SNHG3 in human cancers

Jinming Tang, Min Su, Yuhang Xiao, Wei Ou, Wenxiang Wang, Ren-Wang Peng, Zhining Wu

Clinical performance of GAAD score, alpha-fetoprotein, and PIVKA-II in diagnosing hepatocellular carcinoma in the Vietnamese cohort

Thuy Thi Thu Pham, Dat Tan Ho, Toan Bao Nguyen, Hai Thanh Phan

Disulfidptosis mechanisms and therapeutic implications in cancer metabolic reprogramming and future perspectives

  • Open Access
  • Review

Ronghui Chen, Jianhang You, Suxia Weng, Tao Zhao

A bibliometric analysis of atezolizumab in hepatocellular carcinoma

Yuqing Xu, Hucheng Zhang, Haipeng Yu

Association of FANCD2, TFPI, and CD33 genes with prognosis of lung adenocarcinoma: a bioinformatics study

  • Open Access
  • Analysis

Guixin He, Ting Ge, Lijiang Ji, Yaoyao Guo, Ping Zhao

Alpha 5 integrin as a prognostic biomarker for survival in carcinomas: a systematic review

  • Open Access
  • Review

Natalie Ap. Rodrigues Fernandes, Milena Moraes de Carvalho, Lélio Fernando Ferreira Soares, Wafa Wahbi, Tuula Salo, Ahmed Al-Samadi, Carlos Rossa Junior

Clinical study of aumolertinib versus osimertinib in the treatment of EGFR-mutated advanced non-small cell lung cancer

Sheng-Xi Yang, Jia-De Zhu, Ling Ma, Yan Pan, Qiu-Rui Li, Wen-Lian Tu, Zhi-Qing Zhang

Malignant progression of MES-like cells mediated by COL22A1 in the spatial heterogeneity of glioblastoma

Guangyuan Chen, Zhonghua Fu, Xulin He, Zhaoli Shen

Multimodal imaging and advanced quantitative techniques for HER-2 status prediction in breast cancer

Qingxue Wang, Ning Zheng, Qingqing Yu, Shuo Shao

Endoscopic submucosal dissection in Helicobacter pylori-negative early gastric adenocarcinoma with diffuse large B-cell lymphoma: a two-case report and literature review

Bo Zhang, Xue-Guo Sun, Qing-Juan He, Li Chen, Ti-Dong Shan

WNK1 promotes head and neck squamous cell carcinoma progression through activation of NF-κB signaling pathway

Ru-zhen Chen, Rui Li, Bing-lin Cheng, Si-bei Lu, Wen Hu, Feng Lin, Xin Wen, Yue Chen, Ying-lei Wang, Mo-ting Zhang, Xiao-hong Hong, Xin-ran Tang

Untargeted metabolomics reveals gut microbiota metabolite alterations and their correlation with serum biomarkers in gastric cancer patients from high-altitude regions

Linghong Zhu, Zhaoxin Jin, Yanqing Ma, Xiao Feng, Caihong Ci, Yunsong Zhou, Qiaoling Gu, Yongmei Lan, Zilong Zhang

LncRNA LINC02381/miR-133b axis promotes tumorigenesis and predicts survival in pancreatic cancer

Junna He, Ronglin Bai, Xuehu Song, Yu Wang, Yichuan Zhang, Zhulin Luo

A clinical analysis of 19 cases of chordomas with poor differentiation treated using diverse therapeutic modalities

Wei Wang, Yajie Cui, Renkun Nie, Lirong Mao, Yue Su, Chao Liu, Wenhuan Chen, Jie Ding, Zhengzheng Shen, Jianzhi Gao, Jingli Du

Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis

Li Wang, Jian-wei Yang, Kang-yu Wang, Si-yu Chen, Li Yang

Global trends in retroperitoneal sarcomas surgery: a bibliometric analysis from 2005 to 2024

Junxiang Zhang, Kai Deng, Yukai Zheng, Bo Ban, Gan Li, Jie Lian, Yanjun Sun, Xuqi Li, Shufeng Wang

CD8 T cell exhaustion-associated LncRNA signature reveals novel molecular subtypes and immune targets in hepatocellular carcinoma

Jiahui Feng, Dezhong Yan, Lingling Jiang, Fengqian Song

Bibliometric analysis of global research trends in delivery systems for breast cancer immunotherapy

Jun-Yi Yang, Xin-Yu Li, Si-Lu Xiang, Xiao-Yi Wang

Sulforaphane from broccoli, an epigenetic modulator in cancer cells

Soayébo Dabre, Abdou Azaque Zoure, Lassina Barro, Jeanne d’Arc Wendmintiri Kabre, Mousso Savadogo, Aida Dje Traore, Florencia Djigma, Jacques Simpore

The global, regional, and national burden of acute lymphoblastic leukemia, 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study

Chen Yuan, Meiping Zhu, Yi Shi, Qian Chen, Hongzhou Ye, Yinjie Ling, Jing Fang, Wenyuan Liu

Database analysis reveals endophilin A expression as a marker of metastasis and prognosis in breast cancer

Vikrant Mehta, Sohidul Islam, Harit Kasana, Harish Chander

A meta-analysis based on propensity analysis studies comparing neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma

Zixian Jin, Jiani Zhu, Jian Zhang, Jianfei Shen, Bo Zhang

Advances in biomarkers of resistance to KRAS mutation-targeted inhibitors

Lihao Wang, Dandan Wei, Shanshan Li, Shiqing Jiang

Development of a novel 4-protein signature for prognostic prediction in hepatitis B virus-induced hepatocellular carcinoma

HaiFeng Xie, Yuhong Zhao, Xianzhong Luo, Heran Zhou, Pengcheng Tong

Epithelial guardians against cancer: integrating cell competition and extrusion in early tumor control

  • Open Access
  • Review

Grecia Riofrio-Chung, César Rivera

Mendelian randomization analysis reveals protective effects of LIFR and CXCL5 against breast cancer risk

Yuchuan Liu

Elucidating biomarkers of carcinogenesis in ulcerative colitis: insight from Mendelian randomization and transcriptomics

Xiang Xiao, Xuanyu Wu, Tian Liu, Yi Cai

Anticancer role of Gramicidin A in myeloid leukemia

Syeda Maham, Mudassir Khan, Aleeha Noor, Fazal Adnan, Salik Javed Kakar, Afsar Ali Mian, Dilawar Khan

Pan-cancer analysis of HOMER1 in hepatocellular carcinoma revealing diagnostic potential and immune landscape with experimental validation

Guohong Yan, Ziyan Lu, Jiakao Zhang, Xiang Wang, Shutian Mo, Yongguang Wei, Meifeng Chen, Jiaming Liang, Chuangye Han, Xinping Ye

SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer

Travis J. Gates, Dechen Wangmo, Kyra M. Boorsma Bergerud, Bridget M. Keel, Christopher Staley, Subbaya Subramanian

Pan-cancer and machine learning reveal the role of cell adhesion molecules in prognosis, immune remodeling, and anti-tumour therapy in lower-grade gliomas

Xu Zheng, Jianpeng Liu, Jiheng Zhang

Single-cell profiling of ERBB family receptors identifies ERBB3 as a key regulator in head and neck squamous cell carcinoma progression

  • Open Access
  • Research

Yuling Luo, Youwei Li, Shuqin Liu, Renmei Hu, Jinzhi Wu

The choice of adjuvant radiotherapy in adrenocortical carcinoma patients after radical adrenalectomy: a population-based analysis

Minjuan He, Minqin He

The value of circulating methylated septin 9 in the diagnosis and prognostic assessment of gastric cancer

Jingru Ni, Xiaohe Hao, Yongkang Wu, Xiangguo Yu, Heng Liu, Xinkai Mo, Qinghai Lin

Development and validation of a leukemia prognostic model through single-cell RNA sequencing and machine learning approaches

Doujia Chen, Jie Yang, Mengting Wang, Tianye Jian

Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer

Zhiyang Ma, Yining Hao, Wei He, Xin Xie, Danfeng Xu, Chenghe Wang

Expression and prognosis of CXCL13 in uterine corpus endometrial carcinoma based on bioinformatics analysis

Zhu Wang, Yongning Gao

Impact of immune cells on renal cancer risk: a Mendelian randomization analysis with clinical cohort validation

Shunqi Chen, Xiangkun Li, Chunyu Wu, Xiaoli Wang

B cell-associated research in non-small cell lung cancer: a bibliometric analysis of current landscapes and future directions

  • Open Access
  • NSCLC
  • Research

Yuxin Zhang, Xiuyu Chen, Wanzi Mai, Linxuan Wang, Yuli Wang, Chunzheng Ma, Honglin Li

Transcriptomic landscape of NK cell–related genes in hepatocellular carcinoma: associations with prognosis and therapeutic response

Yuxiang Wang, Wenqiang Liao, Jianbo Lin, Jun Li, Jian Gong

Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels

  • Open Access
  • Analysis

Xuanshuo Liu, Bohua Chen, Jianghao Yuan, Shuhao Li, Lei Gao, Mingyan Chu, Shicang Fan, Weiwei Fan

Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies

Biao Ran, Xinyi Wang, Bohan Liu, Junjiang Ye, Liangren Liu, Zhaofa Yin, Zhongli Huang

An exploratory study on the potential of angiogenic genes in early HNSCC detection

Mao-Ling Huang, Fa-Zhang Lan, Lei Xu, Bin He, Long Huang, Zheng Tang, Zhen-Dong Jiang, Tao Liu, Wen-jun Shan, Cheng Zhong

Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential

Muhammad Alaa Eldeen, Abdelrahman Mostafa, Farag Mamdouh, Waleed K. Abdulsahib, Dalal Sulaiman Alshaya, Eman Fayad, Hassan M. Otifi, Hesham M. Hassan, Mohammed Alshehri, Aiysha Althobaiti, Ghadi Alsharif, Mohamed A. Soltan

PH responsive hydrogel nanocomposites for targeted Shikonin delivery enhance anti PDL1 immunotherapy in osteosarcoma

Xiang-yi Chen, Xian-qin Yang, Ming-yang Wang

Identifying the causal role and therapeutic potential of immune-related genes in bladder cancer: a Mendelian randomization study

Yonggang Chen, Qingfeng Yu, Xiaomei Jiang, Lin Li, Le Kang

Recent advances in immunotherapy for breast cancer

Yi Guo, Gang Zheng, Yu Fan, Liangchang Li, Yang Sun

Circulating metabolites and bladder cancer: a Mendelian randomization and multi-omics study

Zhe Chang, Jirong Wang, Li Wang, Zongjian Hu, Siyu Chen, Li Yang

Integration of machine learning to reveal the correlation between ferroptosis and M2 macrophages in head and neck squamous cell carcinoma

  • Open Access
  • Analysis

Juntao Huang, Ziqian Xu, Lixin Cheng, Chongchang Zhou, Zhenzhen Wang, Hong Zeng, Yi Shen

Elucidating the causal triad of cardiovascular disease, cancer, and lipid traits: a bidirectional Mendelian randomization study with genetic mediation analysis

Weijie Wu, Aiming Zeng, Yunzhe Yu, Liqun Liao, Yuheng Jiao, Jiaqi Hu, Jiansheng Chen

Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction

  • Open Access
  • Analysis

Jianhui Chen, Xinyi Wu, Guo Han, Chao Xu

In vitro assessment of benzothiadiazole-based photoactive polymers against ovarian, prostate and bladder cancer cell lines for photodynamic therapy

Rolan Mansour, Fawziye Tarhini, Nicolas Bruce, Jamie Blanche, Mahmoud Wagih, Ahmad Taha, Karin Williams, Jonathan Copper, Muhammad Imran, Karin Oien, Hadi Heidari, David Flynn

Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study

Zhandong Zhang, Shuaibing Lu, Liangqun Peng, Fusheng Ge, Bin Zhang, Yonglei Zhang, Fei Ma, Yawei Hua, Xiaobing Chen, Wei Yang

Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression

Ying Dong, Yue Deng, Longyan Zhu, Rongji Li, Huilin Yang, Lihua Yang

Identification and validation of a prognostic model for HER2-low breast cancer based on unfolded protein response-related genes

Yanjiao Zhao, Yuanyuan Gao, Hui Yan, Ping Hu

Bibliometric analysis reveals global thymoma research trends collaborations and emerging frontiers from 2010 to 2024

  • Open Access
  • Research

Zhen Yu, Yu-han Li, Qi Han, Xin-peng Wang, Xin-tao Yu, Jian Cui, Xiang Gao, Xing-guo Yang, Lei Yu

The influence of ferroptosis-associated gene HSPA5 on the prognosis and immune evasion of lung adenocarcinoma

  • Open Access
  • Research

Lei Xiong, Xiang Gao, Lixin Wang, Liguo Luo, Jun Su, Yanqing Wang, Yi Shen

Comprehensive analysis of immune escape-related prognostic signature in high-grade glioma

Chongkang Ren, Jinyi Cai, Yanhua Liu, Zeshang Guo, Xinyu Hong

Mapping the future of early breast cancer diagnosis: a bibliometric analysis of AI innovations

Şevki Pedük

Endoscopic therapy versus surgical resection for rectal gastrointestinal stromal tumors: a population-based comparative analysis of long-term survival outcomes

Jiayi Ding, Luojie Liu, Ye Ye

Visualization and bibliometric analysis of global research trends on oral cancer screening and early diagnosis

  • Open Access
  • Research

Guangcong Huang, Haojun Deng, Shuohui Sun, Shishu Fang, Junli Ma

Enhanced multi-omics analysis reveals a lncRNA signature with 12 RNA modifications to predict tumor heterogeneity and potential therapy in non-small cell lung cancer

  • Open Access
  • Analysis

Hua You, Mingyu Fan, Limei Yin, Feifei Na, Liting You

Endometrial cancer: from clinical reality to molecular treatment

  • Open Access
  • Review

Léa-Isabelle Renaud, Elisabeth St-Laurent, Coralie Compare, Raphaëlle Proulx, Jasmine Nolan, Eric Asselin

Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer

Xu He, Peng Chen, Zhihao Zhao, HyokChol Choe, Tanveer Ali, Kaiyue Ding, Xingchen Wu, Junnan Ma, Lin Zhang

Multiomics analysis of COL12A1 as a promising prognostic biomarker for immune-related treatment of gastric cancer

  • Open Access
  • Research

Jin Shi, Chenggong Zhang, Zihao Gao, Fan Ding, Dezhu Dai, Xu Wu, Xiao Han, Liang Shi, Xudong Song, Guoquan Tao

LINC01123: a pan-cancer “molecular commander” deciphering the CeRNA network atlas for precision diagnosis and therapy

  • Open Access
  • Review

Zheng Chen, Weijian Zhu, Qiang Yi, Xinting Ouyang, Kui Zhong, Qiong Ge, Mengying Zhang, Qinfu Yan, Jianing Zhong, Jinghua Zhong

Identification of palmitoylation-related lncRNAs as prognostic biomarkers and immune modulators in HCC

  • Open Access
  • Research

Yongkang Zou, Xuejun Zhao, Shengpeng Yang, Yan Liu, Shuaimin Zhang, Xiangang Xu, Gen Chen, Yi Zhang

Strategies for managing EMA/CO resistant in gestational trophoblastic neoplasia a systematic review and meta analysis

  • Open Access
  • Research

Febia Erfiandi, Setyo Teguh Waluyo, Candra Novi Ricardo Sibarani, Gatot Nyarumenteng Adhipurnawan Winarno, Aini Sofa Haniah, Nicholas Adrianto

Advances and challenges in immunotherapy and molecular imaging for hepatocellular carcinoma

  • Open Access
  • Review

Tu Haibin

The hotspots and publication trends in photodynamic therapy/photothermal therapy for gastric cancer: a bibliometric analysis

  • Open Access
  • Research

Zhiyong Zhang, Jiechen Zhang, Shun Zhi, Wenlin Li, Yifei Yuan

Interleukin-1 receptor-associated kinase-1 is a therapeutic target for gastric cancer

  • Open Access
  • Research

Hui Shi, Jie Zhang, Xiaohua Bao

Predictive role of a novel nutrition and inflammation-based model in the short-term clinical outcomes and health-related quality of life of patients undergoing radical gastrectomy: a retrospective cohort study

  • Open Access
  • Research

Pengfei Li, Chunhua Zhou

Mapping the global intellectual landscape of inflammatory tumor microenvironment in colorectal cancer pathogenesis and prognostic research since this century

Hui Mu, Yushu Zhu, Feihu Yan, Can Lv, Xiaoyu Tu, Junyan He, Zhaoming Wang, Yi Zeng, Zhiwei Liu, Jiaojiao Chen, Bai Li, Enda Yu, Xuan Zheng

Emerging therapeutic advancements in pancreatic cancer: a contemporary review

Midhun Malla, Yara Sakr, Garima Gupta, Mehmet Akce, Bassel El-Rayes

Strategies to reduce intestinal toxicity in neoadjuvant management of locally advanced rectal cancer

Hoda Mahdavi, Sahar Dashti, Shima Jafari

Inhibition of NR2F2 suppresses invasion ability and modulates EMT marker in head and neck squamous cell carcinoma

Joo Kyung Noh, Seon Rang Woo, Min Kyeong Lee, Jung Woo Lee, Young Chan Lee, Seong-Gyu Ko, Young-Gyu Eun

Development of an ADME gene signature for prognostic and therapeutic stratification in gastric cancer

Dandan Wang, Xuejian Wang, Lin Chen, Huiying Wang, Xiangfei Meng, Zhenwei Miao, Yang Zhao

Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway

Dengyi Cao, Jiawei Chen, Shaobo Zhou, Jie Tang, Zixiang Liu, Zixiang Zhang

Pan-cancer analysis of INHBA indicates its potential prognostic value and correlation with HNSC and LIHC

  • Open Access
  • Analysis

Shumin Li, Beibei Xu, Guanghui Wang, Luan Xu, Liya Ding, Xiaopei Wu, Baoying Zheng, Yuefeng Han

Integrated bioinformatics analysis of common molecular mechanisms and biomarkers in oral squamous cell carcinoma and periodontal disease

Lin Wu, Peng She, Chenguang Qiu, Hongtao Sun, Fanzhi Kong, Hong Wang, Yu Tian, Jun Yang, Zhenwei Mao

A prognostic nomogram to predict clinical outcomes of patients with primary malignant and benign retroperitoneal tumors

  • Open Access
  • Research

Yunfei Zhang, Jing Wu, Abudusalamu Tuersunmaimaiti, Gang Yao, Xiapukaiti Fulati, Yilizhati Azhati, Alimujiang Mamuti, Tao Li, Tuerhongjiang Tuxun

Identification of an E2Fs-based gene signature for predicting prognosis and therapeutic response in colorectal cancer

Feifan Zhang, Zhiwei Sun, Zhenyu Zhang, Kexin Jiang, Bowen Wei, Xiaoqi Yu, Yunfei Zuo, Shuangyi Ren

Multi-omics analysis identified LGALS1 (Galectin-1) as a novel therapeutic target for clear cell renal cell carcinoma via targeting epithelial or endothelial cells

Xiangyin Tan, Yingfei Chen, Chao Jiang, Jialiang Shao, Xiang Wang

Ferroptosis and radiotherapy-related genes in head and neck squamous cell carcinoma: diagnostic and prognostic significance

Liyuan Fan, Liang Shi, Zhongchao Wang, Jinghan Wang, Yandong Mu

Neutrophil extracellular traps (NETs)-score: a novel prognostic marker for colorectal cancer patients

Xiao-Li Wu, Di Hu, Guo-Fa Xu, Mei-Yu Zhou, Bin Li, Xiao-Qiao Hu, Gen-Dou Zhou, Ya Fu, Rui Huang, Shou-Yan Xiang, Miao-Miao Tao, Hong-Bo Ma

Blood expression of CTLA-4, PD-1, and PD-L1 as potential prognostic and diagnostic markers for breast cancer: a systematic review

Mina Niusha, Saba Hajazimian, Nayemeh Soltani, Pouya Goleij, Parisa Pagard, Farshid Oruji, Javad Behroozi, Shima Shabani, Alireza Isazadeh, Behzad Baradaran

Suppressing CDCA8/CDK1 improves oral squamous cell carcinoma by modulating proliferation, apoptosis, cell cycle and migration

Jiang Zhu, Chen Chu, Yu Xue, Wei Guan, Jianping Qiu, Aijun Guo, Weiming Chu

Clinicopathological characteristics of BRCA1-associated breast carcinoma patients in Kazakhstan

Ainur Samigatova, Nursulu Altaeva, Yerlan Suleimenov, Petr Sibiryakov, Kuantkan Zhabagin, Zhanar Zhakypbekkyzy, Bakhytzhan Seksenbaev

The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression

Zahra Farjami, Zahra Mohammadzadeh, Bita Saifi, Mahasti Tavakoli Nezhad, Mohammad Mehdi Akbarin

Clinicopathological characteristics and molecular genetic analysis of inflammatory and nested testicular sex cord tumor: a case report and literature review

Yan Wang, Yun Xi, Meijuan Wu

A prognostic signature based on insulin-signaling-pathway genes for hepatocellular carcinoma

Yanyan Zhang, Haoqian Song, Wenshuai Cui, Kunwei Peng

Correction: Smoking and alcohol specific alterations in miRNA expression in head and neck squamous cell carcinoma

  • Open Access
  • Correction

Mohd Younis Bhat, Vishalakshi Nanjappa, Mariana Brait, David Sidransky, Aditi Chatterjee, Jayshree Advani

Integrated single-cell and Mendelian randomization analyses: dissecting underlying causes of varied efficacy in immune neoadjuvant therapy for esophageal carcinoma

Jiaxin Li, Sibo Meng, Ying Zhou, Yufeng Cheng

Integrative analysis of angiogenesis-related genes highlights prognostic indicators in colorectal cancer through single-cell sequencing and immune infiltration analysis

Neelam Bhola, Sameer Bhardwaj, Chanchal Bareja, Daman Saluja

Deciphering TICRR's oncogenic landscape in pancreatic adenocarcinoma: molecular insights and clinical implications

Ke-Jie He, Haitao Wang

The expression of miR-381-3p in acute myeloid leukemia and its effect on corresponding cell proliferation and apoptosis

Jiali Hu, Peixin Zhang, Hongxia Zhang

Knowledge mapping and visualization of immune checkpoint inhibitor-related pneumonitis: a bibliometric analysis

Yanyan Jiang, Mingling Xu, Shanlin Xu, Qian Wu

RNA adenosine modification writers define characteristics of immunity and prognosis in head and neck squamous cell carcinoma

  • Open Access
  • Analysis

Rong Wang, Yingpeng Peng, Ruotong Chen, Rui Liu, Yijing Ye, Qijiu Chen

Causal plasma metabolites for breast cancer risk: a two-sample Mendelian randomization study with colocalization evidence

Hanghang Chen, Yueyuan Xu, Zepeng Wang, Xufeng Cheng

The effects of genetically determined plasma methyltransferases on digestive system cancers: a comprehensive bidirectional two-sample Mendelian randomization analysis

Congcong Zhang, Xueying Li, Zhebin Dong, Yihui Weng, Weiming Yu, Xianlei Cai

Gut microbiota and risk of cervical cancer: a Mendelian multivariable randomization study

Lihuan Lu, Zhengqi Li, Ping Qiang, Yang Shao

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencing

Hangyu Liu, Tingxin Wang, Yuying Cui, Biao Zhang, Dong Shang, Huiyi Song

Ubiquitin-specific protease 34 serves as a novel prognostic biomarker through correlating with immune responses and cell proliferation in acute myeloid leukemia

Zhihui Li, Cuijuan Shi

Immune cell dynamics and prognostic role of M2 macrophages and LDOC1 in colon adenocarcinoma

Laibin Luo, Zhimin Xu, Hongwu Lin, Rong Huang

Mendelian randomization reveals contrasting effects of immune signaling molecules on bone and articular cartilage malignancies

Haiying Huang, Yanshan Lin, Ming Xiang, Jiehui Fu

The crosstalk between MiRNAs and autophagy in leukemia: mechanisms and therapeutic insights

Alireza Faghiri Beyrami, Ali Akbar Movasaghpour Akbari, Leili Aghebati-Maleki, Sanam Dolati, Mehdi Yousefi

COVID-19, inflammatory cytokines, and digestive system cancers: a bidirectional Mendelian study and mediation analysis

Yi Liang, Wei Xiao, Bo Deng, Qiu Chen

Identification of anoikis-related tumor microenvironment characteristics and prognostic signature in ovarian cancer at bulk and single-cell levels

Zhenye Tang, Chenfei Zhou, Yinyin Xu, Zhizai Chen, Shuting Huang, Jing Chen, Ping Jin, Jiemei Hu, Shanyang He

Observation of the impact of applying the fast track surgery concept during the perioperative period of breast-conserving surgery for breast cancer on the effectiveness of patient care and complications

Yu-Ting Li, Zhong-Ru Cao

Comprehensive analysis of KLHL35 expression and its prognostic value in cancer: implications for colorectal cancer diagnosis and therapy

Rong Qin, Yiyao Duan, Shasha Bao, Hui Wang, Jing Zhou, Xirui Fan, Xiang Li, Guoyu Li, Jun Hu

Log odds of negative lymph nodes/T stage as a novel predictor of post-resection outcome in non–small cell lung cancer patients

  • Open Access
  • NSCLC
  • Analysis

Liu Shao, Haoyang Cao, Hao Yang, Dongmei Li

High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma

Inga Marte Charlott Seuthe, Markus Ruwe, Franz Mitze, Steffi Silling, Eric Ehrke-Schulz, Sabine Eichhorn, Jonas Jae-Hyun Park

Thymoquinone-conjugated liposomes improve cytotoxic and proapoptotic effects against hepatocellular cancer by altering the EGFR/ERK/MEK signaling axis

Shaymaa A. Abdulmalek, Fatma A. Mahmoud, Doaa Awad, Abdulrahman M. Saleh, Ayman I. Elkady, Doaa A. Ghareeb, Mahmoud Balbaa

Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study

Jun Xiang, Guangming Xiang, Ming Zhan, Lingyun Zhang, Huaqian Zeng, Xinyu Song

Pan-cancer analysis of role of LOXL4 and experiment validation in osteosarcoma

Wenjie Chen, Fujie Xie, Jie Lv, Dixi Huang, Ronghao Zhong, Zhijia Wen, Jiangsen Sun, Shaowei Zheng, Weile Liu, Haobo Zhong, Shoubin Huang

Identification of promising lung cancer targets from human plasma proteins via Mendelian randomization

Xiao-dong Shao, Zhou-lin Miao, Wei-jie Yu

Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the pan cancer landscape

Jing Lin, Wenzhe Chen, Yaodong Zhao, GuanZhong Qiu

Recent advances in the study of FAT family genes in lung cancer

Xiaoyue Deng, Zhiqiong Yu, Weihua Hu

Unveiling the global research status and intellectual map of cancer and immunosuppressants

Tianyi Yuan, Yamin Zhao, Yunna Ma, Yue Ben, Tianqi Wu, Hongrun Shi, Jun Pu, Jue Gu

EGFR gene amplification in IDH-wildtype glioblastomas: an integrative bioinformatic and histopathological analysis using immunohistochemistry and fluorescence in situ hybridization

Anass Oukhdouch, Basma Zinbi, Souad Sellami, Hanane Rais

Third-generation versus first-generation EGFR tyrosine kinase inhibitors in Asian patients with advanced EGFR mutant non-small cell lung cancer: a meta-analysis of randomized controlled trials

Manzhen Xu, Wei Ding, Linlin Wan, Wenxiong Zhang

Study on the in vitro and in vivo killing effects of PD-1 antibody-secreting c-Met-targeted CAR-T cells on esophageal cancer cell line ECA109

Shang Peng, Yanqiu Li, Yanjun Zhang, Jingting Min, Ran An, Nana Du, Haipeng Li, Xiangcheng Zhen, Fei Chu, Zhenghong Li

D-mannose suppresses HIF-1α mediated metabolic reprogramming in clear cell renal cell carcinoma

Ziyin Tian, Ruonan Zhang, Yan Ma, Jiaxi Li, Yunliang Li, Lei Lv

Identification and validation of prognostic genes for lung adenocarcinoma prognosis based on PANoptosis-related genes

  • Open Access
  • Research

Guo-qiang Song, Yu-ying Wu, Tian-li He, Ke-jie Ji, Yi-meng Duan, Jia-wen Zhang, Sheng-qi Fei, Guo-qiang Hu

Emerging photothermal agents combined with immunotherapy for cancer treatment

Tian Xu, Xueping Yang, Xinyu Chen, Qilin Wang, Juncai Ye, Chuanyu You, Jiao Zhu, Yan Gui

Ferroptosis in AML: nanoparticles, biomarkers, and immune rewiring for therapeutic breakthroughs

Farzaneh Tavakoli, Mohammad ali Araskhan, Fatemeh Karimpour, Hamed Soleimani Samarkhazan, Hoda Hasheminasab, Elham Roshandel, Nader Vazifeh Shiran, Ali Dehghanifard, Mohammad Hossein Mohammadi

Left-sided clear cell renal cell carcinoma initially presenting with isolated abdominal wall metastasis: a case report

Ji Yu, ZhongRu Sun, Qingyu Chen, Ming Yin

Potential causal association and mechanistic insights of chronic HBV infection in extrahepatic cancer progression

Zhihui Wei, Weiqiang Wu

Identification and characterization of lLF2 as a prognostic biomarker in HER2-positive breast cancer using Mendelian randomization and machine learning

Xiyun Quan, Yi Deng, Meiyuan Huang, Huimei Yi, Ming Li

The oncogenic role of miR-155 on oral cancer progression and treatment strategies

  • Open Access
  • Review

Alexandra Iulia Aghiorghiesei, Nikolay Mehterov, Andreea Nutu, Boyan Vladimirov, Boyan Nonchev, Christos K. Kontos, Rares Buduru, Cornelia Braicu, Ioana Berindan-Neagoe

From cold to hot tumors: feasibility of applying therapeutic insights to TNBC

Shaozhang Yan, Xinyue Sun, Kuanyu Wang

Macrophage-mediated delivery of ganciclovir nanocomplexes inhibits the pathogenicity of Kaposi’s sarcoma-associated herpesvirus

  • Open Access
  • Research

Haopeng Tan, Lixia Yao, Runa Zhang, Mengchan Ye, Shanzhe Shi, Jinli Zhang, Jianyu Xu, Dongdong Cao, Fangling Li, Dongmei Li

TAM family kinases are potential candidate targets for therapeutic intervention in chronic myeloid leukemia

Maryam Yousaf, Khadija Arif, Dilawar Khan

COL22A1 expression identifies aggressive glioma and independently predicts survival through integrated multiomics and clinical validation

Wei-Wen Hsu, Wen-Shin Song, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

Epidemiological trends in laryngeal cancer burden: insights from GBD 2021 and SEER databases

Jie Zhang, Shuixiu Yu, Feng Wang, Weijuan Jiang, Lihua Fan

Amino acid metabolism-related LncRNAs as prognostic biomarkers and predictors of immunotherapy response in hepatocellular carcinoma

Jiaxing Zhang, Xiaojing Zhu, Long Hu, Liyue Yu, Yan Xu

Molecular characterization of macrophage-related prognostic factors in glioblastoma revealed by combined analysis on single-cell and bulk transcriptome data

Zhihao Wei, Hongchao Liu, Yajun Yang, Mengting Liu

Causal roles of cathepsins family members in breast cancer subtypes: insights from Mendelian randomization and bioinformatics analysis

Lin Tan, Junlian Xiang, Yi Lu, Xiaoli Zhong

Protein interacting with C-kinase 1 is correlated to prognosis and immune infiltrates of gastric cancer

Ying Zhou, Biqin Zhang, Feng Li, Xiaohong Li, Yutao Zhang, Yaoqiang Du

Peripheral SNCA+ cells as a poor prognostic factor for nivolumab therapy in advanced gastric cancer

Chie Kudo-Saito, Hiroshi Imazeki, Kengo Nagashima, Hirokazu Shoji, Kai Tsugaru, Naoki Takahashi, Takeshi Kawakami, Yusuke Amanuma, Takeru Wakatsuki, Naohiro Okano, Yukiya Narita, Yoshiyuki Yamamoto, Rika Kizawa, Kei Muro, Narikazu Boku

Current strategies and novel immunotherapeutic approaches for overcoming immune resistance in glioblastoma

Mehrdad Nourizadeh, Saeid Mohammadzadeh Mounesyar, Mahdi Salimi Movahhed, Kasra Alipour, Rozhan Zekavatbakhsh, Mobina Hoseinzadeh, Shaghayegh Davari, Mehdi Amirhooshangi, Hadi Amirhoushangi, Sina Hamzehzadeh

Comprehensive pan-cancer evaluation of NUP85 prognosis, immune infiltration response, and validation in prostate cancer

Zhijun Chen, Han Guan, Long Chen, Xinwei Yuan, Wenyan Sun, Ming Chen

Kaempferols from Echinacea purpurea demonstrate anti-cancer potential by targeting anexelekto in breast cancer therapy using chemoinformatics approach

Saviour God’swealth Usin, Daniel Ogbonnaya Nwankwo, Anas Haruna Ruggah, Adebesin Ayomide Oluwadarasimi, Md. Ahad Ali, Timothy Oluwatimileyin Ayeni, Abass Abdulateef Ohilebo, Abdulsamad Omotayo Aiyelabegan, Opeyemi Christianah De Campos, Kayode Raheem Yomi, Siham Lakrikh, Awotunde Oluwasegun Samson, Cornelius Ayodeji Aboderin, Bodun Damilola Samuel, Abdulwasiu Ibrahim, Toheeb Adewale Balogun

CER1 as a manganese ion metabolism gene drives gastric cancer progression and therapeutic potential via oxidative stress and tumor microenvironment regulation

Juan Hu, Ruian Zhu, Qiushi Huang, Xiaosong Li

Prognostic significance of GPR132 in papillary thyroid carcinoma: insights from integrated machine learning and its role in regulating TPC-1 cell growth

Jinghua Gao, Zihan Cai, Shoupeng Ding, Lanxin Ma, Jian Han, Yi-Yi Luo, Xueli Yang, Liqin Zhou, Wen Mei, Xiangfang Li, Lin Meng, Heng Luo

Correction: Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential

  • Open Access
  • Correction

Muhammad Alaa Eldeen, Abdelrahman Mostafa, Farag Mamdouh, Waleed K. Abdulsahib, Dalal Sulaiman Alshaya, Eman Fayad, Hassan M. Otifi, Hesham M. Hassan, Mohammed Alshehri, Aiysha Althobaiti, Ghadi Alsharif, Mohamed A. Soltan

Evaluation of serum MUC5AC for identifying high grade cervical lesions in a prospective cohort from Türkiye

Ilkbal Temel Yüksel, Gazi Güner, Neçirvan Çağdaş Çaltek, Semih Tek, Ayşe Hazırbulan, Gözde Şahin

Therapeutic positioning of asciminib in chronic myeloid leukemia patients previously treated with multiple tyrosine kinase inhibitors in Qatar

Rola Ghasoub, Anas Hamad, Susanna El Akiki, Shehab Fareed, Anil Ellahie, Omar Ismael, Mohamed A. Yassin

The potential of luteolin-conjugated mesoporous silica nanoparticles functionalized with folic acid in targeted cancer therapy in an in vitro model

Maryam Hosseini, Masoud Homayouni Tabrizi, Bita Behboodian, Mozhgan Soltani

Chemotherapy induced neurotoxicity in cancer survivors assessed through a dual database bibliometric analysis from 2005 to 2025

Boxiang Zhang, Lucy Yue Lau, Zhimin Wu, Yi Chen

Functional and in silico evidence for the role of microRNAs 148a-5p and 199a in migration and invasion of papillary thyroid carcinoma cells

Karina Colombera Peres, Mateus Leandro Bezerra, Leonardo Augusto Marson, Mônica Pezenatto Santos, Alexandre Hilário Berenguer Matos, Irena Dus-Ilnicka, Larissa Teodoro Rabi, Alfio José Tincani, Priscila Costa Tincani, Natassia Elena Bufalo, Murilo Vieira Geraldo, Laura Sterian Ward

Mendelian randomization and single-cell analysis reveal novel genetic risk factors and cellular heterogeneity in glioblastoma

Jun Li, Jing Xu, Lianshu Ding, Jialuo Chen

RAD51-AS1 inhibits the migration and invasion of prostate cancer cells by up-regulating RARA to activate ZYX transcription

Zhijun Chen, Xinwei Wang, Likai Mao, Han Guan, Ming Chen

Prognostic and immunological characterization of elderly acute myeloid leukemia evaluated by butyrate metabolism-related genes

Yiwei Li, Liming Shan

GNPNAT1 acts as a prognostic biomarker associated with immune infiltration in lung adenocarcinoma and promotes the proliferation and invasion of cancer cells

Qingfeng Li, Qingyin Lan, Hongmiao Wang, Jingyi Li, Yijia Tang, Xue Yi, Meigui You, Yujuan Tang, Yaping Xu

Factors associated with taxane-associated acute pain syndrome in pancreatic cancer patients receiving gemcitabine and nab-paclitaxel

Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara

Deciphering the causal relationships between plasma metabolites, peripheral cells, inflammatory factors and DLBCL for discovering novel therapeutic targets

Ming Xu, Li Xu, Wenhua Zhu, Ming Ruan, Jiayue Xu, Yanjie Qu, Li Wang, Weirong Zhu

The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma

Laiwei You, Yang Zhou, Yong Cheng, Huan Wang, Hao Li, Jianrong Guo

Advances in polycythemia vera treatment with targeted therapies and clinical trials

Doaa Hassanien, Rashid A. AlYafei, Omar H. Metwally, Izzaldin Alremawi, Abdulla Khalid Al-Kaabi, Mohamed Elahtem, Talal AL-Sayed, Mohamed A. Yassin

Integrated WGCNA retrieval of T-cell exhaustion genes related to radiosensitivity in locally advanced cervical cancer and prediction of immunotherapy efficacy

Meilian Dong, Chunyan Zhang, Xiangxian Zhang, Yuehui Su

Clinical value of the novel inflammatory-nutritional marker PALR in predicting early postoperative recurrence of colorectal cancer

Shiwei Xu, Durong Liao, Chunzai Feng, Hao Zhang, Hui Ye, Zhe Yuan, Zhiping Chen, Hongzhi Luo, Shihai Zhou

Microenvironmental regulation and remodeling of breast cancer angiogenesis: from basic mechanisms to clinical therapeutic implications

Ziling Zhou, Hanyi Zhong, Han Wang, Shoutang Wang, Wala Ben Kridis, Ruo Wang, Kunwei Shen, Zheng Wang, Renhong Huang

Comprehensive analysis of mitochondria-associated genes in glioblastoma via single-cell and bulk RNA sequencing

Fangyuan Wang, Ao Huo, Minghe Li, Chenglin Zhao, Yupei Guo, Zhou Jing, Qingyi Wang, Bingqi Lu, Hao Li, Wulong Liang, Weihua Hu, Xudong Fu

Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma

Shuyang Zhou, Jirui Sun, Jinmei Li, Xing Zhou, Xiaoyu Shi, Minghan Yang, Yanjing Wang, Jinku Zhang

CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis

Chunling Yuan, Qian Li, Min luo, Chaoyong Liang, Lu Huang, Lifen Wei, Qinglin He, Zhihui Liu, Liming Shang

A rare case of primary transverse colon adenocarcinoma penetrating the abdominal wall

Boren Tan, Lei Liu, Huiming Wu, Qi Bao, Xiaoming Xu, Hongfeng Cao, Liuhong Wang, Yeting Hu, Jingjing Wu, Jian Wang

Neoadjuvant immunochemotherapy versus chemotherapy alone for locally advanced esophageal squamous cell carcinoma: a real-world retrospective study

Lin Zhou, Yaochen Huang, Yan Qian, Chun Cai, Xiangning Fu, Yangkai Li

Integrative multi-omics and preclinical analyses identify miR-4776-5p as a prognostic radiosensitizer for patients undergoing radiotherapy for head-and-neck cancer

Yo-Liang Lai, Chun-Chieh Wang, Kai-Wen Hsu, Ching-Fang Yu, Yung-Lun Lin, Pei-Chun Shen, Meng-Hsin Tsai, Fang-Hsin Chen, Wei-Chung Cheng

LRP11 as a potential predictor of poor prognosis and immune suppression in lung adenocarcinoma

  • Open Access
  • Research

Runlin Feng, Yanping Tao, Huimin Liu, Chenhui Deng, Chengmeng Liu, Xing Zhou, Zhaohui Long, Li Yin, Siwei Qi

Integrative analysis of single-cell and transcriptome RNA sequencing to establish a NAT10-related signature for prognostic prediction of uveal melanoma

  • Open Access
  • Analysis

Wancheng Liu, Ying Xu

Unveiling the role of protein palmitoylation in gastric cancer diagnosis via machine learning

  • Open Access
  • Research

Zhong hua Shen, Jingyu Wu

Mediation Mendelian randomization study of plasma proteomics reveals the causal relationship and potential mechanisms between iron and colorectal adenocarcinoma

  • Open Access
  • Analysis

Xin Chen, Shaojie Fu, Fan Li, Sensen Su

Prognostic model for pediatric brain tumors based on tumor microenvironment-specific gene signatures

Yuxin Liu, Longgang Sang, Alexandr N. Chernov, Guodong Liu, Tao Jiang, Guanjian Zhao

CENP-F promotes HCC cell proliferation mediated by super enhancer reader BRD4

Yunhui Liu, Wenjiao Chen, Yuxin Niu, Xiaoqin Dong, Jie You, Zhongyuan Yang

S-adenosylmethionine enhances anti-PD-1 efficacy in uveal melanoma by targeting EZH2

Guo-jun Gao, Jin Yuan, Jin-jin Huang, Jin-jin Shen

Characterization of PANoptosis-based markers for ischemic stroke and their appealing implications in improving prognosis and in glioma patients

Jianli Zhang, Caiwen Liu, Weimin Zhong, Maoshu Zhu, Ruidian Lin, Lili Wang, Aidi Lei

ADAM9 drives PD-L1 shedding via IL-6 suppression and exploring therapeutic role of Bufalin treatment in hepatocellular carcinoma

Mandana AmeliMojarad, Melika AmeliMojarad, Alireza Pourmahdian

The immune infiltration and prognostic significance of complement and coagulation cascade-related genes in lung adenocarcinoma

  • Open Access
  • Analysis

Chunhui Li, Zongqian Yuan, Chengrui Fu, Qian Zhao, Junfeng Zhao, Baosheng Li

Comprehensive analysis of a machine learning prognostic model for the interaction between mitochondrial function and lactylation in lung adenocarcinoma

  • Open Access
  • Analysis

Yaozong Xia, Zhongxun Li, Xiu Cao, Xuxiang Zheng, Bin Nie

Antimicrobial peptides for anticancer and antiviral therapy: last promising update

Aisa Bahar, Mahyar Porbaran, Meisam Khazaei, Hamed Tahmasebi

A rare case of cellular angiofibroma with sarcomatous transformation occurred in the popliteal fossa

  • Open Access
  • Case Report

Lina Zhao, Zhenyu Liu, Feng Guan, Jingping Yuan, Huihua He, Juan Zeng, Jiacai Ren, Yun Cao, Honglin Yan

TRIM21 as a potential prognostic biomarker and therapeutic target affects the growth of pancreatic cancer

Dingfa Sun, Shijun Zheng, Siyi Wang, Yongqi Xue, Shaohan Song, Youlan Bai, Xin Li, Yunzhe Ci

The causal association between psychiatric disorders and gynecological cancer: a bidirectional Mendelian randomization study

Yaru Wang, Lin Qi, Yitong Li, Qi Fu, Huanran Ma, Li Li

Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer

KanKan Yang, Rui Chen, Bing Jiang

Multidimensional analysis of hsa-miR-140-3p and CKS1B correlation via the MAPK/ERK pathway in lung adenocarcinoma progression

  • Open Access
  • Research

Kexin Luo, Meihan Liu, Yaoshu Song, Haiyang Zhao, Yuanze Cai, Shan Chen, Yumeng Lei, Daiyuan Ma, Hongpan Zhang, Yongsheng Zhao

Harnessing the power of exosomes in leukemia: from molecular messengers to clinical applications

Mohammad Amin Ansarian, Mahsa Fatahichegeni, Yuqi Wang, Juan Ren, Xiaoning Wang

B7-H3: a promising target for immunotherapy in glioma

Xin-Li Feng, Gang Su, Qi Jia, Qiong-Hui Wu, Zhen-Chang Zhang

PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p

  • Open Access
  • NSCLC
  • Research

Hao Ding, Yan Deng, Rong Zeng, Guoqiao Zhang, Qingqing Zheng, Qiaofen Fu, Rongqing Li

Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro

Zhen Li, Jianlin Fang, Hongzhou Ge, Xiaoyong Wang, Hui Dong, Hang Yu, Yansha Liu, Tao Li

Retraction Note: Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor

Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali

Unveiling the expression and mechanistic role of SYCP2 in cervical lesions

Yuanhang Zhu, Zhongchen Hou, Chunli Wang, Huina Hu, Zhenan Zhang, Xin Yang, Ling Liu, Chenchen Ren

Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning

Changan Chen, Tingmei Yang, Caiyuan Yu, Lijiao Cui, Bingjun Cai, Zhenkai Li, Shicai Ye, Yijie Weng

Integrated analysis of single-cell and bulk RNA sequencing identifies GSTM4 as a tumor suppressor and prognostic biomarker in breast cancer

Zhen Yu, Weikang Yun, Qian Zhang, Xianglan Li, Chunbo Zhao, Xu Liu

Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer

Hong Wang, Caijuan Liang, Yanqiu Yu, Jing Lin, Yanan Dong, Xiaolan Hong, Huikai Huang

Bladder metastasis arising from right: sided invasive lobular carcinoma in bilateral synchronous discordant primary breast cancers—a rare case

Ting Wen, Shiying Liu, Xiaomei Li, Yingjie Qi, Jintao Hu, Minjie Yang, Donghong Peng, Guijing Jia

Non-coding RNAs-mediated regulation of the MAPK pathway in gastric cancer: translational perspectives

Darmadi Darmadi, Komeil Aghazadeh-Habashi, Sona Ayvazyan, Arshia Bozorgnia, Elnaz Khodabandehloo

Re-sensitization of cancer multidrug resistance through P-gp, MRP1 and BCRP modulation: advances in terpenoids based cancer therapy

Pratibha Pandey, Ajay Singh, Sorabh Lakhanpal, M. Rekha, Swayamsidha Mangaraj, Meenakshi Verma, Vijay Jagdish Upadhye, Fahad Khan

Elevated NUF2 and CD52 expression predict platinum-based chemoresistance and poor prognosis in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Bo Liu, Zhansheng Lu, Jing Yao

Development and validation of a nomogram for predicting postoperative survival in patients with multifocal hepatocellular carcinoma

Bojun Liu, Gongming Zhang, Guangming Li

The bidirectional regulatory effects of bacteria on blood vessels in the tumor microenvironment

Wei Peng, Xiaomei Huang, Yinquan Pu, Yi Zhang, Yujun Luo, Maosen Feng, Xiaoan Li

LncRNA NEAT1 modulates myeloma cell autophagy and apoptosis by competitively binding miR-195-5p to regulate CEBPA

  • Open Access
  • Research

Ting Wang, Hongyue Xu, Wei Tao, Bin Bai, Xiuhui Chen, Bingyun Zhang, Yingchao Liu, Xueyong Zhang

Identification of biomarkers related to the progression of cutaneous melanoma and construction of survival prognosis model

Kana Chen, Wei Ye, Longjun Chi, Shujie Xie

Fibrinogen beta chain as a prognostic biomarker and therapeutic target in tobacco-associated lung adenocarcinoma

Jijun Xue, Wenfeng Han, Wentao Zhao, Xiaoqi Li

FAM3B overexpression correlates with poor prognosis and immune dysregulation in colorectal cancer: insights from bioinformatics and Mendelian randomization analyses

Peng Huang, Pei Li, Chengshuo Zhang, Jialin Zhang

Intracavitary infusion of FOLactis Lactobacillus leads to disappearance of MPE in patient with advanced lung adenocarcinoma

Mingzhen Zhou, Juan Zhang, Sihui Zhu, Yan Zhao, Baorui Liu, Jie Shen

Web-based explainable machine-learning tool for predicting five-year recurrence of colorectal cancer after curative resection: multicentre retrospective cohort study

Chi-Sheng Chen, Tai-Han Lin, Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Cherng-Lih Perng, Ping-Ying Chang, Wen-Yen Huang, Chao-Yang Chen, Yu-Chun Lin, Hung-Sheng Shang

Collaboration networks and knowledge structure in cancer and cellular senescence research (2000–2025): a bibliometric perspective

  • Open Access
  • Research

He Zhu, Shuangjia Pan, Yujia Zhou, Baozhu Yi, Yuqing Jing, Luyi Ruan, Lingxiao Huang, Xueqiong Zhu

Changing patterns of colorectal cancer in China between 2000 and 2016 based on tertiary hospital data

Junling Wu, Hanwen Zhang, Zhe Luan, Jun Chen, Zhizhuang Zhao, Yiming Zhao, Congyong Li, Wei Zhang, Yi Chen, Jiaqi Zhang, Jiwei Zhao, Shuhuang Peng, Hanfei Liu, Jing Wang, Shufang Wang, Gang Sun

Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer

Gamze Guney Eskiler, Ayten Haciefendi, Kayhan Ozdemir, Cemil Bilir

Cuproptosis scoring system identifies novel molecular subtypes and modulates biological behavior in breast cancer

Rongyang Zou, Qiong Wu, Wanjun Zhao

Integrated summary data-based Mendelian randomization and colocalization analysis reveals TNNT3 as a target of Deer-Antler-Ginseng-formula for triple-negative breast cancer

Jianling Jia, Yuan Ma, Di Wu, Yanhong Dou, Jingyi Yuan, Feng Liu, Aiping Shi

Integrating single-cell transcriptomics and machine learning reveals 4-aminobiphenyl exposure signatures and novel diagnostic biomarkers in bladder cancer

Yangyang Xu, Xiujia Wang, Xinxin Wang, Kaiqiang Li, Xiuwang Wei

Causal links and immune mediators between blood cells and breast cancer risk: a mendelian randomization study

Meizi Song, Yu Liu, Jiaxu Dong, Jiafang Xu, Minghao Yang, Qingjie Hu, Siqi Yin, Xun Bi

Integration of exosome-related genes and differential expression analysis reveals potential biomarkers for prostate cancer

Shengnan Huang, Chunyan Hu, Zhongqi Guo, Xiaojing Zhang, Tiantian Wu, Yuqing Zeng, Chen Qing, Shulin Cheng

RANBP1 promotes immune evasion in triple-negative breast cancer by suppressing T cell infiltration via the miR-769-5p/PRUNE2 axis

Pengxia Song, Xianglin Liu, Huiping Qiu, Yanhui Cao, Jie Liu, Xin Zheng, Shuihong Yao, Meng Cao

Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study

Zi-Jian Huang, Lv Wu, Ying-Long Peng, Zhi-Hong Chen, Chong-Rui Xu, Yu Deng, Hong-Hong Yan, Chang Lu, Qing Zhou

Occult breast cancer with CSF TBA positivity and abnormal involuntary movements

Wenyan Zhang, Yajie Liu, Jin Zhen

Systems biology-driven identification of biomarkers and significant pathways in radiation-induced hormone-sensitive cancers

Suvitha Anbarasu, Sathyanarayan Balaji, Sudha Ramaiah, Anand Anbarasu

Conditional survival prediction in elderly patients with hormone receptor positive locally advanced breast cancer using a competing risks model

Jun Zhang, Yunyun Zhao, Wenhui Wang

CircPPP1CB subtype, hsa_circ_0007439, promotes nasopharyngeal carcinoma progression by upregulating KRT1

Fei Li, Ting Xu, Rui Sun, Yue He, Jin-Fei Lin, Haisheng Chen, Jiasheng Wang, Junru Chen, Peiling Chen, Qiqi Guo, Qian Yang, Wulin Cai, Chunmou Li, Maozhen Zeng, Jingyue Cao, Jiaxi Fan, Xuan Huang, Qi Wang, Qing Zhang

PLOD1 promotes gastric cancer metastasis and immune escape by mediating extracellular matrix remodeling

Yinkui Chen, Xing Wu

Inflammation related proteins and PLCG1 may contribute to papillary thyroid carcinoma risk through a potential regulatory axis

  • Open Access
  • Analysis

Shi-Qi Wang, Miao Yang, De-Wei Rao, Yan-Jun Su, Ruo-Chuan Cheng

Global trend and geographic distribution of thyroid cancer from 1990 to 2021 and its prediction until 2030

Zahra Maleki, Jafar Hassanzadeh, Mohammad Aryaie, Haleh Ghaem

Exploration of prognosis and immune infiltration characteristics in glioblastoma multiforme based on lipid metabolism related genes

Peng-Cheng Li, Hua-Xuan Chen, De-Bo Yun, Qian-Yi Huang

Analyzing histopathological images using fused CNN features based on the geometric active contour method for early diagnosis of lung and colon cancer

Yousef Asiri, Ebrahim Mohammed Senan, Hanan T. Halawani, Ibrahim Abunadi, Aisha M. Mashraqi, Eman A. Alshari

Global research dynamics in metabolic biomarkers and cancer: a bibliometric study from 2015 to 2025

Longtao Zhang, Yanxiao Sun, Yuxia Ma

The role and application potential of cytochrome c in breast cancer therapy

Hongshuang Yue, Yumei Fu, Xiuyue Fan, Fulin Zhou, Shu Liu

rs604702 confers breast cancer risk by influencing PCAT18/miR-759/SPRR3 axis

Xin-Xin Zhang, Ya-Jie Li, Xi-Ting Zhou, Hong-Li Song, Hao Guo, Hai-Yan Li, Li-Yuan Tian, Chang Sun

Spatial transcriptomic landscape and cellular neighborhood heterogeneity in cervical cancer: integrative single-cell and spatial RNA sequencing analysis

Dieyi Mo, Huana Cao, Shaojuan Lai, Jinding Luo, Weijie Ye

Assessing the efficacy of darolutamide in metastatic hormone-sensitive prostate cancer based on subgroup meta-analysis and reconstructed individual patient data

Fuxun Zhang, Zhirong Luo, Qi Xue, Xuyan Guo, Qiang Fu, Wei Zhang, Yang Xiong, Pati-Alam Alisha, Uzoamaka Adaobi Okoli, Geng Zhang, Yong Jiao

Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis

Pu-Yu Wang, Yi-Ping Zheng, Yu-Lin Zhao

Aurora Kinase A inhibitor alisertib failed to exert its efficacy on TNBC cells due to consequential enrichment of polyploid giant cancer cells (PGCCs)

Debanjan Thakur, Debomita Sengupta, Shinjini Kar, Jayanta Chakrabarti, Sagar Sen, Srabanti Hajra, Arka Laha, Elizabeth Mahapatra, Salini Das, Parimal Karmakar, Sutapa Mukherjee

The Reg gene family: roles in gastric and colorectal cancer progression and its potential for targeted therapy

Fei Liao, Xun Xiao

Role of exosomes in cancer: from diagnosis to therapy

Mojgan Esparvarinha, Hamid Nickho, Mohsen Dashti, Majid Ebrahimi Warkiani, Mehdi Yousefi

Prognostic significance of dipeptidyl peptidase-7 (DPP7) in HPV16-negative head and neck squamous cell carcinoma treated with induction chemoradiotherapy

Amal F. Gharib, Haytham Dahlawi, Shereen El Tarhouny, Nermin Raafat, Mohamed Khalifa, Dalya A. Iskandarani, Tamer Saber, Wael H. Elsawy

Identification of potential oncogenic miRNA clusters with a special focus on miR-106b/25 cluster-regulated networks and their clinical utility in hepatocellular carcinoma

Shreyas Hulusemane Karunakara, Manju Moorthy, Gopalakrishna Ramaswamy, Vinutha Shanubhoganahalli Puttamallapa, Maheshkumari Prakash, Rohit Mehtani, Shama Prasada Kabekkodu, Prashant M. Vishwanath, Prasanna Kumar Santhekadur

Proteome-wide Mendelian randomization and colocalization analysis uncovers druggable targets for lung cancer across multiple phenotypes and complications

Yunpeng Chen, Xiaohong Dai, Peng Zhang, Lijuan Yao, Qing Wang, Zhihong Qin, Tianmin Gao, Junguo Zhang

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

  • Open Access
  • Review

Hemant Joshi, Isha Rani, Vikas Sharma, Ujjawal Sharma, Tanisha Dimri, Manoj Kumar, Ritu Chauhan, Abhishek Chauhan, Damandeep Kaur, Shafiul Haque, Faraz Ahmad, Hardeep Singh Tuli

Multi-omics study of prognostic models and molecular networks related to ovarian cancer

Piaopiao Bian, Shaoyan Liu, Wei Zhang, Qiuping Luo, Zhongtang Xiong

Association between weight loss and survival outcomes in patients with colorectal cancer: a meta-analysis

Guofang Wang, Ziyan Liu, Dandan Gong, Changfeng Man, Yu Fan

Efficacy and safety of anlotinib maintenance therapy in limited-stage small cell lung cancer

  • Open Access
  • SCLC
  • Research

Sha Li, Zhonghua Chen, Jie Lv, Xiaohong Zhou

Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling

Ou Tang, Ling Yang, Zhenyu Cheng, Anchun Xu, Tao Ma, Mengxi Jiang

The role of liquid biopsy in the management of concurrent Hodgkin lymphoma and ovarian carcinoma treated with nivolumab

Veronika Hanáčková, Jan Grohmann, Helena Urbánková, Hana Študentová, Eva Buriánková, Lenka Henzlová, Tomáš Papajík, Veronika Bachanová, Vít Procházka

Metformin’s multifaceted role in colorectal cancer: mechanisms of action and synergy with standard treatments

Haniye Rahimi Kolour, Nastaran Bahrami, Ehsan Nazemalhosseini-Mojarad, Amir Sadeghi, Mehdi Shamsara, Nayeralsadat Fatemi

iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis

  • Open Access
  • NSCLC
  • Research

Xunhua Huang, Yongzhong Chen, Jiayuan Chen, Jinkun Lin, Yixue Zhuang, Meixia Huang, Hongmin Yu, Mingfei Wang, Yingzheng Wang, Yinghao Wang

Integrative SMR and single cell & spatial analysis reveals the spatial heterogeneity and prognostic value of CASP9-mediated apoptotic pathways in clear cell renal cell carcinoma

Zijie Yu, Xinghan Yan, Wenchuan Shao, Lingchen Cai, Da Zhong, Xiyi Wei, Ninghong Song

Mechanisms of synergistic regulation of the tumor microenvironment by fibroblasts and keratinocytes in esophageal squamous cell carcinoma

  • Open Access
  • Analysis

Yujie Weng, Rong Jia, Pengfei Ning

Causal association between rheumatoid arthritis and pancreatic cancer: a bidirectional two-sample Mendelian randomization study

Jujie Li, Hao Hua, Luyao Fu

Peiminine suppresses prostate cancer progression by regulating cell proliferation, motility, apoptosis, and mitochondrial dysfunction

Yang Yu, Xiaobo Chen, Fei Xiong

Inflammation-driven prognostic model and immune landscape profiling in osteosarcoma

Rongquan Zhang, Xueliang Zhou, Chenxiao Shen

Targeting the LINC00265/miR-485-5p axis for diagnosis and therapeutic intervention in breast cancer

Qiang Jiang, Suya Han, Ru Chang, Jianzhen Pan, Bingjie Zhang

Serum urate levels and colorectal cancer risk: a prospective cohort study in of the UK biobank and a Mendelian randomization analysis

Yuhan Zhou, Kemin Xu, Hui Hu, Qinwen Ba, Na Shen, Yanjun Lu

Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives

YuHan Wang, YiShan Li, Peng Huang, Chun Li, ShengJin Tu, Hua Yang

A global bibliometric perspective on autophagy and tumor microenvironment in cancer research

  • Open Access
  • Analysis

Ishita Debnath, Moumita Kundu

Characterization, expression, and mutational analysis of endosomal protein lethal giant disc (Lgd/CC2D1A) as a biomarker in patients with T-cell acute lymphoblastic leukemia

Sandeep Pandey, Ranjana Singh, Nimra Habib, Rashmi Kushwaha, Abbas Ali Mahdi

Mapping the landscape: a comprehensive bibliometric analysis of immunotherapy advances in glioblastoma research

Wei Li, Ruimin Guo, Rongrong Zhang, Yuxin Wang, Ruijie Cao, Yunzhi Liu, Runzhe Chen, Guojia Wu, Dong Wang

A comprehensive bibliometric and visual analysis of tumor-associated macrophages in hepatocellular carcinoma

GuanBo Zhang, Gang Li, JinSong Li, Jie Zhang, Zhi Yang, Lin Yang, ShiJie Jiang, ShiFan Zhu, JiaXing Wang

A robust EMT-related prognostic model for ccRCC integrating single-cell and bulk transcriptome data

Zhiyu Yin, Zijian Ye, Zhengbin Li, Ruping Qing, Yifan Zhang, Xin Zhu, Biao Xie

Precision hyperthermia-induced HSP20 inhibits gastric cancer cell invasion, migration, and proliferation

Qiannan Sun, Ziyang Long, Yong Wang, Jun Ren, Daorong Wang

Extracellular vesicle-enclosed microRNAs serve as non-invasive biomarkers in the major upper and lower gastrointestinal tract tumors: a bibliometric analysis (2010–2025)

Guanlan Zhang, Jincheng Li, Jingwen Ling, Guoqiang Chen, Beibei Huang, Kunhua Xiong, Rongquan He, Diyuan Qin, Gang Chen, Siyan Chen, Mingyu Lai

LEP and FOXO1 genes, as a proposed tumor suppressor autophagic cell death related genes, can be targeted by antidiabetic therapy in nondiabetic breast cancer patients

Gizem Ayna Duran, Yağmur Kiraz, Deniz Baykara

The role of circadian genes in predicting immunotherapy response and survival outcomes in cancer patients

Chunlan Wu, Qinghua Li, Yanan Yuan, Jie Liu, Luying Wan, Rixiong Wang

The value of dual-energy CT radiomics in evaluating vascular maturity and prognosis in clear cell renal cell carcinoma

Ruobing Li, Kun Li, Zhongyuan Li, Peiji Song, Xue Bing, Haitao Sun, Aimei Ouyang

Bile acid metabolism and invasion-related genes as therapeutic monitoring biomarkers in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Analysis

Guangteng Wu, Lin Zhu, Feng Xue, Yanyi Zhao

Pan-cancer multi-omics analysis reveals IQCE as a malignant cell-restricted oncogenic biomarker driving immunosuppression and chemoresistance in cutaneous melanoma

Qing Luo, Jingya Wang, Ting Chen, Jielong Li

Doege-Potter syndrome in a patient with solitary fibrous tumor of the retroperitoneum: a case report and literature review

Qais Baheen, Mingkun Tan, Bo Zhang, Tao Liu, Xueli Liu, Zhiqiang Ma, Bin Jiang

Research on the interactive mechanisms between mitochondrial variations and immune responses in gliomas based on integrated visualization analysis

Shiwang Li, E. Lu, Lin Mi, Changda Li, Hongling Guan, Taijian Cao, Qiang Zhang

Prognostic and immunological profiling of SEC61G in cervical squamous cell carcinoma and adenocarcinoma

  • Open Access
  • Analysis

Yang Ye, Li Song, Jingzhi Zhang, Shupeng Liu, Songtao Han

Comprehensive analysis of zinc finger protein 367 as a potential pan-cancer diagnostic and prognostic biomarker and underlying biological mechanisms

Qi Feng, Ding-Fan Guo, Ting Wang, Kun-He Zhang

Correction: The expression and prognostic value of CCL19 in breast cancer

  • Open Access
  • Correction

Zonghao Ding, Lei Yang, Xinyu Wang, Yong Wang, Xiao Chen

Publisher Correction: An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma

Han Fan, Peng Qiu, Yun Lu, Zhengdong Deng, Li Tian

Correction: Rutin suppresses the malignant biological behavior of gastric cancer cells through the Wnt/β-catenin pathway

Hui Huang, Jianguo Shi, Wei Chen, Lei Liu

Single-cell hdWGCNA identifies ICI–related–colitis key CD8 + T cells linked to immunotherapy response and prognosis in colon cancer

Shuiqing Wu, Wenxuan Tang, Shaocong Mo, Jie Liu, Qingquan Gong, Wanwei Zheng

CPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2

Rongkui Luo, Wen Huang, Huimei Wang, Minying Deng, Zixiang Yu, Zhaomeng Cui, Huiyu Bao, Yufeng Liu, Chen Xu, Yingyong Hou

Development of machine learning models for survival prediction in nasopharyngeal carcinoma using population-based data

  • Open Access
  • Analysis

Guoxiang Lin, Qiyan Mo, Lu Han, Shaohan Sun, Zhiqiang Xiao, Weiming Zhang

Deciphering the causal effects of plasma metabolomics and lipids on breast cancer risk: a Mendelian randomization analysis

  • Open Access
  • Analysis

Lingyao Zhou, Yangwen Du, Kumar Ganesan, Sitong Xian, Caiyue Lin, Hongbing Liu, Jianhua Chen, Chen Lin, Jianping Chen

Case report of curative resection after preoperative bevacizumab and sintilimab therapy in hepatocellular carcinoma with lymph node metastasis

Shujie Pang, Yingcheng Yang, Zhe Sun, Ning Yang

Global research landscapes of ALDH2 and cancer revealed by bibliometric analysis

  • Open Access
  • Research

Tongtong Zhang, Xiaodong Chen, Wenjie Yu, Zhe Yang, Yan-Dong Miao, Jiong Deng, Fang Zhang

Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization

Hanjun Ma, Ju Liao, Zonglong He, Mingxuan Liu, Fengxu Wei, Qi Wei, Qunqiang Luo

Unveiling oncogene-induced senescence: a new frontier in prostate cancer prognosis and therapy

YunZhen Peng, Xin Qiu, JunJie Cai, YongZhong Li, XueYan Wei

Lablab purpureus bioactive fractions as potent anticancer agents: an in vitro and in Silico study

  • Open Access
  • Research

Smitha S. Bhat, Sushma Jahagirdar, Sarana Rose Sommano, D. Rashmi, Pradeep Matam, Sheikh F. Ahmad, Haneen A. Al-Mazroua, Gamaleldin I. Harisa, Shiva Prasad Kollur, Chandan Shivamallu, Shashanka K. Prasad

Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns

Hao Fei, Wen Huang, Yueyuan Chen, Shuo Yang

Causal relationships between blood metabolites and glioblastoma risk: a large-scale Mendelian randomization study

Lin Huang, Yazhou Tang, Yali Tan, Wei Lei, Yuan Wang, Yongjie Luo

Investigating the effect of stearoyl-coenzyme desaturase 1 Inhibition on inflammatory and anti-inflammatory patterns in luminal A breast cancer patients’ peripheral blood mononuclear cells

Neda Naghashi, Esmaeil Babaei, Zohreh Sanaat, Amir Mehdizadeh

Identification of 5mC regulatory factors mediating methylation patterns and prognosis models in head and neck squamous cell carcinoma

  • Open Access
  • Analysis

Yanwei Li, Yunfeng Cao, Nuerbiyamu Maimaitiyiming, Yue Li

The efficacy and safety of mirvetuximab soravtansine for the treatment of recurrent ovarian cancer: an update systematic review and meta-analysis

Qiling Dai, Jiawen Tang, Ting Du, Qin Huang

Proteome-wide mendelian randomization identifies FCRL3 and LY9 as potential therapeutic targets for lymphoma

Qianqian Guo, Juanjuan Shang, Bingyu Liu, Mei Ding, Yang Han, Yingshu Luo, Xin Wang, Shunfeng Hu

Extent of reoperation predicts survival in recurrent IDH-wildtype glioblastoma based on institutional data and individual patient data meta analysis

Alim Emre Basaran, Ann-Catalin Wellkisch, Erdem Güresir, Johannes Wach

Role of microRNA-183 based theranostics through targeting TPM1 in bladder cancer

Samah Mamdouh, Tarek Aboushousha, Eman Hemida, Rady E. El-Araby, Khaled Elesaily, Gehan Hammad, Mona Magdy

Vestibular schwannoma clinical prognostic factors and nomogram construction using SEER database

Yuyu Wei, Jialong Tian, Xiaojun Pang, Huai Chen, Xuhong Jin, Zibin Zhang

Prolonged neoadjuvant hormonal therapy enhances IL-17 A/STAT3-mediated inflammation in prostate cancer

Yirui Wei, Yifan Chu, Siqi Wang, Dawei Xie, Hao Wang, Weifeng He, Pushen Yang, Jianwen Wang

Decoding breast cancer: insights into molecular pathways & therapeutic approaches

Tanjima Tarique Laskar, Hasina Mehnaj Laskar, Jiaul Ahmed Mazumder, Rupajit Bhattacharjee, Md Ikbal Husain, Bandana Das, Panchami Das, Paromita Dutta Choudhury, Monica Arora, Sudarshana Borah, Debarupa Chakraborty, Prithviraj Chakraborty, Amlan Das

Intracranial undifferentiated pleomorphic sarcoma of right frontal lobe: a case report

Yulong Deng, Yueqiao Deng, Lurong Li, Xiaozhi Cheng, Qiwen Chen, Er Zhou

Exploration of the roles of CAFs in melanoma based on single-cell transcriptomics and spatial transcriptomics

Sheng Hong, Yuhan Zhao, Anni Hu, Yizhong Zhang, Yuming Li, Yan Rong, Zukai Li, Wenzhuo Su, Lude Zhu

Immunotherapeutics in metastatic cancer management

Manisha Shukla, Poorna Shri, Sunil Kumar Mahobiya, Rohit Kumar Vishwakarma

Integrative Mendelian randomization and spatial transcriptomics analysis reveals causal links between plasma lipidome and non–small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Baiquan Zhang, Jintao Liu, Qian Guo, Huanqin Wang, Lijun Miao, Lu Zhou

The impact of immune cells on the risk of breast cancer: a Mendelian randomization study

  • Open Access
  • Analysis

Nana Zhang, Hao Wang, Zhenfeng Huang, Zibo Shen, Peng Zhang, Guoqiang Zhang

SGLT2 inhibitors and their role in reducing mortality among cancer patients with type 2 diabetes undergoing immune checkpoint inhibitor therapy

Fabiana Lucà, Iris Parrini

Primary tumor resection improves survival in colon cancer patients with unresectable liver only metastases

Yunbin Ma, Wenguo Yang, Jialin Chen, Xiaoli Chen, Jianan Chen

Designing a web-based platform for dynamic estimation of individualized conditional survival in grade 3 gliomas

  • Open Access
  • Analysis

Zhihao Yang, Regina Chizi Tunje, Jiajie Xia, Chenjun Sun

Serum miR-200c-3p and miR-6134 as diagnostic biomarkers for epithelial ovarian cancer

  • Open Access
  • Research

Rina Kawahara, Eiji Nishio, Aya Iwata, Haruki Nishizawa, Naoki Yamamoto, Takuma Fujii

Research trends and hotspots of Lamin family in cancer: a bibliometric analysis

  • Open Access
  • Analysis

Fang Liu, Min Wang, Tian Zhu, Guangming Wang

Real-world comparison of doxorubicin–ifosfamide versus gemcitabine–docetaxel regimens in metastatic uterine leiomyosarcoma: a multicenter retrospective study

  • Open Access
  • Research

Salih Tunbekici, Gokhan Sahin, Haydar Cagatay Yuksel, Caner Acar, Imge Akın, Hasan Aslanhan, Mert Iscı, Ceren Kabaoglu, Hamit Bal, Abdullah Sakin, Alper Coskun, Mustafa Seyyar, Mehmet Sıddık Dilek, Mahmut Kara, Ali Solmaz, Teyfik Demir, Evrican Zin, Aytac Terzi, Fatih Kus, Ilgın Koc Kus, Zafer Arık, Ali Aytac, Özge Demirkıran, Bilgin Demir, Havva Yesil, Sedat Biter, Tolga Koseci, Ertugrul Bayram, Ahmet Unsal, Ahmet Ozveren, Alper Sevınc, Duygu Ozaskın, Meltem Baykara, Ahmet Unlu, Arıf Kus, Cengiz Karacin, Merih Yalcıner, Galip Can Uyar, Osman Sutcuoglu, Esmanur Kaplan, Teoman Sakalar, Elif Sahin, Gamze Emin, Atilla Yıldırım, Ceren Mordag, Irem ugurlu, Ilhan Hacıbekiroglu, Ibrahim Tunbekici, Pınar Gursoy, Ulus Ali Sanli, Erdem Goker

Expression of ITGA3 in pan-cancer tissues and its relationship to prognosis and immune infiltration

  • Open Access
  • Analysis

Zidi Zhang, Mengjun Zhang, Hongyang Liu, Meidi Liang, Lindong Zhang

MISP promotes the progression of lung adenocarcinoma through Inhibition of the Hippo signaling pathway

  • Open Access
  • Research

Yuanjun Cheng, Yumei Shen, Wei Fang, Shanzhou Duan, Yifei Wang, Xiaoxiao Dai, Yongbing Chen

High expression of GRB14 is associated with cancer progression and poor prognosis in gastric cancer

Haijie Hu, Xiaomin Feng, Yuxiu Zou, Xiaoqiong Jia, Hao Yang, Xuegang Luo

Single cell transcriptomic analysis reveals molecular mechanisms of chemoresistance and immune microenvironment remodeling in ovarian cancer

Xia Hu, Caifang Du, Dongjie Du, Yonghua Zhang, Haijian Gao, Minxian Tao

Adenylosuccinate lyase (ADSL) is a pan-cancer prognostic and immune biomarker with distinct roles in hepatocellular carcinoma

Weixiong Zhu, Xuefan Zeng, Jianqi Qin, Xinyue Qi, Wence Zhou

CD5+ primary hepatosplenic large B-cell lymphoma and rhupus syndrome in a patient: a case of concurrent diagnosis?

Shujun Lin, Jun Yin, Zewen Zhang, Xingxing Wang

TKI resistance related genes in LUAD predict patient prognosis and tumor immune microenvironment with LHX2 as a hub gene

Ruohan Huang, Qi Liang, Hongya Wang, Huizhu Qian, Renhua Guo

Integrative eQTL and Mendelian randomization analysis reveals key genes in colorectal cancer

Jun Zhou, Haihong Lin, Ju Zheng, Xiaoling Wang

Utilizing a novel mitochondrial-related gene signature for predicting the prognosis and immunological impact in bladder cancer

Gongping Wu, Chengwei Fan, Xueming Ma, Dongnuan Yao, Weitao Yu, Junqiang Tian

Anti-Müllerian hormone plays a bidirectional role in cancer: a multi-database and multi-method study

Yanan Wang, Zirui Xi, Yuzheng Peng, Yuan Gao, Xiangdong Guo, Guanyu Qu, Zhihua Wang, Hao Peng

Applications of bioluminescence-mediated photodynamic therapy (BL-PDT) for the treatment of deep-seated tumours

Mpho Mohlongo, Blassan P. George, Heidi Abrahamse

Development and validation of an AI-augmented deep learning model for survival prediction in de novo metastatic colorectal cancer

Merih Yalçıner, Efe Cem Erdat, Engin Eren Kavak, Güngör Utkan

A pan-cancer analysis of the oncogenic role of KDELR2 in human cancers

  • Open Access
  • Research

Yu Xie, Dong Chen, Qi Zhang

Induction chemotherapy followed by definitive chemoradiation in patients with inoperable esophageal squamous cell carcinoma: a multicenter retrospective study

Taha Koray Sahin, Imdat Eroglu, Ismail Dilli, Osman Sutcuoglu, Elvin Chalabiyev, Deniz Can Guven, Burak Yasin Aktas, Dilsa Mizrak Kaya, Ozturk Ates, Nuriye Ozdemir, Suayib Yalcin, Omer Dizdar

VDAC1 as prognostic marker and therapeutic target in lung adenocarcinoma: a study integrating bioinformatics and experimental validation

Lei Cheng, Deping Zhao

A systems biology approach to identify key targets in KRAS/BRAF-mutated colorectal cancer

Shiva Shiravi, Negar Mottaghi-Dastjerdi, Behzad Shahbazi, Nahid Ahmadi, Mohammad Soltany-Rezaee-Rad, Abozar Ghorbani, Hamed Montazeri

DOCK2 modulates immune checkpoint inhibitor responsiveness and prognosis in cutaneous melanoma through multi-omics and single-cell T cell dynamics profiling

Huicong Wang, Chao Feng, Chengjun Lao, Yitong Liu, Min Yan, Jiliang Wang, Zhenyan Li, Juan Li

Proteomic analysis of Burkitt lymphoma tissues: insights into the impact of age and EBV infection on protein expression and molecular characteristics

Yu Huang, Shuang Zheng, Xinyi Huang, Shuqi Li, Wenhui Zhang, Man Shu, Qinghua Cao

Integrative genomic analysis reveals causal relationships between breast mammary tissue gene expression and breast cancer risk using multi-method Mendelian randomization

Rongrong Xiao, Ruqing Li

Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer

Yue Feng, Sijiang Zhou, Bing Yang, Jian Yang, Shengyu Wang, Zhu Yu, Chao Quan, Junqiang Chen

Exploring the biological mechanisms of obesity affecting breast cancer from a multidimensional perspective

Yingying Rao, Suyuan Wang, Xianglin Liu, Changhua Shao, Hengyu Li

Development and validation of nomograms for distant metastasis and prognosis of small intestinal neuroendocrine tumors

Changyan Xu, Yuxi Feng, Jinyi Xu, Wei Wang, Heng Huang, Jiwei Wang, Bin Lai

Transformation and survival in patients with Waldenström macroglobulinemia: a population-based study

Yu Du, Xiaona Chang, Xiangxiang Li, Shugang Xing

Inhibition of FXa could be a novel therapeutic target associated with hypoxia-associated tumor behavior?

Ozge Bayrak, Nazlı Mert, Yasemin Basbinar, Serdar Bayrak

Prognostic factors and the role of chemotherapy in patients with pT3N0M0 gastric cancer: a propensity score matching analysis based on the SEER database

Tao Hu, Xinhao Chen, Wangwang Chen

Evaluation of the molecular mechanisms of histological transformation in follicular lymphoma via bioinformatics analysis

Ming Hu, Yirong Chen, Min Liu, Hongyu Zhang, Wenwen Jiang, Jianqing Deng

Integrative analysis reveals SRD5A2 as a central mediator in PPCPs induced modulation of the prostate cancer immune microenvironment

Tao Zhou, Yuqi Li, Peng Ji, Chunyang Meng, Zhiyu Liu, Zhiqiang Zeng, Yuming Yang, Tao Li

Therapeutic potential of green tea’s epigallocatechin-3-gallate in oral cancer: a comprehensive systematic review of cellular and molecular pathways

Saranya Ramsridhar, Vishnu Priya Veeraraghavan, Pooja Narain Adtani, Arul Prakash Francis, Chandini Rajkumar, Murali Balasubramanian, Dhanraj Kalaivanan

Global research status and frontiers on autophagy in triple negative breast cancer (TNBC): a comprehensive bibliometric and visualized analysis

Hongyi Liang, Hanhan Chen, Guangxi Shi, Jingwei Li

Bibliometric evaluation of research trends and hotspots concerning the interaction between immune checkpoint inhibitors and glioma

Dingwen Xu, Liang He, Xu Zhao, Zhe Yang

Prediction of regional lymph node metastasis in rectal cancer: a novel model based on transrectal contrast-enhanced ultrasound

Qin Huang, Hua Zhuang, Yuan Luo, Zhongfan Liao, Yin Yang, Dilimire Abuliezi, Anqi Tao

Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth

Guopeng Pan, Zexiong Cheng, Yiwei Wang, Changxi Wu, Fang Wang, Qing Li, Xiangyu Wang, Yuequan Zeng, Yuqin Li, Kai Li, Xi Lin, Fan Xing, Youwei Huang, Jun Liu, Rui Wang

Development and explanation of a machine learning model for identifying non-localized early-onset T1 colorectal cancer

Yin Zhang, Fuzhou Han, Mingyu Zheng, Duo Xu, Nan Yao, Wenqiang Li, Jun Qu

Artificial intelligence in head and neck cancer: a bibliometric and visualization analysis (1995–2025)

Chuyi Cai, Jingfeng Zhang, Chunshu Pan, Zachary James Drew, Xiaohui Wang, Qi Dai, Guoping Chen, Kai Li

Multi-omics analysis reveals different cholesterol metabolism subtypes in colorectal cancer

Yu Sun, Deyang Kong, Huiru Zhang, Jialiang Fan, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Lin Feng, Haizeng Zhang

CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation

Zengjin Liu, Shewei Guo, Yahui Bai, Zhenyu Song

PDK4 as a tumor suppressor in gastric cancer: implications for metabolic regulation, immune modulation, and prognostic potential

Jin Xu, Jie Sun, Nannan Zhang, Nan Sang, Buwei Teng, Wei He

SLIT2 inhibits lung adenocarcinoma progression by suppressing epithelial-mesenchymal transition

  • Open Access
  • NSCLC
  • Research

Zhimeng Chen, Hu Chen, Yuan Cui, Jun Chen, Weibiao Zeng, Jian Yang, Yu Li, Xiaobei Peng, Xin Tong, Jun Zhao

Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints

Xinyu Yin, Ying Yang, Songjiang Liu

Epstein-Barr virus: biology, pathogenesis and therapy of lymphomas

Jing Chen, Shan Zhang, Yi Zhao, Fang Zheng, Fanjun Cheng

Chemotherapy and age stratified survival outcomes in colorectal cancer based on a population analysis from the surveillance epidemiology and end results program 2010 to 2020

Guoshuai Xu, Wenqiang Li, Nan Yao, Fuzhou Han, Guoyong Yu, Jun Qu

A pancancer analysis reveals the oncogenic role of glutaminase 1 (GLS1) in tumor metabolism and immune evasion: a bioinformatics analysis

Jianjun Liu, Shikai Hong, Kangsheng Gu

A bibliometric study on microenvironment-mediated drug resistance in interventional liver cancer treatment

Qiang Wang, Xu Feng, Guo Xiao, Yaoyong Chen, Quanji Yue, Zhongyao Chen, Yanjie Yang, Jun Zhu

Keratin 80 serves as a potential biomarker in metastatic breast cancer

Feng Sun, Dan Wang, Mengmeng Chen, Xiaona Lin

Elevated expression of SIGLEC8 in skin cutaneous melanoma predicts better prognosis associated with hematopoietic cell lineage pathway

Feng Li, Zhi Yang, Na Lin

Research progress on chronic stress stimulation and gastric cancer metastasis

Juntao Chen, Yanling Zhang, Tianyou Zhang, Zhipeng Wen, Yongfeng Li, Yinzhuo Ye, Zili Zhou, Guiqing Jia

IgE based therapeutics are an emerging modality in cancer treatment

Shikha Kumari, Sanjay Ghosh, Achim Doerner

Decoding the cholesterol–apoptosis axis in HCC: a machine learning-based multi-omics integration and single-cell transcriptomic analysis

Yang Li, Jun Shi, Aiqing Zhao, Jing Huang, Lei Dai

Factors associated with herbal medicine use among patients with cancer attending a tertiary hospital in Southwestern Uganda: a cross-sectional study

Samuel Michael Nono, Julius Kyomya, Casim Umba Tolo, Amos Oyuru, Alex Duhimbaze, Tadele Mekuriya Yadesa

Epigenomic characterization and therapeutic challenges of melanoma arising in giant nevi in pediatric patients

Evelina Miele, Sabrina Rossi, Alessandra Stracuzzi, Sara Patrizi, Sabina Barresi, Marta Cajozzo, Lucia Pedace, Isabella Giovannoni, Fabio Dell’Otto, Andrea Diociaiuti, Francesca Grussu, Flavia Vinciarelli, Alessandro Crocoli, Aurora Castellano, Maria Carmen Garganese, Angela Mastronuzzi, Franco Locatelli, Rita Alaggio, May El Hachem, Mario Zama, Maria Debora De Pasquale

Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma

Chike O. Abana, Adam S. Garden, G. Brandon Gunn, Gregory M. Chronowski, Abdallah S. R. Mohamed, Andrew J. Frankart, Natalie Geier, Houda Bahig, Carly E. A. Barbon, Kate Hutcheson, Vinita Takiar, Clifton D. Fuller, Steven J. Frank, David I. Rosenthal, Jack Phan

Ferroptotic resistance involved in PTEN-loss prostate cancer progression

Yaoyao Jing, Donghui Xing, Zhigang Zhao, Xiaofang Wang

No significant link found between Helicobacter pylori serological antibodies and the development of esophageal adenocarcinoma

Jing Tang, Siqi Wei, Yi Zhou, Yuanming Li, Ping Zhao

Integration of Mendelian randomization and transcriptome wide association studies for causal gene identification in ovarian cancer genetic architecture

Qin Yang, Zurui Zeng, Jie Wang, Xiangcai Wei

Clinical trials in small-cell lung cancer treatment: a cross-sectional analysis of trial discontinuation and non-publication

  • Open Access
  • SCLC
  • Research

Haiyong Chen, Kengqiang Lin, Zujian Dai, Shan Pan

Evaluating the carcinogenic potential and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human stomach using organoids and bulk sequencing data: a multi-machine learning approach combined with computational simulation

Youfu Tian, Dede Ma, Ke Yan, Bing Xiao, Jie Liu, Miao Tan

Global research trends and prospects related to telomerase within breast cancer: a bibliometric and visual analysis

Limeng Qu, Shirong Ding, Qian Long, Wenjun Yi

Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking

Chengwei Bi, Kexun Li, Yong Yang, Yuanlong Shi, Guoying Zhang, Bing Zhao, Yuanpeng Duan, Yapeng Xing, Wei Luo, Libo Yang, Yu Zhang, Yunchao Huang

FSTL1 is a prognostic marker and promotes invasion and metastasis of colon cancer

Chao Zhong, Zhaorui Cheng, Yuansen Shu, Xiaojuan Yang, Jia Hu, Ling He, Xiushen Li, Xu Xiang Chen, Yun Liu

High linc00473 expression indicated worse cancer prognosis, based on the meta-analysis

  • Open Access
  • Research

Ze He, Wang Chen, Pengge Wang, Tiewei Sun

Retraction Note: Decoding core genes and intercellular communication in osteosarcoma: bioinformatic investigation and immune cell profiling for diagnostic and therapeutic insights

Kuan Rong, Haoming Kuang, Liang Ou, Rui Fang, Jianjun Kuang, Hui Yang

Integrated analysis of the oncogenic value of CPNE3 in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Pei Pang, Lanxin Tian, Jianjie Zhu, Yuanyuan Zeng, Xiaoyu Xu, Li Lin, Shenhua Chen, Jian-an Huang, Wenwen Du

Crossroads of cell fate: miR-34-mediated regulation of apoptosis and autophagy in glioblastoma

Tareq Nayef AlRamadneh, Waleed K. Abdulsahib, Sajida Hussein Ismael, R. Roopashree, Priya Priyadarshini Nayak, S. Usha Nandhini, Vimal Arora, Ashish Singh Chauhan, Oybek Ruziyev

Exploration of oxidative stress-related molecular signature for clear cell renal cell carcinoma

Zhenghui Jin, Bintao Hu, Shiqing Zhu, Sen Fu, Zhiyao Deng, Chengwei Wang, Jihong Liu, Tao Wang, Yue Wu

Histidine ammonia lyase expression characteristics in primary liver cancer: hepatocellular carcinoma and cholangiocarcinoma

Hope K. Fiadjoe, Tamara Hoteit, Harlan P. Jones, In-Woo Park, Pankaj Chaudhary

Clinical applications of artificial intelligence in the histopathology of lymphoma: diagnosis, treatment and prognosis

Mengyao Kang, Zibo Yang, Tian Yu, Dongyu Li, Zhiqiong Wang, Liting Chen

Machine learning-based models for predicting glioma-associated epilepsy: a systematic review and meta-analysis

Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Parmida Shirzadi, Salem M. Tos, Azin Ebrahimi, Rana Hashemi, Dorsa Najari, Fatemeh Ghorbanpouryami, Ehsan Bahrami Hezaveh, Mohammad Amin Habibi

Overexpression of Sterol Regulatory Element-binding Transcription Factor 2 is associated with an adverse prognosis in cytogenetically normal acute myeloid leukemia

  • Open Access
  • Analysis

Ruoqi Shan, Jiachi Wang, Ping Chen, Tingting Wu, Fang Pang, Ruoling Yang, Yujun Wei, Qiling Liu, Yaowei Liu, Ran Zhang, Man Song, Xia Li, Lili Dong, Cong Feng, Sai Huang

Chronic stress-related neuroendocrine mediators and ovarian cancer

Hengwei Du, Guoxing Yu, Ruiqi Hu, Jing Du, Cuilan Liu

Apigenin combined with cisplatin suppressed the progression of colorectal cancer by targeting the KRT23/Wnt/β-catenin signaling pathway

Lei Dong, Feng Yang, Xue Wang, Wei Zhang, Jucai Song, Panpan Jiao, Mengjie Kang, Qianqian Guo, Liangzhu Si, Shuhan Zhang, Mei Huang, Linshan Luo, Yongwei Li, Yuesheng Gong

Prognostic impact of primary tumor resection and nomogram development for survival prediction in colonic neuroendocrine carcinoma patients with liver metastasis: a SEER database-based study

Jingxiong Chen, Haizhou Diao, Kai Qian, Kaiguang Zhang, Tengyue Zhang, Jizhong Song

Exploring the TRIM15 protein interaction network as a drug target using machine learning in pancreatic cancer

  • Open Access
  • Research

Kübra Sena Bas Topcu, Kubra Temiz, Ercan Cacan

Integrated mendelian randomization and bioinformatics approach unveiling the immunological and prognostic significance of FBXO2 in breast cancer

  • Open Access
  • Research

Rongzhi Huang, Zhibai Chen, Min Mao, Shenglian Lai, Jiehua Li

Advancing liver cancer diagnosis and treatment with multi-omics approaches: a systematic review

  • Open Access
  • Review

Esraa M. Hashem, Ayat M. Karrar, Mai S. Mabrouk

Feasibility of different meningioma delineation approaches on [18F]SiTATE PET/CT imaging

  • Open Access
  • Research

Sophie Carina Kunte, Lena M. Unterrainer, Simon Lindner, Adrien Holzgreve, Wolfgang G. Kunz, Michael Winkelmann, Alexander Nitschmann, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Claus Belka, Niklas Thon, Christian Schichor, Peter Bartenstein, Marcus Unterrainer

A case of metachronous cervical and early-stage breast cancer

  • Open Access
  • Case Report

Iason Psilopatis, Julius Emons, Stefanie Burghaus, Paul Gass, Frederik A. Stuebs, Anja Seibold, Andreas Füller, Matthias W. Beckmann, Patrik Pöschke

Genomic profiling of AKT1 and NRAS mutations using NGS in Egyptian hepatocellular carcinoma

  • Open Access
  • Research

Magdy M. Mohmed, Randa M. Talaat, Moustafa A. Sakr, Mohamed K. Khalifa, Mofida A. Keshk, Ehab A. Ahmed, Mohmed A Selim, Sawsan M. Abdelmonam, Ghada M. Nasr, Manal O. El Hamshary

Impact of surgery on survival in TNBC with bone metastases only: a propensity score-matched SEER database analysis

Shengbin Cai, Qiran Lu, Luxin Wei, Zhe Zhang, Xiao Chen, Yujie Gu, Yue Yu, Lifeng Zhang

Clinical and pathological analysis of intravascular large B-cell lymphoma of the prostate

  • Open Access
  • Case Report

Jiangying Zhao, Lu Li, Jia Yang, Jiao Peng, Chunlin Li

Publisher Correction: Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the Pan cancer landscape

  • Open Access
  • Publisher Correction

Jing Lin, Wenzhe Chen, Yaodong Zhao, GuanZhong Qiu

Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma

  • Open Access
  • Research

Yan Li, Songsong Wang, Yilong Lin, Junting Li, Xin Lan, Anqi Lv, Junwei Chen, Ziming Liu

Causal associations between circulating metabolites and risk of neuroblastoma: a bidirectional Mendelian randomization study

  • Open Access
  • Analysis

Han Wu, Zhe Zhao, Changlin Chen, Qiuhui Pan, Qizhi Diao, Chaoyan Yue

Investigation of the pan-cancer property of SDC1 and its expression pattern affected patients’ overall survival for breast cancer

  • Open Access
  • Research

Yao Song, MeiLing Lu, Qifeng Luo, Chunhua Lu, Xiaofeng Xu, Shunjie Yuan, Bin Xu, Hua Huang, Qing Lin

A prognostic model based on gamma-glutamyl transpeptidase-derived neutrophil-platelet for predicting intrahepatic recurrence in hepatocellular carcinoma

Zhixiao Huo, Lihua Yan, Wentao Kuai, Wei Liu, Kunyan Qiao, Qinghai Dai, Bei Jiang, JianXu, Yu Cao, Kai Ye, Liang Xu, Rui Su

Using single cell sequencing to investigate tumor microenvironment differences in left and right colon cancer and prognosis-related core genes

  • Open Access
  • Research

Yuhuan Jiang, Ziying Li, Ziqian Liu, Wanqian Xu, Xiajing Yu, Zhiwen Cheng, Linfeng Jin, Wenqing Zhu, Yi Lin, Zhenfang Xiong

Prognostic factors in gastric cancer survivors comparing Cox proportional hazards and machine learning using a Korean National cohort

  • Open Access
  • Analysis

Joonki Lee, Aesun Shin

WNT6 promotes choriocarcinoma progression by driving proliferation, invasion, and metastasis

  • Open Access
  • Brief Report

Meilian Peng, Tianfu Lin, Caijin Wu, Chengyu Lv, Xiaodan Mao, Qibin Wu

NAP1L4 in hepatocellular carcinoma progression and treatment from gene expression to clinical impact

  • Open Access
  • Clinical Trial

Junjie Lin, Hehe Yin, Zihan Xie, Meihui Liu, Lulu Kong, Ruixuan Yao, Guang Chen, Yuyao Li, Jiaojiao Shen, Qingling Wang, Kexing Han, Honghai Xu, Yufeng Gao

DNA methylation-mediated ADA overexpression drives pancreatic cancer progression

  • Open Access
  • Analysis

Jingyi Zeng, Juying Jiao, Bo Lin, Hegen Li, Weijie Xu

Efficacy and safety of PD-1 inhibitors combined with anti-angiogenic agents in patients with recurrent or metastatic nasopharyngeal carcinoma: a systematic review and meta-analysis

  • Open Access
  • Research

Jingjing Gao, Dan Zong, Yiyue He, Jingshu Xu, Xia He

Triglyceride glucose related indices predict incident breast cancer risk in a population based cohort study

  • Open Access
  • Research

Qing Xie, Yaolan Zhen, Zhixing Fan, Ying Hu

LINC01063 promotes colon cancer progression via the miR-134-5p/KRAS axis and serves as a prognostic biomarker

  • Open Access
  • Research

Qianli Liu, Sijia Sun, Rui Fan

Correction: A case of metachronous cervical and early-stage breast cancer

  • Open Access
  • Correction

Iason Psilopatis, Julius Emons, Stefanie Burghaus, Paul Gass, Frederik A. Stuebs, Anja Seibold, Andreas Füller, Matthias W. Beckmann, Patrik Poeschke

Global trends in prostate cancer burden among adults aged 80 years and older from 1990 to 2021 based on the global burden of disease 2021

  • Open Access
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Xin Zhu, Yazhe Zhou, Xin Yang, Kaizhuo Zhou, Mi Zhou

Construction of a novel G2/M checkpoint-related gene signature for prognosis in hepatocellular carcinoma based on machine learning

  • Open Access
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Kunxiong Guo, Yucong Lin, Wanting Lin

Causal association between inflammatory markers and malignant neoplasms of bone and articular cartilage using Mendelian randomization

  • Open Access
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Chang Liu, Chaoqun Yu, Wenzhe Wang, Haining Zhang

Blastic plasmacytoid dendritic cell neoplasm (BPDCN): international, multi-center collaboration and global registry program

Astghik Voskanyan, Maria Badikyan, Marina Konopleva, Alvaro Alencar, Arusyak Ivanyan, Carolyn Owen, Consolato M. Sergi, Ching-Tien Peng, Dickran Kazandjian, Justin Taylor, Funda Tekkesin, Hasanein Ghali, Karen Bedirian, Maria Paola Martelli, Enrico Attardi, Maria Teresa Voso, Mariam Abramashvili, Mazin Faisal Al-Jadiry, Michalis Michael, Min-Yu Su, Nare Martirosyan, Nerses Ghahramanyan, Nino Totogashvili, Pavel P. Kotoucek, Rejin Kebudi, Robin Ohannessian, Ruzanna Papyan, Shushan Hovsepyan, Salma Elashwah, Sameer Bakhshi, Samvel Bardakhchyan, Samvel Danelyan, Shaimaa El-Ashwah, Tezer Kutluk, Deniz Tuğcu, Ahmad Alhuraiji, Vassilios Lazaris, Gevorg Tamamyan, Naveen Pemmaraju

Surgical outcomes and prognostic factors in 228 patients with brain metastases: a focus on en bloc resection and multimodal therapy

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Peng Sun, Chunyu Gu, Haoran Wang, Yanzhen Zhang, Jianping Cao, Junpeng Ji, Mingshan Zhang

Artificial intelligence based quantification of T lymphocyte infiltrate predicts prognosis in high grade breast cancer using deep learning and statistical validation

  • Open Access
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Elham Saleh Albalawi, Jibran Qayyum, Junaid Qayyum

Novel common target genes for breast cancer and colorectal cancer: a Mendelian randomization and spatial transcriptomics study

Pengyu Miao, Zhaokai Zhou, Ling Zhang, Xufeng Huang, Zhengrui Li, Shouxin Wei, András Hajdu

M2 macrophage infiltration associated with CXCL8 predicts grade 4 prognosis and differentiates glioma grades

Wei-Hsiu Liu, Cheng-Chin Lee, Yu-Jia Chang, Ai-Wei Lee, Chien-Yu Huang, Tuan Ngoc Anh Vo, Yung-Fu Wu, Jang-Chun Lin

Bibliometric analysis of global research on liquid biopsy for gastric cancer

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Huazhen Zheng, Peng Wang, Huijie Zheng, Feiwen Deng, Yifan Xv, Huanwei Chen, Zhenling Ji, Huoqiang Chen, Qiucheng Lei

Identification of an efficient immunohistochemical panel for precise differential diagnosis of sebaceous carcinoma of eyelid

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Sitao Yu, Qingyuan Lin, Weimin Ren, Tianhai Ji

Resveratrol synergizes with cisplatin to suppress osteosarcoma U2-OS cells via up-regulating Cx43 and inducing ROS-dependent apoptosis

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Hong-Bo Xing, Hao-Yu Li, Gui-Zhou Zheng, Qi-Hao Zhang, Lei Zhai, Xiang Wu, Shi-Xin Du, Xue-Dong Li

Roles, mechanisms, and clinical implications of circHIPK3 in female malignancy: a comprehensive review

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Yue-Feng Liu, Ni Jiang, Yan-Jiao Huang, Han Ye, Xia Zhou, Wei-Min Luo, Lu-Bin Liu, Dan Li

Epigenetic reprogramming as the nexus of cancer stemness and therapy resistance: implications for biomarker discovery

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Chu Xin Ng, Shin Yuh Lee, Xin Yi Yap, Yong Hui Wong, Jian Sheng Loh, Kuan Ping Ang, Wen Hwei Lee, Wei Xu, Phelim Voon Chen Yong, Sau Har Lee

Charting the landscape and evolution of research on cell death in acute lymphoblastic leukemia: a comprehensive bibliometric analysis (1990–2024)

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Shen Wang, Xuhan Zhang, Zhang

Mendelian randomization analysis unveils causal associations between immune cells, metabolites, and lung cancer risk

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Yanqing Mao, Ting Fu, Yanan Wang, Ling Wang

Luteolin regulates pyroptosis of triple-negative breast cancer cells through AKT signaling

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Gu Junwei, Lan Tian, Hu Zujian, Luo Hua

Integration analysis of single-cell and spatial transcriptomics identifies prognostic genes associated with neddylation in colorectal cancer

  • Open Access
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Ziming Zhu, Xinyue Zhang, Song Wang, Yunsi Huang, Xuedong Han, Dongping Lai, Xin Yao, Weixuan Lan, Hui Nong, Wenbin Zeng, Yanhua Mo, Ri’an Xu, Tao Zhang

Multiomic analysis of CCNE1 amplification associated molecular and immune features in gynecological cancers

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Linlin Liu, Wenjin Zheng, Liang Wen, Zhe Zhang, Yuanguang Meng

Multi-omics approaches including single-cell analysis and machine learning were used to identify the roles of telomere-related genes in esophageal squamous cell carcinoma

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Shuang Li, Nan Wang, Yazhou Liu, Haitao Ma, Kai Xie, Zheng Tao

Potential function of miRNA as a diagnostic biomarker for human ovarian cancer

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Furong Liu, Zihao An, Chao Tang, Xiaoliang Han

Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives

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Junyan Li, Shifan Deng, Wei Yu, Qian Ye, Dongxing Liu, Zhiling Yi, Chuanjian Liu, Jixiang Huang, Jinghua Zhong, Xiangcai Wang

Metastatic patterns and survival outcomes across molecular subtypes in a large cohort of breast cancer patients from the Shiraz breast cancer registry

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Majid Akrami, Raha Shahrokhi, Sina Masoumi, Amirhesam Moosazadeh, Nastaran Tavakolian, Zahra keumarsi, Masoumeh Ghoddusi Johari, Vahid Zangouri

Nomogram for predicting postoperative recurrence in elderly patients with hepatocellular carcinoma based on multimodal ultrasound

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Yinling Jiang, Lina Zhao

Development and validation of a deep learning model for individualized survival prediction in advanced cervical cancer

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Wanying Sun, Qingqing Liu, Yiping Hao, Yi Liu, Xuji Jiang, Chuanli Feng, Lianlian Feng, Yi Yu, Dapeng Li, Xiaofang Zhang, Baoxia Cui, Teng Zhang

A rare primary adult-type fibrosarcoma of tibia

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Yueming Mu, Yinping Jiang, Xudong Zhu, Shenglong Li

Bibliometric analysis of global research on breast cancer with HER2-low expression

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Junpeng Zhu, Jin Hu, Hao Lei, Runze Li, Yu Zhao, Yaqi Zhao, Hengyu Chen, Lei Li, Chong Lu, Chunping Liu

Integrated machine learning and causal inference reveal CHRDL1 as a diagnostic and functional biomarker in NSCLC

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Chao Shen, Jin Wang, Yufeng Tu, Peng Wang, Zijian Luo, Fanzhong Meng

Current progress and future trends in nanoparticle applications for lymphoma: a bibliometric analysis from 2004 to 2024

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Hongwei Lin, Xiaolin He, Luming Huang, Xiao Xiao, Qijun Hou, Huafang Wang, Yang Gao

Prediction of bone or lung metastasis in prostate cancer using machine learning: a SEER-based study with external validation

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Mingyan Zhong, Ru Chen

Bibliometric analysis reveals the current status and future trends of cancer associated fibroblasts research in breast cancer

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Shixue Jing, Siping Zhou, Cui Jia, Yongfeng Wang, Hui Cao, Lushun Zhang, Xinlian Liu

Relationship between the BRAF-V600E variant allele frequency and clinicopathological characteristics of papillary thyroid carcinoma and its clinical application

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Shijia Wang, Yu Ding, Xiang Geng, Wenze Wu, Feng Ju, Xiaoyi Yan, Yuan Li, Guojun Lyu

Single cell RNA sequencing decodes cellular heterogeneity and identifies prognostic immune signatures in bladder cancer microenvironment

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Kai Cao, Yunfeng Shi, Bin Wu, Honglei Shi, Zhong Lv, Hongqian Guo, Rong Yang

Association of LAMA3 expression with perineural invasion and chemoresistance in pancreatic ductal adenocarcinoma

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Yang Yang, Yongqiang Chen, Xiaohong Wang, Qikai Sun, Yeben Qian

Integrated bioinformatics analysis to elucidate cellular communication in the microenvironment of breast cancer

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Man Wang, Hua Li, Xingong Zhang, Zhijian Zha, Mengjia Zhao, Qi Wang, Danfeng Zhang

OTUD4 suppresses colorectal cancer progression through deubiquitinating p53

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Xianyue Bu, Yingxu Wang, Jinzhen Pan, Shuai Li, Penghao Li, Bing Zheng

Genes associated with epithelial mesenchymal transition (EMT) in cervical cancer progression

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Kiran Kumari, Raviranjan Kumar Gupta, Saket Kumar, Shyam Babu Prasad

Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review

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Meng Huang, Jian Li, Bo Liu, Yuxiang Liao, Bin Wang, Haipeng Liu, Ying Liu, Jie Zhao

Non-coding RNAs in programmed cell death regulation in melanoma: mechanisms and therapeutic insights

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Yang Liu, Chenqi Guo, Yunsheng He, Yun Pu, Xinming Chen, Yu Zhang

Prognostic value of anoikis- and epithelial–mesenchymal transition-related genes and development of a prognostic risk model in thyroid cancer

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Kai-fang Xiang, Ling Wang, Yan Wu, Dong Zhang

DCUN1D5 is a novel potential biomarker for predicting the prognosis of bladder cancer

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Xiaomin Han, Lanqi Li, Yuzhe Jia, Lijuan Ai, Xingyu Wang, Chen Xu, Rui Guo, Rihan Wu, Yilin Dong, Shouyu Fang, Ruixue Li, Jiaming Zhang, Jiaxin Luo, Ziqi Zhou, Yiju Wei, Li Yang, Hongge Ju, Qiang Ma, Kewen Zheng

Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study

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Hengqiu He, Rongxin Liao, Xue Wu, Fanghao Cai, Rui Kong, Xiaoyue Zhang, Zaicheng Xu, Zhenzhou Yang, Yuan Peng

Identification of candidate susceptibility genes for cutaneous malignant melanoma through integrated multi-method analysis

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Ping Zhou, Xin Jiang, Wanchun Wang, Dan Wang

Multi-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability

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Mumtaz Hussain, Mehreen Ishfaq, Syeda Amber Hameed, Afshan Syed Abbas, Mujeeb ur Rehman Bhanbhro, Qurat ul Ain, Mostafa A. Abdel-Maksoud, Abdulaziz Alamri, Saeedah Almutairi, Taghreed N. Almanaa, Muhammad Mazhar Ayaz, Yasir Hameed

Construction of an eight-basement membrane related gene signature for predicting prognosis and immune response in hepatocellular carcinoma

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Xiaohan Zhang, Guanlin Wu, Jiayao Li, Lianhong Yin, Meng Gao, Xu Han, Xuerong Zhao, Lina Xu

Hsa_circ_0062522 affects the progression and tamoxifen resistance of estrogen receptor-positive breast cancer by targeting miR-3163

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Yan Bian, Yanjun Ma, Yinxiang Xu, Jiayuan Mao, Lina Huang

Bioinformatics analysis of macrophage-associated genes reveals prognostic signatures and immune landscape in gastric cancer

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Rongbo Han, Fei Wang, Xiujuan Wang, Benxin Zhao

A global bibliometric and visualization study of the adaptive radiotherapy research landscape

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Zhengyu Zhou, Chuan Huang, Xiaoying Li, Yihan Ye, Man Wang, Qiongyu Lan, Qing Li

Genetic evidence for causal association between platelet count and glioma risk through Mendelian randomization analysis

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XiaoYong Han, Mengyan Chen, Zhisheng Ji, Hui Zhang

Decreased IL20RA expression serves as a predictor of unfavorable prognosis in endometrial cancer

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Yue-Feng Liu, Dan Li, Ke Shi, Lu-Bin Liu, Ni Jiang, Wei-Min Luo, Qun-Xian Zhang

Transient Receptor Potential Melastatin 4 (TRPM4) is associated with an immuno-stimulatory TME and better prognosis in BLCA

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Yiqiang Da, Xuerui Chen, Lanxin Yu, Yunxin Li, Zixu Chen, Yuyue Zhang, Hualin Wang, Zhuang Zhu, Yuan Liu, Yao Geng

A pan-cancer analysis of CTSC as a candidate prognostic and immune-related biomarker

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Lan Zheng, Xin Liu, Yiling Xi, Dacai Gong, Bin Ge, Xing Wei, Jinwen Cai, Peng Chen

The role of genes related to excitotoxicity in glioma prognosis

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Qiang Zhao, Kunpeng Du

Global trends and future directions in COVID-19 and leukemia research from 2020 to 2024

  • Open Access
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Zelin Yang, Hui Zhao, Jie Tian

Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma

  • Open Access
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Mengna Li, Xintao Cen, Yan Yan, Li Li, Wei Lai

Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy

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Yayu Huang, Tianlin He

A prognostic model derived from PANoptosis-associated subtypes unveils immunological features and therapeutic vulnerabilities in cervical cancer

  • Open Access
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Yuehong Tong, Wei Deng, Lili Xu, Yao Li, Keke Zhang

Expression and prognostic diagnostic significance of RGS gene family in breast cancer

  • Open Access
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Huanhuan Wang, Ming Feng, Hong Huang, Xiaoqing Zhang, Chang Yao

Identification and external validation of a prognostic signature based on N6-methyladenosine- and tertiary lymphoid structures-related genes to evaluate survival prognosis and treatment efficacy in lung adenocarcinoma

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Xiangbao Yang, Chengwen Zheng, Yinpeng Pan, Shuoming Wu

Lactylation-related lncRNAs can forecast prognosis and immune response of lung adenocarcinoma

  • Open Access
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Le Zhou, Zhongjiang Lan, Bo Han, Yinjiao Yuan, Zhuowei Dong, Yijing Shi, Ruinian Zheng

Cuproptosis-related gene DLD expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

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Cheng Qian, Hu He, Ganhua You

Detection of circulating tumor cells and microemboli in the blood of lung adenocarcinoma in situ patients case reports

  • Open Access
  • Case Report

Yubin Huang, Houlu Zhang, Daming Fan, Zerui Wang, Xuanzhe Qin, Xiaoming Sun, Liangming Zhu

GRB10 as a pan-cancer biomarker linking oncogenic signaling, immunosuppression, and immunotherapy resistance

  • Open Access
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Haoran Guo, Junjie Chen

Pan-cancer atlas analysis of FANCB and its potential mechanism in cholangiocarcinoma

  • Open Access
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Youjie Fan, Jianhua Li, Haipeng Wang, Lei Yao, Xiaolei Wang

A signature constructed with circadian rhythm-related genes to predict the prognosis and therapy response for low-grade gliomas

  • Open Access
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Yiqiang Zhou, Ruwei Ke, Ziliang Hu, Zhepei Wang

Charting the growth of programmed cell death studies in uveal melanoma: a bibliometric evidence

  • Open Access
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Jie Zhang, Li Li

Potential value of m6A-related lncRNAs in diagnosis and therapy of pancreatic cancer

  • Open Access
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Long Wu, Yunting Zhang, Dandan Wu

LINC00519 promotes the progression of cholangiocarcinoma through regulating the axis of miR-876-3p/GATA1

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Kaixuan Hui, Zhenlong Chai, Xiao Yang, Lina Huang

Exploring targeted therapies against RFPL3 for non-small cell lung cancer with lymph node metastasis

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Chuan Lin, Yi Jiang, Fei Xu

Prediction of prognostic biomarkers for hepatocellular carcinoma and immune microenvironment infiltration based on single-cell sequencing and RNA-Seq integration

  • Open Access
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Yiyan Zhai, Xuan Fan, Peiying Lu, Huiling Lei, Jiangying Liu, Meiling Guo, Shuqi Liu, Tong Zhao, Peizhi Ye, Jiarui Wu

Integrated multi-omics analysis identifies key biomarkers associated with post-translational modifications and RNA methylation in clear cell renal cell carcinoma

  • Open Access
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Taisen Pang, Yongzhi He, Jie Liao, Xiuwang Wei

CEBPB emerges as a key regulatory factor in human cancers through diverse molecular mechanisms and clinical implications

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Anbang He, Cunjin Wu, Dan Xia, Yi Zhu

Machine learning multiomics Deciphers GRHL2 associated tumor microenvironment evolution guiding precision therapeutics in breast cancer

  • Open Access
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Jingjing Zhao, Zhengkuo Wei, Jun Tang, Yuanyuan Zhu

Regulation of carbonic anhydrase IX gene expression through the LncRNA TRPM2-AS is associated with tumor progression in colorectal tumors

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Marziye Emamian, Samane Sharif, Baratali Mashkani, Mohammadreza Abbaszadegan, Abdolamir Allameh

Single-cell aggrephagy landscape delineates intercellular communication of tumor microenvironment associated with ovarian cancer progression and immunotherapy

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Feng Fang, Jiemiao Chen, Xinran Li, Cao Zhou, Yilan Dai, Yuanyuan Chen, Xin Yang, Yong Xie, Fujie Qin, Huijiao Fu

Targeted drug conjugates and molecular mechanisms in overcoming lung cancer drug resistance

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Lu Ye, Shuang Xiang, Rou Xue, Yihao Zhang, Yanan Wang, Xinrong Xiong, Chuan Qin, Song Duan

Prognostic and microenvironmental analysis of pancreatic cancer by tumor location

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Zedian Chen, Zichang Dai, Shaomei Lin

Amino acid metabolic reprogramming drives pathogenesis and therapy in hematologic malignancies

  • Open Access
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Dexiang Ren, Rong Liu, Wei Li, Linzhou Li, Xueyin Lv, Xiaojun Xia, Xudong Lei

Research productivity and trends in gastric neuroendocrine neoplasms in the early 21st century: a bibliometric and visualized analysis

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Xinyu Chen, Xuanwei Huang, Xinting Lv

Nanomedicine and nutraceutical-based nanocarriers for specific delivery to cancer stem cells: targeted drug delivery at the STEM frontier

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Enas Daoud, Waleed K. Abdulsahib, Sajida Hussein Ismael, R. Roopashree, Subhashree Ray, Jayshree Nellore, Gunjan Mukherjee, Ashish Singh Chauhan, Mohigul Kholiyeva

Ganglioside therapy in cancer molecular insights and therapeutic opportunities

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Avisek Banerjee, Sounak Banerjee, Soham Raj Maity, Avishek Das

A Mendelian randomization-based risk model using aging-related genes for prognosis in lung adenocarcinoma

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Shaowen Feng, Xiaowang Liu, Huiqin Yang, Jiazheng Huang, Ziang Wang, Hui Li, Jiahao Cai, Zhonghe Liu

CXCL10 promotes non-small cell lung cancer (NSCLC) progression by modulating the phosphate to urate ratio (PUR)

  • Open Access
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Yonglun Zhang, Qian Li

Neddylation related gene signature for prognostic biomarkers in colorectal cancer with integrated bioinformatics and experimental analysis

  • Open Access
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Li Zhou, Lujuan Pan, Haisheng Lan, Houji Guo, Xusen Huang, Hua Li, Qianli Tang

Role of non-coding RNAs in radiotherapy sensitivity in non-small cell lung cancer

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Peipei Yang, Rui Chen, Huijuan He

Pan-cancer analysis identified DOK3 as a novel biomarker for predicting prognosis and immunotherapy effectiveness

  • Open Access
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Zichen Xu, Lizhen Cai, Qingkun Jiang, Yuqi Xin, Shaoqing Chen, Jianwei Liu

The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study

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Tingting Shen, Lei Sheng, Hua Zhan, Sihan Chen

Comprehensive pan-cancer analysis of p62 reveals its contribution to shaping tumor microenvironment and anti-tumor immunity

  • Open Access
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Zahra Nayeri, Elahe Tavakol, Marveh Rahmati, Marco Cordani, Mojgan Djavaheri-Mergny, Vahid Shariati, Mohammad Amin Moosavi

Lipid metabolism-related genes correlate with immune microenvironment and regulate the efficacy of immunotherapy via ferroptosis in melanoma

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Hengxiang Zhang, Yuhan Chen, Sen Guo, Weinan Guo

Mapping cellular interactions and communication landscapes in cervical cancer via single-cell transcriptomics

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Shaoli Zhuang, Xiaoxiao Deng, Furong Fu, Zhang Zhang

Breast cancer detection using optimized hyperbolic graph attention with bidirectional convolutional neural network

  • Open Access
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Sangeeta Parshionikar, Vijaya Babu Burra, Debnath Bhattacharyya, Tai-Hoon Kim

Identification of ITGA2 as a methylation-regulated oncogene through a CeRNA network in papillary thyroid carcinoma

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Guoliang Wu, Xinyu Wang, Yiming Zhu, Shaoyan Liu, Song Ni

LTBP2 promotes meningioma progression by enhancing glycolysis via the PI3K/AKT/mTOR/c-Myc signaling pathway

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Xuemin Li, Chonggong Zhang

Identifying predictive factors for recurrence risk in pediatric craniopharyngioma after surgery using a clinical prediction model

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Lihua Tian, Liyong Zhong

Chlormethine gel effectiveness as second-line treatment in mycosis fungoides: a single-centre retrospective study

  • Open Access
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Corrado Zengarini, Alba Guglielmo, Ludovica Vocale, Andrea Filippini, Federico Bardazzi, Erika Morsia, Iria Neri, Martina Mussi, Bianca Maria Piraccini, Alessandro Pileri

Predictive value of immunomodulatory-related genes for the prognosis of lung adenocarcinoma based on bioinformatics analysis

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Luyu Yang, Zhimin Cao, Xing Yuanfang, Teng Ma, Huan Ye, Dongchang Wang

Natural products as therapeutic interventions for inflammation-mediated cancer

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Srabaita Roy, Ranjit Shaw, Akanksha Pandey, Surendra Kumar Trigun

Caspase-3 deficiency inhibits the development and anti-tumor response of bone marrow-derived dendritic cells

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Jinqiang Liu, Kunli Du, Yaozhen Chen, Gaozan Zheng, Hongwei Zhang, Wen Zhang, Xingbin Hu, Fan Feng

Targeting ferroptosis by noncoding RNAs as a novel therapeutic strategy for hepatocellular carcinoma

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Yaser Mohammadi, Mohammad Ali Mahdiabadi, Zahra Ourang, Elham Bahreini, Ali Abaszade-Cheragheali

Identification of FGF14-AS2/MPP2 axis as prognostic biomarkers in colorectal cancer based on CeRNA network

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Rongrong Zhou, Zhineng Zeng, Ying Xu, Qiong Tang, Songnan Zhang, Junfeng Zhu

Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study

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  • Analysis

Jie Cui, Tie-Jun Wang, Yue-Chen Zhao, Xuan-Peng Zhou

Tailored radiotherapy for brain metastases improves precision and outcomes

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Jing Bao, Xuxu Xu, Shepeng Wei, Zhenjiang Pan

Peptide antibody tools to dissect specific functions of eIF4A paralogs in cancer

  • Open Access
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Shobhit Srivastava, Azeezat Osikoya, David Terrero, Dayanidhi Raman

Deep learning model outperforms traditional models in clinical data-based prognostic prediction for adult-type diffuse glioma

  • Open Access
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Xiaopeng Li, Chongshun Zhao, Yanpeng Xia, Ya Zhang, Qian Zhang, Mengdan Miao, Zhijiang Xie, Hongjing Yan, Tao Zhou, Shuanli Xin

Causal relationship between blood metal levels and breast cancer risk: a Mendelian randomization study in East Asian populations

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  • Analysis

Jingyi Zhang, Fu Xiong, Shucheng Hu, Jun Chen, Jinyao Yuan, Yuhui Che, Xiangjuan Sun

Machine learning-Based integration develops a metastasis-Related rhythmic gene signature for improving outcomes in pancreatic cancer

  • Open Access
  • Analysis

Zhiyuan Cheng, Chuting Yu, Bin Quan, Kena Zhou, Chongxin He, Shuangjun Shen, Xiaowan Wu, Guo Yu, Leheng Liu, Zihao Guo, Haoran Sun, Rong Wan, Kai Zhao, Zhanjun Lu, Weiliang Jiang

Prognostic and therapeutic response prediction in glioblastoma multiforme using a lactylation-associated gene signature

  • Open Access
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Huan Zhu, Guanjun Li, Tingting Li, Xiangdi Yang, Yongqin Yang, Yifei Li, Zhigang Liu

Single-cell sequencing reveals the complexity of cutaneous T-cell lymphoma

  • Open Access
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Jun Du, Hao-Ran Yuan, Zi-Han Lin, Yi-En Pan, Shu-Qi Zhang, Zi-Jin Ye, Jun-Ting Lyu

Analysis of research hotspots on the detection of vascular endothelial growth factor C and its receptor vascular endothelial growth factor receptor-3 in cervical squamous cell carcinoma

  • Open Access
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Yaowen Hu, Qun Fang

Lon peptidase 1 promotes proliferation and metastasis in breast cancer via interleukin 6 signaling

  • Open Access
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Yue Gao, Chunyu Duan, Sha Luan, Xinyu Wang, Peng Xu, Yuying Jiao, Peng Fu, Changjiu Zhao

Immunological factors underlying radiation-induced toxicity in prostate cancer patients: a systematic review

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Lucas Mose, Hady Aboelroos, Adam Zabini, Cristian Fernandez-Palomo, Thomas Zilli, Alan Dal Pra, Osama Mohamad, Daniel M. Aebersold, Verdiana Trappetti, Mohamed Shelan

AMPK: an enzyme that may be effective in cancer and metabolic diseases

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Sümeyye Güney Kalkan, Meltem Ceylan Ünlüsoy

Hyperthermia-induced BRCA2 reduction potentiates PARPi sensitivity in BRCA2-proficient ovarian carcinoma

  • Open Access
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Bingjie Mei, Junyang Li, Xiaoyu Hou, Jie Zhang, Dengfeng Wang, Jianming Huang, Guonan Zhang

Lactylation modification regulates acute myeloid leukemia pathogenesis and immune microenvironment

  • Open Access
  • Analysis

Ruixue Dai, Guodong Sui

KRTCAP2 is a prognostic biomarker associated with immune infiltration in kidney renal clear cell carcinoma

  • Open Access
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Runlin Feng, Yuanyuan Han, Lijuan Feng, Changxing Ke, Yanping Tao, Tao Zhang

Mapping the global research landscape of perineural invasion in gastrointestinal malignancies: a bibliometric visualization analysis

  • Open Access
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Shijie Yang, ChengZhang Zhu, Hui Cai

Angiogenesis in metastatic colorectal cancer: a bibliometric analysis of 5875 publications between 2000 and 2023

  • Open Access
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Yujian Xia, Chaoran Yu, Shenjia Wang, Zhaoqiang Chen, Chenglei Yuan, Yousheng Li, Xin Zhao

Exploring tumor heterogeneity and drug resistance in cervical cancer through single-cell and bulk transcriptomics

  • Open Access
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Yinxia Yang, Sirong Cheng, Yuxuan Zhong, Pengyu Sun, Xiaoru Deng, Bohui Zhou

Systems biology analysis of long non-coding RNAs and targets to identify key modules and biomarkers in breast cancer

  • Open Access
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Chao Ma, Xueling Zhang, Rui Zhang, Hanteng Yang, Junling Wang, Chengyun Li

A comprehensive pan-cancer analysis of the prognostic role and immunotherapy efficacy evaluation of Glyoxalase 1

  • Open Access
  • Research

Yi-Qi Zhao, Jue Zhao, Yan-Mei Zheng, Qian-Qian Wang

Exploring the association between air pollutants and non-small cell lung cancer using network toxicology and machine learning

  • Open Access
  • Analysis

Qiang Zhao, Zhiqiang Zhao, Kunpeng Du

Predictive molecular alterations of prostate cancer brain metastases based on a companion diagnostic assay

  • Open Access
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Antonio Rodríguez-Calero, Andrej Benjak, Sina Maletti, Dilara Akhoundova Sanoyan, Martin Zoche, Marta Nowak, Holger Moch, Mark A. Rubin

Metastatic de novo lung cancer presenting as acute jejunojejunal intussusception: an unusual case report

  • Open Access
  • Case Report

Marwa Aloui, Saida Sakhri, Mohamed Ali Ayadi, Nadia Boujelbene, Ines Zemni, Tarek Ben Dhiab

Prognostic significance of circulating tumor DNA in non-metastatic colorectal cancer

  • Open Access
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Ruiyang Li, Shuchao Wang, Jie Xu, Min Zhao, Heng Zhang, Yibo Yin, Xue Han, Baojun Liu, Wenjian Liu

Identification of Gαi1 as a key regulator of tumor progression in nasopharyngeal carcinoma

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Yan Lv, Hui-Jun Yang, Yiran Sha, Ting Chen, Donghui Li, Ling Ji

Genetic and immune regulatory links between inflammatory bowel disease and breast cancer involving the JAK STAT PD L1 axis

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Ling Zeng, Jingzhi Zhang, Xue Liu, Xueping Yang, Qihong Nie

A novel inositol phosphate metabolism signature predicts survival prognosis in low grade glioma

  • Open Access
  • Analysis

Yihao Zhu, Fuduo Bo, Jindou Wei, Yang Xu, Chunfa Qian

Decoding epithelial-T cell interactions in colorectal cancer through single-cell and spatial transcriptomics

  • Open Access
  • Analysis

Rentao Yu, Xinyu Lu, Zhuangzhuang Yue

Five cases report and literature review of malignant peripheral nerve sheath tumor

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  • Case Study

Xinmeng Wu, Yan Zhang, Xiaomei Liu, Qingqin Zhang, Qinghui Yang, Min Zhang, Ping Lu

Integrated network toxicology and molecular simulations uncover the molecular mechanism and core targets of DNBaP-induced lung cancer

  • Open Access
  • Analysis

Peng He, Zhongting Lu, Yunfei zhao, Tao Li, Jing Chen

Research progress and frontier trends in liver cancer immunotherapy in the post-COVID-19 era (2020–2024): a visualization analysis based on bibliometric methods

  • Open Access
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Shicai Liang, Xusheng Zhang, Xuebo Wang, Yannan Xie, Jialong Wang, Jiawei Wang, Bendong Chen

Dexmedetomidine and dezocine targets (NR1H3 and ADRB1) are potential prognostic biomarkers for breast cancer

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Shaochun Zhang, Fang Yuan, Jing Ke

Survival outcomes and prognostic predictors after adrenalectomy for renal cell carcinoma adrenal metastasis

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Wencong Han, Kun Peng, Zejin Ou, Shiwei Chen, Tai Kang, Xiaoteng Yu, Zheng Zhang

MiR-205-5p downregulation and circ_100290 upregulation in glioblastoma patients are associated with tumor aggressiveness

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Sanaz Eghtedari, Sedigheh Arbabian, Fereshteh Rezagholizadeh, Morteza Talebi, Reza Bahrami, Maliheh Entezari, Mohammad Taghi Joghataei

PTBP1 functions as a suppressor of ferroptosis in endometrial carcinoma cells by stabilizing SLC7A11 mRNA

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Keke Zhu, Ke Zhang, Hui Li, Yao Shen, Lu Wang, Qinghong Hu, Hanwen Xing, Liping Han

A comprehensive review redefining viruses as therapeutic agents in cancer treatment

  • Open Access
  • Review

Anjana Jadhav, Aravind J, Trupti Patel

Innovations in cancer treatment as novel potential and the myth of personalized vaccines, immunotherapy, CRISPR/Cas9, and bacteriotherapy as promising therapeutic strategies

  • Open Access
  • Review

Akmal Zubair, Safa Wdidi

A case study of gastritis cystica profunda mimicking a submucosal tumor treated with endoscopic submucosal dissection

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Ya-Li Wang, Chen-Fei Liang, Yan-Li Cheng

Systematic pan-cancer analysis of IL3RA carcinogenesis in human tumors, combined with bioinformatics analysis

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Rongyang Zou, Qiong Wu, Fang Fang, Yundi Cao

CCDC86 modulates immune cell infiltration and disease progression in head and neck squamous cell carcinoma

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Fei He, Yang Liu, Xinjian Zhang, Rongrong Zhang, Jiaxuan Qiu, Sijia Na

Mapping the landscape of predictive biomarkers for immune checkpoint inhibitors a bibliometric analysis

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Xiaodong Wang, Jing He, Gouping Ding, Yixuan Tang, Qianqian Wang

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Keynote webinar | Spotlight on progress in colorectal cancer

On-demand video coming soon

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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Keynote webinar | Spotlight on functional neurological disorder

FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognize FND and what are the treatment options?

Prof. Mark Edwards
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images