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Clinical and Translational Medicine
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Open Access 01-12-2017 | Research

Differences in immune response to anesthetics used for day surgery versus hospitalization surgery for breast cancer patients

Authors: Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya, Morihito Okada

Published in: Clinical and Translational Medicine | Issue 1/2017

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Abstract

Background

Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for breast cancer were compared in a prospective study.

Methods

Between February 2012 and August 2014, 21 breast cancer patients underwent day surgery and 16 breast cancer patients underwent hospitalization surgery. The former group received lidocaine/propofol/pethidine, while propofol/systemic opioid- and sevoflurane/propofol/systemic opioid-based anesthesia were administered to the latter group. Surgical stress response was evaluated based on time of operation and amount of bleeding during operation. Immune function was assessed based on natural killer (NK) cell activity, CD4/8 T cell ratio, and cytokine levels of IL-6 and IL-10 that were detected before surgery, after surgery, and on the first postoperative day.

Results

Operation time did not differ between the two groups. Blood loss was significantly less for the hospitalization surgery group. No change in NK cell activity was observed for either group, although the CD4/8 T cell ratio increased transiently following day surgery. Levels of IL-6 increased significantly in both groups following surgery, and these levels tended to be higher in the hospitalization surgery group. One patient who underwent hospitalization surgery had higher levels of IL-10.

Conclusions

There were few differences in immune response between the two groups, potentially since a majority of the hospitalization surgery patients received propofol-based anesthesia. We hypothesize that the use of volatile anesthetic/opioid analgesia in hospitalization surgery has a greater influence on immune function in breast cancer patients than local anesthetic/propofol-based anesthesia in day surgery.
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Metadata
Title
Differences in immune response to anesthetics used for day surgery versus hospitalization surgery for breast cancer patients
Authors
Ryungsa Kim
Ami Kawai
Megumi Wakisaka
Yuri Funaoka
Shoichiro Ohtani
Mitsuya Ito
Takayuki Kadoya
Morihito Okada
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2017
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-017-0163-4

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