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European Journal of Medical Research
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Open Access 01-12-2017 | Research

Diagnostic value of microRNA-143 in predicting in-stent restenosis for patients with lower extremity arterial occlusive disease

Authors: Zhi-Hai Yu, Hai-Tao Wang, Can Tu

Published in: European Journal of Medical Research | Issue 1/2017

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Abstract

Purpose

This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD).

Methods

From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography. A logistic regression analysis was conducted to analyze the risk factors for ISR in LEAOD patients. A receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of miRNA-143 in predicting ISR for LEAOD patients.

Results

There were 74 and 91 patients in the restenosis and non-restenosis groups, respectively. Before the treatment, there were significant differences in history of diabetes, smoking status, blood sugar level (BSL) at admission, low-density lipoprotein cholesterol (LDL-C) level, and stent diameter between the restenosis and non-restenosis groups (all P < 0.05). Serum miRNA-143 expression was lower in the restenosis group than in the non-restenosis group (P < 0.05). Serum miRNA-143 expression in the restenosis group was correlated with smoking status, history of diabetes, BSL, and LDL-C (all P < 0.05). Logistic regression analysis demonstrated that miRNA-143, LDL-C, and smoking status were correlated with the postoperative ISR (all P < 0.05). ROC curve analysis revealed that the area under the curve (AUC) of miRNA-143 in predicting ISR for LEAOD patients was 0.866.

Conclusion

Our results indicate that miRNA-143 can be a promising tool for predicting the ISR in LEAOD patients.
Literature
1.
He XM, Zheng YQ, Liu SZ, Liu Y, He YZ, Zhou XY. Altered plasma MicroRNAs as novel biomarkers for arteriosclerosis obliterans. J Atheroscler Thromb. 2016;23(2):196–206.CrossRefPubMed
2.
Soga Y, Iida O, Hirano K, Yokoi H, Nanto S, Nobuyoshi M. Mid-term clinical outcome and predictors of vessel patency after femoropopliteal stenting with self-expandable nitinol stent. J Vasc Surg. 2010;52(3):608–15.CrossRefPubMed
3.
Ichihashi S, Higashiura W, Itoh H, Sakaguchi S, Nishimine K, Kichikawa K. Long-term outcomes for systematic primary stent placement in complex iliac artery occlusive disease classified according to Trans-Atlantic Inter-Society Consensus (TASC)-II. J Vasc Surg. 2011;53(4):992–9.CrossRefPubMed
4.
5.
Castagna MT, Mintz GS, Leiboff BO, Ahmed JM, Mehran R, Satler LF, et al. The contribution of “mechanical” problems to in-stent restenosis: an intravascular ultrasonographic analysis of 1090 consecutive in-stent restenosis lesions. Am Heart J. 2001;142(6):970–4.CrossRefPubMed
6.
Lopes LB, Brophy CM, Flynn CR, Yi Z, Bowen BP, Smoke C, et al. A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model. J Vasc Surg. 2010;52(6):1596–607.CrossRefPubMedPubMedCentral
7.
8.
Long G, Wang F, Duan Q, Chen F, Yang S, Gong W, et al. Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. Int J Biol Sci. 2012;8(6):811–8.CrossRefPubMedPubMedCentral
9.
Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, et al. Prospective study on circulating MicroRNAs and risk of myocardial infarction. J Am Coll Cardiol. 2012;60(4):290–9.CrossRefPubMed
10.
Ren J, Zhang J, Xu N, Han G, Geng Q, Song J, et al. Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. PLoS ONE. 2013;8(12):e80738.CrossRefPubMedPubMedCentral
11.
12.
Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, et al. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009;460(7256):705–10.PubMedPubMedCentral
13.
Li T, Cao H, Zhuang J, Wan J, Guan M, Yu B, et al. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta. 2011;412(1–2):66–70.CrossRefPubMed
14.
15.
Lin J, Li D, Yan F. High-resolution 3D contrast-enhanced MRA with parallel imaging techniques before endovascular interventional treatment of arterial stenosis. Vasc Med. 2009;14(4):305–11.CrossRefPubMed
16.
Kraitzer A, Kloog Y, Zilberman M. Approaches for prevention of restenosis. J Biomed Mater Res B Appl Biomater. 2008;85(2):583–603.CrossRefPubMed
17.
Wang Z, Zhang X, Chen S, Wang D, Wu J, Liang T, et al. Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1alpha. PLoS ONE. 2013;8(1):e55471.CrossRefPubMedPubMedCentral
18.
O’Sullivan JF, Martin K, Caplice NM. Microribonucleic acids for prevention of plaque rupture and in-stent restenosis: “a finger in the dam”. J Am Coll Cardiol. 2011;57(4):383–9.CrossRefPubMed
19.
Santulli G. microRNAs Distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis. Adv Exp Med Biol. 2015;887:53–77.CrossRefPubMedPubMedCentral
20.
Taibi F, Metzinger-Le Meuth V, M’Baya-Moutoula E, Djelouat M, Louvet L, Bugnicourt JM, et al. Possible involvement of microRNAs in vascular damage in experimental chronic kidney disease. Biochim Biophys Acta. 2014;1842(1):88–98.CrossRefPubMed
21.
Popovich IM. The role of micro-RNA/143/145 in evolution of intra-stent restenosis. Kardiologiia. 2011;51(9):17–21.PubMed
22.
He M, Gong Y, Shi J, Pan Z, Zou H, Sun D, et al. Plasma microRNAs as potential noninvasive biomarkers for in-stent restenosis. PLoS ONE. 2014;9(11):e112043.CrossRefPubMedPubMedCentral
23.
Kim JS, Kim MH, Lee BK, Rim SJ, Min PK, Yoon SJ, et al. Effects of increasing particle size of low-density lipoprotein on restenosis after coronary stent implantation. Circ J. 2008;72(7):1059–64.CrossRefPubMed
24.
Wihanda D, Alwi I, Yamin M, Shatri H, Mudjaddid E. Factors associated with in-stent restenosis in patients following percutaneous coronary intervention. Acta Med Indones. 2015;47(3):209–15.PubMed
Metadata
Title
Diagnostic value of microRNA-143 in predicting in-stent restenosis for patients with lower extremity arterial occlusive disease
Authors
Zhi-Hai Yu
Hai-Tao Wang
Can Tu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2017
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-016-0240-y

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