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17-07-2024 Hypertension News

The lower the better for blood pressure treatment

Reducing systolic blood pressure to less than 120 mmHg versus 140 mmHg prevents major vascular events in patients at high cardiovascular risk, suggests the ESPRIT trial.

Editor's Choice

Necrotizing myopathy in a woman with type 1 diabetes

Open Access Diabetes-associated Diseases Case Study

Identifying the cause of muscle necrosis can be a diagnostic challenge, as shown by this case of diabetic myonecrosis complicated by pyomyositis and abscess caused by Escherichia coli.

Greater weight loss with tirzepatide than semaglutide

16-07-2024 Obesity News

Treatment with tirzepatide leads to greater weight loss than semaglutide in people with overweight or obesity, regardless of type 2 diabetes.

Managing lipids in diabetic kidney disease

Open Access Diabetic Nephropathy Review

People with diabetic kidney disease have an increased risk of cardiovascular disease but good lipid management can improve outcomes. Find out more with these practical recommendations.

Immune checkpoint inhibitor-induced diabetes

Free for a limited time Other Specific Types of Diabetes Review

ICIs have advanced cancer treatment but can trigger immune-related adverse events. Explore the pathogenesis, progression, and treatment strategies for ICI-induced diabetes.

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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by: Abbott Diabetes Care

Prof. Samuel Seidu
Developed by: Adis

Case Studies

Necrotizing myopathy in a woman with type 1 diabetes

Open Access Diabetes-associated Diseases Case Study

Identifying the cause of muscle necrosis can be a diagnostic challenge, as shown by this case of diabetic myonecrosis complicated by pyomyositis and abscess caused by Escherichia coli.

Abnormal glycated hemoglobin level in a patient with diabetes

Open Access Type 2 Diabetes Case Study

HbA1c levels that don’t match the clinical picture need further investigation. Other factors, such as Hb variants, can interfere with the HbA1c measurement and make glycemic control difficult to achieve.

A challenging case of CAP

Open Access Community-Acquired Pneumonia Case Study

A woman presenting with community-acquired pneumonia developed several serious complications, likely due to co-existence of poorly controlled diabetes and a late diagnosis of thyroid cancer.

Episode 10: Disease-modifying therapy for type 1 diabetes

Reducing the burden of type 1 diabetes

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

Prof. Chantal Mathieu

Current Reviews

Pregnancy in various forms of monogenic diabetes: A systematic review

Monogenic diabetes (MD) represents a cluster of different types of diabetes produced by a mutation of a single gene. The commonest type of MD is maturity-onset diabetes of the young (MODY) which has several subtypes, and neonatal diabetes mellitus …

Ciliopathies are responsible for short stature and insulin resistance: A systematic review of this clinical association regarding SOFT syndrome

Open Access Insulins

SOFT syndrome (Short stature-Onychodysplasia-Facial dysmorphism-hypoTrichosis) is a rare primordial dwarfism syndrome caused by biallelic variants in POC1A encoding a centriolar protein. To refine the phenotypic spectrum of SOFT syndrome, recently …

Low fetal fraction and adverse pregnancy outcomes— systematic review of the literature and metanalysis

Cell-free fetal DNA(cffDNA) testing, which is based on the isolation of syncytiotrophoblastic apoptotic fragments as a result of the physiologic continuous turnover of the villous trophoblast of the placenta, has been available clinically in a …

Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives

A metabolic disorder is a condition that disrupts the body's normal metabolism, leading to changes in how it processes and distributes macronutrients like lipids, carbohydrates, and proteins. Metabolic disorders may occur as a result of typical …

Insulins Clinical Trial Summary

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

Developed by: Springer Medicine

CME & eLearning

Videos | Case Scenarios | Infographics (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Tweetorials | Vodcasts | Infographics (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)

Stay up to date with the rapidly changing CGM landscape. Learn how to implement and integrate CGM into diabetes management to improve patient care and outcomes.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Vodcasts | Case Scenarios (Link opens in a new window)

Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Further Reading

Potentials of bone marrow cells-derived from naïve or diabetic mice in autoimmune type 1 diabetes: immunomodulatory, anti-inflammatory, anti hyperglycemic, and antioxidative

Open Access Insulins Original Article

Type 1 diabetes mellitus (T1DM) is a medical disorder resulting from an autoimmune disease, wherein pancreatic β-cells are destroyed by autoreactive T cells targeting and attack, leading to insulitis and a total absence of insulin secretion [ 1 ].

Ciliopathies are responsible for short stature and insulin resistance: A systematic review of this clinical association regarding SOFT syndrome

Open Access Insulins

SOFT syndrome (Short stature-Onychodysplasia-Facial dysmorphism-hypoTrichosis) is a rare primordial dwarfism syndrome caused by biallelic variants in POC1A encoding a centriolar protein. To refine the phenotypic spectrum of SOFT syndrome, recently …

Enhanced Domain Adaptation for Foot Ulcer Segmentation Through Mixing Self-Trained Weak Labels

Open Access Diabetic Foot

Wound management requires the measurement of the wound parameters such as its shape and area. However, computerized analysis of the wound suffers the challenge of inexact segmentation of the wound images due to limited or inaccurate labels. It is …

Bone Fragility in High Fat Diet-induced Obesity is Partially Independent of Type 2 Diabetes in Mice

Open Access Type 2 Diabetes Original Research

Obesity and type 2 diabetes (T2D) are risk factors for fragility fractures. It is unknown whether this elevated risk is due to a diet favoring obesity or the diabetes that often occurs with obesity. Therefore, we hypothesized that the fracture …

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