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Advances in assessing myocardial microcirculation in diabetes

Imaging techniques are enhancing our understanding of the myocardial microcirculation and providing insights into the early stages of microvascular dysfunction in people with diabetes.

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Editor's Choice

Modest increase in NAION risk with semaglutide

Increased risk for nonarteritic anterior ischemic optic neuropathy associated with semaglutide treatment in people with type 2 diabetes is not as great as previously reported.

Novel berberine-based treatment for type 2 diabetes

Berberine ursodeoxycholate, a gut–liver anti-inflammatory metabolic modulator, significantly reduces HbA1c and improves hepatic and cardiometabolic parameters in people with type 2 diabetes.

Minimizing glycemic variability in type 1 diabetes

Recommendations proposed to reduce glycemic variability and improve glycemic management in people with type 1 diabetes, focusing on physical activity, dietary habits, insulin therapy, and other causes of increased variability.

Delayed diagnosis of monogenic diabetes

Complete heterozygous deletion of HNF1B was incidentally discovered in a woman who was enrolled in a clinical trial for type 1 diabetes and received immunosuppressive treatment for 4 years when she was a child.

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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by:
  • Abbott Diabetes Care
Prof. Samuel Seidu
Developed by: Adis
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Podcast

Case Studies

Delayed diagnosis of monogenic diabetes

Complete heterozygous deletion of HNF1B was incidentally discovered in a woman who was enrolled in a clinical trial for type 1 diabetes and received immunosuppressive treatment for 4 years when she was a child.

Semaglutide for comorbid obesity and cocaine use disorder

Semaglutide therapy achieved weight loss and reduced cocaine craving in a man with obesity and chronic cocaine abuse. Could this be a new strategy to address substance craving in patients with comorbid obesity?

Treatment of MODY with an SGLT2 inhibitor

Adding empagliflozin to sulfonylurea improved glycemic control in a woman with maturity-onset diabetes of the young. No adverse effects were noted, including no increase in ketonemia or ketonuria.

Episode 10: Disease-modifying therapy for type 1 diabetes

Reducing the burden of type 1 diabetes

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

Prof. Chantal Mathieu
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Podcast

Current Reviews

Effects of Lifestyle Interventions to Promote Physical Activity on Physical Activity and Glycated Hemoglobin in Patients with Type 2 Diabetes: a Systematic Review and Meta-Analysis

Unhealthy lifestyles have contributed to an increase of type 2 diabetes (T2D) cases worldwide, affecting more than 536.6 million people in 2021 [ 1 ]. Several risk factors are associated with T2D, including physical inactivity, obesity, and weight …

The interactions between melatonin and the renin–angiotensin system (RAS) in vascular attenuation in diabetic and non-diabetic conditions

Chronic diabetes mellitus (DM) is common globally. Many epidemiological research on DM prevalence have been done in recent decades [ 25 ]. Vascular complications are the most deadly DM symptoms [ 26 ]. Diabetes-related microvascular complications …

Clonal haematopoiesis of indeterminate potential: an emerging risk factor for type 2 diabetes and related complications

The accumulation of acquired somatic mutations is a natural consequence of ageing, but the pathophysiological implications of these mutations beyond cancer are only beginning to be understood. Most somatic mutations are functionally neutral, but a …

Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved

Obesity and type-2 diabetes mellitus (T2DM) are interrelated metabolic disorders primarily driven by overnutrition and physical inactivity, which oftentimes entails a transition from obesity to T2DM. Compromised musculoskeletal health consistently …

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

Developed by: Springer Medicine
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CME & eLearning

Videos | Case Scenarios | Infographics (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Tweetorials | Vodcasts | Infographics (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)

Stay up to date with the rapidly changing CGM landscape. Learn how to implement and integrate CGM into diabetes management to improve patient care and outcomes.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Vodcasts | Case Scenarios (Link opens in a new window)

Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Further Reading

Effects of Lifestyle Interventions to Promote Physical Activity on Physical Activity and Glycated Hemoglobin in Patients with Type 2 Diabetes: a Systematic Review and Meta-Analysis

Unhealthy lifestyles have contributed to an increase of type 2 diabetes (T2D) cases worldwide, affecting more than 536.6 million people in 2021 [ 1 ]. Several risk factors are associated with T2D, including physical inactivity, obesity, and weight …

Impact of changes in gestational diabetes mellitus diagnostic criteria during the COVID-19 pandemic

Gestational Diabetes Mellitus (GDM) may be defined as carbohydrate intolerance resulting in hyperglycaemia of variable severity with first onset or recognition during pregnancy [ 1 ]. The majority of GDM cases are due to impaired glucose tolerance …

A simple score-based strategy to improve equity of the UK biennial diabetic eye screening protocol among people deemed as low risk

Diabetic retinopathy is a common complication of diabetes that may result in sight loss [ 1 , 2 ]. Early treatment of sight-threatening diabetic retinopathy (STDR) can prevent or delay sight loss, and hence early diagnosis is key [ 3 ]. For this …

Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes

Manufactured melatonin is used globally to relieve sleep problems and jet lag, with its usage increasing the past decade even at doses above 5 mg/day [ 1 ]. Melatonin is a hormone constitutively secreted predominantly by the pineal gland, with …

Related topics

Advances in assessing myocardial microcirculation in diabetes

Imaging techniques are enhancing our understanding of the myocardial microcirculation and providing insights into the early stages of microvascular dysfunction in people with diabetes.

Read more

Advances in assessing myocardial microcirculation in diabetes

Imaging techniques are enhancing our understanding of the myocardial microcirculation and providing insights into the early stages of microvascular dysfunction in people with diabetes.

Read more

Minimizing glycemic variability in type 1 diabetes

Recommendations proposed to reduce glycemic variability and improve glycemic management in people with type 1 diabetes, focusing on physical activity, dietary habits, insulin therapy, and other causes of increased variability.

Read more