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Interleukin-17A and diabetic kidney disease

IL-17A is gaining recognition for its potential role in DKD and could represent a promising therapeutic target. Examine the latest research findings and potential mechanisms underlying the cytokine’s involvement in DKD.

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Editor's Choice

What role does ferroptosis play in DCM progression?

Emerging evidence highlights ferroptosis as a key player in the progression of diabetic cardiomyopathy. Discover the mechanistic links between ferroptosis and DCM, and the promising therapeutic strategies targeting them.

Implementing AI-driven clinical decision support systems in diabetes care

Explore the recommendations from the European Diabetes Forum working group, convened to examine good diabetes care in the context of AI-driven clinical decision support systems.

How to overcome DME treatment challenges

Gain patient and physician insights on managing diabetic macular edema, including current challenges with anti-VEGF injections, and emerging strategies to reduce treatment burden and improve outcomes.

The continuum of obesity-associated metabolic disorders

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  • Obesity
  • Review

Reframing obesity-related metabolic disorders as progressive stages within a continuous and dynamic process of metabolic dysfunction could facilitate more accurate risk assessment, earlier intervention, and coordinated care.

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Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
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Video

Case Studies

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Misdiagnosis of diabetic ketoacidosis

A woman with abdominal pain was diagnosed with ureteral stones, but her pain persisted despite stent placement. A prior diagnosis of type 2 diabetes led to diabetic ketoacidosis being identified as the cause of the pain. 

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
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Video

Current Reviews

Tailored Exercise Prescription for People with COPD and Clinically Relevant Comorbidities: A Consensus Statement of the EXPERT Working Group and Experts in Pulmonary Rehabilitation

Chronic obstructive pulmonary disease (COPD) is a heterogeneous chronic lung condition often accompanied by comorbidities and systemic manifestations that affect the person’s clinical condition and prognosis and often require specific treatment.

The Role of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in Improving Type 2 Diabetes Through Modulation of Gut Microbiota and Metabolites

With the rising incidence of type 2 diabetes mellitus (T2DM) worldwide, the search for effective treatments has become an important direction of contemporary medical research. Bariatric metabolic surgery, as a new therapeutic approach, has made …

Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome

Obesity is defined as a medical condition caused by an imbalance between energy intake and energy consumption in the body [ 1 ]. In 2016, the World Health Organization reported that over 1.9 billion adults were overweight, with more than 650 …

Neonatal and Syndromic Forms of Diabetes

In the last several years genome sequencing technology has become significantly less expensive and faster [ 1 ]. This has opened the door to broader access to genetic testing for patients for a multitude of likely genetic conditions including …

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Further Reading

Once-weekly administration of insulin in the real-world management of type 2 diabetes. A Delphi-like consensus

Diabetes is a major health issue with an increasing prevalence worldwide, posing challenges at different levels [ 1 ]. Diabetes imposes a burden on both the affected individuals and the health care systems [ 2 ], as it is associated with …

Neonatal and Syndromic Forms of Diabetes

In the last several years genome sequencing technology has become significantly less expensive and faster [ 1 ]. This has opened the door to broader access to genetic testing for patients for a multitude of likely genetic conditions including …

An exposure–safety analysis to support the dosage of the novel AKT inhibitor capivasertib

The phosphatidylinositol 3-kinase (PI3K)/Akt serine/threonine kinase (AKT) signaling pathway is an important signaling pathway regulating cell proliferation and survival [ 1 , 2 ]. Hyperactivation of the pathway due to PTEN deficiency or activating …

Doege-Potter syndrome in a patient with solitary fibrous tumor of the retroperitoneum: a case report and literature review

Doege-Potter syndrome in solitary fibrous tumor of the retroperitoneum is rare. Here, we present a 45 years old Chinese male patient who was admitted to our center after discovering an abdominal mass for 5 years and intermittent episodes of …

Related topics

What role does ferroptosis play in DCM progression?

Emerging evidence highlights ferroptosis as a key player in the progression of diabetic cardiomyopathy. Discover the mechanistic links between ferroptosis and DCM, and the promising therapeutic strategies targeting them.

Read more

Interleukin-17A and diabetic kidney disease

IL-17A is gaining recognition for its potential role in DKD and could represent a promising therapeutic target. Examine the latest research findings and potential mechanisms underlying the cytokine’s involvement in DKD.

Read more

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Read more
Image Credits
Chronic kidney disease model/© amazing studio / stock.adobe.com, Digital heart dissolving/© Eoneren / Getty Images / iStock, Medical team sitting around a table engaged in a discussion/© MP Studio / stock.adobe.com / Generated with AI, Glowing arrow breaking through wall/© peshkov / stock.adobe.com, Woman making a frame with her hands as she looks into the distance/© oatawa / Getty Images / iStock (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Human antibodies/© Svisio / Getty Images / iStock, Woman holding her baby/© Amorn Suriyan / iStock / Getty Images Plus (symbolic image with models), Downward arrows/© akinbostanci / Getty Images / iStock, Spotlight on obesity series 4x3 image/© smartboy10 / Getty Images / iStock, Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Woman with abdominal pain/© Srisakorn / iStock / Getty Images Plus (symbolic image with model), Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Person walking/© _KUBE_ / Stock.adobe.com, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Doctor and pregnant woman at hospital/© Syda Productions / stock.adobe.com (symbolic image with models), Marble run/© Juan L Zavala / iStock / Getty Images Plus, Man looking at sunset on the horizon/© BartekSzewczyk / Getty Images / iStock, Semaglutide plus nutrition therapy for obesity concept illustration/© JDawnInk / DigitalVision Vectors / Getty Images, Plaque builds up inside an artery/© bodym / iStock / Getty Images Plus, Fat cells 3D render/© Spectral-Design / Stock.adobe.com, Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model), Man lying on a sofa/© urbazon / E+ / Getty Images (symbolic image with model), 3D rendered risk index concept image/© Wong Yu Liang / Moment / Getty Images, Woman scheduling an appointment/© Andrey Popov / Stock.adobe.com (symbolic image with model), A large enhancing tumor in the pelvic cavity before and after embolization/© (M) 2025, Atefeh Jannatalipour et al, BMC Endocr Disord