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Tackling the psychological burden of diabetes

Explore the interplay between diabetes and mental health conditions, the consequences and implications for clinical practice, and the role of endocrinologists in recognizing and managing psychological difficulties.

Read more

Editor's Choice

Ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

  • Diabetes
  • Independent Medical Education

1.0 AMA PRA Category 1 Credit(s)

Discover current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them. Lower the barriers to effective prevention of diabetic ketoacidosis. 

Supported by:
  • Abbott

Type 1 diabetes, aging, and frailty: an underexplored intersection

The life expectancy of people with type 1 diabetes has improved, but type 1 diabetes may accelerate aging and contribute to the development of frailty. Explore the underlying mechanisms, frailty assessment, and prevention strategies.

Orforglipron may offer superior efficacy over oral semaglutide

The novel oral GLP-1 receptor agonist orforglipron shows noninferior and potentially superior glycemic control versus oral semaglutide in type 2 diabetes, but with more gastrointestinal adverse events.

Cardiorenal and metabolic dimensions of cardiomyopathies

Metabolic and renal dysfunctions can influence the disease trajectory, treatment response, and prognosis of cardiomyopathies. A holistic and multidisciplinary approach is key to identifying the appropriate therapies.

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Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?

Dr. Alice Cheng
Watch now

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
Watch now
Video

Case Studies

Neurological complications of rapid weight loss

A 37-year-old woman developed acute encephalopathy and treatment-induced neuropathy of diabetes after 3 months of semaglutide use. Benefits of GLP-1 agonists outweigh the risks, but clinicians should be alert to potential sequelae.

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

Impact of adjunctive melatonin in periodontal therapy on glycated hemoglobin levels in patients with type 2 diabetes and periodontal disease: a systematic review and meta-analysis

Background Melatonin has demonstrated anti-inflammatory, antioxidant, and immunomodulatory properties, making it a potential adjunct in periodontal therapy. However, its systemic metabolic effects, particularly on glycemic control in patients with …

RSSDI guidelines for management of type 2 diabetes mellitus in older adults

The Research Society for the Study of Diabetes in India (RSSDI) Guidelines for the Management of Diabetes in Older Adults provide evidence-based, India-specific recommendations addressing the growing challenge of type 2 diabetes mellitus (T2DM) in …

MicroRNAs in type 2 diabetes mellitus and its cardiovascular complications: mechanistic insights and translational potential

Diabetes mellitus (DM) is a multifactorial disease driven by genetic and environmental factors, with type 2 diabetes mellitus (T2DM) constituting the majority of cases. A major cause of morbidity and mortality in diabetic patients is …

Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis

Intermittent fasting (IF) aids the management of obesity and impaired glucose homeostasis, although the comparative efficacy of different modes of IF on glycemic control remains unclear. The current review therefore aimed to investigate the …

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Independent Medical Education Grant:
  • Abbott
Video

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Independent Medical Education Grant:
  • Abbott

Further Reading

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

  • Open Access
  • Insulins
  • Original Research

The gastrointestinal tract plays a crucial role in maintaining metabolic and glucose homeostasis. Beyond its role in digestion and absorption, it regulates systemic metabolism and glucose levels through modulation of gut hormone secretion and the …

Long-Term Outcomes of Pouch Resizing with Ring Augmentation for Dumping Syndrome and Weight Trajectory after Roux-en-Y Gastric Bypass: A Single-Center Experience

Metabolic bariatric surgery (MBS) is the most effective treatment option for achieving sustained weight loss in patients with obesity, while also improving obesity associated medical problems [ 1 , 2 ]. Among the various surgical options, Roux-en-Y …

Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY

Accurate interpretation of genetic variants in MODY genes is critical for diagnosis but remains a challenge in clinical practice. Variant classification remains challenging due to uncertainty regarding functional impact, the complexity of disease …

Different clinical autoimmune polyglandular syndrome phenotypes among patients with thyroid diseases

Autoimmune thyroid diseases (AITDs), primarily Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), represent the most prevalent organ-specific autoimmune disorders (ADs) in Western countries [ 1 – 3 ]. The prevalence of HT-related hypothyroidism …

Related topics

Tackling the psychological burden of diabetes

Explore the interplay between diabetes and mental health conditions, the consequences and implications for clinical practice, and the role of endocrinologists in recognizing and managing psychological difficulties.

Read more

Type 1 diabetes, aging, and frailty: an underexplored intersection

The life expectancy of people with type 1 diabetes has improved, but type 1 diabetes may accelerate aging and contribute to the development of frailty. Explore the underlying mechanisms, frailty assessment, and prevention strategies.

Read more
Image Credits
Mental health conditions concept illustration/© Dragon Claws / Stock.adobe.com, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Older man in wheelchair with an insulin pump/© Halfpoint / Stock.adobe.com (symbolic image with model), Man taking a pill/© golfcphoto / iStock / Getty Images Plus (symbolic image with model), Wooden heart and kidneys/© (M) Hiroshi Watanabe / Photodisc / Getty, Insulin injection needles / pens /© digicomphoto / iStock / Getty Images Plus, Close-up of yellow pills/© Ladanifer / iStock / Getty Images Plus, Proliferative diabetic retinopathy/© Kateryna Kon / Science Photo Library / Getty Images, Older man with chest pain sitting on a bench/© ashtproductions / stock.adobe.com (symbolic image with model), Woman prepares self-injection pen/© Jon Challicom / Getty Images (symbolic image with model), Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Biopsy findings indicating severe axonal neuropathy after rapid weight loss from GLP-1 agonist use/© 2025, Ali Zahir et al, BMC Neurol, Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Foods to support a healthy digestive system/© fcafotodigital / e+ / Getty Images, Lung and pancreas icons/© (M) PrettyVectors / Stock.adobe.com, Hands, one depicting acromegaly/© Magorzata / Stock.adobe.com (symbolic image with models), 3D render of stairs leading to flying paper plane/© bpawesome / iStock / Getty Images Plus, City lights on map of Europe/© nasa_gallery / stock.adobe.com, Close-up of teeth with periodontitis/© Vera Kuttelvaserova / stock.adobe.com (symbolic image with model), Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model), Diabetes kit/© ArtComma / iStock / Getty Images Plus, Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model)