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Prediabetes plus myocardial dysfunction increases HF risk in people with hypertension

Hypertension and prediabetes in combination with subclinical myocardial injury or stress associated with significantly elevated risk for heart failure.

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Editor's Choice

Hormone therapy may enhance benefits of tirzepatide in postmenopausal women

Using tirzepatide with systemic hormone therapy improves weight loss and cardiometabolic outcomes versus tirzepatide alone in postmenopausal women with overweight or obesity.

SGLT2 inhibitors outperform GLP-1 RAs for kidney protection in type 2 diabetes

SGLT2 inhibitors may offer greater protection against acute and chronic kidney outcomes than GLP-1 receptor agonists in people with type 2 diabetes.

Childhood type 1 diabetes screening feasible in the UK

Two-year findings from the Early Surveillance for Autoimmune Diabetes (ELSA) study demonstrate that screening for type 1 diabetes in children is feasible in the UK.

Pregnancy outcomes linked to adult-onset MS risk

Being born large for gestational age and being exposed to maternal diabetes increase the risk for adult-onset multiple sclerosis.

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Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

  • Live
  • Webinar | 16-02-2026 | 18:00 (CET)

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?

Watch it live: Monday 16 February 2026, 18:00-19:00 (CET)

Dr. Alice Cheng
Register now
Webinar

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
Watch now
Video

Case Studies

Neurological complications of rapid weight loss

A 37-year-old woman developed acute encephalopathy and treatment-induced neuropathy of diabetes after 3 months of semaglutide use. Benefits of GLP-1 agonists outweigh the risks, but clinicians should be alert to potential sequelae.

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

Comparing Cardiovascular Outcomes of GLP-1 Receptor Agonists Versus Metabolic Bariatric Surgery: A Systematic Review and Meta-Analysis

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, responsible for approximately 17.9 million deaths annually [ 1 ]. Among all the factors contributing to CVD, Obesity plays a dominant role by promoting CVD risk …

Lower extremity outcomes in diabetic foot osteomyelitis: A systematic review and meta-analysis

Diabetic foot ulcers (DFUs) result from a complex combination of neuropathy, peripheral arterial diseases, foot deformities, and infections [ 1 ]. Foot infections are more frequent among people with diabetes and potentially have debilitating …

Clinical presentation, biochemical profile, and imaging characteristics of patients with genetically confirmed maturity-onset diabetes of the young (MODY) type 5: Our experience and systematic review

Hepatocyte nuclear factor-1β ( HNF1B ), also known as transcription factor-2 ( TCF2 ), plays a pivotal role in the development of the pancreas, liver, kidneys, genito-urinary tract, and a few other organs as well [ 1 ]. Molecular alterations of …

The evolving concept from Cardiovascular-kidney-metabolic syndrome to metabolic associated liver-cardiovascular-kidney syndrome: insights from endocrinology

Metabolic diseases, cardiovascular diseases (CVD), and chronic kidney disease (CKD) often coexist. To understand the complex relationships between these conditions, the American Heart Association first proposed the concept of …

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Further Reading

Use of transoral outlet reduction endoscopy (TORE) in the management of resistant dumping syndrome

Luton and Dunstable Hospital (Bedfordshire Hospitals NHS Foundation Trust) is a high-volume tertiary referral bariatric unit in the UK providing obesity care services encompassing a population of 11 million. We maintain a database of all patients …

Circulating miR-326 and miR-532-3p: novel biomarkers for early gestational diabetes mellitus detection with high diagnostic accuracy

Gestational diabetes mellitus (GDM), characterized by impaired glucose tolerance first recognized during pregnancy, is one of the most prevalent metabolic disorders affecting pregnant women worldwide [ 1 ]. The International Diabetes Federation …

Glucose and Lactate Concentrations in Plasma, Cerebrospinal Fluid, and Brain Parenchyma Following Aneurysmal Subarachnoid Hemorrhage: A Cross-compartmental Correlation Study

In patients with aneurysmal subarachnoid hemorrhage (aSAH), a major contributor to poor functional outcomes is secondary brain injury, which has increasingly been a focus of research in recent years, leading to a more comprehensive understanding …

Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways

  • Open Access
  • Insulins
  • Original Research

Maternal and fetal genotypes both contribute to fetal growth [ 1 – 6 ]. Fetal insulin is a key regulator of fetal growth [ 7 , 8 ]. The fetal insulin hypothesis [ 9 , 10 ] proposed that fetal genes related to insulin deficiency and insulin …

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Image Credits
Older man with chest pain sitting on a bench/© ashtproductions / stock.adobe.com (symbolic image with model), Woman prepares self-injection pen/© Jon Challicom / Getty Images (symbolic image with model), Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, One red and several untreated wooden figures in front of a doctor holding a stethoscope/© Nadzeya Haroshka / iStock / Getty Images Plus, Pregnant woman holding her stomach/© Orientfootage / Getty Images / iStock (symbolic image with model), Insulin injection needles / pens /© digicomphoto / iStock / Getty Images Plus, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Biopsy findings indicating severe axonal neuropathy after rapid weight loss from GLP-1 agonist use/© 2025, Ali Zahir et al, BMC Neurol, Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Man receiving vaccination/© anon / stock.adobe.com (symbolic image with models), Combination padlock casting a shadow/© Javier Zayas Photography / Moment / Getty Images, 3D rendering of chylomicrons in the blood/© Love Employee / Getty Images / iStock, llustration of tirzepatide drug molecules and GLP-1 transmembrane receptors/© Juan Gaertner / Science Photo Library / Getty Images, Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model), Digital health concept image/© DSN_1 / stock.adobe.com, Arrow pointing in the opposite direction/© tolgart / Getty Images / iStock, 3D illustration of red blood cells and glucose in the vein/© iLexx / Getty images / iStock, Diabetes kit/© ArtComma / iStock / Getty Images Plus, Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model), Man lying on a sofa/© urbazon / E+ / Getty Images (symbolic image with model)