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Hypertension and prediabetes in combination with subclinical myocardial injury or stress associated with significantly elevated risk for heart failure.
Using tirzepatide with systemic hormone therapy improves weight loss and cardiometabolic outcomes versus tirzepatide alone in postmenopausal women with overweight or obesity.
Two-year findings from the Early Surveillance for Autoimmune Diabetes (ELSA) study demonstrate that screening for type 1 diabetes in children is feasible in the UK.
Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?
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Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.
A 37-year-old woman developed acute encephalopathy and treatment-induced neuropathy of diabetes after 3 months of semaglutide use. Benefits of GLP-1 agonists outweigh the risks, but clinicians should be alert to potential sequelae.
A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec.
What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?
In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.
Find out what caught their attention and why, and what they're looking forward to in 2026.
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, responsible for approximately 17.9 million deaths annually [ 1 ]. Among all the factors contributing to CVD, Obesity plays a dominant role by promoting CVD risk …
Diabetic foot ulcers (DFUs) result from a complex combination of neuropathy, peripheral arterial diseases, foot deformities, and infections [ 1 ]. Foot infections are more frequent among people with diabetes and potentially have debilitating …
Hepatocyte nuclear factor-1β ( HNF1B ), also known as transcription factor-2 ( TCF2 ), plays a pivotal role in the development of the pancreas, liver, kidneys, genito-urinary tract, and a few other organs as well [ 1 ]. Molecular alterations of …
Metabolic diseases, cardiovascular diseases (CVD), and chronic kidney disease (CKD) often coexist. To understand the complex relationships between these conditions, the American Heart Association first proposed the concept of …
In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.
Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.
Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.
Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.
Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.
Luton and Dunstable Hospital (Bedfordshire Hospitals NHS Foundation Trust) is a high-volume tertiary referral bariatric unit in the UK providing obesity care services encompassing a population of 11 million. We maintain a database of all patients …
Gestational diabetes mellitus (GDM), characterized by impaired glucose tolerance first recognized during pregnancy, is one of the most prevalent metabolic disorders affecting pregnant women worldwide [ 1 ]. The International Diabetes Federation …
In patients with aneurysmal subarachnoid hemorrhage (aSAH), a major contributor to poor functional outcomes is secondary brain injury, which has increasingly been a focus of research in recent years, leading to a more comprehensive understanding …
Maternal and fetal genotypes both contribute to fetal growth [ 1 – 6 ]. Fetal insulin is a key regulator of fetal growth [ 7 , 8 ]. The fetal insulin hypothesis [ 9 , 10 ] proposed that fetal genes related to insulin deficiency and insulin …
Using tirzepatide with systemic hormone therapy improves weight loss and cardiometabolic outcomes versus tirzepatide alone in postmenopausal women with overweight or obesity.
Metformin improves maternal glucose levels and lowers neonatal hypoglycemia risk versus standard care in women given antenatal betamethasone due to preterm delivery risk.