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New atherosclerosis treatments target inflammatory pathways

Inflammatory mechanisms play a crucial role in the development of atherosclerotic plaques. What new therapeutic targets do these pathways offer?

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Editor's Choice

Adding SGLT2 inhibitors to type 1 diabetes treatment

Should the use of SGLT2 inhibitors be extended to adults with type 1 diabetes? Learn about their potential and the practical aspects that need to be considered, including the risk of ketoacidosis.

Circulatory collapse due to autoimmune adrenal insufficiency

A rare case of new onset autoimmune adrenal insufficiency in a 7-year-old boy, presenting with severe cardiogenic shock requiring ECMO. Steroid replacement is critical.

Intense simplified strategy for early type 2 diabetes with severe hyperglycemia

People with newly diagnosed type 2 diabetes and severe hyperglycemia may benefit from an intense simplified strategy of short-term intensive insulin followed by metformin and linagliptin.

Remnant cholesterol and cardiovascular risk in diabetes

People with diabetes have a residual risk of cardiovascular disease even after treatment to lower LDL cholesterol levels. Is elevated remnant cholesterol to blame?

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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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Using CGM to optimize type 2 diabetes management with non-intensive insulin treatment in primary care

With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report. 

Supported by:
  • Abbott Diabetes Care
Prof. Samuel Seidu
Developed by: Adis
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Case Studies

Circulatory collapse due to autoimmune adrenal insufficiency

A rare case of new onset autoimmune adrenal insufficiency in a 7-year-old boy, presenting with severe cardiogenic shock requiring ECMO. Steroid replacement is critical.

Maternally inherited diabetes and deafness

Genetic testing was needed to diagnose the mitochondrial disorder MIDD in a woman with diabetes, weight loss, and poor glycemic control. Glycated hemoglobin and pancreatic function improved after treatment with a DPP-4 inhibitor.

Stevens-Johnson syndrome/toxic epidermal necrolysis complicated with fulminant type 1 diabetes

A rare case of fulminant type 1 diabetes induced by SJS/TEN, which had developed in a patient taking carbamazepine and phenytoin. Glucose monitoring should be considered for patients with SJS/TEN.

Episode 10: Disease-modifying therapy for type 1 diabetes

Reducing the burden of type 1 diabetes

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

Prof. Chantal Mathieu
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Current Reviews

The value of lncRNAs as a biomarker for the pregnancy outcomes of gestational diabetes: a meta-analysis

Gestational diabetes mellitus (GDM) is a glucose intolerance that begins in pregnancy or is detected during pregnancy. The incidence of GDM has been on the rise in recent years and has become a growing public health problem [ 1 – 3 ]. GDM puts …

GHRH and its analogues in central nervous system diseases

Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hormone (GH) in the anterior pituitary gland, which subsequently regulates the production of hepatic insulin-like growth …

Sodium-glucose cotransporter-2 inhibitors in acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials

We aimed to assess the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus placebo, initiated within the hospitalization period, in addition to habitual treatment, for treating adult patients with confirmed acute …

Current Perspectives in Pre- and Diabetic Peripheral Neuropathy Diagnosis and Management: An Expert Statement for the Gulf Region

Peripheral neuropathy (PN) significantly impacts the quality of life, causing substantial morbidity and increased mortality, as well as escalating healthcare costs. While PN can have various causes, the most common form, diabetic peripheral …

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

Developed by: Springer Medicine
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CME & eLearning

Videos | Case Scenarios | Infographics (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Tweetorials | Vodcasts | Infographics (Link opens in a new window)

1.5 AMA PRA Category 1 Credit(s)

Stay up to date with the rapidly changing CGM landscape. Learn how to implement and integrate CGM into diabetes management to improve patient care and outcomes.

Supported by:
  • Abbott
Developed by: Springer Healthcare IME

Vodcasts | Case Scenarios (Link opens in a new window)

Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Further Reading

Residual metabolic burden in young psoriasis patients successfully treated with biologics

Metabolic disorders are common in patients with psoriasis and contribute significantly to an increased cardiovascular risk. While biologic therapy is very successful in clearing skin lesions, its impact on metabolic parameters is uncertain. Our …

Effect of fenofibrate on residual beta cell function in adults and adolescents with newly diagnosed type 1 diabetes: a randomised clinical trial

Type 1 diabetes is an autoimmune disease where insulin-producing beta cells of the pancreas are destroyed by infiltrating immune cells, leading to insulin deficiency. More than 8 million individuals worldwide have type 1 diabetes, and the incident …

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium

Human molecular genetics has brought incredible insights into the variants that confer risk for the development of tissue-specific autoimmune diseases, including type 1 diabetes. The hallmark cell-mediated immune destruction that is characteristic …

Expert panel opinion on the optimal educational pathway for diabetes educators for training people with type 1 diabetes on the MiniMed™ 780G system: a Delphi consensus

The MiniMed™ 780G system is an advanced insulin pump system, designed for diabetes management. It incorporates an Advanced Hybrid Closed Loop (AHCL) algorithm that automatically adjusts insulin delivery based on glucose levels. One recent …

Related topics

Adding SGLT2 inhibitors to type 1 diabetes treatment

Should the use of SGLT2 inhibitors be extended to adults with type 1 diabetes? Learn about their potential and the practical aspects that need to be considered, including the risk of ketoacidosis.

Read more