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Time to rethink our approach to obesity-related HFpEF?

Obesity-related heart failure with preserved ejection fraction is increasingly recognized as a multiorgan cardio-renal-hepatic-metabolic syndrome but is not adequately addressed by conventional HF therapies. Is it time to rethink our approach?

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Editor's Choice

The expanding therapeutic pipeline for obesity

Incretin-based therapies have transformed obesity care, and new-generation therapies targeting multiple metabolic pathways aim to build on this success. What do we know so far about their mechanisms, efficacy, and safety?

Glucocorticoid-induced diabetes: what you need to know

Glucocorticoid-induced diabetes represents an important yet often overlooked complication of GC therapy. Review the current knowledge on the mechanisms, prevalence, and risk factors in patients with autoimmune rheumatic diseases.

Heart failure in people living with diabetes

The first of three podcast episodes on the identification and management of heart failure in people with diabetes, with practical guidance from a cardiovascular specialist, an endocrinologist, and a primary care physician.

GLP-1 RAs may be linked to ED in men with type 2 diabetes

Men with type 2 diabetes starting GLP-1 receptor agonists may have a modestly higher risk for erectile dysfunction risk than those given DPP4 inhibitors.


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GLP-1 medicines

Enhance your knowledge of the advances being made with GLP-1 medicines with our clinical collection. Discover the latest news stories and journal articles or take a deep dive into our clinical trial summary, podcast, and video series.

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Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
Watch now
Video

Case Studies

Glucocorticoid-induced diabetes: what you need to know

Glucocorticoid-induced diabetes represents an important yet often overlooked complication of GC therapy. Review the current knowledge on the mechanisms, prevalence, and risk factors in patients with autoimmune rheumatic diseases.

Sparing muscle reduction in type 2 diabetes with SBMA

Semaglutide use in a man with type 2 diabetes and spinal and bulbar muscular atrophy treated with leuprorelin. Over 2 years glycemic parameters improved and fat mass reduced, with only a minor annual decrease in muscle mass.

ICI-induced fulminant type 1 diabetes

A case of fulminant type 1 diabetes in a woman on tislelizumab for lung adenocarcinoma highlights the need for proactive monitoring of fasting glucose, HbA1c, and islet function in people given an immune checkpoint inhibitor.

Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. Learn how once-weekly insulin therapy be implemented to optimize patient care.

Dr. Alice Cheng
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Video

Current Reviews

Pharmacist-led interventions for optimizing type 2 diabetes mellitus management and medication safety in Southeast Asian countries: A systematic review and meta-analysis

Type 2 Diabetes Mellitus (T2DM) is an escalating public health issue in Southeast Asia, propelled by swift urbanization, inactive lifestyles, and changes in food habits. The International Diabetes Federation (IDF) indicated that in 2021, Southeast …

Microbiome modulating remedies for chronic diseases: a review of current interventions and future directions

The human microbiome has an enormous and multifaceted ecosystem of microorganisms like fungi, protozoa, bacteria, and viruses that live in our bodies, mainly in the gut, and is crucial in maintaining our health. The published evidence supports …

Imaging findings of diabetic complications from head to toe: a comprehensive radiologic review

Diabetes mellitus is a systemic metabolic disease that causes a wide spectrum of complications affecting multiple organs. Advances in imaging modalities have substantially improved the detection, characterization, and clinical management of these …

Glucagon-Like Peptide-1 Receptor Agonists: Their Therapeutic Potential in Cystic Fibrosis

Cystic fibrosis (CF) is a monogenic disorder leading to pulmonary disease, pancreatic insufficiency and cystic fibrosis-related diabetes (CFRD). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now being investigated in people with cystic …

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Independent Medical Education Grant:
  • Abbott
Video

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Independent Medical Education Grant:
  • Abbott

Further Reading

Reversion to normoglycemia with tirzepatide vs semaglutide in participants with obesity and prediabetes: a post hoc analysis of SURMOUNT-5

Obesity and overweight are the most common modifiable etiologic risk factors for type 2 diabetes (T2D). The global prevalence of obesity is expected to grow to 1.13 billion by 2030 [ 1 ]. Furthermore, the prevalence of prediabetes in adults is also …

Microvascular complications and risk of osteoporosis and fractures in type 2 diabetes: a nationwide Asian cohort study

Fracture risk in type 2 diabetes mellitus (T2DM) is increasingly recognized as a clinically important yet underappreciated complication. Despite patients with T2DM often presenting with normal or even elevated bone mineral density (BMD), numerous …

The Lived Experiences of Adult Continuous Glucose Monitor Users with Type 1 Diabetes with Recurrent Severe Hypoglycemic Events and Impaired Awareness of Hypoglycemia: A Qualitative Study

Current clinical management of type 1 diabetes (T1D) with insulin and continuous glucose monitors (CGMs) and/or automated insulin delivery systems (AID) is focused on maintaining glucose levels in a narrow range and hemoglobin A1c (HbA1c) ≤ 7% to …

The effect of aerobic exercise on bladder function and lower urinary tract symptoms in women who have diabetes mellitus with lower urinary tract symptoms: a randomized controlled

Lower urinary tract symptoms (LUTS) has been defined as a series of clinical symptoms indicating bladder storage and voiding dysfunction [ 1 ]. Diabetes Mellitus (DM) is a chronic disease characterized by disorders of carbohydrate, fat, and protein …

Related topics

Glucocorticoid-induced diabetes: what you need to know

Glucocorticoid-induced diabetes represents an important yet often overlooked complication of GC therapy. Review the current knowledge on the mechanisms, prevalence, and risk factors in patients with autoimmune rheumatic diseases.

Read more

Time to rethink our approach to obesity-related HFpEF?

Obesity-related heart failure with preserved ejection fraction is increasingly recognized as a multiorgan cardio-renal-hepatic-metabolic syndrome but is not adequately addressed by conventional HF therapies. Is it time to rethink our approach?

Read more

Heart failure in people living with diabetes

The first of three podcast episodes on the identification and management of heart failure in people with diabetes, with practical guidance from a cardiovascular specialist, an endocrinologist, and a primary care physician.

Read more

Fear of hypoglycemia in youth with type 1 diabetes and their caregivers

FOH is an unsurprising occurrence in youth with type 1 diabetes and their caregivers, and can be a barrier to optimal self-management. This review provides an update of the FOH literature published from 2016 to 2025 for this population.

Read more
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Man experiencing pain in his chest/© motortion / stock.adobe.com (symbolic image with model), Abstract colorful zigzag arrows/© Vertigo3d / E+ / Getty Images, Syringes, vials, tablets, and capsules on a table/© Sviatlana Barchan / Getty Images / iStock, Microphone and recording equipment/© StockPhotoPro/stock.adobe.com, Doctor offering patient support/© Halfpoint / stock.adobe.com (symbolic image with models), 3D render of GLP-1 molecules/© CIPhotos / iStock / Getty Images Plus, Vial and syringe needle/© Amornrat Phuchom / Getty Images / iStock, Woman receiving injection/© Antonio_Diaz / Getty Images / iStock (symbolic image with models), Alert symbol/© AlexSecret / Getty Images / iStock, Patient being prepared for eye surgery/© andresr / E+ / Getty (symbolic image with models), Heart model and ECG representation/© Nataliia_Trushchenko / Generated with AI / Stock.adobe.com, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Histological image of mammalian skeletal muscle/© sinhyu / Stock.adobe.com, Enhanced chest CT showing a solid lesion in the lower left lung/© 2026, Yuanzhen Feng et al, J Med Case Reports, Insulin injection needles / pens/© digicomphoto / iStock / Getty Images Plus, Medicine Matters Podcast promo image/© Springer Medizin GmbH, White pills in rows/© DIGICOMPHOTO/ Science Photo Library / Getty , Question mark filled with pills/© narvo vexar / iStock / Getty Images Plus, Person walking/© _KUBE_ / Stock.adobe.com, Ketogenic foods and red dumbbell/© Sasithorn Phuapankasemsuk / iStock / Getty Images Plus, EASD 2025: The benefits and challenges of continuous ketone monitoring – Ketan Dhatariya/© Springer Medicine, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Blood pressure measurement of elderly woman/© Lourdes Balduque / Moment / Getty (symbolic image with models), Bariatric surgery/© subway84 / Stock.adobe.com, Pediatrician speaking to an adolescent boy and his father/© bluecinema / Getty images / iStock (symbolic image with models), Woman completing online survey/© Scandistock / E+ / Getty Images (symbolic image with model), Mental health conditions concept illustration/© Dragon Claws / Stock.adobe.com, Older man in wheelchair with an insulin pump/© Halfpoint / Stock.adobe.com (symbolic image with model), Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model)