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Stopping weight management medication rapidly reverses treatment benefits

People using weight management medications return to their pretreatment bodyweight within 2 years of stopping treatment, with reversal of beneficial effects on cardiometabolic markers.

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Editor's Choice

Digital interventions and adherence in type 1 diabetes

Digital health interventions have gained prominence in the management of chronic diseases, but how do they impact clinical and patient-related outcomes and health behavior in people with type 1 diabetes?

Obesity, pre-eclampsia, and diabetes increase liver disease risk in pregnancy

Obesity, pregestational diabetes, and pre-eclampsia increase the risk for steatosis and increased liver stiffness in the third trimester of pregnancy.

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

CGM for the management and prevention of type 2 diabetes

Examine the evidence supporting the expanding role of CGM in type 2 diabetes, from active management of established disease to early identification of dysglycemia in individuals with prediabetes.

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Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

  • Live
  • Webinar | 16-02-2026 | 18:00 (CET)

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?

Watch it live: Monday 16 February 2026, 18:00-19:00 (CET)

Dr. Alice Cheng
Register now
Webinar

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
Watch now
Video

Case Studies

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

Hypertension in Diabetes: Numbers or Outcomes?

Hypertension is one of the most frequent and consequential comorbidities in people with diabetes, yet its management remains less straightforward than guideline tables might suggest. Epidemiological evidence confirms the high prevalence and the …

Integrative analysis of placental metabolic reprogramming and microbiome alterations in gestational diabetes mellitus (GDM)

Gestational diabetes mellitus (GDM) significantly impacts placental metabolism and microbial composition, leading to transformations at the maternal–fetal interface. In response to hyperglycemia, the placenta undergoes extensive metabolic …

Decoupling weight loss from organoprotective benefits in GLP-1RA, dual agonists, and SGLT2I therapy: A narrative review

Over the past decade, incretin-based therapies and SGLT2 inhibitors have redefined management of type 2 diabetes (T2D) and obesity. While their glucose-lowering and weight-reducing properties are well established, growing evidence highlights …

Community-Based Models for Type 2 Diabetes Care: A Review of Effectiveness, Implementation, and Health System Integration

Type 2 diabetes mellitus (T2DM) is a leading contributor to the global burden of noncommunicable diseases (NCDs), affecting over 537 million adults worldwide [ 1 ]. Its prevalence is disproportionately high and growing rapidly in low- and …

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Supported by:
  • Abbott
Developed by: Springer Health+ IME

Further Reading

Trends in Adverse Event Reports of Dipeptidyl Peptidase-4 Inhibitor-Associated Pemphigoid in Japan

Type 2 diabetes is a major global health concern. The International Diabetes Federation estimated that 589 million adults (ages 20–79 years) worldwide were living with diabetes, and of these, approximately 90% had type 2 diabetes [ 1 ]. In the USA …

Skeletal muscle expression of the genes associated with glycoprotein 130 signaling in relation to obesity and insulin sensitivity

Glycoprotein 130 (gp130) is a signal-transducing receptor widely expressed across tissues and serves as a key mediator for the interleukin-6 (IL-6) family of cytokines, including IL-6, IL-11, Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic …

Oral health and salivary inflammatory markers in children and adolescents with type 1 diabetes: A cross-sectional study

Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β-cells, leading to lifelong insulin dependence and persistent hyperglycaemia, which causes numerous micro and macrovascular …

Telangiectatic capillaries remodel over time in eyes with persistent diabetic macular edema

  • Open Access
  • Edema
  • Retinal Disorders

The global prevalence of diabetes mellitus (DM) continues to grow [ 1 ] and diabetic eye disease is increasingly becoming a public health concern as a major cause of visual impairment and blindness among the working-age population [ 2 ]. Diabetic …

Related topics

Digital interventions and adherence in type 1 diabetes

Digital health interventions have gained prominence in the management of chronic diseases, but how do they impact clinical and patient-related outcomes and health behavior in people with type 1 diabetes?

Read more

Improving medication adherence in type 2 diabetes

Medication non-adherence remains a significant challenge in the management of type 2 diabetes. How should it be assessed, what are the consequences, and what are the interventions designed to improve adherence?

Read more
Image Credits
Woman stepping on scales/© DragonImages / iStock / Getty Images Plus (symbolic image with model), Digital health concept image/© DSN_1 / stock.adobe.com, Woman at medical appointment/© Lacheev / iStock / Getty Images Plus, Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Woman checking CGM readings on a smartphone/© Javier Zayas Photography / Moment / Getty Images (symbolic image with model), Insulin injection needles / pens /© digicomphoto / iStock / Getty Images Plus, Arrow pointing in the opposite direction/© tolgart / Getty Images / iStock, Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Paradox image: walking in circles /© gremlin / getty, Being overlooked/overshadowed concept image/© Vlatko Gasparic / Moment / Getty Images, Diabetes kit/© ArtComma / iStock / Getty Images Plus, 3D illustration of red blood cells and glucose in the vein/© iLexx / Getty images / iStock, Chronic kidney disease model/© amazing studio / stock.adobe.com, Digital heart dissolving/© Eoneren / Getty Images / iStock, Glowing arrow breaking through wall/© peshkov / stock.adobe.com, Marble run/© Juan L Zavala / iStock / Getty Images Plus, Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model), Man lying on a sofa/© urbazon / E+ / Getty Images (symbolic image with model), 3D rendered risk index concept image/© Wong Yu Liang / Moment / Getty Images