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Periodontitis and diabetes

The bidirectional link between diabetes and periodontitis is well established, but periodontitis remains underdiagnosed in the context of diabetes. Coordinated care could improve inflammation, oral health, and metabolic outcomes.

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Editor's Choice

Tirzepatide may protect against diabetic retinopathy

Tirzepatide reduces the risk for, and progression of diabetic retinopathy compared with lifestyle intervention alone.

Prediabetes plus myocardial dysfunction increases HF risk in people with hypertension

Hypertension and prediabetes in combination with subclinical myocardial injury or stress associated with significantly elevated risk for heart failure.

Hormone therapy may enhance benefits of tirzepatide in postmenopausal women

Using tirzepatide with systemic hormone therapy improves weight loss and cardiometabolic outcomes versus tirzepatide alone in postmenopausal women with overweight or obesity.

SGLT2 inhibitors outperform GLP-1 RAs for kidney protection in type 2 diabetes

SGLT2 inhibitors may offer greater protection against acute and chronic kidney outcomes than GLP-1 receptor agonists in people with type 2 diabetes.

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Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

  • Live
  • Webinar | 16-02-2026 | 18:00 (CET)

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?

Watch it live: Monday 16 February 2026, 18:00-19:00 (CET)

Dr. Alice Cheng
Register now
Webinar

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
Watch now
Video

Case Studies

Neurological complications of rapid weight loss

A 37-year-old woman developed acute encephalopathy and treatment-induced neuropathy of diabetes after 3 months of semaglutide use. Benefits of GLP-1 agonists outweigh the risks, but clinicians should be alert to potential sequelae.

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Sudden onset of arm movements in a woman with diabetes

What could be causing involuntary and uncontrolled movements in the right arm and leg of a woman with a 25-year history of diabetes and hypertension, beginning shortly after an intramuscular betamethasone injection for shoulder pain?

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

The emerging role of pancreatic exocrine fibrosis as a common aetiological driver of islet dysfunction and diabetes: opportunities for novel disease-modifying interventions

Three diseases primarily affecting the exocrine pancreas—chronic pancreatitis, cystic fibrosis and pancreatic ductal adenocarcinoma—are all associated with a high incidence of diabetes. Together, they may account for more cases of diabetes than …

Comparative efficacy of social support on glycemic control for type 2 diabetes in low- and middle-income countries or among minoritized groups in high-income countries: a systematic review and network meta-analysis

A systematic review and network meta-analysis was implemented to compare social support interventions for glycemic control in people with type 2 diabetes from low- and middle-income countries (LMICs) and those from racial and ethnic minoritized …

The Burden of Delayed Diabetic Retinopathy Management and Use of Artificial Intelligence-Driven Screening Tools: A Systematic Literature Review

Diabetic retinopathy (DR) is a microangiopathic disease, resulting from the chronic effects of diabetes mellitus (DM). A total of 103 million adults worldwide are estimated to be affected by DR, which is expected to rise to 161 million individuals …

Comparing Cardiovascular Outcomes of GLP-1 Receptor Agonists Versus Metabolic Bariatric Surgery: A Systematic Review and Meta-Analysis

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, responsible for approximately 17.9 million deaths annually [ 1 ]. Among all the factors contributing to CVD, Obesity plays a dominant role by promoting CVD risk …

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
Listen now
Podcast

CME and eLearning

Integrating ketone and glucose monitoring for optimized diabetes management (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Familiarize yourself with current and emerging ketone monitoring systems and the most useful clinical scenarios in which to use them through our podcasts and e-learning modules. Lower the barriers to effective prevention of diabetic ketoacidosis.

Independent Medical Education Grant:
  • Abbott
Video

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Independent Medical Education Grant:
  • Abbott

Further Reading

Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker

Endometrial cancer (EC) is the most common gynecological tumor, ranking fourth in incidence and fifth in mortality among the female population in the United States [ 1 ]. In 2022, 77,700 new EC cases was reported in China, which made up more than …

Association of corneal nerve parameters with nerve abnormalities and neuropathic pain in prediabetes and type 2 diabetes: the Maastricht Study

Polyneuropathy affects up to 50% of people with diabetes, leading to increased morbidity and reduced quality of life [ 1 – 6 ]. To reduce the increased morbidity, early diagnosis is necessary to enable early therapeutic interventions [ 7 ]. Here …

Feasibility and performance of minimal-volume capillary blood screening for type 1 diabetes and coeliac disease autoantibodies across all age groups: the UNISCREEN population study

Type 1 diabetes and coeliac disease are autoimmune conditions with specific autoantibodies detectable years before clinical onset. Though historically viewed as paediatric disorders, both affect individuals across all age groups, with variable …

A metagenomic study of the gut microbiome in patients with type 2 diabetes mellitus and myocardial infarction

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death among patients with DM, who frequently present with extensive multivessel coronary artery disease and poor long-term outcomes. Although treatment strategies for MI …

Related topics

Periodontitis and diabetes

The bidirectional link between diabetes and periodontitis is well established, but periodontitis remains underdiagnosed in the context of diabetes. Coordinated care could improve inflammation, oral health, and metabolic outcomes.

Read more

Periodontitis and diabetes

The bidirectional link between diabetes and periodontitis is well established, but periodontitis remains underdiagnosed in the context of diabetes. Coordinated care could improve inflammation, oral health, and metabolic outcomes.

Read more
Image Credits
Close-up of teeth with periodontitis/© Vera Kuttelvaserova / stock.adobe.com (symbolic image with model), Proliferative diabetic retinopathy/© Kateryna Kon / Science Photo Library / Getty Images, Older man with chest pain sitting on a bench/© ashtproductions / stock.adobe.com (symbolic image with model), Woman prepares self-injection pen/© Jon Challicom / Getty Images (symbolic image with model), Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, Insulin injection needles / pens /© digicomphoto / iStock / Getty Images Plus, One red and several untreated wooden figures in front of a doctor holding a stethoscope/© Nadzeya Haroshka / iStock / Getty Images Plus, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Biopsy findings indicating severe axonal neuropathy after rapid weight loss from GLP-1 agonist use/© 2025, Ali Zahir et al, BMC Neurol, Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Hyperdense lesion in the left putamen/© 2025, Fondazione Società Italiana di Neurologia, Neurol Sci, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Integrating Ketone and Glucose Monitoring for Optimized Diabetes Management/© Springer Healthcare IME, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, Man receiving vaccination/© anon / stock.adobe.com (symbolic image with models), Combination padlock casting a shadow/© Javier Zayas Photography / Moment / Getty Images, llustration of tirzepatide drug molecules and GLP-1 transmembrane receptors/© Juan Gaertner / Science Photo Library / Getty Images, Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model), Diabetes kit/© ArtComma / iStock / Getty Images Plus, Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model), Man lying on a sofa/© urbazon / E+ / Getty Images (symbolic image with model)