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Open Access 31-08-2024 | Diabetic Retinopathy | Review Paper

Senescent endothelial cells: a potential target for diabetic retinopathy

Authors: Ying-Lu Liao, Yi-Fan Fang, Jia-Xing Sun, Guo-Rui Dou

Abstract

Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Current therapeutic strategies on DR primarily focus on antiangiogenic therapies, which particularly target vascular endothelial growth factor and its related signaling transduction. However, these therapies still have limitations due to the intricate pathogenesis of DR. Emerging studies have shown that premature senescence of endothelial cells (ECs) in a hyperglycemic environment is involved in the disease process of DR and plays multiple roles at different stages. Moreover, these surprising discoveries have driven the development of senotherapeutics and strategies targeting senescent endothelial cells (SECs), which present challenging but promising prospects in DR treatment. In this review, we focus on the inducers and mechanisms of EC senescence in the pathogenesis of DR and summarize the current research advances in the development of senotherapeutics and strategies that target SECs for DR treatment. Herein, we highlight the role played by key factors at different stages of EC senescence, which will be critical for facilitating the development of future innovative treatment strategies that target the different stages of senescence in DR.

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Title: Senescent endothelial cells: a potential target for diabetic retinopathy
Authors: Ying-Lu Liao
Yi-Fan Fang
Jia-Xing Sun
Guo-Rui Dou
Publication date: 31-08-2024
Publisher: Springer Netherlands
Keywords: Diabetic Retinopathy
Diabetic Retinopathy
Published in: Angiogenesis
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-024-09943-7

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