Comparison of GFR estimation in patients with diabetes mellitus using the EKFC and CKD-EPI equations
- Open Access
- 10-01-2025
- Diabetes
- Original Article
Published in:
- Authors
- Felix Eisinger
- Mareike Neumann
- Matthias Wörn
- Andreas Fritsche
- Nils Heyne
- Andreas Peter
- Andreas L. Birkenfeld
- Reiner Jumpertz von Schwartzenberg
- Ferruh Artunc
- Published in
- Journal of Nephrology | Issue 2/2025
Abstract
Background
The estimation of glomerular filtration rate (eGFR) is essential in the early detection of diabetic nephropathy. We herein compare the performance of common eGFR formulas against a gold standard measurement of GFR in patients with diabetes mellitus.
Methods
GFR was measured in 93 patients with diabetes mellitus using iohexol clearance as the reference standard. The performance of the creatinine- and cystatin C-based EKFC formulas (2021, 2023) and the CKD-EPI formulas (2009, 2012) was compared against measured GFR.
Results
Sixty patients with type 2 diabetes mellitus and 33 patients with type 1 diabetes mellitus were included. The creatinine-based EKFC formula showed lower bias and higher accuracy than the CKD-EPI formula. No significant difference was observed between the cystatin C-based formulas. The combined creatinine- and cystatin C-based formulas had the highest accuracy and lowest bias. Body fat or diabetes type did not significantly influence the accuracy of the cystatin C-based formulas.
Conclusions
Our study demonstrated a slight advantage of the creatinine-based EKFC formula over the CKD-EPI formula in patients with diabetes. However, both for the CKD-EPI and the EKFC formula, the best performance was achieved by the combined creatinine- and cystatin C-based formulas.
Graphical abstract
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- Title
- Comparison of GFR estimation in patients with diabetes mellitus using the EKFC and CKD-EPI equations
- Authors
-
Felix Eisinger
Mareike Neumann
Matthias Wörn
Andreas Fritsche
Nils Heyne
Andreas Peter
Andreas L. Birkenfeld
Reiner Jumpertz von Schwartzenberg
Ferruh Artunc
- Publication date
- 10-01-2025
- Publisher
- Springer International Publishing
- Keywords
-
Diabetes
Chronic Kidney Disease - Published in
-
Journal of Nephrology / Issue 2/2025
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059 - DOI
- https://doi.org/10.1007/s40620-024-02202-4
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