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Diabetology Diabetes Therapy

Diabetes Therapy

Orforglipron may offer superior efficacy over oral semaglutide

The novel oral GLP-1 receptor agonist orforglipron shows noninferior and potentially superior glycemic control versus oral semaglutide in type 2 diabetes, but with more gastrointestinal adverse events.

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Editor's Choice

Cardiorenal and metabolic dimensions of cardiomyopathies

Metabolic and renal dysfunctions can influence the disease trajectory, treatment response, and prognosis of cardiomyopathies. A holistic and multidisciplinary approach is key to identifying the appropriate therapies.

SGLT2 inhibitors improve outcomes over DPP4 inhibitors in type 2 diabetes with liver cirrhosis

SGLT2 inhibitors are linked to lower kidney, cardiovascular, and hepatic risks than DPP-4 inhibitors in patients with type 2 diabetes and liver cirrhosis.

CF-related diabetes in the era of highly effective modulator therapy

People with cystic fibrosis are living longer lives with improved pulmonary outcomes but nonpulmonary complications, such as CFRD, are emerging as the next frontier in the journey towards optimizing health.

Gender differences in acromegaly

A gender-medicine driven management approach should be considered for acromegaly. Women tend to have a longer diagnostic delay than men and a worse glycometabolic profile, but milder cardiac abnormalities despite higher CV mortality.

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Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
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Video

Case Studies

Neurological complications of rapid weight loss

A 37-year-old woman developed acute encephalopathy and treatment-induced neuropathy of diabetes after 3 months of semaglutide use. Benefits of GLP-1 agonists outweigh the risks, but clinicians should be alert to potential sequelae.

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
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Video

Current Reviews

RSSDI guidelines for management of type 2 diabetes mellitus in older adults

The Research Society for the Study of Diabetes in India (RSSDI) Guidelines for the Management of Diabetes in Older Adults provide evidence-based, India-specific recommendations addressing the growing challenge of type 2 diabetes mellitus (T2DM) in …

MicroRNAs in type 2 diabetes mellitus and its cardiovascular complications: mechanistic insights and translational potential

Diabetes mellitus (DM) is a multifactorial disease driven by genetic and environmental factors, with type 2 diabetes mellitus (T2DM) constituting the majority of cases. A major cause of morbidity and mortality in diabetic patients is …

Efficacy of different types of intermittent fasting in improving glycemic control in adults with overweight or obesity: a systematic review and network meta-analysis

Intermittent fasting (IF) aids the management of obesity and impaired glucose homeostasis, although the comparative efficacy of different modes of IF on glycemic control remains unclear. The current review therefore aimed to investigate the …

Atypical diabetes subtypes in Black African populations

Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical diabetes …

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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CME & eLearning

Video

Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Independent Medical Education Grant:
  • Abbott

Further Reading

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

  • Open Access
  • Insulins
  • Original Research

The gastrointestinal tract plays a crucial role in maintaining metabolic and glucose homeostasis. Beyond its role in digestion and absorption, it regulates systemic metabolism and glucose levels through modulation of gut hormone secretion and the …

Blood pressure and blood lipids reduction, but not glycemic changes, predict cognitive improvements after exercise training in people with type 2 diabetes: an exploratory analysis in a clinical trial

Type 2 Diabetes Mellitus (T2DM) accelerates cognitive decline rates [ 1 ], diminishes several cognitive domains [ 2 ], and increases dementia incidence [ 1 ], with declines in brain health affecting the patient's quality of life, disease …

Efficacy and Safety of Once-Weekly IcoSema Versus Once-Daily IDegLira in People with Type 2 Diabetes: Systematic Literature Review and Network Meta-analysis

  • Open Access
  • Insulins
  • Original Research

Many people with type 2 diabetes (T2D) on insulin therapy require treatment intensification or early combination approaches, as recognised by current treatment guidelines, including the 2022 American Diabetes Association (ADA)/European Association …

Image Credits
Man taking a pill/© golfcphoto / iStock / Getty Images Plus (symbolic image with model), Wooden heart and kidneys/© (M) Hiroshi Watanabe / Photodisc / Getty, Close-up of yellow pills/© Ladanifer / iStock / Getty Images Plus, Lung and pancreas icons/© (M) PrettyVectors / Stock.adobe.com, Hands, one depicting acromegaly/© Magorzata / Stock.adobe.com (symbolic image with models), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Proliferative diabetic retinopathy/© Kateryna Kon / Science Photo Library / Getty Images, Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model), Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Biopsy findings indicating severe axonal neuropathy after rapid weight loss from GLP-1 agonist use/© 2025, Ali Zahir et al, BMC Neurol, Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Spotlight on obesity series 4x3 image/© smartboy10 / Getty Images / iStock, Person walking/© _KUBE_ / Stock.adobe.com, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME