Combination therapy with a GLP-1 receptor agonist plus thiazolidinedione significantly reduces the risk for major adverse CV events and death versus nonuse in people with type 2 diabetes.
Although it seems to be a rare complication, there should be a high index of suspicion for colonic ischemia in patients taking a GLP-1 receptor agonist who present with abdominal pain.
A thorough overview of the safety and efficacy of once-weekly basal insulin icodec in type 1 and 2 diabetes, covering pharmacology, pharmacokinetics, adverse effects, drug interactions, and dose recommendations.
Semaglutide increases walking capacity and improves symptoms and quality of life versus placebo in people with type 2 diabetes and peripheral artery disease.
Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.
With the growing importance of primary care in diabetes, this podcast discusses the evidence on continuous glucose monitoring (CGM) use, the role of primary healthcare, and practical tips for interpreting the ambulatory glucose profile (AGP) report.
Although it seems to be a rare complication, there should be a high index of suspicion for colonic ischemia in patients taking a GLP-1 receptor agonist who present with abdominal pain.
Complete heterozygous deletion of HNF1B was incidentally discovered in a woman who was enrolled in a clinical trial for type 1 diabetes and received immunosuppressive treatment for 4 years when she was a child.
Semaglutide therapy achieved weight loss and reduced cocaine craving in a man with obesity and chronic cocaine abuse. Could this be a new strategy to address substance craving in patients with comorbid obesity?
Type 1 diabetes (T1D) remains one of the most prevalent chronic illnesses diagnosed in childhood, and is an immune-mediated disease directed against pancreatic β-cells, resulting in severe endogenous insulin deficiency and subsequent hyperglycemia …
Fecal microbiota transplantation (FMT) has emerged as a potential therapeutic strategy for modulating gut dysbiosis in diabetes mellitus. This review critically evaluates preclinical and clinical evidence on FMT in type 1 (T1D) and type 2 diabetes …
Diabetes mellitus is a metabolic disorder, characterized by elevated blood sugar levels (hyperglycemia) and insulin dysregulation. This disease is associated with morbidity and mortality, including significant potential vascular complications.
Around 4.5 million people in the UK are currently living with diabetes, with half of these over 65 years old [ 1 , 2 ]. Despite posing a significant disease burden for older adults, this group is unfortunately frequently excluded from larger …
Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.
Prof. Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.
Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills.
Expert guidance on the multidisciplinary approach to identifying and managing chronic kidney disease in patients with type 2 diabetes, plus patient scenarios to assist your decision-making and put the latest clinical guidelines into context.
This program is not available to users in the UK and US.
The pancreatic islets regulate blood glucose levels, and defects in their development or function are associated with diabetes. While animal studies provide insights into islet development and diabetes, significant differences in islet structure …
Gestational diabetes mellitus (GDM) represents a significant health challenge, with prevalence rates ranging from 3 to 25%, depending on ethnic composition, diagnostic criteria employed, and underlying population characteristics [ 1 , 2 ]. This …
Diabetes mellitus is a metabolic disorder, characterized by elevated blood sugar levels (hyperglycemia) and insulin dysregulation. This disease is associated with morbidity and mortality, including significant potential vascular complications.
Contrary to historical teaching, it is now well established that people living with type 1 diabetes are not spared from suffering from overweight or obesity [ 1 ]. There is a worrying increase in the reported prevalence of overweight and obesity …
