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Diabetology Diabetes Therapy

Diabetes Therapy

Editor's Choice

TRAVERSing the findings on TRT use in diabetes prevention

21-02-2024 Hypogonadism News

Testosterone replacement therapy does not prevent progression from prediabetes to diabetes in men with hypogonadism, shows TRAVERSE Diabetes study.

Home insulin pump use feasible for hospitalized children with T1D

Children with type 1 diabetes who are admitted to hospital can continue to receive their insulin via a home-based system while being treated as inpatients.

Resmetirom shows promise for NASH and liver fibrosis

16-02-2024 Fatty Liver News

Daily resmetirom achieved significantly greater histologic improvement of both nonalcoholic steatohepatitis and liver fibrosis than placebo in the MAESTRO-NASH phase 3 trial.

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Current Reviews

Advances in basic research on glucagon and alpha cells

The regulation of plasma amino acid levels by glucagon in humans first attracted the attention of researchers in the 1980s. Recent basic research using animal models of glucagon deficiency suggested that a major physiological role of glucagon is …

Tirzepatide: A Review in Type 2 Diabetes

Tirzepatide Adis Drug Evaluation

Tirzepatide (Mounjaro®), a first-in-class dual incretin agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, is approved for use as an adjunct to diet and exercise to improve glycaemic …

Preoperative Considerations for Ambulatory Surgery: What Is New, What Is Controversial

Pulmonary Hypertension Ambulatory Anesthesia (G Joshi, Section Editor)

Ambulatory anesthesia continues to expand rapidly. Healthcare analysts project that 85% of all procedures will be performed in ambulatory settings by 2028 [ 1 , 2 ]. An increasing number of patients with major comorbidities and advanced age are …

Mapping Lifestyle Interventions for Gestational Diabetes Prevention: A Scoping Review

The incidence of gestational diabetes mellitus (GDM) has significantly increased in the USA over the last decade [ 1 •]. GDM is the most prevalent complication during pregnancy and is associated with a 60% lifetime risk of maternal type 2 diabetes …

Case Studies

Late onset of immune checkpoint inhibitor-induced type 1 diabetes

Open Access Type 1 Diabetes Case Study

A patient with small-cell lung cancer developed type 1 diabetes many weeks after receiving serplulimab, highlighting the need for continued monitoring of blood glucose levels and early signs and symptoms of diabetes.

Type 1 diabetes and chronic kidney disease – monitoring glucose levels during pregnancy

This case indicates that capillary blood glucose monitoring should be used alongside intermittently scanned CGM when pregnancy is complicated by type 1 diabetes and CKD.

Advanced hybrid closed-loop use with diluted insulin in children less than 2 years old

This case series reports the use of advanced hybrid closed-loop technology with diluted insulin in four very young children with a low total daily dose of insulin, including a premature neonate with transient neonatal diabetes.

Digital Treatment Map (Link opens in a new window)

Practical, expert-led digital map designed to guide treatment of type 2 diabetes with GLP‑1RAs.

This program is not available to users in the UK and US.

Supported by:
  • Novo Nordisk A/S
Developed by: Springer Healthcare IME

Webcast | Videos (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Discussion-based webcast addressing the causes of clinical inertia in type 2 diabetes.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

Further Reading

Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study

Open Access Hypoglycemia Original Article

Despite a century of development and refinement of insulin therapy, hypoglycaemia remains the most common complication, affecting virtually all people with type 1 diabetes and most of those with insulin-treated type 2 diabetes [ 1 ]. Thus, people …

An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study

Open Access Insulins Original Research

People with type 2 diabetes are heterogeneous in their disease trajectory. While some progress quickly to insulin, others show good glycaemic control for decades using only oral glucose-lowering drugs. Ideally, one would identify those at risk of …

Effectiveness of oral semaglutide on glucose control and body weight up to 18 months: a multicenter retrospective real-world study

Open Access Semaglutide Original Article

Oral semaglutide stands out as the pioneering orally administered peptide hormone-based treatment for type 2 diabetes (T2D). It harnesses advanced pharmaceutical techniques to ensure efficient absorption and efficacy when taken orally [ 1 ]. Unlike …

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life

Open Access Glibenclamide Original Research

The central role of the ATP-sensitive potassium (K ATP ) channel in glucose-stimulated insulin secretion from pancreatic beta cells is well understood [ 1 ]. Glucose uptake and metabolism leads to an increase in the ATP/ADP concentration that …