Skip to main content
Key Specialties
Anesthesiology Cardiology Dermatology Diabetology Endocrinology Gastroenterology General Medicine Geriatrics Hematology Infectious Diseases Internal Medicine Nephrology Neurology Obstetrics and Gynecology Oncology Pediatrics Psychiatry Radiology Respiratory Medicine Rheumatology Surgery Urology
Congress Coverage
2024 ESMO Congress 2024 ERS Congress 2024 EASD Congress 2024 ESC Congress 2024 EAN Congress 2024 ASCO Annual Meeting 2024 ACC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote series | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the systemic effects of menopause, so you can help patients in your clinics through the transition.

Launching: Thursday 12th December 2024
ADVANCED SEARCH
Log in
Top

Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study

or
Journals by subject

Unlock free access to practice-relevant journal articles

Join our community of medical professionals and register now to access a handpicked selection of journal articles from Springer's Medical portfolio. 

Register today!

Editor's Choice | Journals

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Most read journal articles

Romosozumab for the treatment of osteoporosis

An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain

  • Osteoarthrosis
  • Alternative Treatments for Pain Medicine (C Robinson, Section Editor)

Deprescribing strategies in older patients with heart failure

Real-Life Data of Secukinumab in Patients with Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis, and Ankylosing Spondylitis: Patient Baseline Characteristics Data from the PROMPT Study

Nationwide database study of postoperative sequelae and in-hospital mortality in super-elderly hip fracture patients

Four cases of ICI-related fulminant myocarditis

Latest Journal Issues

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Looking for something specific?

Find articles from over 500 clinical journals from Springer with the search function.

Latest issues in Internal Medicine

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Cardiology

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Diabetes & Endocrinology

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Neurology

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Oncology

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Pediatrics

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

Latest issues in Respiratory Medicine

scroll for more

use your arrow keys for more

scroll or use arrow keys for more

About journals on Springer Medicine

The range of medical journals on Springer Medicine is extremely diverse. It includes the current editions and archives of around 500 English-language journals from almost all medical disciplines published by Springer. 

The specialist literature is usually available both online in full text and as a PDF for download. The online view is optimized in such a way that the specialist texts can be read comfortably on all screen sizes, from desktops to tablets to smartphones. We also include features to support your use of the journals for your research, such as bookmark setting.

Whether you’re interested in internal medicine, surgery, general medicine, gynecology, orthopedics, neurology, or pediatrics, there are excellent journals in almost every subject area, such as the BMC Series, Diabetologia, Breast Cancer Research, Current Obesity Reports, CNS Drugs and many others, all of which are an integral part of the everyday life of doctors across Europe. 

The breadth of content from this suite of journals allows the Springer Medicine team to collect and deliver broad-ranging content across the full spectrum of medical knowledge, with a special focus on topics highlighted by these leading journals and their editorial boards and specialist authors. This guarantees a high quality of content and ensures that our readers are offered the most relevant topics in their respective specialist area. 

Our experienced clinical content managers constantly monitor the needs of medical professionals to provide up-to-date reports from international congresses, expert interviews, and a range of digestible content on emerging topics in the field of medicine.
BMC Cancer
Published in:

Open Access 01-12-2024 | Research

Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study

Authors: Shohei Iyoshi, Mariko Kimura, Masato Yoshihara, Atsushi Kunishima, Emiri Miyamoto, Hiroki Fujimoto, Kazuhisa Kitami, Kazumasa Mogi, Kaname Uno, Sho Tano, Nobuhisa Yoshikawa, Ryo Emoto, Shigeyuki Matsui, Hiroaki Kajiyama

Published in: BMC Cancer | Issue 1/2024

Login to get access

Abstract

Background

The accumulation of ascites is a major symptom of ovarian cancer. The volume of ascites is a pathophysiological indicator of the peritoneal environment, such as inflammation and fibrosis; however, the relationship between the volume of ascites and oncological outcomes remains unclear. We herein retrospectively examined the effects of the volume of ascites on the prognosis of epithelial ovarian cancer in a multi-institutional large cohort using the stratification of clinical characteristics and statistical adjustment methods.

Methods

Of 5,268 patients with ovarian tumors in the Tokai Ovarian Tumor Study Group between 1986 and 2020, we included 1,966 cases of epithelial ovarian cancer and examined the relationship between the volume of ascites at the initial surgery and the prognosis of patients. We performed a multivariate analysis and propensity score weighting for covariate adjustments to precisely estimate the prognostic impact of ascites accumulation. A subgroup analysis was also performed to examine differences in the prognostic implications of ascites accumulation among histotypes.

Results

A reservoir of 100 mL of ascites was confirmed as the cut-off value in our cohort. A Kaplan-Meyer analysis with propensity score adjustments indicated that the accumulation of more than 100 mL of ascites shortened overall survival. The multivariate analysis revealed that the increased accumulation of 100 mL of ascites was an independent prognostic factor for overall survival (HR 1.242; 95% CI 1.050–1.470; P = 0.012). The subgroup analysis showed the prognostic significance of ascites accumulation in mucinous and endometrioid histologies.

Conclusions

The accumulation of even a low to intermediate volume of ascites (≥ 100 mL) was confirmed to be an independent poor prognostic factor in epithelial ovarian cancer. Furthermore, its prognostic impact differed among histotypes.
Appendix
Available only for authorised users
Literature
1.
2.
3.
Lengyel E. Ovarian Cancer Development and Metastasis. Am J Pathol. 2010;09:177:1053–64.CrossRef
4.
Motohara T, Masuda K, Morotti M, Zheng Y, El-Sahhar S, Chong KY, et al. An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment. Oncogene 4/. 2019;38:2885–98.CrossRef
5.
Uno K, Iyoshi S, Yoshihara M, Kitami K, Mogi K, Fujimoto H et al. Metastatic voyage of Ovarian Cancer cells in Ascites with the assistance of various Cellular Components. Int J Mol Sci. 2022;23.
6.
van Baal JOAM, Van de Vijver KK, Nieuwland R, van Noorden CJF, van Driel WJ, Sturk A, et al. The histophysiology and pathophysiology of the peritoneum. Tissue Cell. 2017;49:95–105.CrossRefPubMed
7.
Aziz MAAE, Agarwal K, Dasari S, Mitra AAK. Productive cross-talk with the Microenvironment: a critical step in Ovarian Cancer Metastasis. Cancers. 2019;11.
8.
Naora H, Montell DJ. Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat Rev Cancer. 2005;5:355–66.CrossRefPubMed
9.
Feigenberg T, Clarke B, Virtanen C, Plotkin A, Letarte M, Rosen B, et al. Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascites. Biomed Res Int. 2014;2014:367103.CrossRefPubMedPubMedCentral
10.
Coosemans AN, Baert T, D’Heygere V, Wouters R, DE Laet L, VAN Hoylandt A, et al. Increased immunosuppression is related to increased amounts of Ascites and Inferior Prognosis in Ovarian Cancer. Anticancer Res. 2019;39:5953–62.CrossRefPubMed
11.
Nasioudis D, Byrne M, Ko EM, Haggerty AF, Cory L, Giuntoli RL, Ii, et al. Ascites volume at the time of primary debulking and overall survival of patients with advanced epithelial ovarian cancer. Int J Gynecol Cancer. 2021;31:1579–83.CrossRefPubMed
12.
Nasioudis D, Byrne M, Ko E, Haggerty A, Cory L, Giuntoli R, et al. Ascites volume at the time of primary debulking and overall survival of patients with advanced-stage epithelial ovarian cancer. Gynecol Oncol. 2021;162:S91.CrossRef
13.
Szender JB, Emmons T, Belliotti S, Dickson D, Khan A, Morrell K, et al. Impact of ascites volume on clinical outcomes in ovarian cancer: a cohort study. Gynecol Oncol. 2017;146:491–7.CrossRefPubMedPubMedCentral
14.
Quan Q, Zhou S, Liu Y, Yin W, Liao Q, Ren S, et al. Relationship between ascites volume and clinical outcomes in epithelial ovarian cancer. J Obstet Gynaecol Res. 2021;47:1527–35.CrossRefPubMed
15.
Janco JMT, Glaser G, Kim B, McGree ME, Weaver AL, Cliby WA, et al. Development of a prediction model for residual disease in newly diagnosed advanced ovarian cancer. Gynecol Oncol. 2015;138:70–7.CrossRefPubMed
16.
17.
Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN. Pathology and classification of ovarian tumors. Cancer. 2003;97(10 Suppl):2631–42.CrossRefPubMed
18.
Zeppernick F, Meinhold-Heerlein I. The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer. Arch Gynecol Obstet. 2014;290:839–42.CrossRefPubMed
19.
Tokunaga H, Shimada M, Ishikawa M, Yaegashi N. TNM classification of gynaecological malignant tumours, eighth edition: changes between the seventh and eighth editions. Jpn J Clin Oncol. 2019;49:311–20.CrossRefPubMed
20.
21.
Komiyama S, Katabuchi H, Mikami M, Nagase S, Okamoto A, Ito K, et al. Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of ovarian cancer including primary peritoneal cancer and fallopian tube cancer. Int J Clin Oncol. 2016;21:435–46.CrossRefPubMed
22.
Suzuki S, Kajiyama H, Shibata K, Ino K, Nawa A, Sakakibara K, et al. Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients? Ann Oncol. 2008;19:1284–7.CrossRefPubMed
23.
Rustin GJS, Vergote I, Eisenhauer E, Pujade-Lauraine E, Quinn M, Thigpen T, et al. Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG). Int J Gynecol Cancer. 2011;21:419–23.CrossRefPubMed
24.
Rosenbaum PR, Rubin DB. Reducing Bias in Observational studies using subclassification on the Propensity score. J Am Stat Assoc. 1984;79:516–24.CrossRef
25.
Yoshihara M, Uno K, Tano S, Mayama M, Ukai M, Kondo S, et al. The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study. Crit Care. 2015;19:369.CrossRefPubMedPubMedCentral
26.
Manning-Geist BL, Hicks-Courant K, Gockley AA, Clark RM, Del Carmen MG, Growdon WB et al. A novel classification of residual disease after interval debulking surgery for advanced-stage ovarian cancer to better distinguish oncologic outcome. Am J Obstet Gynecol. 2019;221:326.e1-326.e7.
27.
Dabi Y, Huchon C, Ouldamer L, Bendifallah S, Collinet P, Bricou A, et al. Patients with stage IV epithelial ovarian cancer: understanding the determinants of survival. J Transl Med. 2020;18:134.CrossRefPubMedPubMedCentral
28.
Li Y, Mao AS, Seo BR, Zhao X, Gupta SK, Chen M, et al. Compression-induced dedifferentiation of adipocytes promotes tumor progression. Sci Adv. 2020;01:6:eaax5611.CrossRef
29.
Shohei, Iyoshi Masato, Yoshihara Kae, Nakamura Mai, Sugiyama Yoshihiro, Koya Kazuhisa, Kitami Kaname, Uno Kazumasa, Mogi Sho, Tano Hiroyuki, Tomita Keiji, Kajiwara Masayasu, Taki Shigehiro, Yamaguchi Akihiro, Nawa Hiroaki, Kajiyama (2021) Pro‐tumoral behavior of omental adipocyte‐derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer Abstract International Journal of Cancer 149(11) 1961-1972. https://​doi.​org/​10.​1002/​ijc.​v149.​11.
Metadata
Title
Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study
Authors
Shohei Iyoshi
Mariko Kimura
Masato Yoshihara
Atsushi Kunishima
Emiri Miyamoto
Hiroki Fujimoto
Kazuhisa Kitami
Kazumasa Mogi
Kaname Uno
Sho Tano
Nobuhisa Yoshikawa
Ryo Emoto
Shigeyuki Matsui
Hiroaki Kajiyama
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2024
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-024-13218-1

Other articles of this Issue 1/2024

CapeOX as neoadjuvant chemotherapy for locally advanced rectal cancer: might less be more?

Attitudes of oncology patients’ towards biospecimen donation for biobank research

  • Open Access
  • Original Research

Reference-free inferring of transcriptomic events in cancer cells on single-cell data

Beneficial effects of maintaining liver function during hepatic arterial infusion chemotherapy combined with tyrosine kinase and programmed cell death protein-1 inhibitors on the outcomes of patients with unresectable hepatocellular carcinoma

High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer

Comparing clinical and genomic features based on the tumor location in patients with resected pancreatic cancer

Image Credits