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BMC Infectious Diseases
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Open Access 01-12-2024 | Dengue Virus | Research

Dengue epidemiology and molecular characterization of vector mosquitoes; Aedes aegypti and Aedes albopictus in Mizoram, Northeast India

Authors: Van Ramliana, Ralte Vanlalawmpuii, Gabriel Rosangkima, Lalfakzuala Pautu, Hun Ropuia, Nachimuthu S. Kumar, Hmar Lalthanzara

Published in: BMC Infectious Diseases | Issue 1/2024

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Abstract

Background

Dengue is the most important arboviral disease, and Aedes aegypti and Aedes albopictus are the major vectors. It is one of the most recent emerging diseases in Mizoram state with a fast-growing burden over the years. The present study aimed to explore the epidemiological patterns of dengue in Mizoram, and to identify vector mosquito species.

Methods

In the present study, two years secondary data of dengue disease in Mizoram was studied. Dengue vector mosquitoes and dengue virus serotypes circulating in vector mosquitoes in Aizawl City were identified by sequence analysis of COX1 and C-prM genes respectively.

Results

In Mizoram State, the annual case prevalence of dengue was found to be 300.45 per 100,000 persons. Seasonality of the disease was also noted, with the peak season occurring from July to December. There is a significant positive relationship between age and the disease prevalence (p < 0.05, r = 0.909). DENV was detected in 10 pools of Ae. aegypti with a minimum infection rate (MIR) of 18.05, and 8 pools of Ae. albopictus with a minimum infection rate of 16.03. The viral isolates were found to correspond to serotypes 2 (DENV2) and 3 (DENV3). A total of 6 pools of Aedes aegypti and 4 pools of Aedes albopictus tested positive with DENV2 serotype, while 4 pools of Aedes aegypti and 3 pools of Aedes albopictus tested positive with DENV3 serotype. DENV2 serotype was more common, and multiple serotypes (DENV2 and DENV3) were also detected in two pools from one locality.

Conclusions

There is an increasing trend in dengue infection in Mizoram, and seasonality of the disease was observed with the peak season during July to December. The higher incidence rate among the adults indicated that outdoor activities may be related to the high risk of the infection. However, lack of immunity among the older people may also be a possible reason of higher disease incidence rather than the activity pattern. Early identification and frequent monitoring of infected vector mosquitoes will yield an early warning indicator for forecasting dengue epidemics in the future.
Literature
1.
Ferreira-de-Lima VH, Andrade PDS, Thomazelli LM, Marrelli MT, Urbinatti PR, Almeida RMMS, et al. Silent circulation of dengue virus in Aedes albopictus (Diptera: Culicidae) resulting from natural vertical transmission. Sci Rep. 2020;10(1):3855.CrossRefPubMedPubMedCentral
2.
Mustafa MS, Rasotgi V, Jain S, Gupta V. Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control. Med J Armed Forces India. 2015;71(1):67–70.CrossRefPubMed
3.
Palma-da Cunha-Matta A, Soares-Moreno SA, Cardoso-de Almeida A, Aquilera-de Freitas V, Carod-Artal FJ. Neurological complications arising from dengue virus infection. Rev Neurologia. 2004;39(3):233–37.
4.
Pérez-Castro R, Castellanos JE, Olano VA, Matiz MI, Jaramillo JF, Vargas SL, et al. Detection of all four dengue serotypes in Aedes aegypti female mosquitoes collected in a rural area in Colombia. Mem Inst Oswaldo Cruz. 2016;111(4):233–40.CrossRefPubMedPubMedCentral
5.
Isa I, Ndams IS, Aminu M, Chechet G, Dotzauer A, Simon AY. Genetic diversity of Dengue virus serotypes circulating among Aedes mosquitoes in selected regions of northeastern Nigeria. One Health. 2021;13:100348.CrossRefPubMedPubMedCentral
6.
Dutta P, Mahanta J. Potential vectors of Dengue and the Profile of Dengue in the North-Eastern Region of India: an epidemiological perspective. Dengue Bull. 2006;30:234–42.
7.
Lindholm DA, Myers T, Widjaja S, Grant EM, Telu K, Lalani T, et al. Mosquito exposure and chikungunya and dengue infection among travelers during the chikungunya outbreak in the Americas. Am J Trop Med Hyg. 2017;96(4):903–12.CrossRefPubMedPubMedCentral
8.
Pavon JAR, Neves NADS, Silva LCF, Azevedo FKD, Junior JABDF, Nunes MRT et al. Neurological infection by chikungunya and a triple Arbovirus co-infection in Mato Grosso, Central Western Brazil during 2019. J Clin Virol. 2022;146.105056.
9.
Tajudeen YA, Oladunjoye IO, Mustapha MO, Mustapha ST, Ajide-Bamigboye NT. Tackling the global health threat of arboviruses: an appraisal of the three holistic approaches to health. Health PromotPerspect. 2021;11(4):371–81.
10.
11.
Zin T, Mudin KD, Myint T, Naing DKS, Sein T, Shamsul BS. Influencing factors for household water quality improvement in reducing diarrhoea in resource-limited areas. WHO South East Asia J Pub Health. 2013;2(1):6–11.CrossRef
12.
13.
Sailo CV, Ghatak S, Sarathbabu S, Bariha GS, Majumder A, Singh A, et al. Molecular typing of dengue virus in Mizoram, Northeast India. J Infect Dev Ctries. 2022;16(10):1637–42.CrossRefPubMed
14.
Lalmalsawma P, Pautu L, Lalremsiama N. Scenario of scrub typhus disease in Mizoram, Northeast India. Intl J Curr Adv Res. 2017;6(10):6341–4.
15.
Lallawmzuali M, Muniyan S. Probability analysis of annual and monthly rainfall in Mizoram, India: evaluating goodness of fit and identifying best probability distributions. Mausam. 2024;75(3):815–22.CrossRef
16.
Rueda LM. Pictorial keys for the identification of mosquitoes (Diptera:Culicidae) associated with Dengue virus transmission. Zootaxa. 2004;589(1):1–60.CrossRef
17.
Folmer O, Black M, Hoeh W, Lut R, Vrijenhoek R. DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. Mol Mar Biol Biotechnol. 1994;3(5):294–9.PubMed
18.
Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. Rapid Detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992;30(3):545–51.CrossRefPubMedPubMedCentral
19.
Shu PY, Chang SF, Kuo YC, Yueh YY, Chien LJ, Sue CL, et al. Development of group- and serotype-specific one-step SYBR Green I-based real-time reverse transcription-PCR assay for dengue virus. J Clin Microbiol. 2003;41(6):2408–16.CrossRefPubMedPubMedCentral
20.
Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA. 1997;74:5463–7.CrossRef
21.
Pautu L, Zorammuana, Lalmalsawma P, Zoramthara. Report of first dengue outbreak in Aizawl, Mizoram, northeast India: epidemiological and entomological surveillance and observations. Sc Vis. 2017;17(2):61–8.CrossRef
22.
23.
Kaur H, Prabhakar H, Mathew P, Marshalla R, Arya M. Dengue haemorrhagic fever outbreak in October-November. Indian J Med Res. 1996;6:1–3.
24.
Ranjit S, Kissoon N. Dengue hemorrhagic fever and shock syndromes. Pediatr Crit Care Med. 2011;12(1):90–100.CrossRefPubMed
25.
26.
Chatterjee SN, Chakravarti SK, Mitra AC, Sarkar JK. Virological investigation of cases with neurological complications during the outbreak of haemorrhagic fever in Calcutta. J Indian Med Assoc. 1965;45:314–6.PubMed
27.
28.
29.
Alagarasu K, Patil JA, Kakade MB, More AM, Yogesh B, Newase P, et al. Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018. Int J Infect Dis. 2021;111:242–52.CrossRefPubMed
30.
Singh UB, Maitra A, Broor S, Rai A, Pasha ST, Seth P. Partial nucleotide sequencing and molecular evolution of epidemic causing dengue 2 strains. J Infect Dis. 1999;80:959–65.CrossRef
31.
Agarwal A, Ganvir R, Kale D, Chaurasia D, Kapoor G. Continued dominance of dengue virus serotype 2 during the recent Central India outbreaks (2019–2021) with evidence of genetic divergence. Pathog Glob Health. 2024;118(2):109–19.CrossRefPubMed
32.
Dash PK, Parida MM, Saxena P, Abhyankar A, Singh CP, Tewari KN, et al. Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS. Virol J. 2006;3:1–10.CrossRef
33.
Thavara U, Siriyasatien P, Tawatsin A, Asavadachanukorn P, Anantapreecha S, Wongwanich R, et al. Double infection of heteroserotypes of dengue viruses in field populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) and serological features of dengue viruses found in patients in southern Thailand. Southeast Asian J Trop Med. 2006;37(3):468–76.
34.
35.
36.
Bonizzoni M, Gasperi G, Chen X, James AA. The invasive mosquito species Aedes albopictus: current knowledge and future perspectives. Trends Parasitol. 2013;29(9):460–8.CrossRefPubMedPubMedCentral
37.
Jansen CC, Beebe NW. The dengue vector aedes aegypti: what comes next? Microbes Infect. 2010;12(4):272–9.CrossRefPubMed
38.
39.
Zhaki ZA, Dom NC, Alhothily IA. Study on the distribution and abundance of Aedes aegypti and Aedes albopictus in different environment settings for high-rise buildings. Malay J Med Health Sci. 2019;15(SP4):91–8.
40.
Metadata
Title
Dengue epidemiology and molecular characterization of vector mosquitoes; Aedes aegypti and Aedes albopictus in Mizoram, Northeast India
Authors
Van Ramliana
Ralte Vanlalawmpuii
Gabriel Rosangkima
Lalfakzuala Pautu
Hun Ropuia
Nachimuthu S. Kumar
Hmar Lalthanzara
Publication date
01-12-2024
Publisher
BioMed Central
Keyword
Dengue Virus
Published in
BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-024-10264-9

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