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26-07-2023 | Dementia

Recent updates in autonomic research: orthostatic hypotension and cognitive function in Parkinson disease and multiple system atrophy, the skin as a window into synuclein pathology, and RFC1 repeat expansions in hereditary sensory autonomic neuropathies

Authors: Pitcha Chompoopong, Sandra Reiter-Campeau

Published in: Clinical Autonomic Research | Issue 4/2023

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Excerpt

Orthostatic hypotension (OH) reflects insufficient hemodynamic adjustment to postural changes, which may exceed the threshold of cerebral autoregulation resulting in decreased cerebral perfusion during orthostatic stress. Cognitive testing during upright position in Parkinson disease (PD) patients with OH demonstrated transient impairment in cognition with more pronounced deficits in executive function, memory, and visuospatial domains [1]. Patients who experience repeated bouts of OH may be predisposed to chronic brain hypoxia leading to progressive cognitive decline and dementia, especially in the setting of synergistic neurodegenerative processes. Multiple studies have shown the association between OH and dementia as well as cognitive impairment progression to dementia, even when OH was asymptomatic [2, 3]. …
Literature
Metadata
Title
Recent updates in autonomic research: orthostatic hypotension and cognitive function in Parkinson disease and multiple system atrophy, the skin as a window into synuclein pathology, and RFC1 repeat expansions in hereditary sensory autonomic neuropathies
Authors
Pitcha Chompoopong
Sandra Reiter-Campeau
Publication date
26-07-2023
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 4/2023
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-023-00968-4

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