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Molecular Neurodegeneration
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Open Access 01-12-2024 | Dementia | Perspective

Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?

Authors: Sharyn L. Rossi, Diane E. Bovenkamp

Published in: Molecular Neurodegeneration | Issue 1/2024

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Excerpt

Oligodendrocytes (OLs) and their lineage progenitor (OPCs) and precursor cells are widely studied and recognized as promising therapeutic targets for multiple neurodegenerative diseases and disorders including multiple sclerosis, spinal cord injuries, traumatic brain injuries, stroke, Parkinson’s disease, ALS, and others. Yet, their role in Alzheimer’s disease and related dementias (ADRDs), despite their complex, multi-factorial nature, remains largely underappreciated and understudied. Mounting evidence supports the role of oligodendrocyte dysfunction in ADRD which begins with their normal homeostatic role during development and non-disease physiological states. …
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Metadata
Title
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Authors
Sharyn L. Rossi
Diane E. Bovenkamp
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue 1/2024
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/s13024-024-00760-6

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Keynote webinar | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the broader systemic effects of menopause, so you can help patients in your clinics through the transition.   

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