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Open Access 08-10-2022 | Cytostatic Therapy | ASO Author Reflections

ASO Author Reflections: Prediction of the Chemotherapy Effect on the Prognosis of Locally Advanced Pancreatic Cancer

Authors: Masayuki Tanaka, MD, PhD, Thilo Hackert, MD

Published in: Annals of Surgical Oncology | Issue 4/2023

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Excerpt

The use of potent multiagent chemotherapy protocols has resulted in increased opportunities for potentially curative resection, including resection for locally advanced pancreatic cancer (LAPC).1,2 However, identifying the patients who would benefit from conversion surgery for LAPC has been a matter of debate during the past decade.3,4 Evidence-based guidelines for conversion surgery after induction chemotherapy are currently lacking. This study therefore focused on the preoperative factors predictive of overall survival for patients with resected LAPC after induction FOLFILINOX and established a prognostic model with these factors that may guide optimal treatment for LAPC.5
Literature
2.
go back to reference Rombouts SJ, Walma MS, Vogel JA, et al. Systematic review of resection rates and clinical outcomes after FOLFIRINOX-based treatment in patients with locally advanced pancreatic cancer. Ann Surg Oncol. 2016;23:4352–60.CrossRefPubMedPubMedCentral Rombouts SJ, Walma MS, Vogel JA, et al. Systematic review of resection rates and clinical outcomes after FOLFIRINOX-based treatment in patients with locally advanced pancreatic cancer. Ann Surg Oncol. 2016;23:4352–60.CrossRefPubMedPubMedCentral
3.
go back to reference Klaiber U, Hackert T. Conversion surgery for pancreatic cancer: the impact of neoadjuvant treatment. Front Oncol. 2019;9:1501.CrossRefPubMed Klaiber U, Hackert T. Conversion surgery for pancreatic cancer: the impact of neoadjuvant treatment. Front Oncol. 2019;9:1501.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Prediction of the Chemotherapy Effect on the Prognosis of Locally Advanced Pancreatic Cancer
Authors
Masayuki Tanaka, MD, PhD
Thilo Hackert, MD
Publication date
08-10-2022
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 4/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-022-12579-w

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