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09-05-2024 | Cytostatic Therapy | Head and Neck

Incidence of cardiovascular mortality among head and neck cancer patients

Authors: Li-Li Cao, Yan Wang, Shao-Hua Wang, Bing-Bo Yu, Jun Fan

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2024

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Abstract

Background

While treatment advancements have prolonged the lives of patients with head and neck cancer, the subgroups of these patients at higher risk for cardiovascular disease (CVD) mortality remain unclear.

Methods

We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with head and neck cancer from 2000 to 2019. We compared their CVD mortality against the general US population using standardized mortality ratios (SMRs).

Results

Our analysis included 474,366 patients, identifying that 14% of deaths were due to CVD, with an SMR of 1.19. Notably, patients under the age of 39 had a CVD SMR increase of over 100-fold. Those with distant tumor stages showed the highest CVD SMR of 1.52 (95% CI 1.50–1.54). An upward trend in SMR to 2.53 (95% CI 2.51–2.56) was observed from 2011 to 2019. Within the initial 5-year post-diagnosis, the SMR for CVD was 3.17 (95% CI 3.14–3.20), which exceeded the general population’s rates but declined in the 5–20-year range after diagnosis. Patients who did not any therapy had the greatest CVD SMR of 2.26 (95% CI 2.24–2.28). Hypopharyngeal cancer patients exhibited the highest CVD SMR of 1.54 (95% CI 1.52–1.56).

Conclusions

The study highlights that head and neck cancer patients, especially younger individuals and those with advanced disease stages, face substantial CVD mortality risks. The CVD SMR peaks within 5 years following diagnosis. Patients abstaining from treatment bear the highest risk of CVD mortality. Cardioprotective measures should be considered critical for this patient population.
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Literature
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Metadata
Title
Incidence of cardiovascular mortality among head and neck cancer patients
Authors
Li-Li Cao
Yan Wang
Shao-Hua Wang
Bing-Bo Yu
Jun Fan
Publication date
09-05-2024
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 8/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-024-08670-5

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