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23-10-2024 | Cystitis | Urology – Original Paper

Amniotic bladder therapy: study of micronized amnion/chorion for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) at 6 months

Authors: Kyle O’Hollaren, Jack Considine, Codrut Radoiu, Raghav Madan, Aron Liaw, Nivedita Dhar

Published in: International Urology and Nephrology

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Abstract

Background

Intravesical application of birth tissue has been reported to inhibit inflammation, alleviate collagen fiber accumulation, and enhance bladder tissue generation. We have previously reported that intra-detrusor micronized amnion monolayer (AM) injections provide short-term clinical improvement in refractory IC/BPS patients. Herein, we evaluate the therapeutic responses and adverse events of micronized amnion/chorion bilayer (AC) in patients with refractory IC/BPS with 6 months follow-up.

Methods

Fifteen patients affected by IC/BPS who failed conventional therapy received 100 mg of reconstituted micronized AC was injected intra-detrusor via cystoscopy under general anesthesia, using a 23-gauge needle. Twenty 0.5-mL injections were administered into the lateral and posterior bladder walls, avoiding the dome and trigone. Changes in interstitial cystitis symptom index (ICSI), Interstitial cystitis problem index (ICPI), Bladder pain/ interstitial cystitis symptom score (BPIC-SS) and Overactive Bladder Assessment Tool (OAB), from baseline to 6 months post-injection were evaluated retrospectively. The safety of injections was analyzed.

Results

Fifteen total refractory IC/BPS patients with an average age of 41.1 ± 14.5 years were included in the study, receiving intra-detrusor injections of 100 mg of micronized AC. One month after injections, significant improvement in IC/BPS symptom scores was noted in all patients. All patients maintained a sustained clinical response at 6 months post-injection. No product-related adverse events were observed.

Conclusion

Our findings indicate that the AC formulation significantly reduces time to symptom relief in patients with refractory interstitial cystitis/bladder pain syndrome (IC/BPS) and maintains a sustained response up to 6 months post-injection. These results suggest a promising clinical benefit of using an amnion/chorion bilayer product for treating IC/BPS. Further research is needed to confirm these findings and assess the long-term durability of this treatment approach. This study represents the first evidence supporting the clinical advantages of an amnion/chorion bilayer product in managing IC/BPS.
Literature
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go back to reference Considine J, O’Hollaren K, Radoiu C, Madan R, Liaw A, Dhar N (2024) Amniotic bladder therapy: six-month follow up treating interstitial cystitis/bladder pain syndrome. Can J Urol 31(3):11898–11903PubMed Considine J, O’Hollaren K, Radoiu C, Madan R, Liaw A, Dhar N (2024) Amniotic bladder therapy: six-month follow up treating interstitial cystitis/bladder pain syndrome. Can J Urol 31(3):11898–11903PubMed
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go back to reference Chancellor MB, Lamb LE, Ward EP, Bartolone SN, Carabulea A, Sharma P, Janicki J, Smith C, Laudano M, Abraham N, Zwaans BMM (2022) Comparing concentration of urinary inflammatory cytokines in interstitial cystitis, overactive bladder, urinary tract infection, and bladder cancer. Urological Science 33(4):199–204. https://doi.org/10.4103/UROS.UROS_26_22CrossRef Chancellor MB, Lamb LE, Ward EP, Bartolone SN, Carabulea A, Sharma P, Janicki J, Smith C, Laudano M, Abraham N, Zwaans BMM (2022) Comparing concentration of urinary inflammatory cytokines in interstitial cystitis, overactive bladder, urinary tract infection, and bladder cancer. Urological Science 33(4):199–204. https://​doi.​org/​10.​4103/​UROS.​UROS_​26_​22CrossRef
Metadata
Title
Amniotic bladder therapy: study of micronized amnion/chorion for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) at 6 months
Authors
Kyle O’Hollaren
Jack Considine
Codrut Radoiu
Raghav Madan
Aron Liaw
Nivedita Dhar
Publication date
23-10-2024
Publisher
Springer Netherlands
Published in
International Urology and Nephrology
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-024-04251-x

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