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Inflammation Research
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28-09-2024 | Original Research Paper

Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury

Authors: Bin Zhang, Jiasheng Yu, Lei Bao, Dongqian Feng, Yong Qin, Daobo Fan, Xin Hong, Yongyi Chen

Published in: Inflammation Research | Issue 11/2024

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Highlights

Cynarin decreases neuroinflammation levels and attenuates microglial pyroptosis.
Cynarin hinders the formation of NLRP3 inflammasome through Nrf2-dependent expression.
Cynarin-treated mice showed lower levels of reactive oxygen species (ROS) and cell death, as well as reduced neurohistological damage, and improved hindlimb locomotor function compared to untreated mice.
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Metadata
Title
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury
Authors
Bin Zhang
Jiasheng Yu
Lei Bao
Dongqian Feng
Yong Qin
Daobo Fan
Xin Hong
Yongyi Chen
Publication date
28-09-2024
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 11/2024
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-024-01945-x

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