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Journal of Clinical Immunology

Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans

Published in:
Authors
Carlos A. Arango-Franco
Julian Rojas
Carolina Firacative
Mélanie Migaud
Clara Inés Agudelo
José Luis Franco
Jean-Laurent Casanova
Anne Puel
Jairo Lizarazo
Elizabeth Castañeda
Andrés A. Arias
Published in
Journal of Clinical Immunology | Issue 7/2024

Abstract

Background

Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii. Neutralizing autoantibodies (auto-Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryptococcal meningitis have been described since 2013. We searched for neutralizing auto-Abs in sera collected from Colombian patients with non-HIV-associated cryptococcosis in a retrospective national cohort from 1997 to 2016.

Methods

We reviewed clinical and laboratory records and assessed the presence of neutralizing auto-Abs against GM-CSF in 30 HIV negative adults with cryptococcosis (13 caused by C. gattii and 17 caused by C. neoformans).

Results

We detected neutralizing auto-Abs against GM-CSF in the sera of 10 out of 13 (77%) patients infected with C. gattii and one out of 17 (6%) patients infected with C. neoformans.

Conclusions

We report eleven Colombian patients diagnosed with cryptococcosis who had auto-Abs that neutralize GM-CSF. Among these patients, ten were infected with C. gattii and only one with C. neoformans.
Title
Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans
Authors
Carlos A. Arango-Franco
Julian Rojas
Carolina Firacative
Mélanie Migaud
Clara Inés Agudelo
José Luis Franco
Jean-Laurent Casanova
Anne Puel
Jairo Lizarazo
Elizabeth Castañeda
Andrés A. Arias
Publication date
01-10-2024
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 7/2024
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-024-01757-y
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