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06-09-2024 | Original Contribution

Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan

Authors: Meng-Hua Tao, Shu-Chun Chuang, I.-Chien Wu, Huei-Ting Chan, Chiu-Wen Cheng, Hui-Ling Chen, Marion M. Lee, Hsing-Yi Chang, Chao Agnes Hsiung, Chih-Cheng Hsu

Published in: European Journal of Nutrition | Issue 8/2024

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Abstract

Purpose

Previous cross-sectional studies have shown that higher magnesium intake is associated with better cognitive function, particularly in individuals with sufficient vitamin D status. The aim of this study was to evaluate the longitudinal associations between magnesium intake and cognitive impairment in a community-based cohort study in Taiwan.

Methods

The study population included 5663 community-dwelling adults aged ≥ 55 years old recruited from 2009 to 2013 and followed up from 2013 to 2020. Magnesium intake was evaluated from a validated food frequency questionnaire at baseline. Cognitive performance was measured at baseline and follow-up for participants’ Mini-Mental Status Examination (MMSE), Digit Symbol Substitution Test (DSST), and Clock-Drawing Test (CDT), and impairment was defined as MMSE < 24, DSST < 21, and CDT < 3, respectively. Multivariate logistic regression models were used to examine the associations and were stratified by sex and plasma vitamin D levels (≥ 50 or < 50 nmol/L).

Results

Higher baseline magnesium intake was associated with lower odds of a poor performance on the MMSE in both men and women (4th vs. 1st. quartile: OR = 0.43, 95% CI = 0.23–0.82, ptrend < 0.01 in men and OR = 0.53, 95% CI = 0.29–0.97, ptrend = 0.12 in women) and on the DSST in men (OR = 0.23, 95% CI = 0.09–0.61, ptrend < 0.01) at follow-up. Inverse associations between baseline magnesium intake and a poor performance on the MMSE or DSST were observed in men regardless of vitamin D status.

Conclusion

Our study suggested that higher magnesium intake was associated with the development of cognitive impairment in men in a median follow-up period of 6 years.
Appendix
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Metadata
Title
Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan
Authors
Meng-Hua Tao
Shu-Chun Chuang
I.-Chien Wu
Huei-Ting Chan
Chiu-Wen Cheng
Hui-Ling Chen
Marion M. Lee
Hsing-Yi Chang
Chao Agnes Hsiung
Chih-Cheng Hsu
Publication date
06-09-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 8/2024
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-024-03490-z

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