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Critical Care

Issue 1/2025

Content (297 Articles)

Systemic inflammation and cardiac surgery: insights from the RECCAS trial

Minghao Luo

Impact of lumbar cerebrospinal fluid drainage to control intracranial hypertension in patients with severe traumatic brain injury: a retrospective monocentric cohort

Geoffrey Dagod, Marlène Laurens, Jean-Paul Roustan, Pauline Deras, Elie Courvalin, Mehdi Girard, Hugues Weber, Xavier Capdevila, Jonathan Charbit

Visualizing hemodynamics: innovative graphical displays and imaging techniques in anesthesia and critical care

Frederic Michard, Adrian Wong, Vanina Kanoore Edul

Clinical impact of healthcare-associated infections in Brazilian ICUs: a multicenter prospective cohort

Bruno Martins Tomazini, Bruno Adler Maccagnan Pinheiro Besen, Renato Hideo Nakagawa Santos, Antonio Paulo Nassar Jr., Thabata Silva Veiga, Viviane Bezerra Campos, Samira Martins Tokunaga, Elton Sousa Santos, Leticia Galvão Barbante, Renato da Costa Maia, Flavia Cristina Soares Kojima, Ligia Nasi Laranjeira, Leandro Utino Taniguchi, Roberta Muriel Longo Roepke, Cristiano Augusto Franke, Luciana Coelho Sanches, Livia Maria Garcia Melro, Israel Silva Maia, Vicente Cés de Souza Dantas, Rodrigo Cruvinel Figueiredo, Meton Soares de Alencar Filho, Vivian Menezes Irineu, Wilson José Lovato, Cassio Luis Zandonai, Flávia Ribeiro Machado, Beatriz Arns, Giovanna Marsola, Viviane Cordeiro Veiga, Adriano José Pereira, Alexandre Biasi Cavalcanti, Silvana Soares dos Santos, Juliana Coelho, Michelle Tereza Sousa, Bruna Azevedo, Luciana Macedo da Silva Gavinho, Alaís Brito Nascimento, Rodrigo Barbosa Cerantola, Itallo de Lima Neves, Vanessa Cristina de Aquino Leão, Rodrigo Morel Vieira de Melo, Luane Lopes Cavalcante Gomes, Vladimir Miguel Spirale, Roberta Schiavon Nogueira, Lúcio Couto de Oliveira Junior, Daniela Cunha de Oliveira, Marianna Deway Andrade Dracoulakis, Natália Oliveira Santos Alvaia, Andre Luiz Nunes Gobatto, Carolaine Bomfim de Oliveira, Cintia Magalhães Carvalho Grion, Claudia Maria Dantas de Maio Carrilho, Claudia Fernanda de Lacerda Vidal, Fernanda Lopes de Albuquerque Rodrigues, Thiago Costa Lisboa, Cristofer Farias da Silva, Leticia Pierini, Antônio Carlos da Silva, Sheila Mara Bezerra de Oliveira, Maria Brandão Tavares, Igor das Virgens Santana, Tatiana Gozzi Pancev Toledo, Fabio de Carvalho Mauricio, Bianca Ramos Ferronato, André Sant’Ana Machado, Leticia Capeletti, Marina Peres Bainy, Gabriela Martins Teixeira, Dagoberta Alves Vieira Beduhn, Durval Ferreira Fonseca Pedroso, Priscilla Yoshiko Sawada, Caio Cesar Ferreira Fernandes, Juliana Mazzei Garcia, Rafael Nunes Malta, Cindy Medici Toscano Rozetti, Pedro Aniceto Nunes Neto, Valéria Chagas Pereira, Emerson Boschi, Viviane Buffon, Tássio Breno de Sousa Lopes Lavôr, Marcela Dutra, Maria Eduarda Kretzer Silva, Leila Rezegue de Moraes Rego, Adria Vanessa da Silva, Vivian Menezes Irineu, Viviane Aparecida L. S. Correa, Rodrigo Cruvinel Figueiredo, Jackelyne Lopes Silva, Jussara Alencar Arraes, Meton Soares de Alencar Filho, Mariana de Souza Medeiros, Francielle Constantino Pereira, Fernanda Borges Salgado, Vicente Cés de Souza Dantas, Priscilla Alves Barreto, Israel Silva Maia, Cassio Luis Zandonai, Fábio Holanda Lacerda, Rene Rodrigues, Luana Pontes Oliveira, Eliene Sá Sodré Filho, João Lucidio Lobato Paes, Marielle Crsitina Mendes Silva, Debora Maria Brito Pinho, Carolina Miranda, Livia Maria Garcia Melro, Priscila Freitas das Neves Gonçalves, Anelise Franklin, Rafael Botelho Foernges, Maite Souza Magdalena, Felipe Dal Pizzol, Danusa de Castro Damasio, Roberta Machado de Souza, Larissa Liz Cardoso de Araújo, Flávia Ribeiro Machado, Maria Aparecida de Souza, Nicole Alberti Golin, Juliana Giacomazzi, Joana D’arc Vila Nova Jatobá, Maria Tereza Farias de Moura, Luis Eduardo Miranda Paciência, Elaine Silva Bueno, Eliana Bernadete Caser, Larissa Zuqui Ribeiro, Diego Meireles Duarte, Rejane Martins Prestes, Glícia Cardoso Nascimento, Valéria Paes Lima, Kamilla Grasielle Nunes da Silva, Roberta Lacerda Almeida de Miranda Dantas, Eliane Pereira Silva, Hugo Corrêa de Andrade Urbano, Danielle Conceição Aparecida Moreira, Pedro Martins Pereira Kurtz, Cássia Righy Shinotsuka, Everton Macêdo Silva, Julival Ribeiro, Cláudio Dornas de Oliveira, Raquel Caldeira Brant Santiago, Jorge Luiz da Rocha Paranhos, Iany Grinezia da Silva Wiermann, Thiago Gomes Romano, Daniel Cubos

The development of a non-contact tachycardia and tachypnea monitoring system, a clinical trial on shock patients

  • Open Access
  • Shock
  • Correspondence

Akito Saito, Shohei Sato, Tsuyoshi Kobayashi, Guanghao Sun, Kenichi Hashimoto, Yukiya Hakozaki, Takemi Matsui

Comparison of hypothermic and normothermic targeted temperature management in out-of-hospital cardiac arrest patients with acute coronary syndrome: a nationwide retrospective study

Tasuku Matsuyama, Bon Ohta, Makoto Watanabe, Tetsuhisa Kitamura

The elusive concept of appropriate antibiotic for septic patients when a pathogen is not detected by standard culture methods

Alberto Enrico Maraolo, Rita Murri, Danilo Buonsenso, Massimo Fantoni, Maurizio Sanguinetti

The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial

Emma J. Ridley, Michael Bailey, Marianne J. Chapman, Lee-anne S. Chapple, Adam M. Deane, Marlene Gojanovic, Alisa M. Higgins, Carol L. Hodgson, Victoria L. King, Andrea P. Marshall, Eliza G. Miller, Shay P. McGuinness, Rachael L. Parke, Eldho Paul, Andrew A. Udy, Emma J. Ridley, Michael Bailey, Marianne J. Chapman, Lee-anne S. Chapple, Adam M. Deane, Marlene Gojanovic, Alisa M. Higgins, Carol L. Hodgson, Victoria L. King, Andrea P. Marshall, Eliza G. Miller, Shay P. McGuinness, Rachael L. Parke, Eldho Paul, Andrew A. Udy, Farisha Ali, Rebecca Baskett, Magdalena Butler, Keri-Anne Cowdrey, Eileen Gilder, Lydia Gillan, Su-Zahn Koorts, Brittany Mason, Ellie McMahon, Shay McGuinness, Karina O’Connor, Rachael Parke, Melissa Robertson, Samantha Ryan, Anna Small, Andrew Xia, Megan Berner, Christine Choong, Glenn Eastwood, Kate Hamilton, Daryl Jones, Leah Peck, Helen Young, Lauren Ballantyne, Catherine Boschert, Cameron Knott, Bridget Roberts, Julie Smith, Zoe Flick, Kalpesh Gandhi, Barbara Hannah, Yvonne Li, Kiran Nand, Treena Sara, Sylvia Wei, Lina Briek, Graeme Duke, Kym Gellie, Stephanie Hunter, Nicole Robertson, Jonathan Barrett, Brydie Cleeve, Caroline Guille, Gabrielle Hanlon, Sarah Jelly-Butterworth, Julie O’Donnell, Carmel Zoanetti, Zhoe Coram, Karen Edis, Mike Gomez, Alice Goodman, Kavi Haji, Jenny Moss, Jodie Prendergast, Janet Tam, Ravindranath Tiruvoipati, Fiona Turnbull, Julie Cussen, Maimoonbe Gough, Sarah Lovelock, Lisa Mahoney, Andrea Marshall, David Pearson, Mandy Tallott, Emily Ainslie, Kate Flynn, Kerri Gordon, Tim Stewart, Larissa Telfer, Victoria Williams, Vishwanath Biradar, Hanaa Chahine, Edda Jessen, Matia Kapsambelis, Melissa Lydyard, Ashlee Martin, Julie Puccini, Natalie Soar, Leah Sommerfield, Bronwyn Bartholomew, Peter Collins, Claire Filet, Mackenzie Finnis, Chloe Jobber, Katherine Jongebloed, Isabel Anne Leditschke, Kimberley Browning, Jennifer Chang, Dinu Girijadevi, Areege Hussein, Vivian Lai, Rima Song, Tony Williams, Oshara de Silva, Ashlee Gervasoni, Carolyn Hall, Lauren Hanna, Sheree Phillips, Yahya Shehabi, Rebecca Gresham, Matin Jamei, Sheeja Joy, Julie Lowrey, Kristy Masters, Ian Seppelt, Wendy Tu, Christina Whitehead, Tina Aboltins, Hayley Collins, Rachael Evans, Angaj Ghosh, Simone Said, Vivian Tsang, Lynette De Groot, Ra’eesa Doola, Meg Harward, Cassie Jones, Josephine Mackay, Jason Meyer, Tahnie Takefala, James Walsham, Stuart Baker, Anthony Khoo, Shannon Lewis, Alyce Nissen, Alexis Tabah, Alicia Wiese, Lewis Campbell, Miriam Chin, Rebecca Garcia, Kirsty Smyth, Annabel Thallon, Emma Bidgood, Jessica Browne, Kathleen Byrne, Adam Deane, Kate Fetterplace, Hilda Griffin, Sarah Phillips, Kym Wittholz, Jasmin Board, Peta Bretag, Aidan Burrell, Adam Cunningham, Dashiell Gantner, Ramez Hanna, Kate Lambell, Karina Lay, Elisa Licari, Lee Lin Loh, Emma Martin, Phoebe McCracken, Jenna Obeid, Caitlin Rabel, Peter Thanhauser, Andrew Udy, Chloe Vadiveloo, Cyndi Wong, Meredith Young, Cameron French, Greta Hollis, Adrian Powlesland, Kiran Shekar, Marion Vasudevan, Emma Whitmore, Tennealle Direen, Martine Hatzi, Cathy Kurenda, Sandra Peake, Amber Thatcher, Patricia Williams, Michelle Horton, Nima Kakho, Matthew Maiden, Tania Salerno, Jemma Trickey

Limitation of life-sustaining treatments in Asian ICUs: theory versus practice

  • Open Access
  • Matters Arising

Lowell Ling, Andrew Li, Jason Phua, Uzzal Kumar Mallick, Motiul Islam, Tarequl Hamid, A. K. M. Shirazul Islam, Rabiul Halim, Md Arifur Rahman Khan, Mohammad Asaduzzaman, Md Rezaul Karim, Nahim Sarwar, Shamsul Hoque Milon, Rashed Mahmud, A. K. M. Sirajul Islam Hirok, Ashraful Haque, Amina Sultana, Mir Atiqur Rahman Shajal, Farha Andalib, Rashedul Hasan, Khalid Mahmood Khan Nafees, Shah Sudhirchandra Dhansukhlal, Ning Li, Xiaowei Liu, Haiwei Yang, Ming Hou, Ying Li, Jian Zhang, Lifeng Huang, Wenxiong Li, Meili Duan, Taotao Liu, Wei He, Fangyu Ning, Xiaozhi Wang, Xiaoyan Zhou, Sun Yu, Xiang Xiang, Liang Pan, Feihu Zhou, Yaoli Wang, Jian Zhou, Tao Wang, Xuefei Yang, Yu Ma, Xuan Song, Haiying Wu, Chuanyun Qian, Lixin Zhou, Zuohang Xu, Kun Zhang, Zhenjie Hu, Xingsheng Lin, Songjing Shi, Xiaoguang Zhang, Rongguo Yu, Liqin Zhang, Yuan Yuan, Huiru Zhou, Xiandong Wang, Zhonghua Wang, Tiehe Qin, Xianqing Shi, Rui Li, Zhenyang He, Xiangrong Zuo, Quan Cao, Tao He, Yuanda Sui, Tiejun Wu, Ying Xu, Qin Gu, Weizheng Shuai, Hanyu Qin, Bin Du, Hong Qiao, Shuangling Li, Guiying Dong, Xiujuan Zhao, Fengxue Zhu, Junshi Wang, Lei Huang, Tianchang Wang, Hao Wang, Siqing Ma, Zhengping Yang, Yuan Gao, Ruoming Tan, Yun Xie, Ruilan Wang, Jia Jia, Bin Zang, Jun Wang, Ling Lin, Yuwen Wu, Yunfu Wu, Penglin Ma, Yanfang Li, Li Yu, Rui Guo, Jiuzhi Zhang, Xianyao Wan, Feng Shen, Qindong Shi, Jun Xu, Qiang Fang, Shaohua Liu, Tongwen Sun, Mian Zeng, Weiyun Pan, Zhongmin Liu, Qingling Lin, Nan Wang, Jing Pang, Bin Xiong, Deliang Wen, Fuxin Kang, Liuhui Chang, Yun Sun, Jingxiao Zhang, Yongjie Yin, Liu Qing, Jiajun Sun, Nahui Li, Yongqiang Wang, Songtao Shou, Yanfen Chai, Lei Xu, Xiaobo Yang, Xuelian Liao, Xian Kang, Shuangping Zhao, Liquan Huang, Run Zhang, Renhua Sun, Chao Shen, Yan He, Fu Loi Chow, Michele Tang, Philip Lam, Esther Cham, Kin Bong Tang, Lowell Ling, Manimala Dharmangadan, Pauline Yeung Ng, Kin Ho Ling, Vincent Lau, Samir Sahu, Sharmila Chatterjee, Sushmita Basu, Zubair Umer Mohamed, Sudeep Sirga, Siddhartha Reddy Kasireddy, M. A. Aleem, Swarna Deepak Kuragayala, Sai Praveen Haranath, Nagarajan Ramakrishnan, Pravin Amin, Joanne Mascarenhas, Radhika Dash, Venkat Raman Kola, R. Vaidyanathan, Siddharth Agarwal, Pradip K. Bhattacharya, Deepak Jeswani, Parshotum Lal Gautam, Abdul Samad Ansari, Vivek Nangia, Mrinal Sircar, V. M. Balasubramani, S. Maneendra, Sanghamitra Mishra, Anjeev Kumar, Rajesh Chawla, Trevor Francis Sequeira, Om Prakash Shrivastava, T. V. Sreevalsan, Rajesh Mohan Shetty, Manjunath Thimmappa, M. M. Harish, Yatin Mehta, Divya Saxena, Vipul Mishra, Rishi Kumar, Simnt Kumar Jha, Prashant Sakhavalkar, Dnyaneshwar Diwane, Subhal Dixit, Kalaiselvan, Manoranjan Pattnaik, Lalit Singh, Fareed Khan, Mehul Shah, Prasanna, Ziokov Joshi, Sheila Ninan Myatra, Manoj Gorade, Bharat G. Jagiasi, Amol Hartalkar, B. Saroj Kumar Prusty, Yogesh, Ade Winata, Maulydia, Surya Oto Wijaya, Hermin Prihartini, Shinta V. R. Hutajulu, Rudy Manalu, Christrijogo Sumartono, Chrisma Adryana Albandjar, Ira Pitaloka, Dewi Kusumawati, Arifin, Akhmad Yun Jufan, Bambang Pujo Semedi, Vanessy Theodora Silalahi, Yudianto, Erwin Pradian, Achsanuddin Hanafie, Mariza Fitriati, Tinni Trihartini Maskoen, Satriawan Abadi, Calcarina Fitriani Retno Wisudarti, Johan Arifin, Reza Widyanto Sudjud, Prananda Surya Airlangga, Rupi’i, I. Made Wiryana, Anang Achmadi, Patra Rijalul Harly, Edward Kusuma, Primartanto Wibowo, Ade Veronica HY, Jeni Sarah Mandang, Meriwijanti, I. Wayan Aryabiantara, Faisal Muchtar, Fachrul Jamal Isa, Dita Aditianingsiih, Nicolaas Parningotan Simamora, Moch. Hasyim, I. Gusti Putu Manuaba, Novita Anggraeni, Rudy Ariyanto Sanoesi, Arief Munandar, Duma Saurma Siahaan, Sri Rachmawati, Oky Susianto, Liliriawati Ananta Kahar, Zulkifli, Mordekhai Leopold Laihad, Nakada Takaaki, Yoshitaka Hara, Osamu Nishida, Kenji Uehara, Makoto Takatori, Shinichiro Ohshimo, Kazuya Kikutani, Nobuaki Shime, Shin Nunomiya, Shinshu Katayama, Bengo Atari, Takashi Ito, Yasuyuki Kakihana, Kohei Takimoto, Machi Yanai, Moritoki Egi, Tomoaki Yatabe, Yuki Kishiara, Ushio Higashijima, Motohiro Sekino, Kazuaki Atagi, Hiroshi Ogura, Tsunehiro Matsubara, Tadashi Kamio, Shigeki Fujitani, Toru Yoshida, Yukari Aoyagi, Shigehiko Uchino, Masatsugu Hasegawa, Jun Oto, Naoki Yamaguchi, Yuki Enomoto, Masaki Nakane, G. S. Amirova, Murat Daribaev, Markov Viktor Evgenievich, A. A. Vorobiev, A. V. Andrushenko, Aliya Torpakbaeva, M. E. Konkayeva, A. V. Galkin, P. A. Ostanin, Khamsay Detleuxay, Noryani Mohd Samat, Ismail Tan, Nahla Irtiza Ismail, Chew Har Lim, Wan Nasrudin Wan Ismail, Siti Rohayah Sulaiman, Anita Alias, Joanne Tiong Jia Wen, Azmin Huda Abdul Rahim, Asmah Zainudin, Nik Azman Nik Adib, Zihni Abdullah, Hafizah, Mohd Zulfakar Mazlan, Mohd Basri Mat Nor, Munkhasiakhan, Naranpurev, Cho Myint Tun, Thinzar Maw, Cho Cho, Han Sein, Myo Malar Win, Lwin Lwin Hnin, Cho Cho Lwin, Aye Su Mon, Yi Sandar Thein, Khin Le Le Yi, Myo Min Naing, Nu Nu May, Lun Naing, Khin Saw Yu Aung, Moe Thu Lin, Aung Kyi, Kyaw Min Min Tun, Suu New Khin, Khin Pyone Yi, Khin May Waan, Moe Thidar, Kyi Kyi Sann, Mu Mu Naing, Win Win Mar, Naing Naing Lin, Lalit Rajbanshi, Trishant Limbu, Baburaja Shrestha, Ujma Shrestha, Ashish Shrestha, Rosi Pradhan, Ravi Ram Shrestha, Sulav Acharya, Pramesh Sunder Shrestha, Puja Thapa Karki, Moosa Awladthani, Jacob Paul, Nadia Al Badi, Adil Al Kharusi, Khalil Al Kharousi, Sandeep Kantor, Yohannan John, Said Al Mandhari, Geetha Jacob, Amr Muhammad Esmat, B. M. J. Shetty, Ahmed Mostafa, Naveed Haroon Rashid, Muhammad Sohaib, Sonia Joseph, Safia Zafar, Ahmed Farooq, Muhammad Sheharyar Ashraf, Tanveer Hussain, Muhammad Hayat, Ataur Rehman, Syed Muneeb Ali, Saad ur Rehman, Ashok Kumar, Aaron Hernandez, Crystal Aperocho, Raymundo Resurreccion, Debbie Noblezada-Uy, Jose Emmanuel Palo, Julie Visperas, Amer Asiri, Ali Beshabshi, Fahad Al-Hameed, Ohoud Al Orabi, Yaseen Arabi, Eman Al Qasim, Masood Iqbal, Tharwat Aisa, Mohammed Saeed Al Shahrani, Laila Asonto, Ayman Kharaba, Abdullah al Mutairi, Khaild Al Ghamdi, Lama Hefni, Ahmad Al Qurashi, Galeb Al Makhlafi, Roshni Sadashiv Gokhale, Noelle Lim, Manjit Pawar, Venkatesan Kumaresh, Naville Chia Chi Hock, Tan Chee Keat, Tan Rou An, Jared De Souza, Andrew Li, Yip Hwee Seng, Jason Phua, Addy Tan YH, Melvin Tay Chee Kiang, Ng Shin Yi, Ho Vui Kian, Kiran Sharma, Sennen Lew, Lee Rui Min, Do Wan Kim, Yoon Mi Shin, Song-I. Lee, Kyung Chan Kim, Yun-Seong Kang, Soo Hwan Lee, Ho Cheol Kim, Yun Su Sim, Sunghoon Park, Tai Sun Park, Hongyeul Lee, Youjin Chang, Heung Bum Lee, Je Hyeong Kim, Young Seok Lee, Won Gun Kwack, In Byung Kim, Tae Yun Park, Young Jae Cho, Sang-Min Lee, Kyeongman Jeon, Jongmin Lee, Shin Young Kim, Jin-Won Huh, Jong Joon Ahn, Jae Hwa Cho, Won-Yeon Lee, Chin-Kuo Lin, Chang-Ke Chu, Jiun-Ting Wu, Chiung-Yu Lin, Yu-Mu Chen, Kuo-Tung Huang, Han-Chung Hu, Cong-tat Cia, Jung-Yien Chien, Chun-Te Huang, Pin-Kuei Fu, Nattachai Srisawas, Manasnun Kongwibulwut, Kaweesak Chittawatanarat, Worapot Daewtrakulchai, Anakapong Phunmanee, Anupol Panitchote, Boonsong Patjanasoontorn, Chaiwut Sawawiboon, Lê Minh Trung, Đỗ Ngọc Sơn, B. S. Bùi Nhật Hà, Dương Thiện Phước, Huỳnh Quang Đại, Nguyễn Tấn Hùng, Lê Thị Phương Thúy, Hoàng Bùi Hải, Hoàng Trọng Ái Quốc, Trần Hoài Linh, Vũ Hải Yến, Phạm Trà Giang, Nguyễn Thị Ngà, Nguyễn Đăng Tuân

Intubate patients with sepsis before midnight or do it when the time comes?

Tài Pham, Miklos Lipcsey

Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study

  • Open Access
  • Research

Vorakamol Phoophiboon, Antenor Rodrigues, Fernando Vieira, Matthew Ko, Fabiana Madotto, Annia Schreiber, Nannan Sun, Mayson L. A. Sousa, Mattia Docci, Clement Brault, Luca S. Menga, Irene Telias, Thomas Piraino, Ewan C. Goligher, Laurent Brochard

Response to: “Inhalation NO in the HFNC group may result in a meaningless extension of survival time”

  • Open Access
  • Matters Arising

Shahin Isha, Pablo Moreno Franco, Devang K. Sanghavi

A tip for assessing blood flow in distal perfusion catheter during veno-arterial extracorporeal membrane oxygenation

  • Open Access
  • Comment

Xiaoyang Zhou, Bixin Chen, Caibao Hu

Correction: Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation

  • Open Access
  • Correction

Jason H. T. Bates, David W. Kaczka, Michaela Kollisch‑Singule, Gary F. Nieman, Donald P. Gaver

Efficacy of delivery of care with Tele-continuous EEG in critically ill patients: a multicenter randomized controlled trial (Tele-cRCT study) study

Chusak Limotai, Suda Jirasakuldej, Sattawut Wongwiangiunt, Tipakorn Tumnark, Piradee Suwanpakdee, Kwuanrat Wangponpattanasiri, Piyanuch Rakchue, Chaiwiwat Tungkasereerak, Polchai Pleumpanupatand, Phopsuk Tansuhaj, Phattarawin Ekkachon, Songchai Kittipanprayoon, Apiwoot Kerddonfag, Thippamas Pobsuk, Anuchate Pattanateepapon, Kammant Phanthumchinda, Nijasri C. Suwanwela, Iyavut Thaipisuttikul, Kanokwan Boonyapisit, Atiporn Ingsathit, Oraluck Pattanaprateep, John Attia, Gareth J. McKay, Andrea O. Rossetti, Ammarin Thakkinstian, Chutima Rukrung, Patcharapun Kangsananont, Jeerawan Mokkaew, Nittaya Phayaph, Supak Pukpraman, Warangkana Ritrhathon, Youwarat Jarungjitapinan, Jintana Pinpradab, Netphit Khamhoi, Mayuree Nookaew, Patchareeporn Chauywang, Pichai Rojdmapitayakorn, Paworamon Sribussara, Wasunon Tinroongroj, Wisan Teeratantikanon, Tabtim Chongsuvivatwong, Watchara Viratyaporn, Witoon Jantararotai, Komkrit Panyawattanakit, Nopparat Rujirarongrueng, Pornnapat Damthong, Pattama Udom, Molvipa Siengsuwan, Phatcharamai Phonprasori, Karnpidcha Wanmuang, Nattawut Unwanatham, Sasivimol Rattanasiri, Kunlawat Thadanipon, Panutchaya Noivong, Sirincha Pitipanyakul, Watchara Rattanachaisit, Wichuta Muangthong, Rachasiri Wittayawisawasakul, Sunisa Deerassamee, Wannaporn Ruayruen, Supinya Homgrunjarut, Sunisa Deerassamee, Yupapron Ledprased, Maturos Pankong, Pentip Rattanayuvakorn

RECCAS, REMOVE, and SIRAKI02: discrepant outcomes and a potential explanation

Patrick M. Honore, Sydney Blackman, Min-Min Wang

Development and external validation of a machine learning model for brain injury in pediatric patients on extracorporeal membrane oxygenation

  • Open Access
  • ECMO
  • Research

Bixin Deng, Zhe Zhao, Tiechao Ruan, Ruixi Zhou, Chang’e Liu, Qiuping Li, Wenzhe Cheng, Jie Wang, Feng Wang, Haixiu Xie, Chenglong Li, Zhongtao Du, Wenting Lu, Xiaohong Li, Junjie Ying, Tao Xiong, Xiaotong Hou, Xiaoyang Hong, Dezhi Mu

Changes in pulse pressure variation induced by passive leg raising test to predict preload responsiveness in mechanically ventilated patients with low tidal volume in ICU: a systematic review and meta-analysis

  • Open Access
  • Review

Jihad Mallat, Matthew T. Siuba, Osama Abou-Arab, Pedja Kovacevic, Khaled Ismail, Abhijit Duggal, Pierre-Grégoire Guinot

Double cycling with breath-stacking during partial support ventilation in ARDS: Just a feature of natural variability?

  • Open Access
  • Brief Report

Roberto Brito, Caio C. A. Morais, Daniel H. Arellano, Abraham I. J. Gajardo, Alejandro Bruhn, Laurent J. Brochard, Marcelo B. P. Amato, Rodrigo A. Cornejo

Revisiting the oxygen reactivity index in traumatic brain injury: the complementary value of combined focal and global autoregulation monitoring

Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Ihsane Olakorede, Xuhang Chen, Adel Helmy, Andrea Lavinio, Peter J. Hutchinson, Peter Smielewski

A phase 2 randomized, placebo-controlled trial of inulin for the prevention of gut pathogen colonization and infection among patients admitted to the intensive care unit for sepsis

Heekuk Park, Elissa Lynch, Alice Tillman, Kristen Lewis, Zhezhen Jin, Anne-Catrin Uhlemann, Julian A. Abrams, Daniel E. Freedberg

Understanding and addressing a ‘difficult’ family in ICU

Victoria Metaxa, Flavio E. Nacul, Anna Conway Morris

Creatinine production rate is an integrative indicator to monitor muscle status in critically ill patients

  • Open Access
  • Research

Natsuhiro Yamamoto, Kentaro Tojo, Takahiro Mihara, Rae Maeda, Yuki Sugiura, Takahisa Goto

Clinical features and factors associated with outcomes of antibody-negative autoimmune encephalitis in patients requiring intensive care

Zhiyi Li, Xiaofeng He, Dongrui Li, Ruixia Yuan, Yifei Zhai, Junfang Teng, Wenjing Deng

Spectral edge frequency and dilation pupillary velocity in critically ill patients: a pilot study

  • Open Access
  • Correspondence

Mario Zaccarelli, Martina Polato, Fabio Silvio Taccone

Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity

Mohammad M. Banoei, James Hutchison, William Panenka, Andy Wong, David S. Wishart, Brent W. Winston, Cheryl Wellington, Noah D. Silverberg, Sanjay Murthy, Keith Walley, Quynh Doan, Ivan Torres, Prescilla Carrion, Suzanne Vercauteren, Angela Aquino, Keith Yeates, Michael Esser, Karen M. Barlow, Josee Wong, Anne-Marie Guerguerian, Adrienne Davis, Robin Green, Anne Wheeler, Katia Sinopoli, Shannon Scratch, Angela Colantonio, Lili-Naz Hazrati, E. Wilson, Arash Khosroawshahi, Grace Zhang, Leanne Fernandes, K. Hutchison, Jacque Lacroix, Catherine Farrell, Laurence Ducharme-Crevier, Miriam Beauchamp, M.-E. French, David Clarke, Lorelei Audas, Kathleen A. Martin, Lynne Fenerty, Patricia Liaw, Alexis Turgeon

Individualized PEEP titration by lung compliance during one-lung ventilation: a meta-analysis

Wan-Jie Gu, Feng-Zhi Zhao, Federico Piccioni, Rui Shi, Xiang Si, Shuo Chen, Maurizio Cecconi, Hai-Yan Yin

Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study

Nannan Sun, Clement Brault, Antenor Rodrigues, Matthew Ko, Fernando Vieira, Vorakamol Phoophiboon, Michel Slama, Lu Chen, Laurent Brochard

Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis

Shijie Cai, Xiao Li, Chen Zhang, Yuqian Jiang, Yonghui Liu, Zhi He, Shuo Ma, Yuming Yao, Chun-Kwok Wong, Guoqiu Wu, Xun Gao

Cardiovascular effects of lactate in healthy adults

Kristoffer Berg-Hansen, Nigopan Gopalasingam, Mette Glavind Bülow Pedersen, Jakob Tobias Nyvad, Nikolaj Rittig, Esben Søndergaard, Henrik Wiggers, Niels Møller, Roni Nielsen

Correction to: Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry)

  • Open Access
  • Correction

Youn‑Jung Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Byung Kook Lee, Won Young Kim

Incidence of hospital-acquired infections due to carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa in critically ill patients in Italy: a multicentre prospective cohort study

Gennaro De Pascale, Andrea Cortegiani, Matteo Rinaldi, Massimo Antonelli, Sergio Cattaneo, Maurizio Cecconi, Raffaele Cuffaro, Lidia Dalfino, Filomena Di Biase, Abele Donati, Francesca Romana Fasano, Teresa Fasciana, Giuseppe Foti, Antonella Frattari, Roberto Fumagalli, Massimo Girardis, Leonardo Gottin, Alessia Mattei, Marta Milazzo, Giorgia Montrucchio, Daniela Pasero, Fabio Picciafuochi, Emanuela Sensi, Giuseppe Servillo, Maria Alejandra Vidal Pereira, Teresa Spanu, Pierluigi Viale, Salvatore Lucio Cutuli, Eloisa Sofia Tanzarella, Simone Carelli, Luca Montini, Antonino Giarratano, Romina Aceto, Erminia Casari, Luca Brazzi, Antonio Curtoni, Lucia Serio, Filippo Ferrari, Vincenzo Savini, Matteo Taiana, Annarita Mazzariol, Simone Ambretti, Grazia Merola, Linda Degl’Innocenti, Renato Ricciardi, Giovanni Gherardi, Fernando Arnaiz Guerrero, Chiara Vismara, Elena Vittorielli, Erika Casarotta, Maria Vargas, Roberto Rona, Annalisa Cavallero, Angela Muroni, Salvatore Rubino, Bruno Viaggi, Tommaso Giani, Mariachiara Ippolito, Beatrice Tiri, Stefano Cappanera, Alessandro Mariottini, Monica Stufano, Adriana Mosca, Giacomo Monti, Fabio Buffoli

The role of phospholipid transfer protein in sepsis-associated acute kidney injury

Wei Jiang, Lin Song, Weilei Gong, Xianghui Li, Keran Shi, Luanluan Li, Chuanqing Zhang, Jing Wang, Xiaolan Xu, Haixia Wang, Xiaoyan Wu, Jun Shao, Yang Yu, Jiangquan Yu, Ruiqiang Zheng

In-hospital mortality of patients admitted to the intermediate care unit in hospitals with and without an intensive care unit: a nationwide inpatient database study

  • Open Access
  • Research

Hiroyuki Ohbe, Daisuke Kudo, Yuya Kimura, Hiroki Matsui, Hideo Yasunaga, Shigeki Kushimoto

Forty years on, why are we still publishing extracorporeal carbon dioxide removal feasibility studies?

Matthew E. Cove, Alain Combes, Matthias P. Hilty

Interpretable machine learning model for outcome prediction in patients with aneurysmatic subarachnoid hemorrhage

Masamichi Moriya, Kenji Karako, Shogo Miyazaki, Shin Minakata, Shuhei Satoh, Yoko Abe, Shota Suzuki, Shohei Miyazato, Hikaru Takara

The association of capillary refill time and return of spontaneous circulation during out-of-hospital cardiac arrest: an observational study

Matthias Mueller, Michael Holzer, Heidrun Losert, Daniel Grassmann, Florian Ettl, Mathias Gatterbauer, Ingrid Magnet, Alexander Nuernberger, Calvin Lukas Kienbacher, Georg Gelbenegger, Michael Girsa, Harald Herkner, Mario Krammel

Prehospital lactate analysis in suspected sepsis improves detection of patients with increased mortality risk: an observational study

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Maria Andersson, Karin Fröderberg Schooner, Viktor Karlsson Werther, Thomas Karlsson, Lina De Geer, Daniel B. Wilhelms, Martin Holmbom, Mats Fredrikson, Åse Östholm, Sören Berg, Håkan Hanberger

Network of job demands-resources and depressive symptoms in critical care nurses: a nationwide cross-sectional study

Xuting Li, Yusheng Tian, Jiaxin Yang, Meng Ning, Zengyu Chen, Qiang Yu, Yiting Liu, Chongmei Huang, Yamin Li

Renal replacement therapy in ICU: from conservative to restrictive strategy

Khalil Chaïbi, Didier Dreyfuss, Stéphane Gaudry

Longitudinal analysis of in-hospital cardiac arrest: trends in the incidence, mortality, and long-term survival of a nationwide cohort

  • Open Access
  • Research

Feng-Cheng Chang, Ming-Jer Hsieh, Jih-Kai Yeh, Victor Chien-Chia Wu, Yu-Ting Cheng, An-Hsun Chou, Chia-Pin Lin, Chip‐Jin Ng, Shao-Wei Chen, Chun-Yu Chen

Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis

Simon A. Amacher, Tobias Zimmermann, Pimrapat Gebert, Pascale Grzonka, Sebastian Berger, Martin Lohri, Valentina Tröster, Ketina Arslani, Hamid Merdji, Catherine Gebhard, Sabina Hunziker, Raoul Sutter, Martin Siegemund, Caroline E. Gebhard

The role of programmed cell death in organ dysfunction induced by opportunistic pathogens

Yangyanqiu Wang, Li Weng, Xunyao Wu, Bin Du

Pulmonary pathology in culture-negative sepsis: a potential confounder for sepsis treatment and research

Brett Biebelberg

A few words of caution on blood purification in sepsis

Klaus Stahl, Pedro David Wendel-Garcia, Christian Bode, Sascha David

Sorbents therapies in burn patients with septic shock on continuous kidney replacement therapy: an added value for a selected population

Filippo Mariano, Alberto Mella, Domenico Greco’, Luigi Biancone

Solid-state esophageal pressure sensor for the estimation of pleural pressure: a bench and first-in-human validation study

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  • Research

Julien P. van Oosten, Nico Goedendorp, Amne Mousa, Rutger C. Flink, Rik Schaart, Merel Flinsenberg, Peter Somhorst, Diederik A. M. P. J. Gommers, Leo Heunks, Annemijn H. Jonkman

Early phosphate changes as potential indicator of unreadiness for artificial feeding: a secondary analysis of the EPaNIC RCT

C. Lauwers, L. Langouche, P. J. Wouters, A. Wilmer, G. Van den Berghe, M. P. Casaer, J. Gunst

Effect of early administration of fibrinogen replacement therapy in traumatic haemorrhage: a systematic review and meta-analysis of randomised controlled trials with narrative synthesis of observational studies

Tom Burt, Ashley Guilliam, Elaine Cole, Ross Davenport

Heterogeneity of treatment effect: the case for individualising oxygen therapy in critically ill patients

Daniel S. Martin, Michael P. W. Grocott

Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study

Meina Zou, Di Lu, Zhexin Luo, Ninghao Huang, Wenxiu Wang, Zhenhuang Zhuang, Zimin Song, Wendi Xiao, Tao Huang, Renyu Ding

Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study

Xiao Ran, Tingting Xu, Jieqiong Liu, Shaobing Yang, Fang Luo, Rongxue Wu, Juan Tan, Hang Ruan, Qin Zhang

Enhancing cultural competence and communication in ICU: addressing family conflicts

  • Open Access
  • Matters Arising

Amir Vahedian-Azimi

Hallucinations and disturbed behaviour in the critically ill: incidence, patient characteristics, associations, trajectory, and outcomes

Thomas Niccol, Marcus Young, Natasha E. Holmes, Kartik Kishore, Sobia Amjad, Michele Gaca, Rinaldo Bellomo, Ary Serpa Neto

Consistency between metagenomic next-generation sequencing versus traditional microbiological tests for infective disease: systemic review and meta-analysis

Chengxi Liu, Xiao Song, Jihai Liu, Liang Zong, Tao Xu, Xu Han, Fan Li, Bo Li, Huadong Zhu, Di Shi

Correction: Beta-blockers in refractory hypoxemia on venovenous extracorporeal membrane oxygenation: a double-edged sword

  • Open Access
  • ECMO
  • Correction

Dawid L. Staudacher, Tobias Wengenmayer, Matthieu Schmidt

Relationship between skin microvascular blood flow and capillary refill time in critically ill patients

  • Open Access
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Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Maxime Gasperment, Juliette Bernier, Jean-Luc Baudel, Eduardo Kattan, Eric Maury, Jérémie Joffre, Hafid Ait-Oufella

Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development

Rombout B. E. van Amstel, Emma Rademaker, Jason N. Kennedy, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Niklas Bruse, Dave A. Dongelmans, Matthijs Kox, Alexander P. J. Vlaar, Tom van der Poll, Olaf L. Cremer, Christopher W. Seymour, Lonneke A. van Vught

“The NET effect”: Neutrophil extracellular traps—a potential key component of the dysregulated host immune response in sepsis

Andrew Retter, Mervyn Singer, Djillali Annane

Trendelenburg position is a reasonable alternative to passive leg raising for predicting volume responsiveness in mechanically ventilated patients in the ICU

  • Open Access
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Zhiyong Wang, Jie Zhang, Jing Zhao, Yaxuan Wu, Shiya Zhang, Chengfen Yin, Xinjing Gao, Lei Xu

Enhancing depression risk assessment in critical care nurses: a call for quantitative modeling

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  • Matters Arising

Amir Vahedian-Azimi

Effect of an intensive care unit virtual reality intervention on relatives´ mental health distress: a multicenter, randomized controlled trial

Denzel L. Q. Drop, Johan H. Vlake, Evert-Jan Wils, Jasper Van Bommel, Christian Jung, Denise E. Hilling, O. Joseph Bienvenu, Tim I. M. Korevaar, Anna F. C. Schut, Margo M. C. van Mol, Diederik Gommers, Michel E. van Genderen

Time to positivity as a predictor of catheter-related bacteremia and mortality in adults with Pseudomonas aeruginosa bloodstream infection

Daniel N. Marco, Maria Brey, Sergi Anguera, Cristina Pitart, Ignacio Grafia, Marta Bodro, Jose Antonio Martínez, Ana del Río, Carolina Garcia-Vidal, Abiu Sempere, Celia Cardozo, Pedro Puerta-Alcalde, Mariana Chumbita, Marta Hernández-Meneses, Guillermo Cuervo, Patricia Monzo-Gallo, Miguel Ángel Verdejo, Tommaso Francesco Aiello, Mateu Espasa, Climent Casals-Pascual, Laura Morata, Felipe García, Josep Mensa, Àlex Soriano, Sabina Herrera

Assessment of recruitment from CT to the bedside: challenges and future directions

Stefano Giovanazzi, Domenico Nocera, Giulia Catozzi, Francesca Collino, Massimo Cressoni, Lorenzo Ball, Onnen Moerer, Michael Quintel, Luigi Camporota, Luciano Gattinoni

Potent P2Y12 inhibitors in patients with acute myocardial infarction and cardiogenic shock

Jinhwan Jo, Seung Hun Lee, Hyun Sung Joh, Hyun Kuk Kim, Ju Han Kim, Young Joon Hong, Young Keun Ahn, Myung Ho Jeong, Seung Ho Hur, Doo-Il Kim, Kiyuk Chang, Hun Sik Park, Jang-Whan Bae, Jin-Ok Jeong, Yong Hwan Park, Kyeong Ho Yun, Chang-Hwan Yoon, Yisik Kim, Jin-Yong Hwang, Hyo-Soo Kim, Woochan Kwon, Doosup Shin, Junho Ha, Chang Hoon Kim, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee

Postoperative sepsis and its sequential impact on dementia

Mingyang Sun, Fangfang Li, Yangyang Wang, Mengrong Miao, Zhongyuan Lu, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang

Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study

Chahnez Taleb, Elisa Gouvea Bogossian, Carla Bittencour Rynkowski, Kirsten Møller, Piet Lormans, Manuel Quintana Diaz, Anselmo Caricato, Luigi Zattera, Pedro Kurtz, Geert Meyfroidt, Herve Quintard, Maria Celeste Dias, Angelo Giacomucci, Charlotte Castelain, Russell Chabanne, Pilar Marcos-Neira, Stepani Bendel, Ahmed Subhy Alsheikhly, Mohamed Elbahnasawy, Samuel Gay, Maximilian D’Onofrio, Konstantin A. Popugaev, Nikolaos Markou, Pierre Bouzat, Jean-Louis Vincent, Fabio Silvio Taccone, Marco Antonio Cardoso Ferreira, Rafael Badenes, Christian Baastrup Sondergaard, Kirsten Colpaert, Leticia Petterson, Claudia Díaz, Andrés Saravia, Ahmad Bayrlee, Laura Nedolast, Hussam Elkambergy, Haamid Siddique, Jihad Mallat, Nahla AlJaberi, Samer Shoshan, Ayo Mandi, Bruno De Oliveira, Malligere Prasanna, Rehan Haque, Dnyaneshwar Munde, Sara Chaffee, Fatma Alawadhi, Jamil Dibu, Eija Junttila, Teemu Luoto, Simona Šteblaj, Jacques Creteur, Dominique Durand, Caroline Abbenhuijs, Nancy Itesa Matumikina, Filippo Annoni, Leda Nobile, Miguel Ulloa Bersatti, Igor Yovenko, Alexander Tsarev, Jasperina Dubois, Evy Voets, Luc Janssen, Luigi Zattera, Leire Pedrosa, Berta Monleon Lopez, Ainhoa Serrano, Nekane Romero-García, Xavier Wittebole, Antonio Maria Dell’Anna, Camilla Gelormini, Eleonora Stival, Pilar Marcos Neira, Regina Roig Pineda, Lara Bielsa Berrocal, Maite Misis del Campo, Jorge H. Mejía-Mantilla, Ángela Marulanda, Wojciech Dabrowski, Rune Damgaard Nielsen, Markus Harboe Olsen, Helene Ravnholt Jensen, Ida Møller Larsen, Roberta Tallarico, Umberto Lucangelo, Maria Isabel Gonzalez Perez, Carole Ichai, Karim Asenhoune, Karim Lakhal, Charlotte Fernandez-Canal, Samuel Gay, Marie Lebouc, David Bougon, Etienne Escudier, Michel Sirodot, Albrice Levrat, Alix Courouau, Jacques Duranteau, Aurore Rodrigues, Naima Makouche, Gilles Francony, Olivier Vincent, Perrine Boucheix, Clotilde Schilte, Marie Cecile Fevre, Thomas Mistral, Marion Richard, Samia Salah, Pierluigi Banco, Angelina Pollet, Anais Adolle, Thomas Gargadennec, Patricia Dias, Gwenaelle Desanglois, Alexia Meheut, Pauline Cam, Liese Mebis, Alexandra Hendrickx, Pieter Wouters, Sylvia Van Hulle, Alain D’Hondt, Marjorie Beumier, Marc Burgeois, Olivier Simonet, Frederic Vallot, Pablo Centeno, Matias Anchorena, Ximena Benavente, Nydia Funes, Antonio Barra de Oca, Gabriela Izzo, Charlotte Castelain, Filip Soetens, Mario Arias, Diego Morocho, Manuel Jabaja, Diego Tutillo, Elena Perez Solada, Pilar Justo, Amparo Lopez Gomez, Sara Alcantara, Francisco Chico, Maria Fernanda Garcia, Fabricio Picoita, Stela Velasco Eichler, Gabriela Nonticuri Bianchi, João Pedro Britz, Jaqueline Almeida Pimentel, Mário Sérgio Fernandes, Hedi Gharsallah, Zied Hajjej, Walid Samoud, Oleg Grebenchikov, Valery Likhvantsev, Elena Stroiteleva, Nikolaos Markou, Dimitra Bakali, Dionysia Koutrafouri, Sara Maccherani, Janneke Horn, Arezoo Ahmadi, Lien Decaesteker, Daphne Decruyenaere, Ruth Demeersseman, Yves Devriendt, Karen Embo, Ditty van Duijn, Patricia Ormskerk, Melanie Glasbergen-van Beijeren, Raphael Cinotti, Cassia Righy, Serena Silva, Catherine Vandewaeter, Daniel Lemke, Ata Mahmoodpoor, Aaron Blandino-Ortiz, Mathieu Van der Jagt, Walter Videtta

Physiology and pathophysiology of mucus and mucolytic use in critically ill patients

Thomas Roe, Thomas Talbot, Isis Terrington, Jayant Johal, Ivan Kemp, Kordo Saeed, Elizabeth Webb, Rebecca Cusack, Michael P. W. Grocott, Ahilanandan Dushianthan

Noninvasive multimodal neuromonitoring in patients with post-cardiac arrest brain injury: a survey from China’s intensive care units

Yankang Ren, Xiaoxue Nie, Haiyan Liu, Tao Jiang, Yuan Bian, Feng Xu, Yuguo Chen, Xianfei Ji

Authors’ response to: Relationship between leukopenia and mortality among patients with haematological malignancies

Aleece MacPhail, Michael Bailey, David Pilcher, Zoe McQuilten

Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score

Vladimir L. Cousin, Caroline Caula, Jason Vignot, Raphael Joye, Matthieu Blanc, Clémence Marais, Pierre Tissières

Comparative evaluation and performance of large language models on expert level critical care questions: a benchmark study

Jessica D. Workum, Bas W. S. Volkers, Davy van de Sande, Sumesh Arora, Marco Goeijenbier, Diederik Gommers, Michel E. van Genderen

Death by p-value: the overreliance on p-values in critical care research

Sharad Patel, Adam Green

The acute microbiota injury

Sylvain Diop, Maxime Aparicio, Roman Mounier

Correction to: Retrospective ANalysis of multi-drug resistant Gram-nEgative bacteRia on veno-venous extracorporeal membrane oxygenation. The multicenter RANGER STUDY

  • Open Access
  • ECMO
  • Correction

Annalisa Boscolo, Andrea Bruni, Marco Giani, Eugenio Garofalo, Nicolò Sella, Tommaso Pettenuzzo, Michela Bombino, Matteo Palcani, Emanuele Rezoagli, Matteo Pozzi, Elena Falcioni, Elisa Pistollato, Eugenio Biamonte, Francesco Murgolo, Graziella D’Arrigo, Mercedes Gori, Giovanni Luigi Tripepi, Leonardo Gottin, Federico Longhini, Salvatore Grasso, Paolo Navalesi, Giuseppe Foti

Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis

Abraham I. J. Gajardo, Santiago Ferrière-Steinert, Joaquín Valenzuela Jiménez, Sebastián Heskia Araya, Thomas Kouyoumdjian Carvajal, José Ramos-Rojas, Juan Nicolás Medel

Urinary proteomics in sepsis-associated AKI

Jill Moser, Tamar J. van der Aart, Hjalmar R. Bouma

Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury

Magdalena Kasprowicz, Cyprian Mataczyński, Agnieszka Uryga, Adam I. Pelah, Eric Schmidt, Marek Czosnyka, Agnieszka Kazimierska, Audny Anke, Ronny Beer, Bo-Michael Bellander, Erta Beqiri, Andras Buki, Manuel Cabeleira, Marco Carbonara, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Endre Czeiter, Marek Czosnyka, Bart Depreitere, Ari Ercole, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Ana Kowark, David K. Menon, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Oliver Sakowitz, Peter Smielewski, Nino Stocchetti, Nina Sundstrom, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Andreas Unterberg, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler

Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study

M. C. Delignette, A. Riff, T. Antonini, T. Soustre, M. Bodinier, E. Peronnet, F. Venet, M. Gossez, S. Pantel, J. Y. Mabrut, X. Muller, K. Mohkam, F. Villeret, D. Erard, J. Dumortier, F. Zoulim, L. Heyer, C. Guichon, A. Blet, F. Aubrun, G. Monneret, F. Lebossé

The green ICU: how to interpret green? A multiple perspective approach

  • Open Access
  • Perspective

Elisabeth Smale, Heather Baid, Marko Balan, Forbes McGain, Scott McAlistar, Jan J. de Waele, Jan Carel Diehl, Erik van Raaij, Michel van Genderen, Dick Tibboel, Nicole Hunfeld

An index of the initial blood pressure response to angiotensin II treatment and its association with clinical outcomes in vasodilatory shock

  • Open Access
  • Shock
  • Research

Daniel E. Leisman, Patrick M. Wieruszewski, Laurence W. Busse, Lakhmir S. Chawla, Kathryn A. Hibbert, Damian R. Handisides, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges, Rinaldo Bellomo

Limitations of SpO2 / FiO2-ratio for classification and monitoring of acute respiratory distress syndrome—an observational cohort study

Rolf Erlebach, Una Pale, Tilman Beck, Sasa Markovic, Marko Seric, Sascha David, Emanuela Keller

Gaps in PLTP mechanism research in sepsis-associated acute kidney injury and improvement strategies based on new evidence

Dongrui Liang, Xiaodong Li

Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study

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Erwan d’Aranda, Stéphanie Pons, Jonathan Chelly, Enora Atchade, Laure Bonnet, Chloé Allary, Laure Bonnet, Marie Bruyere, Erwan d’Aranda, Stéphanie Deryckere, Agnès Gendre, Marion Griton, Stéphane Fournier, Mehdi Hafiani, Florence Lallemant, Charlotte Martin, Jean-Claude Pauchard, Stéphanie Pons, Mathieu Schoeffler, Clémentine Taconet, Laurent Zieleskiewicz, Claire Dahyot-Fizelier, Bernard Allaouchiche, Roland Amathieu, Emmanuel Besnier, Fanny Bounes, Belaid Bouhemad, Benjamin Chousterman, Olivier Collange, Claire Dahyot-Fizelier, Vincent Degos, Mathieu Desmard, Inès Lakbar, Yoann Launey, Jordi Miatello, Nicolas Mongardon, Jérôme Morel, Léa Satre Buisson, Pierre Trouiller, Toufik Kamel, Fanny Giannoni, Olivier Collange, Emmanuel Besnier, Mathieu Schoeffler, Nicolas Mayeur, Pierre-Louis Quere, Ludivine Marecal, Cyril Pernod, Cyrille Geay, Pierre Esnault, Raphaël Cinotti, Hélène Beloeil, Marwan Bouras, Raphaël Cinotti, François Depret, Alexandre Godon, Alice Jacquens, Sébastien Kerever, Élodie Lang, Maxime Léger, Aurélien Mazeraud, Ludovic Muret, Vincent Pey, Céline Monard, Amélie Rolle, Stéphanie Sigaut, Magali Cesana, Pierre-Julien Cungi

Assessing fluid responsiveness with central venous oxygen saturation: the complex relationship between oxygenation and perfusion

  • Open Access
  • Comment

Jaume Mesquida

Human judgment error in the intensive care unit: a perspective on bias and noise

I. P. Peringa, E. G. M. Cox, R. Wiersema, I. C. C. van der Horst, R. R. Meijer, J. Koeze

Tocilizumab in treating children with refractory septic shock

En-Pei Lee, Shih-Hsiang Chen, Han-Ping Wu

A narrative review on the future of ARDS: evolving definitions, pathophysiology, and tailored management

Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Mohammad Araydah, Denise Battaglini, Suhib Abushehab, Gustavo A. Cortes-Puentes, Marcus J. Schultz, Patricia R. M. Rocco

Correction: Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure

Alexandre Demoule, Amandine Baptiste, Arnaud W. Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin, Jean-Pierre Frat

Response to “Relationships between dyspnea, oxygenation and prognosis in hypoxemic respiratory failure”

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  • Dyspnea
  • Matters Arising

Alexandre Demoule, Amandine Baptiste, Maxens Decavèle, Lisa Belin, Jean-Pierre Frat

A review of gut failure as a cause and consequence of critical illness

Danielle E. Soranno, Craig M. Coopersmith, Jessica F. Brinkworth, Faith N. F. Factora, Julia H. Muntean, Monty G. Mythen, Jacob Raphael, Andrew D. Shaw, Vidula Vachharajani, Jeannette S. Messer

Volume kinetics in a translational porcine model of stabilized sepsis with fluid accumulation

Son Ly Hong, Hugo Dumargne, Robert G. Hahn, Abdessalem Hammed, Romain Lac, Axel Guilpin, Charlotte Slek, Maxime Gerome, Bernard Allaouchiche, Vanessa Louzier, Auguste Dargent

Effect of trunk upward verticalization on pulmonary vascular resistance in ARDS

Martín H. Benites, Jaime Retamal

Further considerations on the clinical applicability of time to positivity as a prognostic tool for catheter-related pseudomonas aeruginosa bloodstream infections

Yufan Liao, Xinmin Deng, Heng Xiao

Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient

Yongzhen Sun, Jiale Tao, Jinjun Jiang, Shujing Chen

Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients

Adrián García-Concejo, Belén Sánchez-Quirós, Esther Gómez-Sánchez, Laura Sánchez-de Prada, Álvaro Tamayo-Velasco, María Sherezade Tovar-Doncel, Mario Lorenzo, Estefanía Gómez-Pesquera, Rodrigo Poves-Álvarez, David Bernardo, Marta Martín-Fernández, Hugo Gonzalo-Benito, Paula Moreno-Portales, Rosa Prieto-Utrera, Miguel Bardají-Carrillo, Rocío López-Herrero, María Fernández Arranz, Rosario Calaveras-Fernández, Fé Tomillo-Cebrián, Teresa Aydillo, María Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez, Salvador Resino, María Heredia-Rodríguez, Pedro Martínez-Paz, Eduardo Tamayo

An international observational study validating gene-expression sepsis immune subgroups

David B. Antcliffe, Estelle Peronnet, Frédéric Pène, Kristoffer Strålin, David Brealey, Sophie Blein, Richard Cleaver, Maria Cronhjort, Jean-Luc Diehl, Guillaume Voiriot, Aurore Fleurie, Claudia Lannsjö, Anne-Claire Lukaszewicz, Johan Mårtensson, Tài Pham, Nicolas De Prost, Jean-Damien Ricard, Mervyn Singer, Gabriel Terraz, Jean-François Timsit, Christian Unge, Antoine Vieillard-Baron, Rebecka Rubenson Wahlin, Jean-François Llitjos, Anthony C. Gordon

Alterations in the lipid profile of critically ill children in relation to outcome

Lauren De Bruyn, Sarah Vander Perre, Sascha Verbruggen, Koen Joosten, Greet Van den Berghe, Lies Langouche

Development and validation of intracranial hypertension prediction models based on radiomic features in patients with traumatic brain injury: an exploratory study based on CENTER-TBI data

Yingchi Shan, Yajun Xue, Jun Zhu, Thijs Vande Vyvere, Dana Pisică, Andrew Maas, Shuo Zhang, Guoyi Gao

Machine learning models compared with current clinical indices to predict the outcome of high flow nasal cannula therapy in acute hypoxemic respiratory failure

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Hang Yu, Sina Saffaran, Roberto Tonelli, John G. Laffey, Antonio M. Esquinas, Lucas Martins de Lima, Letícia Kawano-Dourado, Israel S. Maia, Alexandre Biasi Cavalcanti, Enrico Clini, Declan G. Bates

Standardizing persistent and chronic critical illness: impact of definitions variability on prevalence and mortality

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  • Matters Arising

Toshinobu Nakai, Yuki Kotani, Yoshiro Hayashi

Sodium azide (NaN3) intoxication, “the man who lived”: potential effective antidote and treatment strategy

Jasper X. Geerdink, Greetje van der Wal, Lutea A. A. de Jong, Erik J. H. Olyslager, Thomas W. van den Goorbergh, Leo A. J. Kluijtmans, Peter E. Spronk

Correction: An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity

  • Open Access
  • Correction

Yuki Kotani, Annamaria Di Gioia, Giovanni Landoni, Alessandro Belletti, Ashish K. Khanna

Being an observer of one’s own life—a meta-synthesis on the experience of mechanically ventilated patients in intensive care units

  • Open Access
  • Review

Fritz Sterr, Mareike Hechinger, Lydia Bauernfeind, Christian Rester, Rebecca Palm, Sabine Metzing

Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations

Dag Seldén, Nicolas Tardif, Jan Wernerman, Olav Rooyackers, Åke Norberg

Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury

Mayson L. A. Sousa, Luca S. Menga, Annia Schreiber, Mattia Docci, Fernando Vieira, Bhushan H. Katira, Mariangela Pellegrini, Sebastian Dubo, Ghislaine Douflé, Eduardo L. V. Costa, Martin Post, Marcelo B. P. Amato, Laurent Brochard

Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial

Yun-Xiao Bai, Hui-Liang Wu, Wan-Li Xie, Xia Li, Jing-Jing Han, Jie Liu, Shi-Qiang Chen, Ping Yin, Nian-Guo Dong, Qing-Ping Wu

The promise of transcranial focused ultrasound in disorders of consciousness: a narrative review

Dongdong Yang, Shengqi Fu, Meng Zhao, Yu Shi

Advancements in imaging techniques for monitoring the respiratory muscles

Martin Dres, Jonne Doorduin, Samia Boussouar, Damien Bachasson

Short and long-term complications of prehospital arterial catheterisation performed by a Helicopter Emergency Medical Service in the United Kingdom

  • Open Access
  • Correspondence

Edwin Li Ping Wah-Pun Sin, Owen Hibberd, James Price, Kate Lachowycz, Rob Major, Paul Rees, Ed Barnard

Characteristics, outcomes, and complications among nonagenarian and centenarian patients admitted to the intensive care unit: a scoping review

  • Open Access
  • Review

Je Min Suh, Nattaya Raykageeraroj, Boris Waldman, Nuanprae Kitisin, Cilla Haywood, Rinaldo Bellomo, Anoop N. Koshy, David Pilcher, Dong-Kyu Lee, Laurence Weinberg

Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock

Oskar Kjærgaard Hørsdal, Mark Stoltenberg Ellegaard, Alexander Møller Larsen, Halvor Guldbrandsen, Niels Moeslund, Jacob Eifer Møller, Ole Kristian Lerche Helgestad, Hanne Berg Ravn, Henrik Wiggers, Roni Nielsen, Nigopan Gopalasingam, Kristoffer Berg-Hansen

Impact of comorbidities on management and outcomes of patients weaning from invasive mechanical ventilation: insights from the WEAN SAFE study

  • Open Access
  • Research

Omid Khazaei, Caoimhe M. Laffey, Rionach Sheerin, Bairbre A. McNicholas, Tài Pham, Leo Heunks, Giacomo Bellani, Laurent Brochard, Andrew J. Simpkin, John G. Laffey

Social media insights on sepsis management using advanced natural language processing techniques

Ravi Shankar, Amartya Mukhopadhyay

Subphenotyping prone position responders with machine learning

Maxime Fosset, Dario von Wedel, Simone Redaelli, Daniel Talmor, Nicolas Molinari, Julie Josse, Elias N. Baedorf-Kassis, Maximilian S. Schaefer, Boris Jung

Streamlining data recording through optical character recognition: a prospective multi-center study in intensive care units

  • Open Access
  • ECMO
  • Research

Prompak Nitayavardhana, Keibun Liu, Kiyomitsu Fukaguchi, Mineto Fujisawa, Itaru Koike, Aina Tominaga, Yuta Iwamoto, Tadahiro Goto, Jacky Y. Suen, John F. Fraser, Pauline Yeung Ng

The sicker the patient, the higher the mortality

Hendrik Wietse Zijlstra, Wilhelmina Aria Christina Koekkoek, Esther Karlijn Haspels

ICU mortality of post-myocardial infarction ventricular septal defect complicated by cardiogenic shock: a retrospective multicentric cohort

Levi-Dan Azoulay, François Bagate, Clément Delmas, Sylvie Paulus, Nicolas Mongardon, Osama Abou-Arab, Pierre Squara, Michel Habis, Hélène Nougue, Tristan Morichau-Beauchant, Antoine Kimmoun, Aurélien Seemann, Costin Radu, Quentin de Roux, Henri Treille de Grandsaigne, Jean-Luc Fellahi, Christophe Beyls, Bernard Cholley, Thomas Klein, Antoine Gaillet, Armand Mekontso Dessap, Paul Masi, Thierry Folliguet, Eric Bergoend, Antonio Fiore, Romain Gallet, Madjid Boukantar, Stéphane Aubert, Claude Vaislic, Laurent Guesnier, Bruno Pouzet, Christophe Kucharski, Gabriel Ghorayeb, Wassim Khoury, Philippe Maribas, Hervé Michon, Hakim Haouache, Bertrand Marcheix, Fanny Vardon-Bounes, Paul Achouh, Bastien Poitier, Jérôme Fichet, Stéphane Thierry, Fabrice Daviaud, Jean-Michel Maillet, Julien Nahum, Mathieu Godement, Nicolas Bonnet, Patrick Mesnildrey, Thibault Schoell, Thierry Caus, Léa Didier, Delphine Chesnel

Early exercise therapy in patients with severe traumatic spinal cord injury: is it feasible in the ICU?

Antoine Dionne, David Magnuson, Andréane Richard-Denis, Yvan Petit, Dorothy Barthélémy, Francis Bernard, Jean-Marc Mac-Thiong

Questioning the classification of “high blood flow” versus “low blood flow” ECCO₂R in ultra-low tidal volume ventilation studies: a call for functional classification

Minmin Wang, Qiang Yao, Mingli Zhu

Cardiovascular effects of lactate in healthy adults: D-lactate, the forgotten enantiomer

Neven Stevic, Laurent Argaud, Martin Cour

Rethinking caution: a critical appraisal of extracorporeal blood purification in sepsis

Gabriella Bottari, V. Marco Ranieri, Can Ince, Antonio Pesenti, Filippo Aucella, Anna Maria Scandroglio, Claudio Ronco, Jean-Louis Vincent

Intraosseous versus intravenous vascular access in out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials

Sanam Alilou, Ari Moskowitz, Sina Rashedi

Clinical outcomes and peripheral tissue oxygen saturation monitoring of the knee region by near-infrared spectroscopy in circulatory shock: a prospective observational cohort study

  • Open Access
  • Shock
  • Research

Elina Varis, Maria Heliste, Johanna Hästbacka, Suvi T. Vaara, Markus B. Skrifvars, Ville Pettilä, Mitja Lääperi, Anne Kuitunen, Annukka Vahtera, Erika Wilkman

Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses

Shu-Li Cheng, Tien-Wei Hsu, Yu-Chen Kao, Chia-Ling Yu, Trevor Thompson, Andre F. Carvalho, Brendon Stubbs, Ping-Tao Tseng, Chih-Wei Hsu, Fu-Chi Yang, Yu-Kang Tu, Chih-Sung Liang

The mechanism of PLTP on sepsis-associated acute kidney injury: some hints

Lin Song, Wei Jiang, Yang Yu, Jiangquan Yu, Ruiqiang Zheng

Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions

Tomonori Takeuchi, Alexander H. Flannery, Lucas J. Liu, Lama Ghazi, Augusto Cama-Olivares, Kiyohide Fushimi, Jin Chen, Sarah C. Huen, Ashita J. Tolwani, Javier A. Neyra

The novel biomarker t6A accurately identified septic patients at admission but failed to predict outcome

Marcin F. Osuchowski, Barbara Adamik, Waldemar Gozdzik, Tomasz Skalec, Daniel Mascher, Heinz Redl, Johannes Zipperle, Gerhard Fritsch, Wolfgang Voelckel, Martin S. Winkler, Onnen Moerer, Helmut Schütz, Hermann Mascher

Ventilation-induced acute kidney injury in acute respiratory failure: Do PEEP levels matter?

Martín H. Benites, Fernando Suarez-Sipmann, Eduardo Kattan, Pablo Cruces, Jaime Retamal

Influence of SARS-CoV-2 variants and corticosteroid use on the effectiveness of baricitinib therapy in critical COVID-19

Seung-Hun You, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim

Detection of hypovolemia by non-invasive hemodynamic monitoring during major surgery using Ringer´s solution, 5% albumin, or 20% albumin as infusion fluid: a post-hoc analysis of a randomized clinical trial

  • Open Access
  • Research

François Jardot, Robert G. Hahn, Markus Huber, Patrick Y. Wuethrich

Influence of alcohol on in-hospital survival rate among patients with traumatic brain injury: a nationwide cohort study

Kazuma Sasaki, Takashi Tagami, Hirofumi Obinata, Chie Tanaka, Kosuke Otake, Yudai Yoshino, Akihiro Watanabe, Ami Shibata, Kentaro Kuwamoto, Junichi Inoue, Shoji Yokobori

Elevated serum pre-arrest cathepsin D concentrations are associated with higher mortality in in-hospital cardiac arrest

Taline Lazzarin, Paula Schmidt Azevedo, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, Filipe Welson Leal Pereira, Raquel Simões Ballarin, Marcos Ferreira Minicucci

Bayesian methods as a complementary tool: balancing innovation and rigor in critical care research

  • Open Access
  • Matters Arising

Sen Lu, Kai Liu, Xin-yun Chen, Jing-chao Luo

Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury

Bengi S. Tavris, Christian Morath, Christoph Rupp, Roman Szudarek, Florian Uhle, Timothy E. Sweeney, Oliver Liesenfeld, Mascha O. Fiedler-Kalenka, Simon Dubler, Martin Zeier, Felix C. F. Schmitt, Markus A. Weigand, Thorsten Brenner, Christian Nusshag

Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds

Bruno Levy, Anais Curtiaud, Kevin Duarte, Clément Delmas, Julien Demiselle, Nicolas Girerd, Caroline Eva Gebhard, Julie Helms, Ferhat Meziani, Antoine Kimmoun, Hamid Merdji

Adjuvant therapies for management of hemorrhagic shock: a narrative review

  • Open Access
  • Shock
  • Review

Yann Daniel, Frédérique Dufour-Gaume, Amandine Vergnaud, Manon Denis, Louise Giaume, Bertrand Rozec, Nicolas Prat, Benjamin Lauzier

Unlocking the potential of high-resolution multimodality neuromonitoring for traumatic brain injury management: lessons and insights from cases, events, and patterns

Stefan Yu Bögli, Erta Beqiri, Ihsane Olakorede, Marina Sandra Cherchi, Claudia Ann Smith, Xuhang Chen, Guido Di Tommaso, Tommaso Rochat, Masumi Tanaka Gutiez, Giada Cucciolini, Virginia Motroni, Adel Helmy, Peter Hutchinson, Andrea Lavinio, Virginia F. J. Newcombe, Peter Smielewski

Incidence and risk factors of weaning-induced pulmonary oedema: results from a multicentre, observational study

Rui Shi, Soufia Ayed, Marion Beuzelin, Romain Persichini, Marie Legouge, Nello D. E. Vita, Bruno Levy, Alexandra Beurton, Kishore Mangal, Thomas Hullin, Vincent Labbe, Max Guillot, Anatole Harrois, Maurizio Cecconi, Nadia Anguel, David Osman, Francesca Moretto, Christopher Lai, Tài Pham, Jean-Louis Teboul, Xavier Monnet

Structural and functional alteration of the gut microbiomes in ICU staff: a cross-sectional analysis

  • Open Access
  • Research

Bing Xie, Chenyang Dong, Xin Zhao, Lianlian Qu, Yongling Lv, Hong Liu, Jiaxin Xu, Zhizhong Yu, Hexiao Shen, You Shang, Xing Zhao, Jiancheng Zhang

Presence of psychologists in the French intensive care units: a gap between requirements and practice

  • Open Access
  • Correspondence

Emilie Marty-Petit, Emilie Aebischer, Cathy Gonzales, Jean-Philippe Rigaud, Gaelle Freitas-Terzi, Anne Renault, Charlotte Garret, Anne-Françoise Rousseau, Guillaume Thiéry

Further considerations on the clinical applicability of time to positivity as a prognostic tool for catheter-related Pseudomonas aeruginosa bloodstream infections

Daniel N. Marco, Àlex Soriano, Sabina Herrera

The role of the Corsano CardioWatch in continuous vital sign monitoring for early sepsis detection

Sven-Olaf Kuhn, Sebastian Gibb, Matthias Gründling

Response to comments from Dr Vahedian-Azim related to our recent article Understanding and addressing a ‘difficult’ family in ICU

Victoria Metaxa, Flavio E. Nacul, Anna Conway Morris

Prognosis of liver abscess in the intensive care unit (POLAIR), a multicentre observational study

Marie Le Goff, Frédéric Martino, Geoffrey Rossi, Aurélia Toussaint, Elsa Moncomble, Danielle Reuter, Charlotte Garret, Maxence Decavèle, Megan Fraissé, Antoine Herault, Laurent Argaud, Pierre Garçon, Clément Saccheri, Juliette Meunier, Guillaume Voriot, Cyril Cadoz, Élise Yvin, Virginie Laurent, Laure Calvet, Etienne de Montmollin, Julien Schmidt, Nahema Issa, Maxime Leclerc, Vincent Das, Virginie Lemiale, Éric Mariotte

Monitoring patients with acute respiratory failure during non-invasive respiratory support to minimize harm and identify treatment failure

  • Open Access
  • Review

Joaquín Perez, Luciano Brandan, Irene Telias

A randomized controlled trial of catheters with different tips and lengths for patients requiring continuous renal replacement therapy in intensive care unit

  • Open Access
  • Research

Zhifeng Zhou, Chen Liu, Peiyun Li, Yingying Yang, Fang Wang, Qing Xu, Lu Jin, Ling Zhang, Ping Fu

Multimodal assessment of favorable neurological outcome using NSE levels and kinetics, EEG and SSEP in comatose patients after cardiac arrest

Aurélie Besnard, Juliette Pelle, Estelle Pruvost-Robieux, Antonin Ginguay, Clara Vigneron, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Sarah Benghanem

Hallucinations in critically ill patients: understanding the unreal

Romain Sonneville

Caution when analyzing zero events in both arms: reanalysis of anaphylaxis risk for gelatin solutions

Hsiang‑Yi Hung, Pei‑Chun Lai, Yen-Ta Huang, Chao-Han Lai

Fluid balance and outcome in cardiac arrest patients admitted to intensive care unit

Marie Renaudier, Jean-Baptiste Lascarrou, Jonathan Chelly, Olivier Lesieur, Jérémy Bourenne, Paul Jaubert, Marine Paul, Grégoire Muller, Pierre Leprovost, Thomas Klein, Mélany Yansli, Cédric Daubin, Matthieu Petit, Nicolas Pichon, Martin Cour, Ghada Sboui, Guillaume Geri, Alain Cariou, Wulfran Bougouin

Exogenous lactate infusion (ELI) in traumatic brain injury: higher dose is better?

Paul Vespa, Stephanie Wolahan, Manuel Buitrago-Blanco, Courtney Real, Jesus Ruiz-Tejeda, David L. McArthur, Jeffrey N. Chiang, Denes Agoston, Thomas C. Glenn

Clinical features and treatments of VEXAS syndrome in critical care: a scoping review

Kasumi Satoh, Yasushi Tsujimoto, Daisuke Kasugai, Kazuki Okura, Sarah Kyuragi Luthe, Takao Ono, Yuki Miyamoto, Tasuku Matsuyama, Manabu Okuyama, Taketo Watase, Hajime Nakae, Tadahiro Goto

Peri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study

Ian Ward A. Maia, Bruno A. M. Pinheiro Besen, Lucas Oliveira J. e Silva, Rafael von Hellmann, Ludhmila Abrahao Hajjar, Benjamin J. Sandefur, Daniel Fontana Pedrollo, Caio Goncalves Nogueira, Natalia Mansur P. Figueiredo, Carlos Henrique Miranda, Danilo Martins, Thiago Dias Baumgratz, Bruno Bergesch, Diogo Costa, Osmar Colleoni, Juliana Zanettini, Ana Paula Freitas, Nicole Pinheiro Moreira, Patricia Lopes Gaspar, Renato Tambelli, Maria Cristina Costa, Samara Silveira, Wilsterman Correia, Rafael Garcia de Maria, Ubirajara A. Vinholes Filho, Andre P. Weber, Vinicius da Silva Castro, Carlos Fernando D. Dornelles, Barbara S. Tabach, Hélio P. Guimarães, Gabriela Stanzani, Thiago F. Gava, Aidan Mullan, Heraldo P. Souza, Otavio T. Ranzani, Fernanda Bellolio, Julio C. G. Alencar, Victor Paro da Cunha, Julio F. Marchini, Patricia Albuquerque Moura, Fernanda Greco, Yasmine Filippo, Rubens Yoshinori Kai, Guilherme Torres Abi Ramia Chimelli, Juan Valdivia, Edson Luiz Favero Junior, Felipe Rischini, Vitor Amorim de Andrade Câmara, Henrique Bertotto, Victor Borges, Juliano Rathke, Renato Melo, Ariadine Augusta Maiante, Sarah Maciel Silva, Clarisse Moreira Ribeiro de Oliveira, Andressa Pi Rocha Reis, Thamyres de Carvalho Rufato, Gabriella Dias, Victoria Sartor Poloni, Kauê Lima, Hilana Zenly, José Carlos Motta, Gabriel Miranda, Alexandre Freitas, Leonardo Gasperini, Thais Raimondi Sudbrack, Ana Paula Ribeiro, Guilherme Henrique A. do Carmo, Andrea de Vargas Tomelero, Augusto Lengler Konrath, Vitor Cremonese Zanella, Natalia Fuhr, Davi Amaral Cesário Rosa, Isabela Lopes Lima, Luiz Fernando Varela, Isabella Baldino, Andre Zimerman, Julia M. Dorn de Carvalho, Molly M. Jeffery

“High blood flow” versus “low blood flow” ECCO2R: how to classify—author’s reply

  • Open Access
  • Matters Arising

Clément Monet, Audrey De Jong, Samir Jaber

Outcomes and cost-effectiveness of intermediate care units for patients discharged from the intensive care unit: a nationwide retrospective observational study

Saori Ikumi, Kunio Tarasawa, Takuya Shiga, Takahiro Imaizumi, Yu Kaiho, Yudai Iwasaki, Shizuha Yabuki, Yukito Wagatsuma, Eichi Takaya, Kiyohide Fushimi, Yukiko Ito, Kenji Fujimori, Masanori Yamauchi

Health-related quality of life correlates with patient-reported and proxy-reported disability in critical illness survivors: a secondary analysis of the ERIC trial

Elena Ribet Buse, Julius J. Grunow, Claudia D. Spies, Björn Weiss, Nicolas Paul

Effects of rapid chest compression technique on intracranial and cerebral perfusion pressures in acute neurocritical patients: a randomized controlled trial

Ricardo Miguel Rodrigues-Gomes, Ángela Prieto Campo, Rosa Martinez Rolán, Miguel Gelabert-González

Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial

Stefanie Vandervelden, Bente Cortens, Steffen Fieuws, Wilma Eegdeman, Stefano Malinverni, Philippe Vanhove, Koen Monsieurs, Jan Breuls, Ives Hubloue, François Stifkens, Jacques Creteur, Lina Wauters, Didier Desruelles

Letter to the editor regarding “Structural and functional alteration of the gut microbiomes in ICU staff: a cross-sectional analysis”

  • Open Access
  • Matters Arising

Wenxiao Zhang

Diagnostic accuracy of multi-organ point-of-care ultrasound for pulmonary embolism in critically ill patients: a systematic review and meta-analysis

  • Open Access
  • Research

Rafael Hortêncio Melo, Luciana Gioli-Pereira, Igor Dovorake Lourenço, Rogério Da Hora Passos, Adriana Tumba Bernardo, Giovanni Volpicelli

Haloperidol is not the “one drug fits all” solution in the treatment of delirium

Johannes Ehler, Axel Petzold

Prevalence and incidence of cognitive impairment following acute respiratory distress syndrome of any cause: a systematic review and meta-analysis

Robert Pohl, Doreen Wolff, Ebru Özkan, Antonia A. Sprenger, Claudia Hasenpusch, Judith Wesenberg, Emrah Düzel, Christian Apfelbacher

The impact of different rates of sodium reduction on the central nervous system in acute hypernatremia in rabbits

Geng Xue, Hongyu Wu, Ruidong Feng, Ling Ma, Rui Cao, Rongli Yang, Shuo Wu

Cardiovascular effects of lactate in healthy adults: d-lactate, the forgotten enantiomer—authors' reply

Kristoffer Berg-Hansen, Mette Glavind Bülow Pedersen, Nigopan Gopalasingam, Nikolaj Rittig, Esben Søndergaard, Niels Møller, Roni Nielsen

Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression

Nekane Romero-Garcia, Chiara Robba, Berta Monleón, Ana Ruiz-Zarco, Maria Pascual-González, Alberto Ruiz-Pacheco, Felipe Perdomo, Maria Luisa García-Pérez, Ana Mugarra, Laura García, Jose Carbonell, Lavienraj Premraj, Fabio Silvio Taccone, Rafael Badenes

Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives

Wenyu Wu, Wanning Lan, Xin Jiao, Kai Wang, Yawen Deng, Rui Chen, Ruifeng Zeng, Jun Li

Regional barriers in POCUS training

Vasiliki Tsolaki, Maria Theodorakopoulou, Epaminondas Zakynthinos

Elevated antibiotic resistance gene abundance of ICU healthcare workers, a multicentre, cross-sectional study

Lingtong Huang, Kangchen Li, Chen Peng, Silan Gu, Xiaohan Huang, Chunhua Gao, Xindie Ren, Minghui Cheng, Guojun He, Yinghe Xu, Yongpo Jiang, Hongyu Wang, Mingqiang Wang, Peng Shen, Qianqian Wang, Xuwei He, Lin Zhong, Shengfeng Wang, Nan Wang, Gensheng Zhang, Hongliu Cai, Chao Jiang

Procalcitonin levels in septic and nonseptic subjects with AKI and ESKD prior to and during continuous kidney replacement therapy (CKRT)

  • Open Access
  • Research

North Foulon, Sarah M. Haeger, Kayo Okamura, Zhibin He, Bryan D. Park, Isadore M. Budnick, David Madison, Matthew Kennis, Rachel Blaine, Makoto Miyazaki, Diana I. Jalal, Benjamin R. Griffin, Muhammad Aftab, James F. Colbert, Sarah Faubel

Lack of preload responsiveness may determine poor clinical outcomes in mechanically ventilated patients with ARDS

Sebastien Preau, Olivier Pouly, Mehdi Ederkaoui, Arthur Durand, Claire Bourel, Thierry Onimus, Laurine Cadart, Julien Labreuche, Michael Howsam, Raphaël Favory, Alexandre Pierre

An urgent call to publish COVID-19 trials: a systematic search revealed ZERO studies regarding the incidence of thromboembolic events in SARS-CoV-2 Omicron-infected COVID-19 patients

Amon Faske, Stefanie Reis, Tamara Pscheidl, Lena Saal-Bauernschubert, Patrick Meybohm, Stephanie Weibel

Diagnosis of in-hospital mortality using admission CT perfusion in severe traumatic brain injury patients (ACT-TBI study)

Jai Shankar, Susan Alcock, Murdoch Leeies, Marco Ayroso, Sarah Unrau, JaeYeon Park, Benjamin Blackwood, Reva Trivedi, Roman Marin, Muhammed Raja, Namita Sinha, Anurag Trivedi, Marco Essig, Douglas Martin, Robert Grierson, Frederick A. Zeiler

The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis

Michelle Carmen Paulus, Max Melchers, Anouck van Es, Imre Willemijn Kehinde Kouw, Arthur Raymond Hubert van Zanten

SIGH35 and end-expiratory occlusion test for assessing fluid responsiveness in critically ill patients undergoing pressure support ventilation

  • Open Access
  • Research

Antonio Messina, Lorenzo Calabrò, Francesco Benedetto, Aurora Villa, Guia Margherita Matronola, Andrea Brunati, Jean-Louis Teboul, Xavier Monnet, Maurizio Cecconi

Cytomegalovirus reactivation in the lower respiratory tract as an independent risk factor for mortality in critically Ill patients

Joong-Yub Kim, Chan Mi Lee, Yoon Hae Ahn, Hong Yeul Lee, Sang-Min Lee, Hyeon Jae Jo, Pyoeng Gyun Choe, Wan Beom Park, Chang Kyung Kang, Jinwoo Lee, Nam Joong Kim

Erroneous calibration of esophageal pressure in case of airway closure

Mattia Docci, Francois Beloncle, Arnaud Lesimple, Thomas Piraino, Davide Raimondi Cominesi, Andrea Restivo, Mayson L. A. Sousa, Emanuele Rezoagli, Alain Mercat, Jean-Christophe Richard, Laurent Brochard

Depression or anxiety and long-term mortality among adult survivors of intensive care unit: a population-based cohort study

Kyung Hun Yoo, Juncheol Lee, Jaehoon Oh, Nayeon Choi, Tae Ho Lim, Hyunggoo Kang, Byuk Sung Ko, Yongil Cho

Dynamic intra-abdominal organ volume changes in patients with sepsis

Shunsuke Tagami, Tomoki Wada, Ryota Inokuchi, Wataru Gonoi, Kent Doi

Liberal transfusion strategies reduce sepsis risk and improve neurological recovery in acute brain injury: an updated systematic review and meta-analysis

Nguyen Nhan, Quang Tri Ho Vinh, David Downes, Bao Nghi Tran, Ngoc Dan Nguyen Vy, Emmanuel Mark M. Velasco Jr.

Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis

Rui Shi, Rayan Braïk, Xavier Monnet, Wan-Jie Gu, Gustavo Ospina-Tascon, Chairat Permpikul, Maxime Djebbour, Alice Soumare, Vincent Agaleridis, Christopher Lai

Association between plasma catecholamine concentration and mortality in hospitalized adults with COVID-19: a secondary analysis of a multicenter randomized trial

Basmah Safdar, Gary Desir, Bin Zhou, Yanhong Deng, Xiaojia Guo, D. Clark Files, Laurence W. Busse, Matthew Shotwell, Mark C. Chappell, Wesley H. Self, Sean P. Collins, David Hager, Matthew W. Semler, Michael A. Puskarich, Lisa H. Merck, Lokesh K. Venkateshaiah, Jeffrey M. Sturek, Brian R. Tiffany, Michelle S. Harkins, Akram Khan, Kevin W. Gibbs, Ali Javaheri, Nicole M. Iovine, Peter Chen, Adit A. Ginde, Derek J. Vonderhaar, Meghan Morrison Joly, Aaron Barksdale, Mark Chappell

Optimizing colistin dosing in patients undergoing continuous kidney replacement therapy: critical considerations for intensivists

Patrick M. Honore, Emily Perriens, Sydney Blackman, Nathan De Lissnyder, Anaëlle Detournay, Salvatore Lucio Cutuli, Gennaro De Pascale, Filippo Mariano

Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial

François Arrive, Sylvain Le Pape, Alejandro Bruhn, Adrien Pépin Lehalleur, Clément Beuvon, Samuel Tuffet, Erik Etien, Laurent Rambault, Jean-Pierre Frat, Rémi Coudroy, Arnaud W. Thille

Left ventricular unloading during extracorporeal cardiopulmonary resuscitation: a target trial emulation of the ELSO registry

Ryan Ruiyang Ling, Ying Chen, Christopher Jer Wei Low, Cara Agerstrand, Jae-Seung Jung, Shir-Lynn Lim, Roberto Lorusso, Thomas Müeller, Yohei Okada, Joseph E. Tonna, Kiran Shekar, Daniel Brodie, Graeme MacLaren, Kollengode Ramanathan

Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study

Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshinori Ohta, Takuya Kimura, Yukitoshi Toyoda, Michihito Kyo, Tetsuya Sato, Masashi Kinjo, Masaki Takahashi, Junichi Maruyama, Hiroshi Matsuura, Kazunori Fukushima, Satoru Murata, Tomoya Okazaki, Tsuyoshi Suzuki, Toshihiro Sakurai, Gaku Takahashi, Tasuku Hanajima, Takeshi Morimoto

Effect of early adjunctive vasopressin initiation for septic shock patients: a target trial emulation

Kyle C White, Rahul Costa-Pinto, Sebastiaan Blank, Stephen Whebell, Lachlan Quick, Stephen Luke, Antony G Attokaran, Peter Garrett, Mahesh Ramanan, Alexis Tabah, Kiran Shekar, Kevin B Laupland, Aashish Kumar, James McCullough, Andrew Udy, Glenn Eastwood, Rinaldo Bellomo, Anis Chaba, Mahesh Ramanan, Prashanti Marella, Patrick Young, Phillipa McIlroy, Ben Nash, James McCullough, Kerina J. Denny, Mandy Tallott, Andrea Marshall, David Moore, Hayden White, Sunil Sane, Aashish Kumar, Lynette Morrison, Pam Dipplesman, Jennifer Taylor, Stephen Luke, Anni Paasilahti, Ray Asimus, Jennifer Taylor, Kyle White, Jason Meyer, Rod Hurford, Meg Harward, James Walsham, Neeraj Bhadange, Wayne Stevens, Kevin Plumpton, Sainath Raman, Andrew Barlow, Alexis Tabah, Hamish Pollock, Stuart Baker, Kylie Jacobs, Antony G. Attokaran, David Austin, Jacobus Poggenpoel, Josephine Reoch, Kevin Laupland, Felicity Edwards, Tess Evans, Jayesh Dhanani, Marianne Kirrane, Pierre Clement, Nermin Karamujic, Paula Lister, Vikram Masurkar, Lauren Murray, Jane Brailsford, Todd Erbacher, Kiran Shekar, Jayshree Lavana, George Cornmell, Siva Senthuran, Stephen Whebell, Michelle Gatton, Sam Keogh

The influence of electronic AKI alert on prognosis of adult hospitalized patients: a systematic review and meta-analysis

Han Wang, Lingling Deng, Ting Li, Kang Liu, Huijuan Mao, Buyun Wu

Diaphragmatic ultrasound and its relationship to breathing effort and load: a prospective observational study

  • Open Access
  • Research

Apostolos–Alkiviadis Menis, Vasiliki Tsolaki, Maria–Eirini Papadonta, Vasileios Vazgiourakis, Konstantinos Mantzarlis, Epaminondas Zakynthinos, Demosthenes Makris

Predicting in-hospital mortality in severe traumatic brain injury patients using admission CT perfusion

Nila Salimi, Ehsan Alimohammadi

Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort

Vincenzo Russotto, John G. Laffey, Elena Tassistro, Sheila N. Myatra, Emanuele Rezoagli, Giuseppe Foti, Laura Antolini, Maria Grazia Valsecchi, Philippe R. Bauer, Konstanty Szułdrzyński, Luigi Camporota, Robert Greif, Andy Higgs, Matteo Parotto, Roberto Fumagalli, Massimiliano Sorbello, Chiara Robba, Giacomo Grasselli, Giacomo Bellani, Pietro Caironi, Jean Baptiste Lascarrou

Traditional Chinese medicine for sepsis: advancing from evidence to innovative drug discovery

Yun Ji, Hongyun Song, Libin Li

The “mechanical paradox” unveiled: a physiological study

  • Open Access
  • Research

Giorgia Pacchiarini, Tommaso Pettenuzzo, Francesco Zarantonello, Nicolò Sella, Gianluca Lumetti, Annalisa Boscolo, Alessandro De Cassai, Gianmaria Cammarota, Paolo Persona, Paolo Navalesi, Giorgia Pacchiarini, Tommaso Pettenuzzo, Francesco Zarantonello, Nicolò Sella, Gianluca Lumetti, Annalisa Boscolo, Alessandro De Cassai, Gianmaria Cammarota, Paolo Persona, Paolo Navalesi, Francesco Monteleone, Gabriele Martelli, Ilaria Godi, Andrea Ballin, Ivo Tiberio, Arianna Peralta, Luisa Muraro, Enrico Petranzan, Elisa Pistollato

Optimum electrical impedance tomography-based PEEP and recruitment-to-inflation ratio in patients with severe ARDS on venovenous ECMO

  • Open Access
  • ECMO
  • Research

Alexandre Coppens, Sarah Aissi James, Hadrien Roze, Charles Juvin, Benjamin Repusseau, Guillaume Lebreton, Charles-Edouard Luyt, Guillaume Hékimian, Juliette Chommeloux, Marc Pineton de Chambrun, Alain Combes, Guillaume Franchineau, Matthieu Schmidt

Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review

Jiale Xie, Adam Renato Carbonara, Al-Waleed Al-Battashi, Amanda Ross-White, J. Gordon Boyd

The personalized treatment of invasive candidiasis still has a long way to go

Lihui Wang, Chunhui Xu, Yue Chen, Mi Zhou, Runjie Li, Bin Lin, Yuetian Yu

Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure

Daan F. L. Filippini, Michael Jiang, Lina Kramer, Tom van der Poll, Olaf Cremer, Teddy Tun Win Hla, Andrew Retter, Lieuwe D. J. Bos

Identifying a unique signature of sepsis in patients with pre-existing cirrhosis

Anushka Dasgupta, Tiffanie K. Jones, Heather Giannini, Rachel Bennett, Gulus Emre, Caroline A. G. Ittner, Alexandra Turner, Mika Esperanza, Kaitlyn Housel, Todd Miano, Matthew Erlich, Brian J. Anderson, Michael G. S. Shashaty, Nuala J. Meyer, John P. Reilly

Reliability of pre-admission patient-reported outcome measures postoperatively assessed via proxies: a prospective, multicenter observational study

  • Open Access
  • Research

Julius J. Grunow, Leonie Hartmann, Bernhard Ulm, Mathilde Maechler, Manfred Blobner, Katharina Seidenspinner, Lukas Schoennagel, Steffen Weber-Carstens, Kristina Fuest, Tobias Wollersheim, Stefan J. Schaller

Severe listeriosis in intensive care units: insights from a retrospective multicentric study

Antoine Villa, Martin Cour, Nicolas De Prost, Antoine Guillon, Benjamine Sarton, Nicolas Terzi, Kada Klouche, Florence Boissier, Paul Nedelec, Sibylle Cunat, Julien Le Marec, Pierre Godard, Thibault Vieille, Mathieu Jozwiak, Damien Contou, Vincent Castelain, Eliott le Basnier, Marie Lecronier, Frédéric Pène, Simon Bourcier, Fabrice Uhel, David Schnell, Guillaume Dumas, Hafid Ait-Oufella

Labour market attachment before and after hospitalisation for sepsis: a Danish cohort study

Camilla Schade Skov, Mikkel Brabrand, Christian Backer Mogensen, Helene Skjøt-Arkil, Flemming Schønning Rosenvinge, Isik Somuncu Johansen, Annmarie Lassen

Re-evaluating the association between alcohol use and in-hospital survival: the role of collider bias

Tomoko Yasuda, Taisuke Shibata, Atsushi Shiraishi

Biomarkers in acute kidney injury settings to predict interventions and outcomes: the MARKISIO study

Khalil Chaïbi, Adrien Picod, Marouane Boubaya, Sarah Tubiana, Vincent Jullien, Sophie Magreault, Sandrine Placier, Jérémie Mallet, Guillaume Louis, Laurent Martin-Lefevre, Dimitri Titeca-Beauport, Béatrice La Combe, Sébastien Besset, Julio Badie, Guillaume Chevrel, Nicolas Chudeau, Saber Barbar, Christophe Vinsonneau, Jean-Marie Forel, Didier Thevenin, Guillaume Lacave, Saad Nseir, Johanna Oziel, Julien Mayaux, Kada Klouche, Jean Reignier, Jean-Damien Ricard, Jean-Pierre Quenot, Alexandre Mebazaa, Feriel Azibani, Didier Dreyfuss, Stéphane Gaudry

Circular material flow of medication in the intensive care unit

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Jasper Klasen, Silke Rijcks, Diederik Gommers, Jan Carel Diehl, Nicole Hunfeld

Endotoxin hemoadsorption in refractory septic shock with multiorgan dysfunction and extreme endotoxin activity

Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Ivan Bajaña, Adolf Ruiz-Sanmartin, Juliana Bastidas, Carolina Maldonado, Pablo Nicolás-Morales, Sergi Cantenys-Molina, Juan José González, Nieves Larrosa, Ricard Ferrer

Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal

Stefan Yu Bögli, Ihsane Olakorede, Erta Beqiri, Xuhang Chen, Andrea Lavinio, Peter Hutchinson, Peter Smielewski

First dose target attainment with extended infusion regimens of piperacillin and meropenem

Gustaf Beijer, Maria Swartling, Elisabet I. Nielsen, Olof Breuer, Christian G. Giske, Erik Eliasson, Johan Petersson

Detection of cytomegalovirus in the lower respiratory tract among patients with critical illness: uncovering enhanced potential benefits

Zhihui Zhang, Xuesong Liu, Rong Zhang, Dongdong Liu, Chun Yang, Sibei Chen, Yimin Li, Xiaoqing Liu

Application of one-way speaking valves in adult tracheostomy patients: the time should be earlier

Shi-Min Zhang, Yi-qi Qian, Yaxiaerjiang Muhetaer, Min-jie Ju, Kai Liu

Computed tomography perfusion assessment of poor neurological outcome in comatose cardiac arrest patients (CANCCAP): a prospective study

Jai Shankar, Susan Alcock, Evan Wiens, Marco Ayroso, JaeYeon Park, Navjit Singh, Benjamin Blackwood, Reva Trivedi, Roman Marin, Namita Sinha, Anurag Trivedi, Iain Kirkpatrick, Marco Essig, Stephen Schaffer

ORAKLE: Optimal Risk prediction for mAke30 in patients with sepsis associated AKI using deep LEarning

Wonsuk Oh, Marinela Veshtaj, Ashwin Sawant, Pulkit Agrawal, Hernando Gomez, Mayte Suarez-Farinas, John Oropello, Roopa Kohli-Seth, Kianoush Kashani, John A. Kellum, Girish Nadkarni, Ankit Sakhuja

Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review

Qing Xu, Zhifeng Zhou, Lu Jin, Chen Liu, Peiyun Li, Fang Wang, Ling Zhang, Ping Fu

Spontaneous diuresis in combination with furosemide stress test (SD-FST) as predictor for successful liberation from kidney replacement therapy: a prospective observational study

Lorenz Weidhase, Stephanie Wille, Helene Foede, Fanny Gilch, Meinhard Mende, Christina Scharf-Janßen, Sirak Petros, Jonathan de Fallois

Phrenic stimulation decreases brain injury biomarkers in sedated mechanically ventilated patients: preliminary observations

Bassi Thiago, Rohrs Elizabeth, Parfait Melodie, Hannigan Brett, Reynolds Steve, Mayaux Julien, Decavèle Maxens, Demoule Alexandre, Similowski Thomas, Dres Martin

Trajectories of fluid management after the initiation of renal replacement therapy in critically ill patients: a secondary analysis of the STARRT-AKI trial

William Beaubien-Souligny, Ehsan Gamarian, Jean-Maxime Côté, Javier A. Neyra, Frederic Baroz, Neill K. J. Adhikari, Kevin Thorpe, Sean M. Bagshaw, Ron Wald

Cardiovascular effects of hypertonic lactate solutions: acid–base or metabolic cause, or both?

Pedro J. Freire Jorge, Rohan Boer, František Duška, Maarten M. W. Nijsten, Micah L. A. Heldeweg

Accuracy of the modified Global Burden of Disease International Classification of Diseases coding methods for identifying sepsis: a prospective multicentre cohort study

Ashwani Kumar, Bala Venkatesh, Simon Finfer, Anthony Delaney, Kelly Thompson, Paul M. Middleton, Anders Aneman, Kavitha Shetty, Deepak Bhonagiri, Manoj Saxena, Frank M. P. van Haren, Celia Bradford, Graham Reece, Simon Rodda, Candice Mackellar, Francess Bass, Lewis Tsang, Sandra Li, Raymond Kwok, Alexander Buckley, Angela Zou, Swathi Sridharan, David Hu, Mark Iskandar, Sarah Frost, Tori Headington, Giuliana Connor, Anthony Klironomos, Sana Shan, Yang Li, Belinda Anderson, Rebecca Sidoli, Deborah Inskip, Matthew Lam, Garnette Fuller, Christopher Yu, Bridget Sigurdson, Richard McNulty, Maeda Sadeghpour, Laurent Billot, Naomi Hammond

The value of dynamic cerebral compliance monitoring after pediatric traumatic brain injury: a STARSHIP study sub-analysis

Stefan Yu Bögli, Ihsane Olakorede, Claudia Ann Smith, Marek Czosnyka, Peter Hutchinson, Shruti Agrawal, Peter Smielewski, Shruti Agrawal, Peter Smielewski, Peter J. Hutchinson, Stefan Yu Bögli, Claudia A. Smith, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford, Marek Czosnyka, Michal Placek, Manuel Cabaleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Roddy O’DonneII, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Garnett, Hari Krishnan Kanthimathinathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Simona Lampariello, Avishay Sarfatti, Anton Mayer, Oliver Ross

Diagnostic performance of the recruitment-to-inflation ratio to assess lung recruitability by PEEP in ARDS. a computed tomography study

Jean-Christophe Richard, Francois Dhelft, Guillaume Deniel, Emmanuel Roux, Hodane Yonis, Mehdi Mezidi, Louis Chauvelot, Maxime Gaillet, Ines Noirot, Eduardo Davila, Rosalie Schoux, Yorick Rodriguez, Florent Baudin, Ludmilla Penarrubia, Loic Boussel, Maciej Orkisz, Laurent Bitker

Effect of initiation of invasive ventilation in acute hypoxemic respiratory failure using sequential trials: treatment efficacy instead of timing

Carmen A. T. Reep, Leo Heunks, Evert-Jan Wils

Advancing traditional Chinese medicine for sepsis—challenges beyond clinical evidence

Wei Huang, Minmin Wang

Exploring the association between computed tomography (CT)-derived skeletal muscle mass and short- and long-term mortality in critically ill patients: a systematic review and meta-analysis

Valeria A. Bertoni Maluf, François R. Herrmann, Alexandra Platon, Aline Mendes, Yves M. Dupertuis, Aude De Watteville, Claudia P. Heidegger, Laurence Genton

Prevalence, risk factors and consequences of early clinical deterioration under non-invasive ventilation in emergency department patients: a prospective, multicentre, observational study of the French IRU Network

Nicolas Marjanovic, Jérémie Lestienne, Frédéric Balen, Fabien Coisy, Camille Gerlier, Jérémy Guenezan, Olivier Mimoz

Impact of the Japanese clinical practice guidelines for management of sepsis and septic shock (J-SSCG) 2020 on real-world adherence and interhospital variation: a nationwide inpatient database study

Hiroyuki Ohbe, Kazuma Yamakawa, Daisuke Kudo, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Tomoaki Yatabe, Moritoki Egi, Hiroshi Ogura, Osamu Nishida, Shigeki Kushimoto

Performance of broad-spectrum targeted next-generation sequencing in lower respiratory tract infections in ICU patients: a prospective observational study

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Chuanxi Chen, Ruizhi Wang, Bilin Wei, Yili Chen, Dejian Gu, Jiangze Xu, Huifang Zheng, Zimeng Xu, Linfang Ding, Xiaonan Chen, Lihua Xiao, Liping Bai, Zimeng Liu, Yongjun Liu, Minying Chen, Peisong Chen, Xiangdong Guan, Jianfeng Wu

Volatile sedation in critically ill adults undergoing mechanical ventilation: a meta-analysis of randomized controlled trials

Taihei Yamamoto, Yuki Kotani, Koya Akutagawa, Tomohisa Nagayama, Maho Tomimatsu, Mayuko Tonai, Toshiyuki Karumai, Yoshiro Hayashi

The metabolic and autoregulatory profile of reversible delayed cerebral ischemia in unconscious patients after aneurysmal subarachnoid hemorrhage: a prospective multimodal neuromonitoring cohort study

Michael Veldeman, Stefan Yu Bögli, Ihsane Olakorede, Nick Kastenholz, Miriam Weiss, Catharina Conzen-Dilger, Katharina Seyfried, Erta Beqiri, Charlotte Weyland, Hans Clusmann, Gerrit Alexander Schubert, Anke Hoellig, Peter Smielewski

Monro-Kellie 4.0: moving from intracranial pressure to intracranial dynamics

Sérgio Brasil, Gustavo C. Patriota, Daniel Agustín Godoy, Jorge L. Paranhos, Andrés Mariano Rubiano, Wellingson S. Paiva

A large language model improves clinicians’ diagnostic performance in complex critical illness cases

Xintong Wu, Yu Huang, Qing He

Capillary refill time as an additional triage criterion to decide ICU admission of deteriorating obstetric patients

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  • Triage
  • Correspondence

Enrique Monares Zepeda, Sebastian Morales, Marco Antonio Heras Garate, Annanda Márquez, Jesús Carlos Briones Garduño, Ricardo Castro, Gustavo Ospina-Tascón, Glenn Hernández, Eduardo Kattan

Tumour necrosis factor-alpha inhibitors decrease mortality in COVID-19: a systematic review and meta-analysis

Ágoston Jánosi, Blanka Bódy, Rita Nagy, Klementina Ocskay, Tamás Kói, Katalin Müller, Ibolya Túri, Miklós Garami, Péter Hegyi, Andrea Párniczky

To explore the application value of modified puncture path in percutaneous coronary intervention in patients with high-risk myocardial infarction supported by ECMO

  • Open Access
  • ECMO
  • Correspondence

Qinglong Feng, Xianyuan Chen, Jueyue Yan, Zhipeng Xu, Yi Zhang

Prevalence of thromboembolic events in critically-ill COVID-19 patients infected with Omicron: results from the French prospective, multicenter SEVARVIR cohort study

Pierre Bay, Etienne Audureau, Slim Fourati, Nicolas de Prost, Sébastien Préau, Raphaël Favory, Aurélie Guigon, Nicholas Heming, Elyanne Gault, Tài Pham, Amal Chaghouri, Matthieu Turpin, Laurence Morand-Joubert, Sébastien Jochmans, Aurélia Pitsch, Sylvie Meireles, Damien Contou, Amandine Henry, Adrien Joseph, Marie-Laure Chaix, Fabrice Uhel, Damien Roux, Diane Descamps, Malo Emery, Claudio Garcia-Sanchez, David Levy, Sonia Burrel, Julien Mayaux, Antoine Kimmoun, Cédric Hartard, Frédéric Pène, Flore Rozenberg, Stéphane Gaudry, Ségolène Brichler, Antoine Guillon, Lynda Handala, Fabienne Tamion, Alice Moisan, Thomas Daix, Sébastien Hantz, Flora Delamaire, Vincent Thibault, Bertrand Souweine, Cecile Henquell, Lucile Picard, Françoise Botterel, Christophe Rodriguez, Armand Mekontso Dessap, Jean-Michel Pawlotsky, Keyvan Razazi, Raphaël Bellaïche, Elie Azoulay, Jean-François Timsit, Guillaume Voiriot, Nina de Montmollin, Stéphane Marot, Djeneba Bocar Fofana, Charles-Edouard Luyt, Djillali Annane, Ferhat Meziani, Louis-Marie Jandeaux, Samira Fafi-Kremer, Cédric Darreau, Jean Thomin, Anaïs Dartevel, Sylvie Larrat, Evelyne Schvoerer, Cédric Hartard, Béatrice La Combe, Séverine Haouisee, Sami Hraeich, Pierre-Edouard Fournier, Philippe Colson, Emmanuel Canet, Berthe Marie Imbert, Guillaume Thiery, Sylvie Pillet, Rémy Coudroy, Nicolas Leveque, Clément Saccheri, Valérie Giordanengo, Kada Klouche, Edouard Tuaillon, Cécile Aubron, Adissa Tran, Jean-Marc Tadié, Jean-Christophe Plantier, Sophie Vallet

Correction: Peri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study

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  • Correction

Ian Ward A. Maia, Bruno A. M. Pinheiro Besen, Lucas Oliveira J. e Silva, Rafael von Hellmann, Ludhmila Abrahao Hajjar, Benjamin J. Sandefur, Daniel Fontana Pedrollo, Caio Goncalves Nogueira, Natalia Mansur P. Figueiredo, Carlos Henrique Miranda, Danilo Martins, Thiago Dias Baumgratz, Bruno Bergesch, Diogo Costa, Osmar Colleoni, Juliana Zanettini, Ana Paula Freitas, Nicole Pinheiro Moreira, Patricia Lopes Gaspar, Renato Tambelli, Maria Cristina Costa, Samara Silveira, Wilsterman Correia, Rafael Garcia de Maria, Ubirajara A. Vinholes Filho, Andre P. Weber, Vinicius da Silva Castro, Carlos Fernando D. Dornelles, Barbara S. Tabach, Hélio P. Guimarães, Gabriela Stanzani, Thiago F. Gava, Aidan Mullan, Heraldo P. Souza, Otavio T. Ranzani, Fernanda Bellolio, Julio C. G. Alencar, Victor Paro da Cunha, Julio F. Marchini, Patricia Albuquerque Moura, Fernanda Greco, Yasmine Filippo, Rubens Yoshinori Kai, Guilherme Torres Abi Ramia Chimelli, Juan Valdivia, Edson Luiz Favero Junior, Felipe Rischini, Vitor Amorim de Andrade Câmara, Henrique Bertotto, Victor Borges, Juliano Rathke, Renato Melo, Ariadine Augusta Maiante, Sarah Maciel Silva, Clarisse Moreira Ribeiro de Oliveira, Andressa Pi Rocha Reis, Thamyres de Carvalho Rufato, Gabriella Dias, Victoria Sartor Poloni, Kauê Lima, Hilana Zenly, José Carlos Motta, Gabriel Miranda, Alexandre Freitas, Leonardo Gasperini, Thais Raimondi Sudbrack, Ana Paula Ribeiro, Guilherme Henrique A. do Carmo, Andrea de Vargas Tomelero, Augusto Lengler Konrath, Vitor Cremonese Zanella, Natalia Fuhr, Davi Amaral Cesário Rosa, Isabela Lopes Lima, Luiz Fernando Varela, Isabella Baldino, Andre Zimerman, Julia M. Dorn de Carvalho, Molly M. Jeffery

Ciprofol versus propofol sedation in ICU patients and norepinephrine requirements: a single-center prospective cohort study

Zengzhu He, Jingyi Liang, Jiaxin Duan, Li Liu, Yuhang Yan, Zisheng Ma, Yue Ouyang, Houcheng Li, Hongbin Hu, Zhenhua Zeng

From indication to initiation of invasive intracranial pressure monitoring time differences between neurosurgeons and intensive care physicians: can intracranial hypertension dose be reduced? TIMING-ICP, a multicenter, observational, prospective study

Lara Mariani, Stefano Calza, Paolo Gritti, Simone Maria Zerbi, Emanuele Russo, Cristian Deana, Dario Filippi, Chiara Robba, Anselmo Caricato, Paola Fassini, Giacomo Dell’Avanzo, Andrea Viscone, Lucio De Maria, Luca Pisapia, Luigi Vetrugno, Gianluigi Zona, Roberto Stefini, Corrado Iaccarino, Nicola Latronico, Simone Piva, Michele Bertoni, Antonio Biroli, Marco Maria Fontanella, Frank Rasulo

Primer on large language models: an educational overview for intensivists

Daphna Idan, Sharon Einav

Invasive group A streptococcus infections in the intensive care unit: an unsupervised cluster analysis of a multicentric retrospective cohort

Tomas Urbina, Lilith Faucheux, Jean-Rémi Lavillegrand, Julien Massol, Marie Lecronier, Quentin de Roux, Matthieu Turpin, William Menard, Melchior Gautier, Guilene Barnaud, Damien Roux, Charles-Edouard Luyt, Antoine Vieillard-Baron, Guillaume Voiriot, Nicolas Mongardon, Maxens Decavele, Frédéric Pène, Jérémie Joffre, Hafid Ait-Oufella, Nicolas de Prost, Eric Maury

Storage duration of packed red blood cells transfused during veno-venous extracorporeal membrane oxygenation is associated with elevated pulmonary artery pressure and lung injury in a sheep model

Fergal T. Temple, Gabriela Simonova, Margaret R. Passmore, Samuel R. Foley, Sara D. Diab, Kimble R. Dunster, Charles I. McDonald, Kiran Shekar, Yoke-Lin Fung, John-Paul Tung, John F. Fraser

Real-time changes in pulse pressure during a 10-second end-expiratory occlusion test reliably detect preload responsiveness

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Francesco Gavelli, Nello De Vita, Christopher Lai, Danila Azzolina, Arthur Pavot, Mathieu Jozwaik, Rui Shi, Imane Adda, Alexandra Beurton, Jean-Louis Teboul, Xavier Monnet

Central nervous system infections rarely underlie presumed delirium in ICU admissions: insights from the Swiss ICU registry

Pascale Grzonka, Sebastian Berger, Simon A. Amacher, Lisa Hert, Tolga D. Dittrich, Martin Lohri, Paulina SC Kliem, Sabina Hunziker, Sarah Tschudin Sutter, Mark Kaufmann, Caroline E. Gebhard, Raoul Sutter

Setting the record straight: revisiting the debate on extracorporeal therapies in sepsis

Klaus Stahl, Pedro David Wendel Garcia, Christian Bode, Sascha David

Post-extubation dysphagia in the ICU−a narrative review: epidemiology, mechanisms and clinical management (Update 2025)

Daniela Bertschi, Francesco Rotondo, Jan Waskowski, Philipp Venetz, Carmen A. Pfortmueller, Joerg C. Schefold

Methodological considerations regarding cardiac arrest studies in hyperoxemia meta-analysis

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  • Matters Arising

Akihiro Sakai, Junichi Izawa

Optimizing microbiological surveillance during selective digestive decontamination in the intensive care unit: an in silico simulation study

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Jelle L. G. Haitsma Mulier, Fleur J. van Dijk, Valentijn A. Schweitzer, Marc J. M. Bonten, Lennie P. G. Derde, Olaf L. Cremer

Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial

Ameldina Ceric, Josef Dankiewicz, Tobias Cronberg, Joachim Düring, Marion Moseby-Knappe, Martin Annborn, Teresa L. May, Matthew Thomas, Anders Morten Grejs, Christian Rylander, Jan Belohlavek, Pedro Wendel-Garcia, Matthias Haenggi, Claudia Schrag, Matthias P. Hilty, Thomas R. Keeble, Matt P. Wise, Paul Young, Fabio Silvio Taccone, Chiara Robba, Alain Cariou, Glenn Eastwood, Manoj Saxena, Susann Ullén, Gisela Lilja, Janus C. Jakobsen, Anna Lybeck, Niklas Nielsen

Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles

Alexandre Pierre, Raphael Favory, Claire Bourel, Michael Howsam, Raphael Romien, Steve Lancel, Sebastien Preau

Can we reliably use pulse pressure as a surrogate for stroke volume? Physiological background and potential clinical implications for shock resuscitation

  • Open Access
  • Shock
  • Perspective

Zbigniew Putowski, Jean-Louis Teboul, Ricardo Castro, Denis Chemla, Jonatan Oras, Sebastian Morales, Eduardo Kattan, Glenn Hernandez

Bayesian reanalysis reinforces the potential mortality benefit of TNF-α inhibitors in COVID-19: a methodological perspective

Jia-Jin Chen, Pei‑Chun Lai, Yen-Ta Huang

What is the optimal approach to analyse ventilator-free days? A simulation study

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Laurent Renard Triché, Matthieu Jabaudon, Nicolas Molinari, Jean-Marie Forel, Jean-Michel Constantin, Bruno Pereira, Sylvie Chevret

Association of epinephrine and outcome in cardiac arrest with refractory shockable rhythm: a population-based, propensity-score matched analysis

Lucie Fanet, François Javaudin, Florence Dumas, Frankie Beganton, Jean-Philippe Empana, Lionel Lamhaut, Daniel Jost, Eloi Marijon, Xavier Jouven, Alain Cariou, Wulfran Bougouin

Can we predict the future of respiratory failure prediction?

Alex K. Pearce, Shamim Nemati, Ewan C. Goligher, Catherine L. Hough, Andre L. Holder, Gabriel Wardi, Philip Yang, Aaron Boussina, Patrick G. Lyons, Sarina Sahetya, Atul Malhotra, Angela Rogers

The Landscape of lower respiratory tract herpesviruses in severe pneumonia patients: a multicenter, retrospective study with prospective validation

Fengqi Liu, Yiqi Zhuang, Xiaohan Huang, Laurent Papazian, Hongliu Cai, Huanzhang Shao, Qiong Chen, Chao Xie, Kankai Tang, KangChen Li, Mingqiang Wang, Yinghe Xu, Peng Shen, Qianqian Wang, Xuwei He, Nan Wang, Hongyu Wang, Muhua Dai, Yonghui Xiong, Lin Zhong, Yujie Pan, Lihong Chu, Bin Yang, Gensheng Zhang, Hua Zhou, Jinfu Xu, Chao Jiang, Lingtong Huang

The effects of extracorporeal blood purification (oXiris®) in patients with cardiogenic shock who require VA-ECMO (CLEAN ECMO): a prospective, open-label, randomized controlled pilot study

  • Open Access
  • ECMO
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Ryoung-Eun Ko, Ki Hong Choi, Kyungho Lee, Junseok Jeon, Hye Ryoun Jang, Chi Ryang Chung, Yang Hyun Cho, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Jeong Hoon Yang

Tocilizumab in improving the hemodynamics of septic children with vasoplegia shock

En‑Pei Lee, Jainn-Jim Lin, Shih‑Hsiang Chen, Han‑Ping Wu

Critical care illness in allogeneic hematopoietic stem-cell transplantation recipients with chronic graft versus host disease

Dara Chean, Romy Younan, Thibault Dupont, Emmanuel Canet, Anne-Sophie Moreau, Muriel Picard, Djamel Mokart, Laura Platon, Julien Mayaux, Florent Wallet, Nahema Issa, Jean-Herlé Raphalen, Frédéric Pène, Anne Renault, Régis Peffault de Latour, Naike Bigé, Elie Azoulay, Antoine Lafarge

Advanced serial analysis of the diaphragm surface EMG: insights into the effect of pressure support on the neuro-ventilatory response during the ICU stay

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R. S. P. Warnaar, A. D. Cornet, A. Beishuizen, D. W. Donker, E. Oppersma

Preoxygenation strategies for endotracheal intubation in resource-limited settings: reframing the basics

Dai Quang Huynh, Ngan Hoang Kim Trieu, Thao Thi Ngoc Pham

A prospective diagnostic study investigating urinary biomarkers of AKI in major abdominal surgery (the AKI-biomas study)

Rishabh Singh, William Maclean, Toolika Singh, Paul Mackenzie, Timothy Rockall, Lui G. Forni

Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP)

Simon Bodot, Alexandre Gros, Lisa Le Gall, Aurélie Martin, Chloé Gisbert-Mora, Jerome Pillot, Claire Ragot, Hubert Grand, Antoine Romen, Alexandre Masri, Antoine Dewitte, Didier Gruson, Renaud Prevel, Sebastien Rubin, Arthur Orieux, Alexandre Boyer

Co-existence of congestion and preload-dependence identified by pulse pressure respiratory variations: right ventricular afterload might be the key

David Bussy, Guillaume Deniel, Laurent Bitker, Jean-Christophe Richard

Cerebral autoregulation in traumatic brain injury: looking upwards

Paolo Gritti, Marco Bonfanti, Rosalia Zangari

Too severe to save? Association between the timing of decompressive craniectomy and mortality in pediatric traumatic brain injury using the German hospital database

Rayan Hojeij, Pia Brensing, Bernd Kowall, Andreas Stang, Michael Nonnemacher, Ursula Felderhoff-Müser, Philipp Dammann, Marcel Dudda, Christian Dohna-Schwake, Nora Bruns

The challenges of using ultrasound to measure the trachea: a brief report

  • Open Access
  • Brief Report

Helen Newman, Jodi Allen, Madan Narayanan, Nchafatso Obonyo, Nur Syahrunnizar, Karen Hammet, David Parry, Sarah Wallace, Anna-Liisa Sutt, Joseph Osterwalder, Daniel Martin

Missing the target in target trial emulation

Martin Urner, Eddy Fan

Serial proteomic and metabolomic profiling for early neuroprognostication after out-of-hospital cardiac arrest: a prospective observational study

  • Open Access
  • Correspondence

Xinyi Liu, Kai Lee Woo, Liyan Chen, Leroy Sivappiragasam Pakkiri, Rachel Liyu Lim, Marcus E.H. Ong, Federico Torta, Radoslaw M. Sobota, Hyungwon Choi, A. Mark Richards, Chester Lee Drum, Shir Lynn Lim

ICU capacity, ICU staffing, and postcardiotomy ECMO outcomes in China: a multilevel cross-sectional study

  • Open Access
  • ECMO
  • Research

Yehan Qiu, Xudong Ma, Zhe Li, Wei Cheng, Yujie Chen, Yanwen Fu, Longxiang Su, Xin Ding, Lu Wang, Jieqing Chen, Wei Pan, Huizhen Jiang, Ziyang Huang, Yaguang Li, Ting Shu, Xiang Zhou, Li Weng, Yan Chen, Shan Li, Jinmin Peng, Run Dong, Xiaoyun Hu, Wei Jiang, Chunyao Wang, Bin Du, Yongjun Liu, Yan Kang, Jing Yan, Erzhen Chen, Bin Xiong, Bingyu Qin, Kejian Qian, Wei Fang, Mingyan Zhao, Xiaochun Ma, Xiangyou Yu, Jiandong Lin, Yi Yang, Feng Shen, Shusheng Li, Lina Zhang, Weidong Wu, Meili Duan, Linjun Wan, Xiaojun Yang, Jian Liu, Zhen Wang, Lei Xu, Zhenjie Hu, Congshan Yang, Longxiang Su, Xiang Zhou

Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis

Yong Gao, Jianling Bai, Zhaohua Gu, Yudi Xie, Wenting An, Zhenyu Liu, Shaowen Tang, Xiao Lu

Improving the patency of the distal perfusion catheter in peripheral VA-ECMO

  • Open Access
  • ECMO
  • Correspondence

Pu Zhang, Le Xiao, Hanqing Li, Jinkun You, Chao Tian, Jing Ma, Xinbo Ding, Yanting Zhang

Indocyanine green clearance as a test of reserve function in the septic liver

Ying Xu, Yingying Hao, Ming Yan, Ning Liu, Chen Qu, Wenkui Yu

Respiratory effort monitoring: a novel, bedside, non-invasive, real-time method

Yinxia Lv, Meiling Dong, Haisong Song, Jinglei Liu, Zhiwen Huang, Zhong Ni, Zhen Wang, Xiaorong Jing, Xiaoyong Zhou, Yongfang Zhou, Yan Kang, Bo Wang

Vasopressin use across shock states: international insights from an international ESICM-endorsed survey: the PRESS Survey

Mathieu Jozwiak, Vladimir L. Cousin, Daniel De Backer, Manu L. N. G. Malbrain, Xavier Monnet, Antonio Messina, Michelle S. Chew

Prognostic value of brainstem auditory evoked potentials (BAEPs) and middle latency auditory evoked potentials (MLAEPs) in unconscious patients after cardiac arrest

Camélia Banana, Estelle Pruvost-Robieux, Wulfran Bougouin, Julie Lévi-Strauss, Camille Legouy, Martine Gavaret, Tarek Sharshar, Alain Cariou, Sarah Benghanem

Longitudinal analysis of lung microbiome, immune response, and metabolism in ventilator-associated pneumonia: a cohort study

Ingrid G. Bustos, Cristian C. Serrano-Mayorga, José L. Guerrero, Jennifer M. Baker, Christopher Brown, Nicole Falkowski, Piyush Ranjan, Alejandro Acosta-Gonzalez, Lina M. Mendez, Acenet Garcia-Cordoba, Adriana Echeverry-Gutierrez, Denis A. Bojaca, Marcela Chisica-Mahecha, Nicol Guarin-Tequia, Liliana Romero-Romero, Norberto Gonzalez-Juarbe, Alejandro Rodriguez, Mónica P. Cala, Ignacio Martin-Loeches, Sanjay H. Chotirmall, Robert P. Dickson, Luis F. Reyes

Limitations of SpO2-based oxygenation indices in ARDS and PARDS severity classification

George Briassoulis, Ioanna Choudetsanaki, Stavroula Ilia

Rezafungin: an opportunity to personalize the treatment of patients with candidemia

Patrick M. Honore, Oliver A. Cornely, Alex Soriano

Family presence policy and waiting room conditions in Japanese intensive care units: A multicentre questionnaire survey

Kasumi Shirasaki, Kaori Shimazu, Shinsuke Hashiuchi, Toru Hifumi, Masaki Okajima, Norio Otani

Reply to: Co-existence of congestion and preload-dependence identified by pulse pressure respiratory variations: right ventricular afterload might be the key

Felipe Muñoz, Cecilia González, Ricardo Castro, Philippe Rola, Glenn Hernández, Eduardo Kattan

Computed tomography (CT)-derived skeletal muscle mass and short and long-term mortality in critically ill patients

Yulan Meng, Xingjuan Jia, Zhenning Liu, Yang Zhao

Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study

Florian Reizine, Juliette Henry, Luc Desmedt, Christophe Camus, Valentin Coirier, François Arrive, Estelle Burban, Gabriel Eustache, Tony Belleville, Antoine Marc, Jolan Malherbe, Pierre Bouju, Paul Jaubert, Olivier Lesieur, Maxime Leclerc, Pierre Fillâtre, Aurélien Frérou, Renaud Prével, Nolwenn Mainguy, Hélène Guegan, Anne Cady, Laurence Delhaes, Sébastien Imbert, Florent Morio, Estelle Perraud, Solène Le Gal, Julie Bonhomme, Marc Pihet, Clarisse Dupin, Damien Du Cheyron, Yoann Launey, Cécile Aubron, Jean-Pierre Gangneux

Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges

Denise Battaglini, Marcus J. Schultz, Gustavo A. Cortes Puentes, John J. Marini, Patricia R. M. Rocco

What should be done with PEEP during weaning from mechanical ventilation?

Wei Song, Caibao Hu

Prehospital thrombolytic treatment of high-risk acute pulmonary embolism

  • Open Access
  • ECMO
  • Correspondence

Hugo Lanz, Leonhard Binzenhöfer, Tom Verbelen, Andrea Stadlbauer, Daniele Camboni, Sebastian Zimmer, Georg Nickenig, Holger Thiele, Enzo Lüsebrink, Federico Pappalardo, Frederic De Roeck, Christiaan Vrints, Aitor Uribarri, Jorge Moisés, Manel Sabate, Jeisson Osorio, Luis Chiscano-Camón, Jordi Riera, Carsten Skurk, Hannah Billig, Christoph Adler, Tobias Tichelbäcker, Peter M. Spieth, Lisa Crusius, Norman Mangner, Christian Jung, Dirk Westermann, Esther Tautz, Alexander Supady, Kirsten Krüger, Karl Toischer, Aschraf El-Essawi, Daniel Hoyer, Jörn Tongers, Jochen Dutzmann, Andreas Schäfer, Mostafa Salem, Derk Frank, Marvin Kriz, Benedikt Schrage, Benedikt Beer, Franz Haertel, Sven Möbius-Winkler, Nicolas Majunke, Tom Adriaenssens, Andreas Verstraete, Tomaz Goslar, Marko Noc, Tobias Graf, Ingo Eitel, Maike Knorr, Clemens Scherer, Laura Villegas Sierra, Nils Gade, Daniel Roden, Inas Saleh, Sabine Hoffmann, Michael Schomaker, Julia Höpler, Marie Kraft, Sebastian Kufner, Karsten Hug, Christian Hagl, Sven Peterss, Nikolaus Kneidinger, Carsten Hullermann, Jan Sackarnd, Alain Combes, Guido Tavazzi, Christof Schmid, Elizabete Terauda, Andrejs Erglis, Evija Camane, Santa Strazdina, Līga Vīduša, Oliver Borst, Helene Häberle, Walter S. Speidl, Robert Zilberszac, Robert H. G. Schwinger, Silvia Klinger, Antonia Wechsler

Effects of different respiratory training methods on respiratory function in patients with spinal cord injury: a network meta-analysis of randomized controlled trials

Jun Chen, Tianyu Chen, Xia Wang, Xin Tang, Shunyan Yang, Kaiyue Lyu, Fei Li, Jishu Xian, Binbin Tan, Yujie Chen

Self-extubation in critically ill patients: from the French OUTCOMEREA Network

Léa Trenchat, Louis-Marie Galerneau, Stéphane Ruckly, Florian Sigaud, Nicolas Terzi, Maité Garrouste, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Anaïs Dartevel, Claire Dupuis, Jean-Marie Forel, Julien Dessajan, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent, Laurent Argaud, Jean Reignier, Guillaume Dumas, Michael Darmon, Jean-François Timsit, Elie Azoulay, Maïté Garrouste-Orgeas, Jean-Ralph Zahar, Bruno Mourvillier, Niccolo Buetti, Corinne Alberti, Stephane Ruckly, Sébastien Bailly, Aurélien Vannieuwenhuyze, Carole Agasse, Bernard Allaouchiche, Olivier Andremont, Pascal Andreu, Elie Azoulay, Francois Barbier, Jean-Pierre Bedos, Jérome Bedel, Asael Berger, Julien Bohé, Lila Bouadma, Jeremy Bourenne, Noel Brule, Frank Chemouni, Julien Carvelli, Martin Cour, Anais Dartevelle, Etienne de Montmollin, Marc Doman, Loa Dopeux, Anne-Sylvie Dumenil, Jean-Marc Forel, Charlotte Garret, Steven Grangé, Antoine Gros, Hédia Hammed, Akim Haouache, Tarik Hissem, Sébastien Jochmans, Jean-Baptiste Joffredo, Hatem Kallel, Guillaume Lacave, Alexandre Lautrette, Clément Le bihan, Virgine Lemiale, David Luis, Jordane Lebut, Bruno Mourvillier, Benoît Misset, Bruno Mourvillier, Mathild Neuville, Laurent Nicolet, Laurent Papazian, Juliette Patrier, Benjamin Planquette, Aguila Radjou, Romain Sonneville, Bertrand Souweine, Carole Schwebel, Romain Sonneville, Michael thy, Gilles Troché, Fabrice Thiollieres, Guillaume Thierry, Michael Thy, Guillaume Van Der Meersch, Marion Venot, Florent Wallet, Sondes Yaacoubi, Olivier Zambon, Jonathan Zarka, Kévin grapin, Francois thouy, Laure Calvet, kevin Grapin, guillaume laurichesse, Neven STEVIC, Mireille Adda, Clémence Barberot, Vanessa Vindrieux, Marion Provent, Pauline Enguerrand, Vincent Gobert, Stéphane Guessens, Helene Merle, Nadira Kaddour, Boris Berthe, Samir Bekkhouche, Kaouttar Mellouk, Mélaine Lebrazic, Carole Ouisse, Diane Maugars, Christelle Aparicio, Igor Theodose, Manal Nouacer, Veronique Deiler, Fariza Nait Sidenas, Myriam Moussa, Atika Mouaci, Nassima Viguier

Liberation from continuous renal replacement therapy due to renal recovery in adults and children: a literature review and Delphi consensus on clinical practice

  • Open Access
  • Consensus Article

Rupesh Raina, Kianoush Kashani, Sidharth Kumar Sethi, Quen Mok, Aadil Kakajiwala, Samir M. Parikh, Kush Doshi, Jieji Hu, Khalid Alhasan, Marcelo de Sousa Tavares, Hui Kim Yap, Arwa Nada, Timothy Bunchman, Javier A. Neyra, Samuel A. Silver, Ashita Tolwani

Estimating bias from withdrawal of life sustaining treatment in clinical trials

  • Open Access
  • Perspective

Clifton W. Callaway, Jonathan Elmer, Peter J. Kudenchuk, Masashi Okubo

Driving pressure vs. oxygenation-based PEEP titration strategies in ARDS patients: a physiological study

Silvia Coppola, Giulia Catozzi, Tommaso Pozzi, Alessandro Monte, Geraldina Besana, Laura Depedri, Davide Chiumello

Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22

Maurizio Cecconi, Massimiliano Greco, Benjamin Shickel, Derek C. Angus, Heatherlee Bailey, Elena Bignami, Thierry Calandra, Leo Anthony Celi, Sharon Einav, Paul Elbers, Ari Ercole, Hernando Gómez, Michelle Ng Gong, Matthieu Komorowski, Vincent Liu, Soojin Park, Aarti Sarwal, Christopher W. Seymour, Fernando G. Zampieri, Fabio Silvio Taccone, Jean-Louis Vincent, Azra Bihorac

Comment on the CIBCD model for chronic critical illness

  • Open Access
  • Matters Arising

Valery V. Likhvantsev, Mikhail Ya. Yadgarov, Alexey A. Yakovlev, Levan B. Berikashvili

Association of early in-hospital endotracheal intubation with clinical outcomes in patients with traumatic coma: a multicenter observational study

  • Open Access
  • Research

Keita Shibahashi, Ken Inoue, Taichi Kato, Kazuhiro Sugiyama

Hemodynamic coherence: a metabolic perspective

  • Open Access
  • Comment

Guillem Gruartmoner, Jaume Mesquida

Early prediction of post-intensive care syndrome in patients at general wards: development of a user-friendly screening tool

Stijn Blot, Farshid Rahimi-Bashar, Abbas Samim, Keivan Goharimoghadam, Amir Vahedian-Azimi

Application progress of machine learning in patient-ventilator asynchrony during mechanical ventilation: a systematic review

Guanxu Jiang, Jiawei Ma, Hao Xu, Zigang Zhu, Yi Xie, Shenhui Ji, Tao Yan, Liang Luo

Beyond survival: the societal value of extracorporeal cardiopulmonary resuscitation

Sasa Rajsic, Benedikt Treml, Robert Breitkopf

Effects of dapagliflozin on urinary output, fluid balance, and biochemistry in critically ill patients: a post-hoc secondary analysis of the DEFENDER trial

  • Open Access
  • Research

Fernando G. Zampieri, Luciano C. P. Azevedo, Ary Serpa Neto, Álvaro Rea-Neto, Paula G. David-João, Cristina P. Amendola, Amanda C. Kozesinski-Nakatani, Thiago C. Filiponi, Guacyra M. B. Almeida, Ricardo R. Bergo, Rodrigo C. Figueiredo, Clewer J. Schuler, Glauco A. Westphal, Rodrigo S. Biondi, Adriano J. Pereira, Thiago D. Correa, Otavio Berwanger, Sean M. Bagshaw, Rinaldo Bellomo, Caio A. M. Tavares

Epidemiology, outcomes, and factors associated with mortality in pediatric acute respiratory distress syndrome in hospitalized Thai children: a nationwide retrospective analysis, 2015–2022

  • Open Access
  • Research

Rattapon Uppala, Phanthila Sitthikarnkha, Leelawadee Techasatian, Suchaorn Saengnipanthkul, Pope Kosalaraksa, Kaewjai Thepsuthammarat, Sirapoom Niamsanit

Mar 25
Issue: Special Issue 1/2025
44th International Symposium on Intensive Care & Emergency Medicine

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