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Internal and Emergency Medicine

29-01-2025 | COVID-19 | THE CUTTING EDGE: RESEARCH UPDATE

Optimizing oxygen targets in COVID-19: cutting-edge insights from the HOT-COVID trial

Authors: Stefania Capuccio, Martina Carosi, Francesca La Rocca, Leonardo Antonio Natola, Caterina Savrié, on behalf of The School of Research Methodology of the Italian Society of Internal Medicine

Published in: Internal and Emergency Medicine

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Excerpt

Hypoxemic respiratory failure caused by COVID-19 pneumonia might require high supplemental oxygen and ICU admission. Many studies have been conducted on the target oxygen saturation in critically ill COVID-19 patients. Most of them focused on invasively ventilated patients, while few addressed non-intubated patients [1]. One study, the HOT-ICU trial, investigated the management of oxygen therapy by comparing the effects of targeting different oxygenation levels (PaO2 of 60 mmHg vs 90 mmHg) in critically ill patients. However, its post hoc analysis did not reveal statistically significant differences in the primary outcome: the number of days alive without life support [2, 3]. …
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Pisciotta W, Passannante A, Arina P, Alotaibi K, Ambler G, Arulkumaran N (2024) High-flow nasal oxygen versus conventional oxygen therapy and noninvasive ventilation in COVID-19 respiratory failure: a systematic review and network meta-analysis of randomised controlled trials. Br J Anaesth 132(5):936–944CrossRefPubMedPubMedCentral
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Schjørring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Siegemund M, Bäcklund M, Keus F, Laake JH, Morgan M, Thormar KM, Rosborg SA, Bisgaard J, Erntgaard AES, Lynnerup AH, Pedersen RL, Crescioli E, Gielstrup TC, Behzadi MT, Poulsen LM, Estrup S, Laigaard JP, Andersen C, Mortensen CB, Brand BA, White J, Jarnvig IL, Møller MH, Quist L, Bestle MH, Schønemann-Lund M, Kamper MK, Hindborg M, Hollinger A, Gebhard CE, Zellweger N, Meyhoff CS, Hjort M, Bech LK, Grøfte T, Bundgaard H, Østergaard LHM, Thyø MA, Hildebrandt T, Uslu B, Sølling CG, Møller-Nielsen N, Brøchner AC, Borup M, Okkonen M, Dieperink W, Pedersen UG, Andreasen AS, Buus L, Aslam TN, Winding RR, Schefold JC, Thorup SB, Iversen SA, Engstrøm J, Kjær MN, Rasmussen BS, HOT-ICU Investigators (2021) Lower or higher oxygenation targets for acute hypoxemic respiratory failure. N Engl J Med. 384(14):1301–1311. https://​doi.​org/​10.​1056/​NEJMoa2032510. (Epub 2021 Jan 20. PMID: 33471452)CrossRefPubMed
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Rasmussen BS, Klitgaard TL, Perner A, Brand BA, Hildebrandt T, Siegemund M, Hollinger A, Aagaard SR, Bestle MH, Marcussen KV, Brøchner AC, Sølling CG, Poulsen LM, Laake JH, Aslam TN, Bäcklund M, Okkonen M, Morgan M, Sharman M, Lange T, Wetterslev J, Schjørring OL (2022) Oxygenation targets in ICU patients with COVID-19: A post hoc subgroup analysis of the HOT-ICU trial. Acta Anaesthesiol Scand. 66(1):76–84. https://​doi.​org/​10.​1111/​aas.​13977. (Epub 2021 Sep 20. PMID: 34425016; PMCID: PMC8653379)CrossRefPubMed
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Metadata
Title
Optimizing oxygen targets in COVID-19: cutting-edge insights from the HOT-COVID trial
Authors
Stefania Capuccio
Martina Carosi
Francesca La Rocca
Leonardo Antonio Natola
Caterina Savrié
on behalf of The School of Research Methodology of the Italian Society of Internal Medicine
Publication date
29-01-2025
Publisher
Springer International Publishing
Published in
Internal and Emergency Medicine
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-025-03875-w

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