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Cardiovascular Diabetology
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Open Access 15-09-2024 | Coronary Heart Disease | Review

MicroRNAs in diabetic macroangiopathy

Authors: Guocheng Rao, Boqiang Peng, Guixiang Zhang, Xianghui Fu, Jingyan Tian, Yan Tian

Published in: Cardiovascular Diabetology | Issue 1/2024

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Abstract

Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy. In this review, we will describe the biogenesis of miRNAs, and summarize their functions in diabetic macroangiopathy, including atherosclerosis, peripheral artery disease, coronary artery disease, and cerebrovascular disease, which are anticipated to provide new insights into future perspectives of miRNAs in basic, translational and clinical research, ultimately advancing the diagnosis, prevention, and treatment of diabetic macroangiopathy.
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Metadata
Title
MicroRNAs in diabetic macroangiopathy
Authors
Guocheng Rao
Boqiang Peng
Guixiang Zhang
Xianghui Fu
Jingyan Tian
Yan Tian
Publication date
15-09-2024
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2024
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-024-02405-w

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