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08-06-2024 | Urology – Review

Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis

Authors: Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov

Published in: International Urology and Nephrology

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Abstract

Context

Contrast-enhanced ultrasound (CEUS) is a cost-effective radiation-free diagnostic method that can be used for renal tumor postoperative visualization after ablative treatment.

Objective

To assess CEUS diagnostic accuracy comparing with CT and MRI as a follow-up method in short-term and long-term postoperative periods after renal tumor ablation.

Materials and methods

A systematic review and meta-analysis were performed in Scopus and Medline databases using the query “(kidney OR rena* OR RCC) AND (ablation OR RFA OR MWA OR cryo*) AND CEUS”. The endpoint of the study was the evaluation of the overall accuracy of CEUS.

Results

Twelve trials were included in the review. With CT or MRI as a reference, for a short-term group (< 6 weeks after ablation) pooled sensitivity was 90.2%, I2 = 0%; pooled specificity was 99.3%, I2 = 0%; pooled NPV was 98.6%, I2 = 0%; pooled PPV was 94.6%, I2 = 0%; the AUC on the SROC curve was 0.971. For the long-term group (> 6 weeks after ablation), pooled sensitivity was 95.3%, I2 = 0%; pooled specificity was 97.6%, I2 = 0%; PPV was 74.2%, I2 = 4%; NPV was 99.4%, I2 = 5%; AUC = 0.93.

Conclusion

CEUS has high sensitivity and specificity in ruling out the presence of local recurrence after renal tumor ablation with a higher risk of false-positive results within follow-up > 6 weeks compared with that for CT or MRI. Further studies with a unified protocol and morphological control of local renal tumor recurrence after ablation are needed.
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Metadata
Title
Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis
Authors
Stanislav Vovdenko
Stanislav Ali
Hussein Ali
Mark Taratkin
Andrey Morozov
Aleksandr Suvorov
Diana Khabib
Leonid Rapoport
Evgeny Bezrukov
Publication date
08-06-2024
Publisher
Springer Netherlands
Published in
International Urology and Nephrology
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-024-04102-9
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