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08-06-2024 | Pediatric Infectious Diseases (I Brook and Y Shachor, Section Editors)

Contemporary Management of Pediatric Invasive Fungal Rhinosinusitis

Authors: Sheng Zhou, Alison Yu, Ethan Frank, Bastien A. Valencia-Sanchez, Sonja Chen, Sean P. Polster, Vijay A. Patel

Published in: Current Infectious Disease Reports

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Abstract

Purpose of Review

Pediatric invasive fungal sinusitis is a devasting disease that classically affects pediatric hematology/oncology patients. It necessitates early intervention and is plagued by a high mortality rate. This work investigates current evidence behind the diagnosis, management, and outcomes for this particular disease in addition to areas of emerging treatment paradigms.

Recent Findings

There is a paucity of concrete clinical guidelines for children regarding the diagnosis and treatment of pediatric invasive fungal rhinosinusitis given its relative rarity. Critical concepts of utmost importance include a high index of suspicion with a low threshold to obtain radiographic imaging and laboratory studies to clinch the diagnosis. Aggressive surgical management remains the cornerstone of treatment in conjunction with antifungal therapy. Recent breakthroughs include drug delivery methods, utilization of cell-free DNA (deoxyribunocleic acid) as a novel diagnostic tool, and emerging antimicrobials.

Summary

New treatment paradigms for pediatric invasive fungal sinusitis include a shift towards early diagnosis and targeted antifungal therapy. There is an urgent need for the development of standardized clinical guidelines regarding the diagnosis, treatment, and long-term surveillance of pediatric patients with invasive fungal rhinosinusitis.
Appendix
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Metadata
Title
Contemporary Management of Pediatric Invasive Fungal Rhinosinusitis
Authors
Sheng Zhou
Alison Yu
Ethan Frank
Bastien A. Valencia-Sanchez
Sonja Chen
Sean P. Polster
Vijay A. Patel
Publication date
08-06-2024
Publisher
Springer US
Published in
Current Infectious Disease Reports
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-024-00844-w
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