Journal of Cardiovascular Translational Research

Open Access 14-04-2025 | Review

Connecting the Dots: Stress Granule and Cardiovascular Diseases

Authors: Gaowei Yang, Yiming Wang, Junfang Guo, Tao Rui

Published in: Journal of Cardiovascular Translational Research

Abstract

Stress granules (SGs) are membrane-less cytoplasmic assemblies composed of mRNAs and RNA-binding proteins (RBPs) that transiently form to cope with various cellular stressors by halting mRNA translation and, consequently, protein synthesis. SG formation plays a crucial role in regulating multiple cellular processes, including cellular senescence, inflammatory responses, and adaptation to oxidative stress under both physiological and pathological conditions. Dysregulation of SG assembly and disassembly has been implicated in the pathogenesis of various diseases, including cardiovascular diseases (CVDs), cancer, viral and bacterial infections, and degenerative diseases. In this review, we survey the key aspects of SGs biogenesis and biological functions, with a particular focus on their causal involvement in CVDs. Furthermore, we summarized several SG-modulating compounds and discussed the therapeutic potential of small molecules targeting SG-related diseases in clinical settings.

Graphical Abstract

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Title: Connecting the Dots: Stress Granule and Cardiovascular Diseases
Authors: Gaowei Yang
Yiming Wang
Junfang Guo
Tao Rui
Publication date: 14-04-2025
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-025-10619-w

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Electrocardiography
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Improve your ECG interpretation skills with this comprehensive, rapid, interactive course. Expert advice provides detailed feedback as you work through 50 ECGs covering the most common cardiac presentations to ensure your practice stays up to date.

PD Dr. Carsten W. Israel

Developed by: Springer Medizin

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Navigating neuroimaging in Alzheimer disease care

Springer Medicine

Abstract

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