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Open Access 03-01-2024 | Computer Aided Design | Head and Neck

Computer-aided designed 3D-printed polymeric scaffolds for personalized reconstruction of maxillary and mandibular defects: a proof-of-concept study

Authors: Davide Mattavelli, Vincenzo Verzeletti, Alberto Deganello, Antonio Fiorentino, Tommaso Gualtieri, Marco Ferrari, Stefano Taboni, William Anfuso, Marco Ravanelli, Vittorio Rampinelli, Alberto Grammatica, Barbara Buffoli, Roberto Maroldi, Ceretti Elisabetta, Rita Rezzani, Piero Nicolai, Cesare Piazza

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2024

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Abstract

Purpose

To investigate the potential reconstruction of complex maxillofacial defects using computer-aided design 3D-printed polymeric scaffolds by defining the production process, simulating the surgical procedure, and explore the feasibility and reproducibility of the whole algorithm.

Methods

This a preclinical study to investigate feasibility, reproducibility and efficacy of the reconstruction algorithm proposed. It encompassed 3 phases: (1) scaffold production (CAD and 3D-printing in polylactic acid); (2) surgical simulation on cadaver heads (navigation-guided osteotomies and scaffold fixation); (3) assessment of reconstruction (bone and occlusal morphological conformance, symmetry, and mechanical stress tests).

Results

Six cadaver heads were dissected. Six types of defects (3 mandibular and 3 maxillary) with different degree of complexity were tested. In all case the reconstruction algorithm could be successfully completed. Bone morphological conformance was optimal while the occlusal one was slightly higher. Mechanical stress tests were good (mean value, 318.6 and 286.4 N for maxillary and mandibular defects, respectively).

Conclusions

Our reconstructive algorithm was feasible and reproducible in a preclinical setting. Functional and aesthetic outcomes were satisfactory independently of the complexity of the defect.
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Metadata
Title
Computer-aided designed 3D-printed polymeric scaffolds for personalized reconstruction of maxillary and mandibular defects: a proof-of-concept study
Authors
Davide Mattavelli
Vincenzo Verzeletti
Alberto Deganello
Antonio Fiorentino
Tommaso Gualtieri
Marco Ferrari
Stefano Taboni
William Anfuso
Marco Ravanelli
Vittorio Rampinelli
Alberto Grammatica
Barbara Buffoli
Roberto Maroldi
Ceretti Elisabetta
Rita Rezzani
Piero Nicolai
Cesare Piazza
Publication date
03-01-2024
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 3/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-023-08392-0