Longitudinal change in thigh muscle cross-sectional area in association with hospitalization among patients undergoing hemodialysis: the Osaka Dialysis Complication Study (ODCS)
- 01-12-2025
- Computed Tomography
- Original article
Published in:
- Authors
- Shota Matsufuji
- Tetsuo Shoji
- Suhye Lee
- Yoshihiro Tsujimoto
- Shinya Nakatani
- Tomoaki Morioka
- Katsuhito Mori
- Masanori Emoto
- Published in
- Clinical and Experimental Nephrology | Issue 3/2026
Abstract
Background
Patients undergoing hemodialysis have decreased skeletal muscle mass which is associated with higher mortality and lower physical functioning. Since these patients frequently experience hospitalizations, we hypothesized that hospital admissions could be a cause of loss of skeletal muscle mass.
Methods
This was a longitudinal observational study among patients on hemodialysis (N = 132). The outcome was the change in thigh muscle cross-sectional area (TMCSA) measured by computed tomography and standardized by squared height (cm2/m2) per year. The exposures were the presence or absence of hospital admissions, the total number of hospital admissions (times), and the total length of hospital stays (nights) between the TMCSA measurements. Association was analyzed by multivariable-adjusted linear regression analysis.
Results
During a median follow-up period of 3.95 years, 104 patients were hospitalized (hospitalization group), whereas 28 patients were not (non-hospitalization group). Both groups showed a significant decrease in TMCSA, and it was more rapid in the hospitalization group than the non-hospitalization group (P = 0.023). Multivariable-adjusted linear regression analysis showed that the total number of hospital admissions and the total length of hospital stays were the independent factors associated with the decrease in TMCSA.
Conclusion
This study showed for the first time that hospital admissions were independently associated with the longitudinal decrease in TMCSA in patients undergoing hemodialysis.
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- Title
- Longitudinal change in thigh muscle cross-sectional area in association with hospitalization among patients undergoing hemodialysis: the Osaka Dialysis Complication Study (ODCS)
- Authors
-
Shota Matsufuji
Tetsuo Shoji
Suhye Lee
Yoshihiro Tsujimoto
Shinya Nakatani
Tomoaki Morioka
Katsuhito Mori
Masanori Emoto
- Publication date
- 01-12-2025
- Publisher
- Springer Nature Singapore
- Keywords
-
Computed Tomography
Computed Tomography - Published in
-
Clinical and Experimental Nephrology / Issue 3/2026
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799 - DOI
- https://doi.org/10.1007/s10157-025-02797-3
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