Skip to main content
Top
Published in: Journal of Cardiothoracic Surgery 1/2024

Open Access 01-12-2024 | Computed Tomography | Research

Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography

Authors: Yuwei Zhou, Xiaoqing Cao, Haiyong Gu, Shenhu Gao, Yuxuan Wu, Haoyang Li, Bing Xiong, Haiyang Dong, Yan Lv, Rong Yang, Yihe Wu

Published in: Journal of Cardiothoracic Surgery | Issue 1/2024

Login to get access

Abstract

Background

The widespread utilization of chest High-resolution Computed Tomography (HRCT) has prompted detection of pulmonary ground-glass nodules (GGNs) in otherwise asymptomatic individuals. We aimed to establish a simple clinical risk score model for assessing GGNs based on HRCT.

Methods

We retrospectively analyzed 574 GGNs in 574 patients undergoing HOOK-WIRE puncture and pulmonary nodule surgery from January 2014 to November 2018. Clinical characteristics and imaging features of the GGNs were assessed. We analyzed the differences between malignant and benign nodules using binary logistic regression analysis and constructed a simple risk score model, the VBV Score, for predicting the malignancy status of GGNs. Then, we validated this model via other 1200 GGNs in 1041 patients collected from three independent clinical centers in 2022.

Results

For the exploratory phase of this study, out of the 574 GGNs, 481 were malignant and 93 were benign. Vacuole sign, air bronchogram, and intra-nodular vessel sign were important indicators of malignancy in GGNs. Then, we derived a VBV Score = vacuole sign + air bronchogram + intra-nodular vessel sign, to predict the malignancy of GGNs, with a sensitivity, specificity, and accuracy of 95.6%, 80.6%, and 93.2%, respectively. We also validated it on other 1200 GGNs, with a sensitivity, specificity, and accuracy of 96.0%, 82.6%, and 95.0%, respectively.

Conclusions

Vacuole sign, air bronchogram, and intra-nodular vessel sign were important indicators of malignancy in GGNs. VBV Score showed good sensitivity, specificity, and accuracy for differentiating benign and malignant pulmonary GGNs.
Appendix
Available only for authorised users
Literature
15.
go back to reference Organisation mondiale de la santé., Centre international de recherche sur le cancer, eds. Thoracic Tumours. 5th ed. International agency for research on cancer; 2021. Organisation mondiale de la santé., Centre international de recherche sur le cancer, eds. Thoracic Tumours. 5th ed. International agency for research on cancer; 2021.
Metadata
Title
Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography
Authors
Yuwei Zhou
Xiaoqing Cao
Haiyong Gu
Shenhu Gao
Yuxuan Wu
Haoyang Li
Bing Xiong
Haiyang Dong
Yan Lv
Rong Yang
Yihe Wu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2024
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-024-02487-3

Other articles of this Issue 1/2024

Journal of Cardiothoracic Surgery 1/2024 Go to the issue