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Highlights of the Day: Gastrointestinal cancer—colorectal and anal

Dr. Christine Parseghian discusses important colorectal cancer research presented at ASCO 2025, focussing on studies that are using precision oncology to drive change in the first-line metastatic setting, such as BREAKWATER.

More from the 2025 ASCO Annual Meeting

CAR T-cell therapy boosts PFS for advanced gastric cancer

Second-line trastuzumab deruxtecan outperforms ramucirumab plus paclitaxel in gastric cancer

Highlights of the Day: Gastrointestinal cancer—gastroesophageal, pancreatic, and hepatobiliary

Durvalumab plus FLOT climbs to success in gastric cancer

Highlights of the Day: Gastrointestinal cancer—colorectal and anal

Highlights of the Day: Breast cancer—metastatic

Encorafenib, cetuximab combination plus chemo boosts survival in colorectal cancer

Camizestrant switch improves PFS in advanced breast cancer

PROTAC therapy vepdegestrant prolongs breast cancer PFS

Dose adjustments of lorlatinib enable long-term treatment

Timing of immunotherapy administration affects oncologic outcome

Improved outcomes with perioperative pembrolizumab in HNSCC

First-line sacituzumab plus pembrolizumab supported for advanced TNBC

AI improves assessment of HER2-expressing breast cancer

Image Credits
Highlights of the Day I: Gastrointestinal Cancer—Colorectal and Anal/© 2025 American Society of Clinical Oncology, all rights reserved., Highlights of the Day I: Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary/© 2025 American Society of Clinical Oncology, all rights reserved., Highlights of the Day II: Breast Cancer—Metastatic/© 2025 American Society of Clinical Oncology, all rights reserved.